Neural Stem Cells (NSC) are present in the developing and adult CNS. In both the embryonic and adult neurogenic regions, β1 integrins may act as sensors for the changing extracellular matrix. Here we highlight the integrative functions that β1 integrins may play in the “niche” by regulating NSC growth factor responsiveness in a timely and spatially controlled manner. β1 integrins may provide NSC with the capacity to react to a dynamic “niche”, and to respond adequately by either remaining as stem (...) cells or by differentiating and migrating away to shape the developing cortex. © 2005 Wiley Periodicals, Inc. BioEssays 27:698–707, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Multidisciplinary Inquiry in the Study of Religion:The Next GenerationF. LeRon Shults (bio)Bob Neville and I began our introduction to Religion in Multidisciplinary Perspective: Philosophical, Theological, and Scientific Approaches to Wesley J. Wildman, by describing the latter as "the most original, audacious, creative, encyclopedic, and integrative thinker working within and across the fields of philosophy, ethics, theology, and the scientific study of religion in our time."1 Notice we did not (...) say "one of the most," but "the most." We stand by the claim. Active members of the Institute for American Religious and Philosophical Thought (IARPT), the professional association that sponsors the American Journal of Theology and Philosophy (AJPT), will be familiar with Wildman's work and not at all surprised by this assertion. For those less well acquainted with Wildman, and so understandably somewhat suspicious of such a claim, I hope that the essays in the special issue—and of course the Festschrift to which they respond—will diminish their skepticism and pique their curiosity.It was Wesley who invited me to join IARPT all those many years ago (when it was still HIARPT), a unique group of pragmatist and process philosophers, most of whom are (more or less religious) naturalists. It is an association of professionals and friends within which I have found a happy home. It has been a joy to be able to put together the book and this special issue to honor Wesley and promote further engagement with his work.It was a difficult task for Bob Neville and me to categorize Wildman's multidisciplinary corpus, but eventually we decided to invite contributors to approach his work from the general direction of one of three areas—philosophy, theology, or science—while simultaneously reaching across disciplines. In the aforementioned introduction, we offered a brief academic biography and summary of some of Wildman's most significant books for those not familiar with his writings. The three major parts of the volume, which I will summarize below, offer several scholarly engagements with Wildman's thought, each approaching it with a multidisciplinary perspective. For those unfamiliar with his philosophy, a good place to start for understanding his approach to philosophy is Religious Philosophy as [End Page 5] Multidisciplinary Comparative Inquiry.2 A good place to begin getting familiar with his approach to theology is In Our Image: Anthropomorphism, Apophaticism, and Ultimacy.3 A good place to get a feel for his approach to the scientific study of religion is Science and Religious Anthropology: A Spiritually Evocative Naturalist Interpretation of Human Life.4Whether in philosophy, theology, or the scientific study of religion, Wildman has not hesitated to "boldly go where no one has gone before." With the courage of a Captain Kirk and the intelligence of a Mr. Spock, not to mention the ingenuity of a Scotty and therapeutic skills of a Dr. McCoy, Wildman has trekked through the unknown (and in the case of theology, he would add, unknowable) conceptual space of more disciplinary systems that one would think possible. His intellectual voyages exploring strange new multidisciplinary worlds have been an inspiration to many in the next generation of scholars interested in engaging American religious and philosophical thought. People who know Wesley well also know how much energy he has committed to nurturing this next generation. The younger authors who have contributed to this special issue may not even get my references to the original Star Trek, which aired in the 1960s, and are perhaps even too young even to remember Star Trek: The Next Generation, which first aired in 1987, with Captain Jean Luc Picard and the gang. Well, one gets to a certain age and one has to come to terms with using the cultural references one has.In the film Star Trek Generations, which came out 30 years ago, the same year (indeed, the same month) that I met Wesley, Captain Picard finds himself facing another galactic crisis and (spoiler alert) ends up being pulled into the "Nexus," an extra-dimensional realm of wish fulfillment, where he finds Captain Kirk, long presumed dead, enjoying himself immensely. Kirk agrees to help Picard alter space-time and together they save the universe (again). OK, let... (shrink)

Recent empirical research seems to show that emotions play a substantial role in moral judgment. Perhaps the most important line of support for this claim focuses on disgust. A number of philosophers and scientists argue that there is adequate evidence showing that disgust significantly influences various moral judgments. And this has been used to support or undermine a range of philosophical theories, such as sentimentalism and deontology. I argue that the existing evidence does not support such arguments. At best it (...) suggests something rather different: that moral judgment can have a minor emotive function, in addition to a substantially descriptive one. (shrink)

In an attempt to discover the facial action units for affective states that occur during complex learning, this study adopted an emote-aloud procedure in which participants were recorded as they verbalised their affective states while interacting with an intelligent tutoring system (AutoTutor). Participants’ facial expressions were coded by two expert raters using Ekman's Facial Action Coding System and analysed using association rule mining techniques. The two expert raters received an overall kappa that ranged between.76 and.84. The association rule mining analysis (...) uncovered facial actions associated with confusion, frustration, and boredom. We discuss these rules and the prospects of enhancing AutoTutor with non-intrusive affect-sensitive capabilities. (shrink)

In defending his interest-relative account of knowledge in Knowledge and Practical Interests (2005), Jason Stanley relies heavily on intuitions about several bank cases. We experimentally test the empirical claims that Stanley seems to make concerning our common-sense intuitions about these bank cases. Additionally, we test the empirical claims that Jonathan Schaffer seems to make in his critique of Stanley. We argue that our data impugn what both Stanley and Schaffer claim our intuitions about such cases are. To account for these (...) results, one must develop a better conception of the connection between a subject's interests and her body of knowledge than those offered by Stanley and Schaffer. (shrink)

At least since the middle of the twentieth century, philosophers have tended to identify weakness of will with akrasia—i.e. acting, or having a disposition to act, contrary to one‘s judgments about what is best for one to do. However, there has been some recent debate about whether this captures the ordinary notion of weakness of will. Richard Holton (1999, 2009) claims that it doesn’t, while Alfred Mele (2010) argues that, to a certain extent, it does. As Mele recognizes, the question (...) about an ordinary concept here is one apt for empirical investigation. We evaluate Mele’s studies and report some experiments of our own in order to investigate what in the world the ordinary concept of weakness of will is. We conclude that neither Mele nor Holton (previously) was quite right and offer a tentative proposal of our own: the ordinary notion is more like a prototype or cluster concept whose application is affected by a variety of factors. (shrink)

Numerous grounds have been offered for the view that healthcare workers have a duty to treat, including expressed consent, implied consent, special training, reciprocity (also called the social contract view), and professional oaths and codes. Quite often, however, these grounds are simply asserted without being adequately defended or without the defenses being critically evaluated. This essay aims to help remedy that problem by providing a critical examination of the strengths and weaknesses of each of these five grounds for asserting that (...) healthcare workers have a duty to treat, especially as that duty would arise in the context of an infectious disease pandemic. Ultimately, it argues that none of the defenses is currently sufficient to ground the kind of duty that would be needed in a pandemic. It concludes by sketching some practical recommendations in that regard. (shrink)

Taking up Kimberlé Crenshaw's conclusion that black feminist theorists seem to continue to find themselves in many ways “speaking into the void” (Crenshaw 2011, 228), even as their works are widely celebrated, I examine intersectionality critiques as one site where power asymmetries and dominant imaginaries converge in the act of interpretation (or cooptation) of intersectionality. That is, despite its current “status,” intersectionality also faces epistemic intransigence in the ways in which it is read and applied. My aim is not to (...) suggest that intersectionality cannot (or should not) be critiqued, nor do I maintain that celebratory applications/interpretations are immune from epistemic distortion when it comes to interpreting intersectionality. Rather, my goal is to demonstrate that critiques of intersectionality are one important site to examine hermeneutic marginalization and interpretive violence; the politics of citation; and the impact of dominant expectations or established social imaginaries on meaning-making. In so doing, I aim to consider more fully how entrenched ways of thinking are frequently relied upon to interpret and critique intersectionality, even as these are often the very frameworks that intersectionality theorists have identified as highly problematic tools of misrepresentation, erasure, and violation. This slippage away from intersectionality's outlooks, whether in critical or laudatory contexts, is a pivotal site of epistemic negotiation we must examine more closely. (shrink)

This paper presents qualitative research that focus on the Reading Groups. The aim is to understand the values of reading and discussing books in group, during the months of lockdown, caused by the Covid-19 health emergency. Using written and structured interviews, we collected the experiences of 73 adult participants in Reading Group in Milan and Bergamo provinces. The results show how, even by the unusual online mode, the Reading Group was a way to defend oneself from the pain of reality, (...) a space of relationship in isolation and a possibility of self-assertion, in situation of strong limitation of individual freedom. Starting from the analysis of what happened, this study wants to outline the potential of Reading Groups as pedagogical environments to produce change. (shrink)

Modern professionals wield considerable power by virtue of their knowledge. However, they also feel beleaguered by the constraints they face and the public disapproval they often experience. These pressures combine to diminish the professional's sense of public responsibility and convert him or her in self-perception to a careerist.

Moral skeptics maintain that we do not have moral knowledge. Traditionally they haven’t argued via skeptical hypotheses like those provided by perceptual skeptics about the external world, such as Descartes’ deceiving demon. But some believe this can be done by appealing to hypotheses like moral nihilism. Moreover, some claim that skeptical hypotheses have special force in the moral case. But I argue that skeptics have failed to specify an adequate skeptical scenario, which reveals a general lesson: such arguments are not (...) a promising avenue for moral skeptics to take. They’re ultimately weaker when applied to morality compared to perception. (shrink)

It is a characteristically Fregean thesis that the sense expressed by an expression is the linguistic meaning of that expression. Sense can play this role for Frege since it meets fundamental desiderata for meaning, that it be universal and invariantly expressed and objectively the same for everyone who knows the language. It has been argued,1 however, that, as a general thesis about natural languages, the identi cation of sense and meaning cannot be sustained since it is in con ict with (...) another characteristically Fregean thesis, that sense uniquely determines reference. The argument is quite simple and can be outlined as follows. Assume the two theses we have just stated. (shrink)

[Emerging Scholar Prize Essay for Spindel Supplement] Some philosophers and psychologists have evaluated psychological egoism against recent experimental work in social psychology. Dan Batson (1991; forthcoming), in particular, argues that empathy tends to induce genuinely altruistic motives in humans. However, some argue that there are egoistic explanations of the data that remain unscathed. I focus here on some recent criticisms based on the idea of self-other merging or "oneness," primarily leveled by Robert Cialdini and his collaborators (1997). These authors argue (...) that the putatively altruistic subjects are acting on ultimately egoistic motives because empathic feelings for someone in distress tend to cause them to blur the distinction between themselves and the other. Employing a conceptual framework for the debate, I argue that the self-other merging explanation fails to explain the empathy-helping relationship on primarily non-empirical grounds, regardless of the empirical results Cialdini and colleagues report. (shrink)

Provides an overview of the theory of psychological egoism—the thesis that we are all ultimately motivated by self-interest. Philosophical arguments for and against the view are considered as well as some empirical evidence.

Gopal Sreenivasan’s “hybrid theory” states that a moral duty is directed toward an individual because her interests justify the assignment of control over the duty. An alternative “plain theory” states that the individual’s interests justify the duty itself. I argue that a strong moral status constraint explains Sreenivasan’s instrumentalization objection to a Razian plain theory but that his own model violates this constraint. I suggest how both approaches can be reformulated to satisfy the constraint, and I argue that a reformulated (...) plain theory can also avoid an insufficiency objection. The hybrid approach consequently has no clear advantage over the plain approach. (shrink)

We criticize the following views: only the rapist is responsible since only he committed the act; no one is responsible since rape is a biological response to stimuli; everyone is responsible since men and women contribute to the rape culture; and patriarchy is responsible but no person or group. We then argue that, in some societies, men are collectively responsible for rape since most benefit from rape and most are similar to the rapist.

Our beliefs about which actions we ought to perform clearly have an effect on what we do. But so-called “Humean” theories—holding that all motivation has its source in desire—insist on connecting such beliefs with an antecedent motive. Rationalists, on the other hand, allow normative beliefs a more independent role. I argue in favor of the rationalist view in two stages. First, I show that the Humean theory rules out some of the ways we ordinarily explain actions. This shifts the burden (...) of proof onto Humeans to motivate their more restrictive, revisionary account. Second, I show that they are unlikely to discharge this burden because the key arguments in favor of the Humean theory fail. I focus on some of the most potent and most recent lines of argument, which appeal to either parsimony, the teleological nature of motivation, or the structure of practical reasoning. (shrink)

This book uses philosophy, psychology, and autobiography in an innovative exploration of the nature and evolution of self-knowledge. Topics include the impact of others, the role of fantasy, the construction of self-image, and playing roles; the second part of the book explores how self-understanding evolves through friendship.

Roughly, psychological egoism is the thesis that all of a person's intentional actions are ultimately self-interested in some sense; psychological altruism is the thesis that some of a person's intentional actions are not ultimately self-interested, since some are ultimately other-regarding in some sense. C. Daniel Batson and other social psychologists have argued that experiments provide support for a theory called the "empathy-altruism hypothesis" that entails the falsity of psychological egoism. However, several critics claim that there are egoistic explanations of the (...) data that are still not ruled out. One of the most potent criticisms of Batson comes from Elliott Sober and David Sloan Wilson. I argue for two main theses in this paper: (1) we can improve on Sober and Wilson’s conception of psychological egoism and altruism, and (2) this improvement shows that one of the strongest of Sober and Wilson's purportedly egoistic explanations is not tenable. A defense of these two theses goes some way toward defending Batson‘s claim that the evidence from social psychology provides sufficient reason to reject psychological egoism. (shrink)

In den letzten Jahren hat sich eine Vielfalt unterschiedlicher Gremien zur Ethikberatung entwickelt: vom Konsil mit einem einzelnen Berater bis zum Ethikkomitee. In dem Band werden die Ethikberatung, ihre Entwicklung und Anwendung, sowie die Gründung von Gremien in Krankenhäusern, Pflegeeinrichtungen, Hospizen und von niedergelassenen Ärzten anhand von Fallbeispielen erläutert. Dabei schlagen die Autoren eine Brücke zwischen traditioneller philosophischer Ethik und anwendungsbezogener klinischer Ethik. Auch rechtliche Fragen werden erörtert.

Book synopsis: The principal aim of this volume is to elucidate what freedom, sovereignty, and autonomy mean for Nietzsche and what philosophical resources he gives us to re-think these crucial concepts. A related aim is to examine how Nietzsche connects these concepts to his thoughts about life-affirmation, self-love, promise-making, agency, the 'will to nothingness', and the 'eternal recurrence', as well as to his search for a 'genealogical' understanding of morality. These twelve essays by leading Nietzsche scholars ask such key questions (...) as: Can we reconcile his rejection of free will with his positive invocations of the notion of free will? How does Nietzsche's celebration of freedom and free spirits sit with his claim that we all have an unchangeable fate? What is the relation between his concepts of freedom and self-overcoming? The depth in which these and related issues are explored gives this volume its value, not only to those interested in Nietzsche, but to all who are concerned with the free will debate, ethics, theory of action, and the history of philosophy. (shrink)

This paper was first presented as a plenary lecture to the Association for Education in Journalism and Mass Communication in August, 1985. The author, who is the Cary M. Maguire University Professor of Ethics at Southern Methodist University, discusses the intellectual, moral, and organizational marks of the professional that led reformers at the beginning of the twentieth century to locate professional training in the university. That discussion is followed by consideration of the moral consequences of university education for professionals, and (...) how journalists and all other professionals are, at base, teachers. The third part of the paper reflects upon the peculiarities of journalism as aprofession, and concludes with considerations of the special mission of journalism. (shrink)

Provides an overview of empirical research relevant to philosophical questions about moral thought, feeling, reasoning, and motivation. Topics include: free will and moral responsibility, egoism and altruism, moral judgment and motivation, weakness and strength of will, moral intuitions, and moral knowledge. [Originally published in 2012. Updated and expanded in 2017.].

My purpose is to argue the following theses: (1) Habituation into virtue, social relations, and paradigmatic persons are central for both Aristotle and Confucius. Both therefore need a notion of self to support them. (2) Aristotle’s individualistic metaphysics cannot account for the thick relations that this requires. (3) The Confucian self, if entirely relationistic, cannot function as a locus of choice and agency; if fully ritualistic, it cannot function as a source of moral norms that might help assess existing social (...) proprieties. I shall suggest that each offers some corrective for the other and urge further dialogue between the friends of Confucius and Aristotle. (shrink)

The analysis of identity as coreference is strongly associated with Frege ; it is the view in Begriffsschrift, and, some have argued, henceforth throughout his work. This thesis is incorrect: Frege never held that identity is coreference. The case is made not by interpretation of “proof-quotes”, but rather by exploring how Frege actually deploys the concept. Two cases are considered. The first, from Grundgesetze, are the definitions of the core concepts, zero and truth; the second, from Begriffsschrift, is the validity (...) of Leibniz's Law. In both cases, if identity is coreference, results ensue that would be unacceptable to Frege. (shrink)

Politics today seems to be marked either by fear or conciliation. The idea of a radical break with the present has, for many, been removed from the agenda. What tie together the thought of Jacques Rancière and Alain Badiou is a commitment to politics as offering the possibility of a break with the present. This paper examines their common thought, as well as what divides them, from the perspective of a renewal of the political project of resistance.

I argue that some instances of constitutional religious establishment can be consistent with an expressivist interpretation of democratic legitimacy. Whether official religious endorsements disparage or exclude religious minorities depends on a number of contextual considerations, including the philosophical content of the religion in question, the attitudes of the majority, and the underlying purpose of the official status of the religious doctrine.

RésuméAu cours de son développement historique, le bouddhisme a montré une capacité remarquable à s'insérer dans les contextes sociaux les plus variés. Les cas de l'Inde et de Ceylan sont examinés, l'un longuement, l'autre brièvement. L'auteur cherche àétablir quelques‐unes des raisons pour lesquelles, à partir d'un donné social analogue, le bouddhisme a disparu de l'Inde, mais s'est maintenu à Ceylan.SummaryIn the course of its historical development Buddhism has shown a remarkable ability to find its way into the most diverse social (...) contexts. The cases of India and Ceylon are studied, the former at length, the latter briefly. The author seeks to establish some of the reasons why, though the social context is similar in both countries, Buddhism has disappeared in India but has survived in Ceylon.ZusammenfassungDer Buddhismus konnte sich im Laufe der Geschichte erstaunlich gut an die unter‐schiedlichsten gesellschaftlichen Verhältnisse anpassen. Der Verfasser geht gründlich auf den Fall Indiens und kurz auf denjenigen Ceylons ein und sucht nach Ursachen, weshalb der Buddhismus in Indien verschwunden ist, sich hingegen in Ceylon zu halten vermochte, obwohl sich die beiden Länder gesellschaftlich durchaus vergleichen lassen. (shrink)