BackgroundReducing the number of animals used in experiments has become a priority for the governments of many countries. For these reductions to occur, animal-free alternatives must be made more available and, crucially, must be embraced by researchers.MethodsWe conducted an international online survey for academics in the field of animal science (N = 367) to explore researchers’ attitudes towards the implementation of animal-free innovations. Through this survey, we address three key questions. The first question is whether scientists who use animals in (...) their research consider governmental goals for animal-free innovations achievable and whether they would support such goals. Secondly, responders were asked to rank the importance of ten roadblocks that could hamper the implementation of animal-free innovations. Finally, responders were asked whether they would migrate (either themselves or their research) if increased animal research regulations in their country of residence restricted their research.ResultsWhile nearly half (40%) of the responders support governmental goals, the majority (71%) of researchers did not consider such goals achievable in their field within the near future. In terms of roadblocks for implementation of animal-free methods, ~ 80% of the responders considered ‘reliability’ as important, making it the most highly ranked roadblock. However, all other roadblocks were reported by most responders as somewhat important, suggesting that they must also be considered when addressing animal-free innovations. Importantly, a majority reported that they would consider migration to another country in response to a restrictive animal research policy. Thus, governments must consider the risk of researchers migrating to other institutes, states or countries, leading to a ‘brain-drain’ if policies are too strict or suitable animal-free alternatives are not available.ConclusionOur findings suggest that development and implementation of animal-free innovations are hampered by multiple factors. We outline three pillars concerning education, governmental influence and data sharing, the implementation of which may help to overcome these roadblocks to animal-free innovations. (shrink)

Event-related brain potentials (ERPs) can reveal online processing differences between native speakers and second language (L2) learners during language comprehension. Using the P600 as a measure of native-likeness, we investigated processing of grammatical gender agreement in highly proficient immersed Romance L2 learners of Dutch. We demonstrate that these late learners consistently fail to show native-like sensitivity to gender violations. This appears to be due to a combination of differences from the gender marking in their L1 and the relatively opaque Dutch (...) gender system. We find that L2 use predicts the effect magnitude of non-finite verb violations, a relatively regular and transparent construction, but not that of gender agreement violations. There were no effects of age of acquisition, length of residence, proficiency or offline gender knowledge. Additionally, a within-subject comparison of stimulus modalities (written vs. auditory) shows that immersed learners may show some of the effects only in the auditory modality; in non-finite verb violations, an early native-like N400 was only present for auditory stimuli. However, modality failed to influence the response to gender. Taken together, the results confirm the persistent problems of Romance learners of Dutch with online gender processing and show that they cannot be overcome by reducing task demands related to the modality of stimulus presentation. (shrink)

The preparation of samples for gene diagnosis is time‐consuming, labor‐intensive and costly. These problems can be overcome by dissolving a biological source in a strong solution of a chaotropic salt, then filtering the solution through an immobilizing membrane. Conditions exist for causing the selective immobilization of either DNA or mRNA. The resultant membrane is immediately ready for reaction with labeled gene probes.

Our study presents an overview of the issues that were brought forward by participants of a moral case deliberation (MCD) project in two elderly care organizations. The overview was inductively derived from all case descriptions (N = 202) provided by participants of seven mixed MCD groups, consisting of care providers from various professional backgrounds, from nursing assistant to physician. The MCD groups were part of a larger MCD project within two care institutions (residential homes and nursing homes). Care providers are (...) confronted with a wide variety of largely everyday ethical issues. We distinguished three main categories: ‘resident’s behavior’, ‘divergent perspectives on good care’ and ‘organizational context’. The overview can be used for agendasetting when institutions wish to stimulate reflection and deliberation. It is important that an agenda is constructed from the bottom-up and open to a variety of issues. In addition, organizing reflection and deliberation requires effort to identify moral questions in practice whilst at the same time maintaining the connection with the organizational context and existing communication structures. Once care providers are used to dealing with divergent perspectives, inviting different perspectives (e.g. family members) to take part in the deliberation, might help to identify and address ethical ‘blind spots’. (shrink)

It is Frege's third contribution that makes the point of departure for the present paper. Not merely did Frege show how to manipulate symbols more exactly; he also gave a searching account of what these symbols mean. Consider a philosophical problem that arises out of the simplest arithmetic. When we say that 5 = 2 + 3, what do we mean? Do we mean that 5 is identical with 2 + 3? But in some ways 5 and 2 + 3 (...) are obviously different. Or do we mean that 5 and 2 + 3 are equal but not identical, equality being a relation that falls short of complete identity? But in that case, some ordinary ways of speaking in mathematics must be false. Suppose a pupil is asked for the positive square root of 25. The phrasing of the question implies that there is one and only one. No doubt he may answer, '5'. But then it follows that the answer '2 + 3' is not allowable, since ex hypothesi 5 and 2 + 3, though equal, are not identical. Yet ordinarily the answer '2 + 3' would be regarded as strange but not as wrong. (shrink)

Demiryolu yük taşımacılığı, yurtiçi ve yurtdışı ekonomik işlemlerin gerçekleştirilmesi bakımından büyük öneme sahiptir. Bu taşımacılık türü ihracatçılara, ara malı tedariki ve tamamlanmış ürünlerin ihraç edilmesinde masrafların azalmasına ve daha fazla mal ihracı sağlaması açısından önemli katkılar sağlamaktadır. Bu olumlu katkılar ise ekonomik büyümenin artmasını sağlayabilmektedir. Türkiye’ de demiryolu taşımacılığında en başarılı gelişmeler Cumhuriyetin ilanından sonraki kalkınma yıllarında yaşanmıştır. Demiryolu taşımacılığının kullanımı, tarihsel süreçte sanayi sektörünün, ekonomik ve sosyal yapının gelişmesine katkı sağlamıştır. Bu çalışmada Türkiye için demiryolu yük taşımacılığının ekonomik büyüme (...) üzerindeki etkileri 1960-2021 dönemi için ARDL sınır testi ekonometrik tekniğiyle analiz edilmesi amaçlanmıştır. Çalışma sonucuna göre demiryolu yük taşımacılığı hem uzun hem de kısa dönemde ekonomik büyüme üzerinde pozitif etki oluşturmuştur. Buna göre uzun dönemde demiryolu yük taşımacılığındaki %1’lik artış ekonomik büyümenin %1,95 oranında artmasını sağlamıştır. Bu noktadan hareketle demiryolu sektörüne yapılması muhtemel yatırımların ekonominin büyümesine ve gelişmesine katkı sunacağı tahmin edilmektedir. (shrink)

ABSTRACTThe historical process underlying Darwin’s Origin of Species did not play a significant role in the early editions of the book, in spite of the particular inductivist scientific methodology it espoused. Darwin’s masterpiece did not adequately provide his sources or the historical perspective many contemporary critics expected. Later editions yielded the ‘Historical Sketch’ lacking in the earlier editions, but only under critical pressure. Notwithstanding the sources he provided, Darwin presented the Origin as an ‘abstract’ in order to avoid giving sources; (...) a compromise he acknowledged and undertook to set right in later editions, yet failed to provide throughout the six editions under his supervision. Darwin’s reluctance to publish the historical context of his theory and his sources, particularly sources which were also ‘precursors’, may be attributed as much to the matter of intellectual ownership as science, or even good literary practice. Of special concern to Darwin were issues of priority or originality over ‘descent with modification’ and especially over Natural Selection. Many later historians have argued that Darwin was unaware of the work of his precursors on Natural Selection. Darwin’s theory was an example of independent discovery, albeit along with such obscure precursors as Matthew or Wells, who were unknown to Darwin until after the publication of the Origin. Both Matthew and Wells had a medical education, like James Hutton or Erasmus Darwin earlier in the eighteenth century, or even Charles Darwin. Evolutionary theory, at least in Britain was a product largely of the medical evolutionists rather than the natural historians which ‘history’ has chosen to select for the focus of attention; and among the medical evolutionists the figure of John Hunter stands out as theorist, experimentalist and teacher: the medical evolutionists were predominantly the product of Hunter’s legacy or of the medical profession and particularly the Scottish Universities. Much recent Darwin scholarship has focused on the private Notebooks, to establish Darwin’s discovery of Natural Selection around 1837–1838 and demonstrate Darwin’s ignorance of his precursors; requiring an explicit acknowledgement by Darwin as the legitimate substantiation of any claim to prior influence. The precursors have been categorized as uniformly obscure or irrelevant to the science of evolution which may be defined exclusively as ‘Darwinian’. The inclination to acknowledge influences, however was not something Darwin was gratuitously given to doing, especially on matters of priority. The Notebooks are not Darwin’s private thoughts; from an early stage he considered them incipient public documents and later sought to protect them as proof of his originality. William C. Wells was not an obscure thinker, but a celebrated scientist whom Herschel, Darwin’s guide to scientific methodology, had recommended as providing a model of scientific method. Darwin discovered Wells through Herschel, and quickly acquired a copy of Wells’ recommended work, no later than 1831, and held it thereafter in his library at Down House. This book, the 1818 edition of Wells’ Two Essays contains a third essay, Wells’ account of Natural Selection. Later, in the Descent of Man Darwin acknowledged his separate discovery of the correlation of colour and disease immunity in man, also earlier recounted by Wells. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:James's Faith-Ladder JAMES C. S. WERNHAM JAMES WROTE OFTEN of a "faith-ladder."' What he said about it has drawn some side-glances from critics, but not yet any sustained and careful look.' That is surprising, for what he says is puzzling enough to invite inquiry. It is also important enough to deserve it. His presentations of the ladder show significant variation, so it is useful to look at a generous (...) sample. In the interest of brevity the following six passages have been extracted from contexts which sometimes have an important bearing on them. The unquoted contexts will get attention as needed. 1. "The inner process is a succession of 'synthetic judgments'. What is so good, may be, ought to be, must be, shall be,--so far as I am concerned, I won't admit the opposite. ''s 2. "[W]e have a conception which being opposed by another is only probab /e. But we feel, it is so good that it isfit to be true, it ought to be true, it must be true etc. And then we say it shall be true for me, it/s true. ''4 3- "Its [faith's] natural logic is the Sorites: fit to be, ought to be, may be, must be, shall be, is etc.''5 4. "The following steps may be called the 'faith-ladder': ~. There is nothing absurd in a certain view of the world being true, nothing self-contradictory; ' To the best of my knowledge, the name "faith-ladder'"does not occur before 19o6. It occurs in "Faith and Reason" and in "Faith and the Right to Believe," both written in that year. But expositions of the thing predate the name. They are found as early as 1899, and in close connection with the will-to-believe doctrine. 9 Levinson's discussion is a partial exception. His treatment is more extended than most. See H. S. Levinson, $c/ence, Metaphysicsand the Chan~e of Salvation (Missoula, MT: Scholars Press, 1978), 161--67; also his The Religious Investigations of Wdliam James (Chapel Hill: University of North Carolina Press, 198 0, 231-34. s Letter to Baldwin, quoted in'R. B. Perry, The Thoughtand Characterof WilliamJames, 2 vols. (Boston: Little, Brown and Co., 1935), 2: 243. 4 Letter to Marshall, Feb. 9, 1899, quoted in Perry, Thought and Character,2: 24~. 5 William James, A Pluralistic Universe (Cambridge, MA and London: Harvard Universit~t Press, 1977), 199. [1o5] lO6 JOURNAL OF THE HISTORY OF PHILOSOPHY 28" 1 JANUARY I990 2. If might have been true under certain conditions; 3- It may be true even now; 4. It isfit to be true; 5- It ought to be true; 6. It must be true; 7- It s/m//be true, at any rate true for me. ''6 5. "Faith's form of argument is something like this: Considering a view of the world: 'It isfit to be true', she feels; 'it would be well if it were true; it might be true; it may be true; it ought to be true', she says; 'it must be true', she continues; 'it shall be true', she concludes, 'for me; that is, I will treat it as if it were true so far as my advocacy and actions are concerned'. ''7 6. "A conception of the world arises in you somehow, no matter how. Is it true or not? you ask. It might be true somewhere, you say, for it is not self-contradictory. It may be true, you continue, even here and now. It is fit to be true, it would be well if it were true, it ought to be true, you presently feel. It must be true, something persuasive in you whispers next; and then--as a final result--it shall be held for true, you decide; it shall be as if true, for you. ''s 9. Between these statements there are clear similarities and clear differences too. Some of them deserve to be noted, some to be noted and explored. a. In these accounts of it the ladder varies in the number of its rungs. By James's own count in one place, it has as many as seven. In... (shrink)

This article aims to study the Hadiths which ascribe morality to Allah, regarding narration and understanding, and how these Hadiths have cont-ributed to the establishment of a moral framework. The primary research problem is based upon understanding the meaning of Allah’s morality, how scholars have dealt with these Hadiths, and how they have benefited from them in the field of Islamic ethics. There are several key research questions, the most important of which are: What is the authenticity of these Hadiths (...) that attribute morality to Allah? What is the intended meaning of Allah’s morality? How have scholars addressed these Hadiths? Perhaps the most significant question is how these Hadiths have contributed to the develop-ment of an ethical theory. The research investigated the Hadiths that attri-bute qualities to Allah and studied them through the analysis of their chains of transmission. It then analysed how the phrase "Allah’s morality" contri-buted to the ethical theory among thinkers. The paper arrived at several conclusions, the most important of which is that there are five Hadiths att-ributing morality to Allah, all of which are weak according to Hadithic principles. However, these Hadiths support each other, and there are addi-tional references that espouse the idea of Allah being characterized by cer-tain morals, such as the Hadiths "Indeed, Allah is Tayyib (Pure)" and "In-deed, Allah is Modest." These Hadiths embrace the notion that Allah has attributes He loves His servants to embody. Therefore, the five Hadiths can be accepted as Hasan (good) due to external support. These Hadiths were accepted by some thinkers who interpreted Allah’s morality as His Beautiful Names (Asmāʾ llāhi al-ḥusnā). Consequently, Allah’s morality is understood as His Beautiful Names. The impact of these Hadiths can be observed in the works of Al-Ḥakīm al-Tirmidhī, Al- Ghazālī, and Al- Rāzī, as they placed the Beautiful Names of Allah at the centre of their ethical views. It is no-teworthy that those who accepted the idea of Allah’s morality were cauti-ous in dealing with it. An important observation is that those who based an ethical perspective on these Hadiths were not Hadith scholars, but rather individuals engaged in other fields of study. This can be ascribed to several reasons: one being that the Hadiths attributing morality to Allah are not authentic, and another being that many Hadith scholars refrained from in-terpretation and were content with the literal meaning of the Hadiths. (shrink)

What kind of reading and viewing space is created within contemporary platforms? While existing research has explored the impact of surveillance, this article moves on to theoretically discuss the intersection of technosocial reading. It examines how algorithmic interpellation and profiling function as enunciative strategies, and how this is explored from a transgender perspective. The article raises theoretical questions about the flattening of enunciation and its implications for a critical reading and observation space. To further explore these concepts, it analyses Ada (...) Ada Ada’s year-long in transitu Instagram performance. Through this analysis, the challenges posed by fixed, binary gender categorisations prevalent on platforms like Instagram are unpacked. Ada Ada Ada’s performance serves as an imminent criticism of the enunciative, representational and gender policies of platforms, demonstrating their arbitrary and absurd nature. Ultimately, in transitu invites platform users to reconsider their roles as technosocial readers and observers. (shrink)

Questions of patient autonomy have formed an important part of ethical debate in medicine from at least the post-war period onwards. Although initially important as a counterweight to widespread medical paternalism, recent years have seen a reaction against a widely perceived ‘triumph of autonomy’. In particular, competent patients' refusal of life-saving or clearly beneficial treatment presents complex dilemmas for both healthcare professionals and ethicists. Discussion of the mechanism provided by the Israel Patient's Rights Act of 1996 for ethics committees to (...) override refusal of treatment by such patients has provided several examples in which it seems an obligation to benefit the patient can outweigh concerns regarding respect for their autonomy. However, such analyses as have been undertaken so far may be seen to omit important elements of the moral decision-making process that takes place even when the latter appears to ‘win out’. In addition to helping better prepare clinicians to meet such challenges in the future, a fuller appreciation of those elements that are present in justified cases of coercive treatment may enable them to arrive at a better understanding of what autonomy itself can mean in a medical context. (shrink)

This is a challenging and original work on the concept of justification and its application to ethical statements. The book divides into two parts. The first part is devoted to a systematic treatment of the nature of justification. It begins with a critical rejection of the deductive model. Wellman presents plausible arguments for the existence of non-deductive evidences in ethics and shows how ethical theories can be tested by "thought-experiment" as analogous to the confirmation of scientific theories by laboratory trials. (...) An interesting kind of inference termed "conductive reasoning" is described. It is argued that this third form of reasoning can be validly used in justifying ethical conclusions. Distinctive of conductive reasoning is its non-formal and inconclusive feature. Its validity is alleged to lie in its dependence upon the content of the argument. But by and large there is no way to judge the validity of these basic ethical arguments but by thinking them through and feeling their logical force." Wellman goes on to develop a challenge-response model for understanding the nature of justification. Justification is "to be understood essentially as a process of responding to challenges made." However, Wellman makes no attempt to consider the role of moral concepts in determining the validity of conductive reasoning and its role in the justification of ethical statements. Part II considers the dimensions of ethical justification in terms of the model of challenge and response. Seven species of challenge are described: truth, truth-value, meaningfulness, validity, validity-value, competence, and knowability. On the whole the book contains challenging views and material for the epistemology of ethics.--A. S. C. (shrink)

This paper proposes a classification of economic models into three types: historical, axiomatic and conditional. Historical or empirical models utilize the historical-deductive method, and are generalizations from the economic regularities and tendencies that we find in the real world. Axiomatic models utilize the hypothetical-deductive method; they are syllogisms whose major premise is an axiom – a self-evident truth; they are appropriate for methodological sciences such as mathematics and econometrics. Conditional economic models are likewise syllogisms, but they are suitable for economics (...) because they make for clearer and more precise economic reasoning. The criterion of truth of the substantive sciences is the conformity with reality, of the methodological science, its internal consistency. When a school of economic thought adopts mainly axiomatic models, as is the case with neoclassical economics, it implicitly falls into contradiction because their best representatives believe in the conformity with reality criterion. (shrink)

Philosophers of chemistry, following the lead of physicists, have been slow to realize that molecular descriptions issuing from quantum mechanics in the absence of chemical theory are fatally flawed. In the wake of this realization, new topics have begun to unfold—including new metaphysical issues, new concerns about the philosophy of chemistry's place in the philosophy of science, and new accounts of how properties are observed, inferred, and presented. A recent collection of essays, Of Minds and Molecules: New Philosophical Perspectives on (...) Chemistry edited by Nalini Bhushan and Stuart Rosenfeld, reveals what some of these new issues are and suggests new directions for the philosophy of chemistry. (shrink)

This is a very readable theological attack on current religious journalism about "the death of God" and its moral consequences. Rightly chiding the "radical" theologians for their tendentious use of words like "new," Hamilton wrongly equates their talk of "the secular" with support of the profane and so sometimes misses the import of their groping for new ways of thinking and acting as Christians. Seen through his eyes, much of their thought is really nineteenth century liberal humanism repackaged for the (...) suburban market. Recognizing the incoherence of the Barth-Bonhoeffer concept of religion, he nevertheless uses it when accusing Bishop Robinson, van Buren, and the rest of replacing Christianity with religion, rather than inaugurating a "religionless Christianity," as they intend. The best part of the book is an analysis of what Bonhoeffer really meant by "religionless Christianity" and other such provocative phrases. Like those he criticizes, Hamilton is quite sure that the Bible supports only his version of Christianity. His unabashed neo-orthodoxy commits him to conceiving of God as an arbitrary dictator, but it also provides him with a keen critical vantage-point, by reference to which all philosophical theologies are damned as modernizing, hypothetical, Hegelian, and un-Christian at heart. His own preference for talk of "natural piety" instead of "secular Christianity" is too sketchily presented to be assessed.--C. P. S. (shrink)

According to qualitativism, thisness is not a fundamental feature of reality; facts about particular things are metaphysically second-rate. In this paper, I advance an argument for qualitativism from ideological parsimony. Supposing that reality fundamentally contains an array of propertied things, non-qualitativists employ a distinct name (or constant) for each fundamental thing. I argue that these names encode a type of worldly structure (thisness structure) that offends against parsimony and that qualitativists can eliminate without incurring a comparable parsimony-offense.

Our study presents an overview of the issues that were brought forward by participants of a moral case deliberation (MCD) project in two elderly care organizations. The overview was inductively derived from all case descriptions (N = 202) provided by participants of seven mixed MCD groups, consisting of care providers from various professional backgrounds, from nursing assistant to physician. The MCD groups were part of a larger MCD project within two care institutions (residential homes and nursing homes). Care providers are (...) confronted with a wide variety of largely everyday ethical issues. We distinguished three main categories: ‘resident’s behavior’, ‘divergent perspectives on good care’ and ‘organizational context’. The overview can be used for agendasetting when institutions wish to stimulate reflection and deliberation. It is important that an agenda is constructed from the bottom-up and open to a variety of issues. In addition, organizing reflection and deliberation requires effort to identify moral questions in practice whilst at the same time maintaining the connection with the organizational context and existing communication structures. Once care providers are used to dealing with divergent perspectives, inviting different perspectives (e.g. family members) to take part in the deliberation, might help to identify and address ethical ‘blind spots’. (shrink)

Sebastian Gardner competently tackles one of Sartre's more complex and challenging works in this new addition to the Reader's Guides series.