Mitochondrial respiration is the predominant source of ATP. Excessive rates of electron transport cause a higher production of harmful reactive oxygen species (ROS). There are two regulatory mechanisms known. The first, according to Mitchel, is dependent on the mitochondrial membrane potential that drives ATP synthase for ATP production, and the second, the Kadenbach mechanism, is focussed on the binding of ATP to Cytochrome c Oxidase (CytOx) at high ATP/ADP ratios, which results in an allosteric conformational change to CytOx, causing inhibition. (...) In times of stress, ATP‐dependent inhibition is switched off and the activity of CytOx is exclusively determined by the membrane potential, leading to an increase in ROS production. The second mechanism for respiratory control depends on the quantity of electron transfer to the Heme aa3 of CytOx. When ATP is bound to CytOx the enzyme is inhibited, and ROS formation is decreased, although the mitochondrial membrane potential is increased. (shrink)

Representations are not only used in our folk-psychological explanations of behaviour, but are also fruitfully postulated, for example, in cognitive science. The mainstream view in cognitive science maintains that our mind is a representational system. This popular view requires an understanding of the nature of the entities they are postulating. Teleosemantic theories face this challenge, unpacking the normativity in the relation of representation by appealing to the teleological function of the representing state. It has been argued that, if intentionality is (...) to be explained in teleological terms, then the function of a state cannot depend on its phylogenetical history, given the metaphysical possibility of a duplicate of an intentional being that lacks an evolutionary history. In this paper, I present a method to produce, according to our current knowledge in genetic engineering, human-like individuals who are not the product of natural selection in the required sense. This variation will be used to shed light on the main replies that have been offered in the literature to the Swampman thought experiment. I argue that these replies are not satisfactory: representations should better not depend on natural selection. I conclude that a non-etiological notion of function is to be preferred for characterizing the relation of representation. (shrink)

Sebastian Luft presents and defends the philosophy of culture championed by the Marburg School of Neo-Kantianism. Following a historical trajectory from Hermann Cohen to Paul Natorp and through to Ernst Cassirer, this book makes a systematic case for the viability and attractiveness of a philosophical culture in a transcendental vein, in the manner in which the Marburgers intended to broaden Kant's approach.

The article discusses the link between freedom, crime and punishment. According to some theorists, crime does not only cause a person to have less freedom; it constitutes, _in and of itself_, a breach of the freedom of others. Punishment does not only cause people to have more freedom, for instance by preventing crimes; it constitutes, _in and of itself_, respect for mutual freedom. If the latter claims are true, crime and punishment must have certain _meanings_ that make them denials/affirmations of (...) freedom irrespective of their consequences. My aim is to show that such an immanent connection between crime/punishment and freedom exists. I do so by explicating the “natural meaning” of crime and punishment. This way of addressing the topic is inspired by Jean Hampton’s use of H. P. Grice’s concept of natural meaning. Expanding on Hampton’s theory, drawing on both H. L. A. Hart and Kant, I argue that crime has the natural meaning of denying freedom, and punishment has the natural meaning of affirming freedom. The paper presents an ideal theory, not a justification for actual criminal justice practices, which in most countries unfortunately fail to instantiate the value of mutual freedom. (shrink)

Reseña del libro Filología, creación y vida: Alfonso Reyes y los estudios literarios, de Sergio Ugalde Quintana,profesor investigador de El Colegio de México.

The following discussion with philosopher and political theorist Wendy Brown revisits some of the arguments of her latest book, Nihilistic Times, in the light of her larger diagnosis presented in Undoing the Demos and In the Ruins of Neoliberalism. Thinking with and against Max Weber, Wendy Brown guides us through and to ways of doing politics and conducting scholarship capable of informing world-making practices that face up to the challenges of a nihilistic world. Picking up on some topics from a (...) previous interview, the larger questions guiding those of this interview were how to redo the demos and how to remake our world democratically. We would like to thank Wendy Brown for the generous contribution of her time. (shrink)

How do we truly live well? Can philosophy actually tell us how to be happy? Constantly under attack in today's day and age, the Church's philosophy of what it means to be human and how to act serves as the logical consequence and culmination of all the truths of her theology and holy religion. But if we do not understand why we should act well according to the light of natural reason, it will be all the more difficult to explain (...) why we should act in a certain way according to the light of supernatural revelation. In short, the Church's philosophical system of ethics may well be the most important thing to learn today and so forms the culmination of our Foundations of Wisdom series. Ethics covers the teachings of Aristotle and St. Thomas Aquinas, showing how living a life according to the Church's perennial philosophy not only is not contrary to reason, but also leads to the culmination of what reason was made for: the perfection of the human person, serving as a vehicle for beatitude. In this fourth and final volume of The Foundations of Wisdom, you will understand the Church's teaching that the human person should act according to the light of natural reason by delving into the teachings of St. Thomas and seeing how natural reason harmonizes with the ethics of Holy Mother Church. Deepen your understanding of our very selves, learning how God made us to come to know Him and see His mark in every aspect of creation. Finally, understand the journey to happiness that God through His Church has provided for us to reach our ultimate end: eternal beatitude by union with God. (shrink)

The origin and the development of scientific disciplines has been a topic of reflection for several decades. The few extensive case studies support the thesis that scientific disciplines are not monolithic structures but can be characterized by distinct social, organizational and scientific–technical practices. Nonetheless, most disciplinary histories of genetics confine themselves largely to an uncontested account of the content of the discipline or occasionally institutional factors. Little attention is paid to the large number of researchers who, by their joint efforts, (...) ultimately shaped the discipline. We contribute to this aspect of disciplinary historiography by discussing the role of women researchers at the Institute for Heredity Research, founded in 1914 in Berlin under the directorship of Erwin Baur, and the sister of the John Innes Institute at Cambridge. This paper investigates how and why Baur built a highly successful research programme that relied on the efforts of his female staff, whose careers, notably Elisabeth Schiemann's, are also assessedin toto. These women undertook the necessary ‘technoscience’ and in some cases innovative work and helped increase the prestige of the institute and its director. Together they played a pivotal role in the establishment of genetics in Germany. Without them the discipline would have developed much more slowly and along a divergent path. (shrink)

Epistemologists increasingly seek inspiration from ethics. Concepts such as reasons, responsibility, excuses, vices, and injustice are regularly borrowed and transposed into the epistemic domain for various theoretical (and often practical) purposes. It is seldom discussed whether it is legitimate to extend specific ethical concepts into epistemology. Cameron Boult’s book is a notable exception. The author displays a high sensitivity to skeptical worries about whether there is such a thing as a distinctively epistemic kind of blame. In the book’s preface, Boult (...) admits to having been an epistemic blame skeptic himself. However, after years of engaging with the philosophical community on this issue, he came to think that epistemic blame gives rise to a puzzle. This puzzle motivates his rigorous but also highly ambitious and interesting treatment of the topic. The book ultimately supports the view that blame and interpersonal relationships should be central to many aspects of epistemological theorizing. Boult thereby pleads for a fundamentally social picture of our epistemic lives. (shrink)

After introducing the concept of compressed sensing as a complementary measurement mode to the classical Shannon-Nyquist approach, I discuss some of the drivers, potential challenges and obstacles to its implementation. I end with a speculative attempt to embed compressed sensing as an enabling methodology within the emergence of data-driven discovery. As a consequence I predict the growth of non-nomological sciences where heuristic correlations will find applications but often bypass conventional pure basic and use-inspired basic research stages due to the lack (...) of verifiable hypotheses. (shrink)

In this article, I deal with the phenomenon, known to today’s philosophers, as the split between analytic and continental philosophy. I provide a historical-institutional explanation for this split and then a propose a type of doing philosophy beyond the divide, which I call “synthetic philosophy.” Synthetic philosophy should take and synthesize the best of both traditions into a new form of philosophy, which I recommend for the future.

The role of speed in innovations needs to be explored more thoroughly. I advocate here that for innovations which rely on scarce materials, research into more abundant substitutes needs to be accelerated while a regulatory-driven extension of the product life should slow down the number of incremental innovations and reduce our overall footprint on scarce resources. Chemical elements need to be established as global commons whose overuse can be regulated if required. Part of the efficiency gains of innovations could be (...) used for research to offset the ‘rebound effect’ and provide the public with a return on early infrastructure investments. (shrink)

Nietzsches Ausnahmestatus als Philosoph gründet nicht zuletzt in seinem künstlerischen Verhältnis zur Sprache. Der Grenzen sprengende Denker erweist sich zugleich als ein Grenzen sprengender Sprachartist, der den traditionellen Unterschied zwischen Philosophie und Dichtung zum Verschwimmen bringt. Während die Forschung meist den Hauptakzent auf den Denker Nietzsche legt, widmet sich der vorliegende Band dem Dichter Nietzsche. Untersucht wird ein großes, von der Forschung bislang erst ansatzweise erschlossenes Korpus von Gedichten und Gedichtfragmenten. Betrachtet werden darüber hinaus auch weitere literarische Ausdrucksformen Nietzsches sowie (...) ausgewählte Stationen seiner Rezeption als Dichter. (shrink)

The idea of immanent transcendence is constitutive for Winch's philosophy of religion and his ethics. Winch's philosophy of religion insists on the ‘immanent’ dimension of religion. His ethics insists on the ‘transcendent’ dimension of ethics. In this sense, both religion and ethics embody a perspective ‘beyond’ this world and yet must have practical consequences in this world. Transcendence without immanence is idle, and immanence without transcendence is empty—this is the kernel of Winch's philosophy of religion and of his ethics.

Samantha Matherne’s Cassirer (in the series Routledge Philosophers) is at the top of the list of newer research testifying to the recent Cassirer renaissance.1 While this book marks a formal end po...

Plato’s Euthyphro, I argue, lays out a metaethics that responds to persistent and unresolved value disagreement. The dialogue’s analysis of disagreement leads to the distinction between three kinds of value, exemplified by the good, the god-loved, and the pious. With this proposal, I reject centuries of scholarship, which ascribe a realist metaethics to the Plato of the Euthyphro. But only the good and the just require a ‘realist’ analysis: we relate to them as features of the world to which we (...) have attitudes, not as features of the world that are conferred by our attitudes. The god-loved is overtly attitudinal, thus calling for an anti-realist account. A compelling account of the pious has both realist and anti-realist dimensions. All three kinds of value, I argue, are to be found in the domain of law. Here, too, the good and the just require a realist, the legal an anti-realist, and the lawful a realist and anti-realist analysis. As important as piety was for millennia, it is a non-issue in today’s metaethics. But its analogue in the domain of the law, the lawful, plays a crucial role in our lives today. While we recognize legality as potentially flawed, respect for the law is an indispensable attitude if we are to strive towards improved lives and improved societies. (shrink)

Talk about evil resonates in ways that are culturally inherited. Historical and religious dimensions of “evil” often seem to be front and center. Nevertheless, we argue that it would be too quick to dismiss the study of evil within secular ethics. We defend an outlook that is inspired by ancient ethics—also called virtue ethics—which accepts the so-called Guise of the Good account of motivation. For an agent to be motivated to perform an action, something about the action must look good (...) to her. We argue that evil actions do not constitute exceptions to the Guise of the Good. To preserve this framework, we entertain a privative account of evil, according to which evil is the absence of the good, and yet appears in a positive light to the agent who performs an evil action. We reject the view that evil is quantitatively extreme badness. An account of evil should permit that some instances of evil are from a third person perspective not extremely bad. On this picture, evil is agent-relative; something can be evil relative to one person without being evil relative to another person. Accordingly, several qualities—rather than only one distinctive quality—can make an action evil. (shrink)

_ Source: _Page Count 16 This paper looks at modern philosophy of history in the sense of the German concept of “Geschichtsphilosophie”. “Geschichtsphilosophie”, as it was formulated since the heydays of German Idealism, always implied the belief that it is possible to make true statements about the future. I will take a closer look at such a version of philosophy of history by reconstructing Odo Marquard’s arguments against “Geschichtsphilosophie” and Heinz Dieter Kittsteiner’s defense of it. These two authors were asking (...) precisely the same question about the essence of “Geschichtsphilosophie”, but came to totally different conclusions. I will defend Marquard’s position and thus will come to the position that history cannot be made or at least cannot be made in the way agents want it to be made. However, my insistence on the inevitable limits of any project to make history as it has been constitutive for modern philosophy of history, in no way precludes the possibility of making politics. Thus, at the very end of my paper, I argue for the fundamental difference between the making of history and the making of politics. (shrink)

El objetivo de las presentes páginas consiste en analizar el concepto de libertad en las Disertaciones de Epicteto, centrándonos sobre la posibilidad de la libertad y su articulación con el concepto de proaíresis. Demostraremos que la libertad no puede ser comprendida en la obra de Epicteto simplemente como un proceso negativo de liberación respecto de determinaciones (externas e internas), sino que exige un momento complementario de sustitución de las determinaciones erróneas por determinaciones racionales/virtuosas. Tal conclusión exigirá precisar que la proaíresis (...) no es en absoluto una facultad naturalmente indeterminada y libre, sino que su libertad opera como un horizonte regulativo al que sólo se puede acceder mediante el correcto cuidado (epiméleia) del alma. (shrink)

The received view on the development of the correspondence rules in Carnap’s philosophy of science is that at first, Carnap assumed the explicit definability of all theoretical terms in observational terms and later weakened this assumption. In the end, he conjectured that all observational terms can be explicitly defined in in theoretical terms, but not vice versa. I argue that from the very beginning, Carnap implicitly held this last view, albeit at times in contradiction to his professed position. To establish (...) this point I argue that, first, Carnap’s ‘Über die Aufgabe der Physik’ is a contribution to the philosophy of science of logical empiricism, contrary to Thomas Mormann and in agreement with Herbert Feigl. Second, Michael Friedman misunderstands the ‘Aufgabe’ with his claim that it describes a method for arriving at explicit definitions for theoretical terms. Another received view on Carnap’s philosophy of science is that it assumed a formalization of physical theories that was too detached from actual physics and thus justly disavowed in favor of the semantic view as, for example, developed by van Fraassen. But the ‘Aufgabe’ and related works including the Aufbau show that from the very beginning to his last works, Carnap suggested formalizing physical theories as restrictions in mathematical spaces, as in the state-space conception of scientific theories favored by van Fraassen. (shrink)

Resumo A partir da concepção de que filosofia, para Nietzsche, é a arte da transfiguração, o texto analisa como Nietzsche incorpora e transfigura Os deuses no exílio, de Heinrich Heine. Nietzsche teria invertido a perspectiva do problema posto por Heine, bem como o seu procedimento expositivo: se o poeta traz o que seria uma humanização e aburguesamento dos antigos deuses como ato de degradação cósmica pelo qual a ascensão do cristianismo seria culpada, Nietzsche analisa a equivocada autodivinização do homem por (...) meio da moral como megalomania trágica, cuja consequência seria a invocação do sofrimento da existência terrena e a esperança numa vida melhor, supraterrena.Taking Nietzsche´s comprehension of philosophy as the art of transfiguration, the text analyses how the philosopher incorporates and transfigures The Gods in Exile, from Heinrich Heine. The philosopher would have inverted the perspective of the problem settled by Heine and his expositive procedure: if the poet bring us what would be an humanization and a “gentifrication” of the ancient gods as a cosmic degradation act by which the ascension of Christianity would be blamed, Nietzsche analyses the mistaken autodivinization of man through morals as a tragic megalomania, whose consequence would be the invocation of a suffering at the core of earthly existence and a hope in a better, ethereal life. (shrink)

Name der Zeitschrift: Deutsche Zeitschrift für Philosophie Jahrgang: 65 Heft: 2 Seiten: 410-416.