Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

1 L’oggettivazione psicologistico-riduzonistico-introiettivistica Nella seconda metà del V secolo a. C. si ha in Grecia una radicale conversione del modo in cui l’uomo intende se stesso e il mondo nel quadro della cultura intellettuale europea che da quel momento sarà poi dominante: si tratta dell’oggettivazione psicologistico-riduzionistico-introiettivistica. Il mondo empirico viene smembrato in seguito alla separazione di un mondo interiore psichico ritenuto diverso per ogni possessore di c...

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Mind blanking is a mental state in which attention does not bring any perceptual input into conscious awareness. As this state is still largely unexplored, we suggest that a comprehensive understanding of mind blanking can be achieved through a multifaceted approach combining self-assessment methods, neuroimaging, and neuromodulation. In this article, we explain how EEG and TMS could be combined to help determine whether mind blanking is associated with a lack of mental content or a lack of linguistically or conceptually determinable (...) mental content. We also question whether mind blanking occurs spontaneously or intentionally and whether these two forms are instantiated by the same or different neural correlates. (shrink)

This volume offers a systematic overview of Kantian philosophy and of central currents and developments in contemporary philosophy.

Die Person ist nur Person, indem sie zugleich prapersonal ist, und bringt doch etwas unvorhersehbar Neues auf: ihre Fahigkeit zur Selbstbestimmung durch Selbstzuschreibung als Fall mehrerer Gattungen. Mit ihrem Durchbruch aus der Gefangenschaft in Situationen entsteht die Welt als Antwort auf das menschliche Ansprechen mit satzformiger Rede, die aus Situationen schopft. Diese Doppelgesichtigkeit von Verankerung und Neubildung in der Epigenese wird in dem Buch an verschiedenen Themen verfolgt. Dazu gehoren u. a. Enge und Weite, Leib und leibliche Kommunikation, Sucht, Intentionalitat, (...) Geschichte und Praxis. Am Schluss steht ein Ruckblick auf das Abendland. Die antike Philosophie mit Welt- und Menschspaltung, das mittelalterliche Christentum mit Bindung des affektiven Betroffenseins an die Macht als zentrales Thema, die Neuzeit mit dem gegen Situationen und leibliche Kommunikation blinden Weltbild der Naturwissenschaft haben die Menschen vom Einblick in ihr wirkliches Leben abgelenkt. Die noch unverlorene Kraft kritischer Aufklarung lasst einige Hoffnung auf einen Neubeginn des menschlichen Selbst- und Weltverstandnisses im Abendland ubrig. (shrink)

RESUMEN Introducción: La educación en el trabajo es la forma fundamental del proceso docente educativo en las carreras de las ciencias médicas y en específico para la asignatura de Medicina Comunitaria de la carrera de Medicina. Objetivo: Exponer elementos referidos a una guía didáctica para la educación en el trabajo de la asignatura Medicina Comunitaria. Método: Se diseñó una guía didáctica para la educación en el trabajo, desde la asignatura Medicina Comunitaria. Se interactuó con estudiantes de segundo año de la (...) carrera de Medicina, la cuak abarcó 4 etapas. Resultados: Se ofrecen las tareas con sus objetivos y acciones a cumplimentar por los estudiantes, amparados por la guía actual de confección del Análisis de la Situación de Salud. Conclusiones: La guía constituye una herramienta que posibilita la realización de las actividades de la educación en el trabajo a la vez que permite el logro de competencias profesionales. ABSTRACT Introduction: The education in the work is the fundamental form of the educational teaching process in the careers of the medical sciences and in specific for the subject of Community Medicine of the career of Medicine. Objective: To exhibit elements referred to a didactic guide for the education in the work of the Community Medicine subject. Method: A didactic guide was designed for the education in the work, from the Community Medicine subject. It was interacted with students of the second year of the career of Medicine, which included 4 stages. Results: The tasks are offered with their objectives and actions to complete for the students protected by the current guide of preparation of the Analysis of the Situation of Health. Conclusions: The guide constitutes a tool that makes possible the achievement of the activities of the education in the work, simultaneously it allows the achievement of professional competitions. (shrink)

Original, or 'old', institutional economics (OIE) – also known as 'institutionalism' – played a key role in its early stages; it could be said that it was once the 'mainstream economics' of the time. This period ran approximately from the first important contributions of Thorstein Veblen in 1898 to the implementation of the New Deal in the early 1930s, where many institutionalists played a significant role. However, notwithstanding its promising scientific and institutional affirmation, institutional economics underwent a period of marked (...) decline that spanned from the mid-1930s to the late 1980s, when a new season for institutional economics was set in motion. In order to cast some light on this complex issue – without any claim of completeness – we have organised the work as follows: in the first section we consider the main interpretations of this phenomenon. In the subsequent sections we analyse a number of 'endogenous' aspects which might have played a significant role in the period of decline: (i) the relations of institutional economics with Keynes's macroeconomic theory; (ii) the links between theoretical and empirical analysis and the supposed lack of a clear theory; (iii) the interdisciplinary orientation. (shrink)

Geschichte der Aesthetik in Deutschland ist ein unveränderter, hochwertiger Nachdruck der Originalausgabe aus dem Jahr 1868. Hansebooks ist Herausgeber von Literatur zu unterschiedlichen Themengebieten wie Forschung und Wissenschaft, Reisen und Expeditionen, Kochen und Ernährung, Medizin und weiteren Genres. Der Schwerpunkt des Verlages liegt auf dem Erhalt historischer Literatur. Viele Werke historischer Schriftsteller und Wissenschaftler sind heute nur noch als Antiquitäten erhältlich. Hansebooks verlegt diese Bücher neu und trägt damit zum Erhalt selten gewordener Literatur und historischem Wissen auch für die Zukunft (...) bei. (shrink)

Charles Darwin's curiosity had a remarkable childlike enthusiasm driven by an almost compulsive appetite for a constant process of discovery, which he never satiated despite his many voyages. He would puzzle about the smallest things, from the wonders of barnacles to the different shapes, colours and textures of the beetles which he obsessively collected, from flowers and stems to birds, music and language, and would dedicate years to understanding the potential significance of everything he saw. Darwin's findings and theories relied (...) heavily on that same curiosity, on seeking and answering questions, however long these would take to clarify. His son Francis Darwin often recalls how "he would ask himself 'now what do you want to say' and his answer written down would often disentangle the confusion". In fact, "disentangling confusions" seems to have been the driving force behind Darwin's scientific pursuits, as he was struck with bewilderment when contemplating the luxuriousness of life. It was also the impetus for this book. The true implications of Darwin's legacy remain as controversial to the critics of our time as they were to his contemporaries. Darwin's impact within and beyond the biological sciences is both daunting and exhilarating, and attests to the need for an interdisciplinary approach by remaining a challenge to many scholars in the most diverse fields. The recent revival of his theories has opened a Pandora's box of different theoretical studies that are particularly receptive to exploring new and exciting angles of research. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)