Mesoscale modeling is often considered merely as a practical strategy used when information on lower-scale details is lacking, or when there is a need to make models cognitively or computationally tractable. Without dismissing the importance of practical constraints for modeling choices, we argue that mesoscale models should not just be considered as abbreviations or placeholders for more “complete” models. Because many systems exhibit different behaviors at various spatial and temporal scales, bottom-up approaches are almost always doomed to fail. Mesoscale models (...) capture aspects of multi-scale systems that cannot be parameterized by simple averaging of lower-scale details. To understand the behavior of multi-scale systems, it is essential to identify mesoscale parameters that “code for” lower-scale details in a way that relate phenomena intermediate between microscopic and macroscopic features. We illustrate this point using examples of modeling of multi-scale systems in materials science and biology, where identification of material parameters such as stiffness or strain is a central step. The examples illustrate important aspects of a so-called “middle-out” modeling strategy. Rather than attempting to model the system bottom-up, one starts at intermediate scales where systems exhibit behaviors distinct from those at the atomic and continuum scales. One then seeks to upscale and downscale to gain a more complete understanding of the multi-scale system. The cases highlight how parameterization of lower-scale details not only enables tractable modeling but is also central to understanding functional and organizational features of multi-scale systems. (shrink)

In the past, Wonder Woman and Superman were depicted as good friends, but as of 2016, in New 52 Wonder Woman comic books, the Amazon princess and the man of steel are in a romantic relationship. The implication seems to be that romantically compatible people cannot be just friends. Thankfully, philosophy can help to debunk this notion and shed some light on the nature of friendship and romance as well. In consuming works of popular culture, people learn what is expected (...) of them in their interpersonal lives: cross‐gender relationships must be romantic, and friendship cannot be as important as romance. The loss of Wonder Woman and Superman as an example of a stable non‐romantic cross‐gender friendship therefore represents not just a change in the treatment of the characters, but a loss of support for the idea that such friendships are possible. (shrink)

_The Promise of Happiness_ is a provocative cultural critique of the imperative to be happy. It asks what follows when we make our desires and even our own happiness conditional on the happiness of others: “I just want you to be happy”; “I’m happy if you’re happy.” Combining philosophy and feminist cultural studies, Sara Ahmed reveals the affective and moral work performed by the “happiness duty,” the expectation that we will be made happy by taking part in that which (...) is deemed good, and that by being happy ourselves, we will make others happy. Ahmed maintains that happiness is a promise that directs us toward certain life choices and away from others. Happiness is promised to those willing to live their lives in the right way. Ahmed draws on the intellectual history of happiness, from classical accounts of ethics as the good life, through seventeenth-century writings on affect and the passions, eighteenth-century debates on virtue and education, and nineteenth-century utilitarianism. She engages with feminist, antiracist, and queer critics who have shown how happiness is used to justify social oppression, and how challenging oppression causes unhappiness. Reading novels and films including_ Mrs. Dalloway_, _The Well of Loneliness_, _Bend It Like Beckham_, and _Children of Men_, Ahmed considers the plight of the figures who challenge and are challenged by the attribution of happiness to particular objects or social ideals: the feminist killjoy, the unhappy queer, the angry black woman, and the melancholic migrant. Through her readings she raises critical questions about the moral order imposed by the injunction to be happy. (shrink)

Feminism is sensational -- On being directed -- Willfulness and feminist subjectivity -- Trying to transform -- Being in question -- Brick walls -- Fragile connections -- Feminist snap -- Lesbian feminism -- Conclusion 1: A killjoy survival kit -- Conclusion 2: A killjoy manifesto.

Weather Omens of Enūma Anu Enlil: Thunderstorms, Wind and Rain. By Erlend Gehlken. Cuneiform Monographs, vol. 43. Leiden: Brill, 2012. Pp. x + 286, 47 plts. $144.

Many examples of calibration in climate science raise no alarms regarding model reliability. We examine one example and show that, in employing Classical Hypothesis-testing, it involves calibrating a base model against data that is also used to confirm the model. This is counter to the "intuitive position". We argue, however, that aspects of the intuitive position are upheld by some methods, in particular, the general Cross-validation method. How Cross-validation relates to other prominent Classical methods such as the Akaike Information Criterion (...) and Bayesian Information Criterion is also discussed. (shrink)

Group decisions raise a number of substantial philosophical and methodological issues. We focus on the goal of the group decision exercise itself. We ask: What should be counted as a good group decision-making result? The right decision might not be accessible to, or please, any of the group members. Conversely, a popular decision can fail to be the correct decision. In this paper we discuss what it means for a decision to be "right" and what components are required in a (...) decision process to produce happy decision-makers. Importantly, we discuss how "right" decisions can produce happy decision-makers, or rather, the conditions under which happy decision-makers and right decisions coincide. In a large range of contexts, we argue for the adoption of formal consensus models to assist in the group decision-making process. In particular, we advocate the formal consensus convergence model of Lehrer and Wagner (1981), because a strong case can be made as to why the underlying algorithm produces a result that should make each of the experts in a group happy. Arguably, this model facilitates true consensus, where the group choice is effectively each person's individual choice. We analyse Lehrer and Wagner's algorithm for reaching consensus on group probabilities/utilities in the context of complex decision-making for conservation biology. While many conservation decisions are driven by a search for objective utility/probability distributions (regarding extinction risks of species and the like), other components of conservation management primarily concern the interests of stakeholders. We conclude with cautionary notes on mandating consensus in decision scenarios for which no fact of the matter exists. For such decision settings alternative types of social choice methods are more appropriate. (shrink)

I focus my discussion on the well-known Ellsberg paradox. I find good normative reasons for incorporating non-precise belief, as represented by sets of probabilities, in an Ellsberg decision model. This amounts to forgoing the completeness axiom of expected utility theory. Provided that probability sets are interpreted as genuinely indeterminate belief, such a model can moreover make the “Ellsberg choices” rationally permissible. Without some further element to the story, however, the model does not explain how an agent may come to have (...) unique preferences for each of the Ellsberg options. Levi holds that the extra element amounts to innocuous secondary “risk” or security considerations that are used to break ties when more than one option is rationally permissible. While I think a lexical choice rule of this kind is very plausible, I argue that it involves a greater break with xpected utility theory than mere violation of the ordering axiom. (shrink)

From the early ninth century until about eight centuries later, the Middle East witnessed a series of both simple and systematic astronomical observations for the purpose of testing contemporary astronomical tables and deriving the fundamental solar, lunar, and planetary parameters. Of them, the extensive observations of lunar eclipses available before 1000 AD for testing the ephemeredes computed from the astronomical tables are in a relatively sharp contrast to the twelve lunar observations that are pertained to the four extant accounts of (...) the measurements of the basic parameters of Ptolemaic lunar model. The last of them are Taqī al-Dīn Muḥammad b. Ma‘rūf’s trio of lunar eclipses observed from Istanbul, Cairo, and Thessalonica in 1576–1577 and documented in chapter 2 of book 5 of his famous work, Sidrat muntaha al-afkar fī malakūt al-falak al-dawwār. In this article, we provide a detailed analysis of the accuracy of his solar and lunar observations. (shrink)

In his late reflections on values and forms of life from the 1920s and 1930s, Husserl develops the concept of personal value and argues that these values open two kinds of infinities in our lives. On the one hand personal values disclose infinite emotive depths in human individuals while on the other hand they connect human individuals in continuous and progressive chains of care. In order to get at the core of the concept, I will explicate Husserl’s discussion of personal (...) values of love by distinguishing between five related features. I demonstrate that values of love (1) are rooted in egoic depts and define who we are as persons, (2) differ from objective values in being absolute and non-comparative, (3) ground vocational lives as organizing principles, (4) are endlessly self-disclosing and self-intensifying, and (5) establish transitive relations of care between human beings. On the basis of my five-partite distinction, I argue that Husserl’s concepts of love and value of love reveal the dynamic character of human subjectivity and intersubjectivity. (shrink)

Although education in the responsible conduct of research is considered necessary, evidence bearing on the effectiveness of these programs in improving research ethics has indicated that, although some programs are successful, many fail. Accordingly, there is a need for systematic evaluation of ethics education programs. In the present effort, we examine procedures for evaluation of ethics education programs from a multilevel perspective: examining both within-program evaluation and cross-program evaluation. With regard to within-program evaluation, we note requisite designs and measures for (...) conducting systematic program evaluation have been developed and multiple measures should be applied in program evaluation. With regard to cross-program evaluation, we argue that a meta-analytic framework should be employed where analyses are used to identify best practices in ethics education. The implications of this multilevel approach for improving responsible conduct of research educational programs are discussed. (shrink)

A common reductionist assumption is that macro-scale behaviors can be described "bottom-up" if only sufficient details about lower-scale processes are available. The view that an "ideal" or "fundamental" physics would be sufficient to explain all macro-scale phenomena has been met with criticism from philosophers of biology. Specifically, scholars have pointed to the impossibility of deducing biological explanations from physical ones, and to the irreducible nature of distinctively biological processes such as gene regulation and evolution. This paper takes a step back (...) in asking whether bottom-up modeling is feasible even when modeling simple physical systems across scales. By comparing examples of multi-scale modeling in physics and biology, we argue that the “tyranny of scales” problem presents a challenge to reductive explanations in both physics and biology. The problem refers to the scale-dependency of physical and biological behaviors that forces researchers to combine different models relying on different scale-specific mathematical strategies and boundary conditions. Analyzing the ways in which different models are combined in multi-scale modeling also has implications for the relation between physics and biology. Contrary to the assumption that physical science approaches provide reductive explanations in biology, we exemplify how inputs from physics often reveal the importance of macro-scale models and explanations. We illustrate this through an examination of the role of biomechanics modeling in developmental biology. In such contexts, the relation between models at different scales and from different disciplines is neither reductive nor completely autonomous, but interdependent. (shrink)

Many physicians have found that the traditional approach to bioethics fails to account for important aspects of their moral experience in practice. New approaches to bioethics theory are challenging the traditional application of universal moral principles based in liberal moral theory. At the same time, a shift in both the goals and methods of bioethics education has accompanied its coming of age in the medical school curriculum. Taken together, these changes challenge both bioethics educators and theorists to come closer to (...) the details and nuances of real clinical encounters. The emerging trend emphasizes the importance of context in bioethics education and in the moral theory and research under-girding it. This article introduces one research approach examining the practical life contexts of medical students' ethical experiences and learning. It calls for increased attention to research and theory in bioethics that more adequately accounts for the ways different contexts produce significant changes in meaning and understanding in medical encounters. (shrink)

Due to the variation, contingency and complexity of living systems, biology is often taken to be a science without fundamental theories, laws or general principles. I revisit this question in light of the quest for design principles in systems biology and show that different views can be reconciled if we distinguish between different types of generality. The philosophical literature has primarily focused on generality of specific models or explanations, or on the heuristic role of abstraction. This paper takes a different (...) approach in emphasizing a theory-constituting role of general principles. Design principles signify general dependency-relations between structures and functions, given a set of formally defined constraints. I contend that design principles increase our understanding of living systems by relating specific models to general types. The categorization of types is based on a delineation of the scope of biological possibilities, which serves to identify and define the generic features of classes of systems. To characterize the basis for general principles through generic abstraction and reasoning about possibility spaces, I coin the term constraint-based generality. I show that constraint-based generality is distinct from other types of generality in biology, and argue that general principles play a unifying role that does not entail theory reduction. (shrink)

Evolutionary systems biology (ESB) aims to integrate methods from systems biology and evolutionary biology to go beyond the current limitations in both fields. This article clarifies some conceptual difficulties of this integration project, and shows how they can be overcome. The main challenge we consider involves the integration of evolutionary biology with developmental dynamics, illustrated with two examples. First, we examine historical tensions between efforts to define general evolutionary principles and articulation of detailed mechanistic explanations of specific traits. Next, these (...) tensions are further clarified by considering a recent case from another field focused on developmental dynamics: stem cell biology. In the stem cell case, incompatible explanatory aims block integration. Experimental approaches aim at mechanistic explanation while dynamical system models offer explanation in terms of general principles. We then discuss an ESB case in which integration succeeds: search for general attractors using a dynamical systems framework synergizes with the experimental search for detailed mechanisms. Contrasts between the positive and negative cases suggest general lessons for achieving an integrated understanding of developmental and evolutionary dynamics. The key integrative move is to acknowledge two complementary aims, both relevant to explanation: identifying the space of possible dynamic states and trajectories, and mechanistic understanding of causal interactions underlying a specific phenomenon of interest. These two aims can support one another in a joint project characterizing dynamic aspects of evolving lineages. This more inclusive project can lead to insights that cannot be reached by either approach in isolation. (shrink)

The aim of this paper is to investigate, if there is a principal disagreement between Husserl's early concept of expression and his later discussions on gestures. In the early work Logical Investigations (1900–1901), Husserl quite bluntly excludes gestures from the category of meaningful expressions; thirty years later (1928), in the second volume of Ideas, he argues to the contrary that gestures are meaningful and expressive in the very same way as linguistic units, words and sentences. The question of this paper (...) is: What happened in Husserl's thinking in the two decades between Investigations and the last versions of Ideas II? I argue that the disagreement between Husserl's early statement and his later discussion on gestural expressions is due to a refinement in his account of embodiment. I claim that Husserl did not abandon his concept of expression, but dismissed his early analysis of embodiment as simplistic and as motivated by a certain preconception about the relationship between nature and spirit. This change became possible for him as he developed conceptual and methodic tools for distinguishing between different meanings of the body: the physical thing or the mere material body, the perceived body, and the sensuous body. The difference between the body as a physical thing and the body as a sensuous-spiritual unit proves to be crucial to the understanding of gestural expressions. (shrink)

In engineering, as in other scientific fields, researchers seek to confirm their models with real-world data. It is common practice to assess models in terms of the distance between the model outputs and the corresponding experimental observations. An important question that arises is whether the model should then be ‘tuned’, in the sense of estimating the values of free parameters to get a better fit with the data, and furthermore whether the tuned model can be confirmed with the same data (...) used to tune it. This dual use of data is often disparagingly referred to as ‘double-counting’. Here, we analyse these issues, with reference to selected research articles in engineering. Our example studies illustrate more and less controversial practices of model tuning and double-counting, both of which, we argue, can be shown to be legitimate within a Bayesian framework. The question nonetheless remains as to whether the implied scientific assumptions in each case are apt from the engineering point of view. (shrink)

The aim of this volume is to offer an updated account of the transcendental character of phenomenology. The main question concerns the sense and relevance of transcendental philosophy today: What can such philosophy contribute to contemporary inquiries and debates after the many reasoned attacks against its idealistic, aprioristic, absolutist and universalistic tendencies—voiced most vigorously by late 20th century postmodern thinkers—as well as attacks against its apparently circular arguments and suspicious metaphysics launched by many analytic philosophers? Contributors also aim to clarify (...) the relations of transcendental phenomenology to other post-Kantian philosophies, most importantly to pragmatism and Wittgenstein’s philosophical investigations. Finally, the volume offers a set of reflections on the meaning of post-transcendental phenomenology. (shrink)

This article argues that common intuitions regarding (a) the specialness of ‘use-novel’ data for confirmation and (b) that this specialness implies the ‘no-double-counting rule’, which says that data used in ‘constructing’ (calibrating) a model cannot also play a role in confirming the model’s predictions, are too crude. The intuitions in question are pertinent in all the sciences, but we appeal to a climate science case study to illustrate what is at stake. Our strategy is to analyse the intuitive claims in (...) light of prominent accounts of confirmation of model predictions. We show that on the Bayesian account of confirmation, and also on the standard classical hypothesis-testing account, claims (a) and (b) are not generally true; but for some select cases, it is possible to distinguish data used for calibration from use-novel data, where only the latter confirm. The more specialized classical model-selection methods, on the other hand, uphold a nuanced version of claim (a), but this comes apart from (b), which must be rejected in favour of a more refined account of the relationship between calibration and confirmation. Thus, depending on the framework of confirmation, either the scope or the simplicity of the intuitive position must be revised. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 20 (2000) 217-229 [Access article in PDF] Christian Insight Meditation: A Test Case on Interreligious Spirituality Springs SteeleUniversity of Scranton, PennsylvaniaIn Joseph Cardinal Ratzinger's 1989 "Letter to the Bishops of the Catholic Church on Some Aspects of Christian Meditation," there is this significant caveat to Catholics: With the present diffusion of eastern methods of meditation in the Christian world and in ecclesial communities, we find ourselves faced (...) with a pointed renewal of an attempt, which is not free from dangers and errors, to fuse Christian meditation with that which is non-Christian (author's emphasis). Proposals in this direction are numerous and radical to a greater or lesser extent. Some use eastern methods solely as a psychophysical preparation for a truly Christian contemplation; others go further and, using different techniques, try to generate spiritual experiences similar to those described in the writings of certain Christian mystics. Still others do not hesitate to place that absolute without image or concepts, which is proper to Buddhist theory, on the same level as the majesty of God revealed in Christ, which towers above finite reality.... These and similar proposals to harmonize Christian meditation with eastern techniques need to have their contents and methods ever subjected to a thorough-going examination so as to avoid the danger of falling into syncretism. 1Two years before Cardinal Ratzinger's letter, Mary Jo Meadow and Kevin Culligan co-authored an analysis of what they saw as remarkable similarities between the spirituality of the Catholic Carmelite John of the Cross and the Theravadan Buddhist vipassana (or "insight") tradition. 2 They went on, with the help of Daniel Chowning, to develop a spiritual practice that seeks to assimilate traditional Buddhist vipassana meditation into the spirituality of John of the Cross. The impetus was to supplement John's rather general instructions on method with the very detailed methodological program of Theravadan insight practice. 3They have designated this approach "Christian Insight Meditation" and maintain that the Buddhist vipassana practice which is its basis can be assimilated to the spirituality of John because, "... although it originates in Theravadan Buddhism, insight meditation itself does not demand belief in the tenets of Buddhist religion." 4 In fact: [End Page 217] We need not agree with any belief items or be willing to call on any supernatural beings to do the practice. This makes the practice available to everyone without any conflict with whatever religious loyalties they have. This practice is simply a way to apply fine-grained, continuous awareness to all of our experiences of mind and body. Although it is this simple, it leads us to the highest stages of spiritual unfoldment as the major spiritual traditions, including John of the Cross, see them. 5The claim is that vipassana meditation is a neutral (i.e., non-tradition-dependent) practice--simply training in the mindful, equanimous observation of breath, body sensations, mental contents, and movements of the will--which, while not requiring acceptance of the theological or metaphysical tenets of any "major spiritual tradition," leads to the presumed identical ultimate goal of each.This claim is simply asserted by the authors, without positive argument or support. While understandable in a non-academic text such as theirs, there are underlying issues connected with the claim that should be addressed. The first is tradition neutrality. The actual method the authors propose did in fact originate and was developed in the Theravadan Buddhist tradition. It presumes the practice of specific moral principles, the development of concentrative ability in a systematic fashion, and training of attention to highly specific perceptual experiences, all of which culminate in an ultimate state or experience designated nibbana in Pali, and Nirvana in Sanskrit. The authors initially present this spiritual practice in the original conceptual framework of Theravadan Buddhism and then "translate" it into the language of Christianity and John of the Cross. Thus instruction in Christian Insight Meditation is functionally training in Theravadan Buddhist vipassana meditation. As such, the practice is organically rooted in the perceptual or cognitive set 6 of Theravadan vipassana practice. In that sense... (shrink)