Advancements in novel neurotechnologies, such as brain computer interfaces and neuromodulatory devices such as deep brain stimulators, will have profound implications for society and human rights. While these technologies are improving the diagnosis and treatment of mental and neurological diseases, they can also alter individual agency and estrange those using neurotechnologies from their sense of self, challenging basic notions of what it means to be human. As an international coalition of interdisciplinary scholars and practitioners, we examine these challenges and make (...) recommendations to mitigate negative consequences that could arise from the unregulated development or application of novel neurotechnologies. We explore potential ethical challenges in four key areas: identity and agency, privacy, bias, and enhancement. To address them, we propose democratic and inclusive summits to establish globally-coordinated ethical and societal guidelines for neurotechnology development and application, new measures, including “Neurorights,” for data privacy, security, and consent to empower neurotechnology users’ control over their data, new methods of identifying and preventing bias, and the adoption of public guidelines for safe and equitable distribution of neurotechnological devices. (shrink)

This paper brings two fresh perspectives on Lewis’s theory of time travel. First: many key aspects and theoretical desiderata of Lewis’s theory can be captured in a framework that does not commit to eternalism about time. Second: implementing aspects of Lewisian time travel in a non-eternalist framework provides theoretical resources for a better treatment of time travel to the future. While time travel to the past has been extensively analyzed, time travel to the future has been comparatively underexplored. I make (...) progress on this topic. Along the way, I discuss Lewis’s lesser-known time travel oeuvre, especially his volume of correspondence and lectures on the topic collected in Beebee and Fisher (2020) and Janssen-Lauret & MacBride (forthcoming). Lewis’s body of unpublished work on time travel yields fruitful insights into his broader thinking on the subject. (shrink)

Obstetric violence – psychological and physical violence by medical staff towards women giving birth – has been described as structural violence, specifically as gender violence. Many women are affected by obstetric violence, with awful consequences. The phenomenon has so far been mainly investigated by the health and social sciences, yet fundamental theoretical and conceptual questions have gone unnoticed. Until now, the phenomenon of obstetric violence has been understood as one impeding autonomy and individual agency and control over the body. In (...) this article I will argue that the phenomenon of obstetric violence occurs in a specific state of embodied vulnerability and that might be destructive for subjectivity since it fails to recognize that state and instead disallows support and demolishes relationships and interdependence. This might introduce a conceptual shift and the phenomenon might be reconceptualized as a moment where vulnerability is misrecognized and ambiguity, relations and support are banned. In this case violence is recognized as cutting the original links to our bodies and the world that constitute our phenomenological condition, instead of as hurting the autonomous subject. Obstetric violence, thus, calls to be reflected upon through de Beauvoir’s ideas on ambiguity, the embodied and situated subject and the subject as essentially construed in relations. I believe that de Beauvoir’s conception of the authentic embodied subject as necessarily ambiguous – immanent and transcendent at the same time and ineludibly linked to the world and its others – will be extremely useful for construing this new understanding of how obstetric violence happens and of what precisely constitutes its damage. (shrink)

Today the phenomenological concept of the lived body figures centrally in several philosophical and special scientific debates. In these wide and widening fields, the concept is used with multiple different meanings. In order to clarify and delineate the debates, this paper provides an explication of the phenomenological-transcendental methods. It argues that these methods help us remove the most fundamental ambiguities of the concept of embodiment by distinguishing between the main constituents of the lived body and by illuminating their mutual relations.

Native and to some extent non-native speakers have shown processing advantages for idioms compared to novel literal phrases, and there is limited evidence that this advantage also extends to memory in L1 children. This study investigated whether these advantages generalize to recognition memory in adults. It employed a learning paradigm to test whether there is a recognition memory advantage for idioms compared to literal phrases in adult L1 and L2 learners considering both form and meaning recognition. Additionally, we asked whether (...) the presence of unfamiliar vocabulary interferes with phrasal learning by looking at recall of such unfamiliar words. When encountering new idioms, L2 learners often must cope with both figurative meaning and unfamiliar vocabulary. While single word meaning need not interfere with idiomatic meaning, it is a building block for the meaning of literal phrases. In Experiment 1, L2 learners showed equal recall for the form and meaning of literal and idiomatic phrases in which either all words were highly familiar, or one word was unfamiliar. However, unfamiliar words decreased overall recognition and were also remembered significantly better in literal compared to idiomatic phrases. In Experiment 2, L1 speakers also showed no recall differences between phrase types, but they displayed a trending increase in recognition in the presence of unfamiliar words. We conclude that there is no inherent recognition memory advantage for idioms based on figurativeness alone, and word- and phrasal meaning interact differently in learner groups. (shrink)

This article focusses on the meta-literary thread in the correspondence exchanged between Sławomir Mrożek and Wojciech Skalmowski. The latter, wondering about the actual reason why writers create literature, provocatively reduced the metaphysical dimension of a work of art to learn about its contemporary actual value; whether it is was only trade-based. Baudelaire’s work as interpreted by Walter Benjamin became a major context indicating the diversity in the perception of the analysed problem depending on historical time. The article discusses how during (...) his exchange with Skalmowski Mrożek tried to answer the title question about the reason why he created literature, and, which is the most important, how he started focussing on elements which he previously missed or marginalised. (shrink)

The coronavirus disease 2019 lockdown meant a greatly reduced social and economic activity. Sound is of major importance to people’s perception of the environment, and some remarked that the soundscape was changing for the better. But are these anecdotal reports based in truth? Has traffic noise from cars and airplanes really gone down, so that more birdsong can be heard? Have socially distanced people quietened down? This article presents a case study of the human perception of environmental sounds in an (...) urban neighborhood in the Basque Country between 15 March and 25 May 2020. The social restrictions imposed through national legislation divided the 69-day period into three phases. We collected observations, field audio recordings, photography, and diary notes on 50 days. Experts in soundscape and architecture were presented with the recordings, in randomized order, and made two separate perceptual analyses. One group rated the recordings for pleasantness and eventfulness using an adapted version of the Swedish Soundscape Quality Protocol, and a partly overlapping group annotated perceived sound events with free-form semantic labels. The labels were systematically classified into a four-level Taxonomy of Sound Sources, allowing an estimation of the relative amounts of Natural, Human, and Technological sounds. Loudness and three descriptors developed for bioacoustics were extracted computationally. Analysis showed that Eventfulness, Acoustic Complexity, and Acoustic Richness increased significantly over the time period, while the amount of Technological sounds decreased. These observations were interpreted as reflecting changes in people’s outdoor activities and behavior over the whole 69-day period, evidenced in an increased presence of Human sounds of voices and walking, and a significant shift from motorized vehicles toward personal mobility devices, again evidenced by perceived sounds. Quantitative results provided a backdrop against which qualitative analyses of diary notes and observations were interpreted in relation to the restrictions and the architectural specifics of the site. An integrated analysis of all sources pointed at the temporary suspension of human outdoor activity as the main reason for such a change. In the third phase, the progressive return of street life and the usage of personal mobility vehicles seemed to be responsible for a clear increase in Eventfulness and Loudness even in the context of an overall decrease of Technological sounds. Indoor human activity shared through open windows and an increased presence of birdsong emerge as a novel characteristic element of the local urban soundscape. We discuss how such changes in the acoustic environment of the site, in acoustic measurements and as perceived by humans, point toward the soundscape being a crucial component of a comprehensive urban design strategy that aims to improve health and quality of life for increasingly large and dense populations in the future. (shrink)

The main theme of Euripides’ Bacchae is Dionysus’ divinity and its recognition by the Thebans. The birth of Dionysus is a key point in the myth to determine that he is a god, consequently the playwright makes several of his characters mention it from different points of view. There are two versions clearly in conflict: on the one hand, Dionysus and his worshippers defend that he is a son of Zeus and, therefore, a god who must be venerated. On the (...) other hand, Pentheus, assuming his aunts’ view, thinks that his aunt Semele, who is Dionysus’ mother, lied when she stated that she had conceived a son of Zeus, in order to conceal a love affair with a mere mortal. Therefore, in the king’s opinion Dionysus is not a god but a mere human being. In addition, there are two characters, Cadmus and Tiresias, whose attitudes with regard to this matter are not so clear and have led scholars to interpret them in opposite ways. In this paper I am analyzing the passages of Bacchae on Dionysus’ birth, with special emphasis on those where Euripides shows or refers to Cadmus’ and Tiresias’ opinions, since my aim is to try to clarify, as far as possible, which stand the playwright made those two characters adopt regarding to Dionysus’ divinity. (shrink)

Prevention of age-related disorders is increasingly in focus of health policies, and it is hoped that early intervention on processes of deterioration can promote healthier and longer lives. New opportunities to slow down the aging process are emerging with new fields such as personalized nutrition. Data-intensive research has the potential to improve the precision of existing risk factors, e.g., to replace coarse-grained markers such as blood cholesterol with more detailed multivariate biomarkers. In this paper, we follow an attempt to develop (...) a new aging biomarker. The vision among the project consortium, comprising both research and industrial partners, is that the new biomarker will be predictive of a range of age-related conditions, which may be preventable through personalized nutrition. We combine philosophical analysis and ethnographic fieldwork to explore the possibilities and challenges of managing aging through bodily signs that are not straightforwardly linked to symptomatic disease. We document how the improvement of measurement brings about new conceptual challenges of demarcating healthy and unhealthy states. Moreover, we highlight that the reframing of aging as risk has social and ethical implications, as it is generative of normative notions of what constitutes successful aging and good citizenship. (shrink)

Though Arthur Prior is now best known for his founding of modern temporal logic and hybrid logic, much of his early philosophical career was devoted to history of logic and historical logic. This interest laid the foundations for both of his ground-breaking innovations in the 1950s and 1960s. Because of the important rôle played by Prior's research in ancient and medieval logic in his development of temporal and hybrid logic, any student of Prior, temporal logic, or hybrid logic should be (...) familiar with the medieval logicians and their work. In this article we give an overview of Prior's work in ancient and medieval logic. (shrink)

In this paper I argue that philosophers of science have an obligation to recognize and engage with the social nature of the sciences they assess if those sciences are morally relevant. Morally-relevant science is science that has the potential to risk harm to humans, non-humans, or the environment. My argument and the approach I develop are informed by an analysis of the philosophy of biology literature on the criticism of evolutionary psychology, the study of the evolution of human psychology and (...) behaviour. From this literature, I tease out two different methods of scientific critique. The first I call the “truth-detectional” approach. Those who take this approach are first and foremost concerned about the truth of EP claims as that truth can be determined by evidence. The second I call the “social-dimensional” approach. Those who take this approach talk about the production and truth of EP claims but within a social framework. On this account, the legitimacy and perceived legitimacy of EP claims are not separate from the institutional and social processes and values that lend to their production. I show that the truth-detectional approach risks harms to society and to the philosophy of science, but that the social-dimensional approach avoids these harms. Philosophers of science, therefore, should take a social-dimensional approach to the assessment of morally-relevant science. (shrink)

This book tackles the most difficult and profound open questions about life and its origins from an information-based perspective.

Implantable neurotechnology devices such as Brain Computer Interfaces and Deep Brain Stimulators are an increasing part of treating or exploring potential treatments for neurological and psychiatric disorders. While only a few devices are approved, many promising prospects for future devices are under investigation. The decision to participate in a clinical trial can be challenging, given a variety of risks to be taken into consideration. During the consent process, prospective participants might lack the language to consider those risks, feel unprepared, or (...) simply not know what questions to ask. One tool to help empower participants to play a more active role during the consent process is a Question Prompt List. QPLs are communication tools that can prompt participants and patients to articulate potential concerns. They offer a structured list of disease, treatment, or research intervention-specific questions that research participants can use as support for question asking. While QPLs have been studied as tools for improving the consent process during cancer treatment, in this paper, we suggest they would be helpful in neurotechnology research, and offer an example of a QPL as a template for an informed consent tool in neurotechnology device trials. (shrink)

Temporal logic as a modern discipline is separate from classical logic; it is seen as an addition or expansion of the more basic propositional and predicate logics. This approach is in contrast with logic in the Middle Ages, which was primarily intended as a tool for the analysis of natural language. Because all natural language sentences have tensed verbs, medieval logic is inherently a temporal logic. This fact is most clearly exemplified in medieval theories of supposition. As a case study, (...) we look at the supposition theory of Lambert of Lagny, extracting from it a temporal logic and providing a formalization of that logic. (shrink)

In the 4th century BC, the Greek philosopher Diodoros Chronos gave a temporal definition of necessity. Because it connects modality and temporality, this definition is of interest to philosophers working within branching time or branching space-time models. This definition of necessity can be formalized and treated within a logical framework. We give a survey of the several known modal and temporal logics of abstract space-time structures based on the real numbers and the integers, considering three different accessibility relations between spatio-temporal (...) points. (shrink)

By presenting a case study based on the argumentative analysis of news in the press, this article introduces and discusses strategic manoeuvring with contextual frames. Drawing on the linguistic notion of frame, I introduce the concept of contextual frame to refer to the news context, that is, the background against which a certain event is presented as a piece of news. I argue that newspapers and journalists make use of contextual frames in the apparently neutral genre of news reporting to (...) propose specific interpretations of the facts at issue, which become the basis for explicit comments and editorials. To show how this works, I investigate in detail a case of newspaper coverage of a complex episode using the pragma-dialectical notion of strategic manoeuvring and the Argumentum Model of Topics to analyse argument schemes. I show that, in the use of contextual frames, there is a prominent relation between presentational devices and topical potential; contextual frames provide the implicit material premises which are at the basis of argumentations through which newspapers interpret and comment on the news. (shrink)

Patient-derived xenografts are currently promoted as new translational models in precision oncology. PDXs are immunodeficient mice with human tumors that are used as surrogate models to represent specific types of cancer. By accounting for the genetic heterogeneity of cancer tumors, PDXs are hoped to provide more clinically relevant results in preclinical research. Further, in the function of so-called “mouse avatars”, PDXs are hoped to allow for patient-specific drug testing in real-time. This paper examines the circulation of knowledge and bodily material (...) across the species boundary of human and personalized mouse model, historically as well as in contemporary practices. PDXs raise interesting questions about the relation between animal model and human patient, and about the capacity of hybrid or interspecies models to close existing translational gaps. We highlight that the translational potential of PDXs not only depends on representational matching of model and target, but also on temporal alignment between model development and practical uses. Aside from the importance of ensuring temporal stability of human tumors in a murine body, the mouse avatar concept rests on the possibility of aligning the temporal horizons of the clinic and the lab. We examine strategies to address temporal challenges, including cryopreservation and biobanking, as well as attempts to speed up translation through modification and use of faster developing organisms. We discuss how featured model virtues change with precision oncology, and contend that temporality is a model feature that deserves more philosophical attention. (shrink)

This chapter contains sections titled: Introduction: Plato in Late Antiquity Middle Platonisms Neoplatonism Late Athenian Neoplatonism The Harmony of Plato and Aristotle Al‐Farabi Redivivus: Leo Strauss Epilogue: al‐Suhrawardi's Return to Plato Note.

The founding of the Carnegie Institute’s Department of Embryology in 1913, alongside its systematization of embryo staging, contributed to the mechanization of developmental stages of embryo growth in the early 20th century. For a brief period in the middle of the century, attention to the detailed interrelation between embryo development and time made pre-existing ideas about pregnancy ends less determinative of ideas about that developmental course. However, the turn to the genetic scale led to the disappearance of this attention, replaced (...) by a sense of biological life as seamlessly scripted. This study examines the history of what I refer to as temporal attention: attention to the live, unfolding potentialities within vital matter. The reintroduction of temporal attention to discussions of development allows us to more fully consider non-human vitality and the experiences of beings that house or otherwise intimately intersect with that vital tissue, regardless of outcomes. (shrink)

Norenzayan, Smith, Jun Kim, and Nisbett (2002) investigated cultural differences in the use of intuitive versus formal reasoning in 4 experiments. Our comment concerns the 4th experiment where Norenzayan et al. reported that, although there were no cultural differences in accuracy on abstract logical arguments, Koreans made more errors than U.S. undergraduates in judging the logical validity of concrete arguments. Norenzayan et al. concluded that Koreans are less likely than European Americans to decontextualize an argument's content from its logical structure, (...) as Koreans were more likely to consider the believability of the conclusion when assessing an argument's validity (a belief bias). Notably, Korean participants were more conservative (less likely to say an argument is valid) than European American participants when assessing arguments. An analysis of the average of the hit and correct rejection rates in each of the conditions (abstract, concrete–believable, concrete–nonbelievable) revealed that, contrary to conclusions of Norenzayan et al., European Americans were no better than Koreans at determining the validity of concrete deductive arguments with conclusions varying in believability. (shrink)

The development of the Area of Freedom, Security and Justice has transformed the European Union and placed fundamental rights at the core of EU integration and its principles of mutual recognition and trust. The impact of the AFSJ in the development of an EU standard of fundamental rights, which has come to the fore since the Treaty of Lisbon, is a topic of great theoretical and practical importance. This is the first systematic academic study of the AFSJ and its implications (...) from the point of view of fundamental rights. The contributions to this collection examine the normative and jurisprudential development of the AFSJ in order to assess its effects on the overall construction of the scope and standards of protection of EU fundamental rights in this particularly complex and sensitive field of integration. The expert contributors systematically map and critically assess this area of EU law, together with the relevant case-law. (shrink)

_ Source: _Volume 23, Issue 2, pp 196 - 235 The role of choice in Gersonides’ theory of miracles, as presented in the Wars of the Lord, is discussed. The theory of miracles in Wars vi.2.10 is shown to be another link in his reconciliation of determinism with choice. After a brief review of his ideas about choice, his astral determinism is elucidated. The third part of the essay reviews his treatment of how miracles occur. Gersonides is shown to have (...) established a “conditional miraculous determinism”; his concern for choice is the key to this solution. (shrink)

Summary Ferdinand von Mueller (1825–96), the German-born Government Botanist of Victoria from 1853 until his death, and concurrently Director of the Melbourne Botanic Garden from 1857 until 1873, was a prolific systematic botanist, but also heavily involved in public educational activities. He conceived of the Garden as an educative place of recreation, but ultimately lost control over it. His loss did not stop his popular writing and lecturing, especially in areas related to the application of botany in horticulture, agriculture, and (...) forestry. The structure of his introductory school text—very different from the intensely logical grammar-like botany texts of the period—owed much to his political masters, but it is characterized by careful attention to language and locality. Mueller's work represents a consistent and pervasive example of attention to the ‘public understanding of science’ that resonates with the concerns of early twenty-first-century funders of scientific research. (shrink)

van Fraassen's constructivist empiricist account of theories makes an epistemic distinction between entities that can and cannot be observed with the naked eye. A belief about the correctness of a theoretical description of an entity that is observable with the naked eye can be warranted by a theory. In contrast, no theory can warrant a belief about the correctness of a description of an unobservable entity. I argue that we ought to instead adopt a view that takes account of the (...) fact that some entities that cannot be observed with the naked eye can nevertheless be observed on the basis of the same physical principle as those entities that can be. This suggests that there is a distinction different from van Fraassen's that might do the work van Fraassen intends his to do, but a distinction that is principled. Understanding why this is so suggests that his distinction is grounded merely in human chauvinism. (shrink)

The creative process has the potential to increase wellbeing and foster human flourishing (Dolan and Metcalfe, 2012 ; Forgeard and Eichner, 2014 ; O’Brien and Murray, 2015 ; Conner et al., 2018 ; Kaufman, 2018 ), yet has received little attention in the humanistic management literature. In this paper, we present three experiments showing that idea originators experience greater relationship conflict with counterparts who have committed perceived “idea theft”, i.e., proposed identical or related ideas. We test a model that identifies (...) a mechanism—self-threat—that mediates the relationship between idea theft and relationship conflict and identifies an intervention to ameliorate that self-threat via self-affirmation. Study 1 demonstrates the idea originator’s attribution of malign attributions to, and negative moral emotions toward, the counterpart. Study 2 demonstrates that idea originators ostracize both those who propose identical ideas and those who propose merely related ideas. In Study 3, evidence for self-threat as the mechanism underlying the negative relational consequences is provided via both a direct test of mediation as well as via moderation by self-affirmation. Our research contributes to the nascent idea theft literature and suggests a way to reduce its negative consequences. (shrink)

One of the most important concepts in Simone de Beauvoir’s existentialist and phenomenological ethics is the concept of freedom. In this article, I would like to argue that Beauvoir’s concept of freedom is problematic in being strongly constrained by its essentially active character. This constraint contradicts some of Beauvoir’s major ideas, such as the one that considers the body as a situation, as a source of activity and of freedom in itself, as well as the idea of eroticism as one (...) of the most important expressions of authenticity. I will show that Beauvoir’s concept of freedom can appear to be less constrained by the necessity to be inherently active if we look at it through the ‘crack’ provided by her conception of the erotic body as already embodying freedom. Using this ‘crack’, I will attempt to shed new light on the aspects of Beauvoir’s idea of the erotic that are productive for her conceptions of ethics and of freedom. (shrink)

El artículo describe aspectos significativos de la conformación histórica del método clínico y hace referencia a personalidades que influyeron desde la medicina hipocrática hasta el siglo XX, detallándose los valores éticos y morales que lo caracterizaban y sus desafíos ante la sociedad. Se significa la necesidad de una reforma de pensamiento de los profesionales de la Medicina, que permita abrir nuevas perspectivas y contribuya a la reflexión siendo revertido en una conducta humanista y atención médica con calidad, con la respectiva (...) satisfacción de la población tal como se pide en los lineamientos del Partido. The article describes significant aspects of the historical formation of the clinical method and refers to personalities that influenced since The Hippocratic Medicine until the 20th Century, making emphasis on the ethical and moral values that characterized it and its challenges before the society. The need for a reform of the medical professionals thinking is meant, which allows to open new perspectives and contributes to the reflection being reversed in a humanist behaviour and a qualified medical care, with the respective satisfaction of the population as requested in the guidelines of the party. (shrink)

Research on dyscalculia in neurodegenerative diseases is still scarce, despite high impact on patients’ independence and activities of daily living function. Most studies address Alzheimer’s Disease; however, patients with Parkinson’s Disease also have a higher risk for cognitive impairment while the relation to arithmetic deficits in financial contexts has rarely been studied. Therefore, the current exploratory study investigates deficits in two simple arithmetic tasks in financial contexts administered within the Clinical Dementia Rating in a sample of 100 PD patients. Patients (...) were classified as cognitively normal or mildly impaired according to Level I consensus criteria, and assessed using a comprehensive neuropsychological test battery, neurological motor examination, and sociodemographic and clinical questionnaires. In total, 18% showed arithmetic deficits: they were predominately female, had longer disease duration, more impaired global cognition, but minor signs of depression compared to PD patients without arithmetic deficits. When correcting for clinical and sociodemographic confounders, greater impairments in attention and visuo-spatial/constructional domains predicted occurrence of arithmetic deficits. The type of deficit did not seem to be arbitrary but seemed to involve impaired place × value processing frequently. Our results argue for the importance of further systematic investigations of arithmetic deficits in PD with sensitive tests to confirm the results of our exploratory study that a specific subgroup of PD patients present themselves with dyscalculia. (shrink)

Mainstreaming Pacifism: Conflict, Success, and Ethics covers the history of philosophy concerning successful political means, and proposes an original interpretation of Machiavelli, Montesquieu, Marx and Gandhi. The book counters the objection that pacifism is ineffective, and proposes that pacifism is not for a sect, but rather draws its most effective strategies from, and contributes them to, the mainstream political tradition.

This paper examines processes of translation through which molecular genetic technologies and practices are incorporated into environmental health research and regulation. Specifically, it considers how scientists, risk assessors, and regulators have used genetically modified mouse models to translate across scientific disciplines, articulate emergent molecular forms, standards, and practices with the extant? gold standard,? and establish roles for molecular knowledge in risk assessment and regulation. Noting variation both within and between regulatory agencies in responses to data from these models, the article (...) describes also the role of public-private networks and their effects on professional and institutional imperatives which shape regulators? responses to the potential applications of these models. The conclusions address the importance of translation for understanding the wider implications of the molecularization of environmental health science. (shrink)

Uno de los principales retos del transhumanismo lo encontramos en su antropología. Nos encontramos ante un reduccionismo en el que el cuerpo aparece despojado de su dignidad y el espíritu no existe. El ejemplo que más me llama la atención de esto es el de la endogénesis: no se valora el hecho de que el ser humano sea gestado dentro del vientre de otro ser humano; para ellos sería preferible tener una máquina que pudiese hacer la misma misión, en lugar (...) de que el embarazo sea un acto de amor que tiene impacto en toda la vida de la persona. Creo que este es el mayor obstáculo en el que nos encontraremos al valorar el transhumanismo, y es especialmente importante: la persona es un edificio de múltiples dimensiones inextricablemente ligadas. Es necesario reconocer la dignidad de nuestro cuerpo, que va más allá de ser sustrato material de nuestra consciencia. El cuerpo forma parte de nuestra naturaleza, en la que cuerpo, emoción, pensamiento y espíritu son dimensiones que están íntimamente ligadas. No podemos renunciar a nuestro cuerpo. Además, me gustaría proponer que dentro del cuerpo existen portales ante la trascendencia. no es lo mismo ser que parecer. Muchos defienden que pronto tendremos robots que estarán dotados de consciencia. Que podrán pasar el test de Turing. Además, la Inteligencia Artificial permite generar mensajes de manera sintética. En algunos casos, estos mensajes son relativamente simples, pero en otros casos, como los chatbots, resultan muy interesantes. Algunos autores estiman que, dentro de poco, estos chatbots podrían llegar a pasar el test de Turing. Una vez tengamos máquinas que pasen el test de Turing, ¿podremos decir que son conscientes? ¿Es lo mismo una máquina que pase el Test de Turing que una máquina consciente? Para algunos, la respuesta es «es indiferente». Yo digo que no, que no es lo mismo. (shrink)

In Democracy without Shortcuts, Cristina Lafont identifies proceduralist or ‘deep pluralist’ conceptions of democracy alongside epistemic and lottocratic approaches as shortcuts that avoid the more challenging but, in her view, preferable path of engaging with and attempting to sway competing views, values and beliefs of fellow citizens. I argue that with the wholesale dismissal of proceduralist accounts of democracy Lafont herself takes two shortcuts: The first concerns the characterization of deep pluralism as unable to explain substantive disagreement after a decision (...) is settled, and the second undervalues proceduralism’s ability to evaluate and criticize the substance of the political decision-making process. While her critique is fitting for minimalist conceptions of proceduralism, a theory of normative proceduralism shares many objectives with Lafont’s vision of a participatory deliberative democracy. Integrating those approaches instead of dismissing proceduralism outright would render her project appealing to theorists who would not otherwise consider themselves deliberative democrats. (shrink)

Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected in vivo the role of SynJ1 in endolysosomal trafficking in zebrafish cone photoreceptors using a SynJ1‐deficient zebrafish mutant, nrca14. We found that loss of SynJ1 leads to specific accumulation of late endosomes and (...) autophagosomes early in photoreceptor development. An analysis of autophagic flux revealed that autophagosomes accumulate because of a defect in maturation. In addition we found an increase in vesicles that are highly enriched for PI(3)P, but negative for an early endosome marker in nrca14 cones. A mutational analysis of SynJ1 enzymatic domains found that activity of the 5'phosphatase, but not the Sac1 domain, is required to rescue both aberrant late endosomes and autophagosomes. Finally, modulating activity of the PI(4,5)P2 regulator, Arf6, rescued the disrupted trafficking pathways in nrca14 cones. Our study describes a specific role for SynJ1 in autophagosomal and endosomal trafficking and provides evidence that PI(4,5)P2 participates in autophagy in a neuronal cell type. -/- . (shrink)

Children learning to read in two different orthographic systems are exposed to cross-linguistic interferences. We explored the effects of school and grade on phonological activation during a visual word recognition task. Elementary school children from Spain completed a lexical decision task in English. The task included real words and pseudohomophones following Spanish or English phonological rules. Using the mouse-tracking paradigm, we analyzed errors, reaction times, and computer mouse movements. Children in the bilingual school performed better than children in the monolingual (...) school. Children in higher grades performed better than children in lower grades. The interference effect of Spanish phonology was weak and became weaker in higher grades. Spanish children differentiate between first and second language grapheme-to-phoneme correspondences since early on in the educational process. In 6th grade, children from the bilingual school responded better to words and Spanish pseudohomophones, while children from the monolingual school were less distracted by the English pseudohomophones. Children in the bilingual school had stronger inhibition of Spanish phonology and stronger activation of English phonology. Instructional method plays an important role on the processing strategies Spanish children rely on when reading in English. School and grade influence the link between orthographic and phonological representations. (shrink)

Biotechnology's promises has been widely recognized as a major enterprise accelerating the commodification of the biological. After the 9/11 events and the subsequent anthrax letters, biotechnologies have additionally been described as contributing to the construction of biosecurity risks. This paper proposes to investigate the collaboration between the FBI and the DIYbio network as a case study illustrating the productive entanglement of biological risks and promises. To do so, the paper explores the social construction of risks and promises associated with the (...) vision of distributed biotechnologies as enacted in this collaboration. We argue that the FBI needs to police the DIYbio network in order to disseminate a specific notion of bioterrorist risk, while, in a counter-intuitive manner, the DIYbio network benefits from being policed by the FBI as it helps them disseminate their socio-technological vision. If the entanglement of technoscientific risks and promises is a well established finding of the STS literature, our case study suggests that such entanglement now additionally comprises the sphere of biosecurity and the promises of a distributed biotechnology available to everyone. (shrink)

Scholars from various disciplines have explored the powerful symbolic function that children occupy within public discourses of technology, but less attention has been paid to the role this plays in the social shaping of the technologies themselves. Virtual worlds present a unique site for studying how ideas about children become embedded in the artifacts adults make for them. This article argues that children’s virtual worlds are fundamentally negotiated spaces in which broader aspirations and anxieties about children’s relationships with play, technology, (...) consumer culture, and the public sphere resurface as “configurations” of an imagined, ideal child player. The article begins with a brief overview of the children's virtual worlds phenomenon, followed by a discussion of related research on children’s play and play technologies. Findings from a case study of six commercial, game-themed virtual worlds targeted specifically to children are then presented, with a focus on how these artifacts configure their child players in highly ideological and normative ways, wherein play is narrowly defined in accordance with a neoromantic, consumerist ethos. The article aims to uncover the hidden politics inscribed within a particular genre of children’s technology and to explore some of the implications for children’s digital play. (shrink)

Researchers have highlighted how gendered associations of femininity with emotional labor can complicate professional women’s attempts to exercise managerial authority. However, current understandings of how race and gender intersect in professional women’s emotional labor remain limited. We draw on 132 interviews from eight white women and 13 women of color who are novice principals. White women began the principalship wanting to establish themselves as emotionally supportive leaders who were open to others’ influence. They viewed emotional labor as existing in tension (...) with showing authority as a leader. Over time, however, most white women reported adopting more directive practices. By contrast, women of color reported beginning the principalship with a more directive, take-charge leadership style. They viewed emotional labor and authority as part of a blended project and did not talk about these two aspects of leadership as existing in tension. Over time, their self-reported leadership style changed little. We analyze our findings in light of recent theorizing about gender and intersectionality. (shrink)

Philosophical writing is challenging for students new to philosophy. Many philosophy classes are populated, for the most part, by students who have never taken philosophy before. While many institutions offer general writing support services, these services tend to be most beneficial for helping to identify problems with style and grammar. They are not equipped to help students with the particular challenges that come with writing philosophy for the first time. We implemented the “Home Base” Mentoring Program in two introductory level (...) philosophy courses to target the specific challenges that novice learners have when learning how to write philosophy. Through the program, students had access to writing mentors who were undergraduate senior philosophy majors. Based on surveys given to the students who have participated in this program, we found that the program boosted student confidence in writing and also worked to develop a welcoming, judgment-free, and encouraging environment in the philosophy department more generally. (shrink)