The integration of biomedical terminologies is indispensable to the process of information integration. When terminologies are linked merely through the alignment of their leaf terms, however, differences in context and ontological structure are ignored. Making use of the SNAP and SPAN ontologies, we show how three reference domain ontologies can be integrated at a higher level, through what we shall call the OBR framework (for: Ontology of Biomedical Reality). OBR is designed to facilitate inference across the boundaries of domain ontologies (...) in anatomy, physiology and pathology. (shrink)

The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or ‘ontologies’. Unfortunately, the very success of this approach has led to a proliferation of ontologies which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing (...) OBO ontologies, including the Gene Ontology, are undergoing a process of coordinated reform and new ontologies being created on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable, logically well-formed, and to incorporate accurate representations of biological reality. We describe the OBO Foundry initiative, and provide guidelines for those who might wish to become involved. (shrink)

The Foundational Model of Anatomy (FMA) symbolically represents the structural organization of the human body from the macromolecular to the macroscopic levels, with the goal of providing a robust and consistent scheme for classifying anatomical entities that is designed to serve as a reference ontology in biomedical informatics. Here we articulate the need for formally clarifying the is-a and part-of relations in the FMA and similar ontology and terminology systems. We diagnose certain characteristic errors in the treatment of these relations (...) and show how these errors can be avoided through adoption of the formalism we describe. We then illustrate how a consistently applied formal treatment of taxonomy and partonomy can support the alignment of ontologies. (shrink)

To enhance the treatment of relations in biomedical ontologies we advance a methodology for providing consistent and unambiguous formal definitions of the relational expressions used in such ontologies in a way designed to assist developers and users in avoiding errors in coding and annotation. The resulting Relation Ontology can promote interoperability of ontologies and support new types of automated reasoning about the spatial and temporal dimensions of biological and medical phenomena.

Tumors, abscesses, cysts, scars, fractures are familiar types of what we shall call pathological continuant entities. The instances of such types exist always in or on anatomical structures, which thereby become transformed into pathological anatomical structures of corresponding types: a fractured tibia, a blistered thumb, a carcinomatous colon. In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a, part_of and transformation_of can facilitate the integration of such ontologies in ways which have (...) the potential to support new kinds of automated reasoning. We here extend this approach to the treatment of pathologies, focusing especially on those pathological continuant entities which arise when organs become affected by carcinomas. (shrink)

The Foundational Model of Anatomy (FMA) is a map of the human body. Like maps of other sorts – including the map-like representations we find in familiar anatomical atlases – it is a representation of a certain portion of spatial reality as it exists at a certain (idealized) instant of time. But unlike other maps, the FMA comes in the form of a sophisticated ontology of its objectdomain, comprising some 1.5 million statements of anatomical relations among some 70,000 anatomical kinds. (...) It is further distinguished from other maps in that it represents not some specific portion of spatial reality (say: Leeds in 1996), but rather the generalized or idealized spatial reality associated with a generalized or idealized human being at some generalized or idealized instant of time. It will be our concern in what follows to outline the approach to ontology that is represented by the FMA and to argue that it can serve as the basis for a new type of anatomical information science. We also draw some implications for our understanding of spatial reasoning and spatial ontologies in general. (shrink)

ABSTRACT Genomic research and biobanking present several ethical, social and cultural challenges, particularly when conducted in settings with limited scientific research capacity. One of these challenges is determining the model of consent that should support the sharing of human biological samples and data in the context of international collaborative research. In this paper, we report on the views of key research stakeholders in Ghana on what should count as good ethical practice when seeking consent for genomic research and biobanking in (...) Africa. This study was part of a multi-country qualitative case study conducted in three African countries: Ghana, Uganda and Zambia under the auspices of the Human Heredity and Health in Africa initiative (H3Africa). Our study suggests that while participants are willing to give consent for their samples and associated data to be used for future research purposes, they expect to receive feedback about the progress of the research and about the kinds of research being undertaken on their samples and data. These expectations need to be anticipated and discussed during the consent process which should be seen as part of an ongoing communication process throughout the research process. (shrink)

Bonginkosi Shozi and Donrich Thaldar’s (2023) contribution is relevant to epistemic justice, which involves efforts to develop an inclusive and global bioethics that takes seriously perspectives fr...

To commemorate 40 years since the founding of the Journal of Business Ethics, the editors in chief of the journal have invited the editors to provide commentaries on the future of business ethics. This essay comprises a selection of commentaries aimed at creating dialogue around the theme Ethics at the centre of global and local challenges. For much of the history of the Journal of Business Ethics, ethics was seen within the academy as a peripheral aspect of business. However, in (...) recent years, the stakes have risen dramatically, with global and local worlds destabilized by financial crisis, climate change, internet technologies and artificial intelligence, and global health crises. The authors of these commentaries address these grand challenges by placing business ethics at their centre. What if all grand challenges were framed as grand ethical challenges? Tanusree Jain, Arno Kourula and Suhaib Riaz posit that an ethical lens allows for a humble response, in which those with greater capacity take greater responsibility but remain inclusive and cognizant of different voices and experiences. Focussing on business ethics in connection to the grand challenge of environmental emergencies, Steffen Böhm introduces the deceptively simple yet radical position that business is nature, and nature is business. His quick but profound side-step from arguments against human–nature dualism to an ontological undoing of the business–nature dichotomy should have all business ethics scholars rethinking their “business and society” assumptions. Also, singularly concerned with the climate emergency, Boudewijn de Bruin posits a scenario where, 40 years from now, our field will be evaluated by its ability to have helped humanity emerge from this emergency. He contends that Milieudefensie v. Royal Dutch Shell illustrates how human rights take centre stage in climate change litigation, and how business ethics enters the courtroom. From a consumer ethics perspective, Deirdre Shaw, Michal Carrington and Louise Hassan argue that ecologically sustainable and socially just marketplace systems demand cultural change, a reconsideration of future interpretations of “consumer society”, a challenge to the dominant “growth logic” and stimulation of alternative ways to address our consumption needs. Still concerned with global issues, but turning attention to social inequalities, Nelarine Cornelius links the capability approach to global and corporate governance, arguing that CA will continue to lie at the foundation of human development policy, and, increasingly, CSR and corporate governance. Continuing debate on the grand challenges associated with justice and equality, Laurence Romani identifies a significant shift in the centrality of business ethics in debates on managing differences, positing that dialogue between diversity management and international management can ground future debate in business ethics. Finally, the essay concludes with a commentary by Charlotte Karam and Michelle Greenwood on the possibilities of feminist-inspired theories, methods, and positionality for many spheres of business ethics, not least stakeholder theory, to broaden and deepen its capacity for nuance, responsiveness, and transformation. In the words of our commentators, grand challenges must be addressed urgently, and the Journal of Business Ethics should be at the forefront of tackling them. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:American Journal of Philology 121.2 (2000) 237-258 [Access article in PDF] The Inauguration of Lentulus Niger Patrick Tansey AppendicesMore than half a century ago, in the course of a groundbreaking article in this journal on the composition of the pontifical college in the first century B.C., Lily Ross Taylor attempted to fix the date of the banquet held in honor of the inauguration of L. Cornelius Lentulus Niger (...) as flamen Martialis. 1 She was partially successful, but the precise date eluded her. Her article remains fundamental, but the question of the date of the banquet can be profitably reconsidered. It so happens that a precise date is not beyond our grasp. What is more, we shall see that once the date of the banquet has been established, a number of important consequences follow.Macrobius preserves a remarkably detailed account of the banquet. For present purposes the guest list will suffice: refero enim pontificis vetustissimam cenam quae scripta est in indice quarto Metelli illius pontificis maximi in haec verba: ante diem nonum kalendas Septembres, quo die Lentulus flamen Martialis inauguratus est, domus ornata fuit, triclinia lectis eburneis strata fuerunt, duobus tricliniis pontifices cubuerunt, Q. Catulus, M. Aemilius Lepidus, D. Silanus, C. Caesar, rex sacrorum, P. Scaevola Sextus, Q. Cornelius, P. Volumnius, P. Albinovanus et L. Iulius Caesar augur qui eum inauguravit; in tertio triclinio Popilia, Perpennia, Licinia, Arruntia virgines Vestales, et ipsius uxor Publicia flaminica et Sempronia socrus eius. 2The passage contains a number of vital clues as to the date of the event. Macrobius states that he derived his account from the index quartus of the pontifex maximus Metellus--that is, Q. Caecilius Metellus Pius (cos. 80), pontifex maximus from 81 until his death in 64 or 63. We are also told that the banquet took place ante diem nonum kalendas Septembres [End Page 237] (22 August), though the year is not specified. In a brief note Mommsen elucidated a further clue and established the basic chronological parameters. He observed that among the pontifices in attendance was the young C. Caesar and that as a consequence the banquet must be dated after Caesar's entry into the pontifical college, which Mommsen placed in 74. 3 He also noted that the mention of Metellus Pius entailed that the banquet could be dated no later than Pius' death in 63. 4 He concluded that the banquet probably occurred not long before 63. 5There matters rested until, many years later, Taylor reconsidered the question at length. She acknowledged that the banquet must date between the years 74/73 and 64/63. However, she employed a complex and ingenious argument to show that the terminus post quem non for the banquet should be set back from 63 to 69. Following a suggestion of Marquardt and Wissowa, she argued that the lists in Macrobius' Saturnalia (3.13.10-11) and in Cicero's De Haruspicum Responsis (12) register the members of the pontifical college in order of their entry into the college. 6 Therefore, since the pontifex P. Sulpicius Galba does not appear [End Page 238] in Macrobius' list and is named after Lentulus Niger by Cicero, it follows that Niger's inauguration must have preceded the co-optation of Galba. Taylor argued further that the date of Galba's entry into the pontifical college could be fixed approximately, as Galba issued coins when curule aedile depicting the emblems of the pontificate, which suggests that he was already a pontifex by the time he held the aedileship. Finally, as Galba was an unsuccessful consular candidate for 63, and hence praetor by 66, Taylor contended that he was aedile at the latest in 69. Thus according to her chain of reasoning, Galba was a pontifex by 69, and the banquet in honor of Niger's inauguration must be dated no later than that year. Hence Taylor dated the banquet between the years 74/73 and 69. 7More recently Marinone used a novel argument in an attempt to fix the date of the banquet more precisely. He argued that Macrobius found the account of the banquet in... (shrink)

Originally published in 1529, the Declamation on the Preeminence and Nobility of the Female Sex argues that women are more than equal to men in all things that really matter, including the public spheres from which they had long been excluded. Rather than directly refuting prevailing wisdom, Agrippa uses women's superiority as a rhetorical device and overturns the misogynistic interpretations of the female body in Greek medicine, in the Bible, in Roman and canon law, in theology and moral philosophy, and (...) in politics. He raised the question of why women were excluded and provided answers based not on sex but on social conditioning, education, and the prejudices of their more powerful oppressors. His declamation, disseminated through the printing press, illustrated the power of that new medium, soon to be used to generate a larger reformation of religion. (shrink)

Review text: "Es gibt Bücher, die durch ihre unprätentiöse, stille und sorgfältige Vorgehensweise auf den ersten Blick über die Sensation hinwegtäuschen, die sie bloßlegen und zur Diskussion anbieten. So ein Buch ist die "Wissenschaftphilosophie? von Jan C. Schmidt, die über die "Instabilität in Natur und Wissenschaft? handelt."Günter Altner in: Naturwissenschaftliche Rundschau 9/2009.

Many attempts have been made in recent months to throw light on the problem of vagueness. That perfect precision is an ideal not to be attained by any language seems clear. But the obvious fact is that words and sentences in our languages are not so precise as we should like to have them, and we are naturally concerned with finding some sort of device by which vagueness can, in the first place, be detected and measured, and, in the second (...) place, eliminated or reduced to a minimum. I shall not be concerned in what follows with these various special attempts to meet the problem. My task is the somewhat more general one of showing that there are other factors contributing to vagueness, one of which is of particular significance when we leave the realm of ostensively defined symbols and begin to concern ourselves with suppositional symbols, constructs and hypotheses. (shrink)

Hans Jonas’ anti-visionary conservation-oriented environmental philosophy—prominently articulated in his seminal book The Imperative of Responsibility: In Search of an Ethics for the Technological Age —had a tremendous impact on public and philosophical debates throughout the 1980s and the 1990s. Jonas argues that the “environmental crisis” reveals an underlying fundamental “crisis” in the human-nature relation. The crisis challenges the metaphysical foundations of our Western culture—including the dominant way humans view and deal with nature. Environmental ethics, therefore, requires critical reflection on and (...) revision of the underlying philosophy of nature: ethics and philosophy of nature, Jonas argues, are twin sisters. This approach provokes severe criticism: the diagnosis objection, the origin analysis objection, the justification objection, and the problem-solution objection. Most objections are not as sound as they claim to be—although Jonas’ argumentative justification is in fact a bit weak. However, a systematic critique of the objections of the critics from an analytic perspective shows that he developed a political and practical “philosophy of nature” in which anthropology, ethics, and politics are conceptualized as a converging domain as one of the core constituents of environmentals ethics for this century. (shrink)

In Time Reborn and elsewhere physicist Lee Smolin identifies Peirce as a precursor to his view that natural laws evolved, a view that runs counter the received opinion within physics that time isn’t real. After discussing Smolin’s arguments for the reality of time, two approaches advoacated by Smolin –cosmological natural selection and Quantum Energetic Causal Set Theory– are discussed in the context of Peirce’s cosmology. It is shown that Peirce’s approach provides a possible ground for a physical theory like Quantum (...) Energetic Causal Set Theory, opening the way for a full-fledged cosmology that does justice to contemporary physics. (shrink)

The place of science.--The structure of science.--Nature: occurrents.--Nature: complexes.--Awareness.--Operations.--Meaning.--Meaning: correlational symbols.--Meaning: constructs and hypotheses.--The development of knowledge.--Models.--Description.--Explanation.--Quantitative methods.

This study examines the self-reported ethics of both current and future advertising practitioners, and compares their responses to four scenarios and 17 statements on advertising ethics. Stepwise discriminant analysis was used to determine the extent to which both groups applied the classical ethical theory of deontology to the scenarios and statements. Results indicate significant differences between both groups. For example, current advertising practitioners are significantly less likely than future practitioners to apply deontology to decision making. The implications of these results (...) are discussed and suggestions for future research are outlined. (shrink)

Bioethics, Volume 36, Issue 3, Page 243-251, March 2022.

Cultural Heritage, Ethics and Contemporary Migrations breaks new ground in our understanding of the challenges faced by heritage practitioners and researchers in the contemporary world of mass migration, where people encounter new cultural heritage and relocate their own. It focuses particularly on issues affecting archaeological heritage sites and artefacts, which help determine and maintain social identity, a role problematised when populations are in flux. This diverse and authoritative collection brings together international specialists to discuss socio-political and ethical implications for the (...) management of archaeological heritage in global society. With contributions by authors from a range of disciplinary backgrounds, including archaeologists, philosophers, cultural historians and custodians of cultural heritage, the volume explores a rich mix of contrasting, yet complementary, viewpoints and approaches. Among the topics discussed are the relations between culture and identity; the potentialities of museums and monuments to support or subvert a people's sense of who they are; and how cultural heritage has been used to bring together communities containing people of different origins and traditions, yet without erasing or blurring their distinctive cultural features. Cultural Heritage, Ethics and Contemporary Migrations is a crucial text for archaeologists, curators, policymakers and others working in the heritage field, as well as for philosophers, political scientists and other readers interested in the links between immigration and cultural heritage. (shrink)

This manuscript draws on the moral norms arising from the nuanced accounts of epistemic (in)justice and social identity in relational autonomy to normatively assess and articulate the ethical problems associated with using AI in patient care in light of the Black Box problem. The article also describes how black-boxed AI may be used within the healthcare system. The manuscript highlights what needs to happen to align AI with the moral norms it draws on. Deeper thinking – from other backgrounds other (...) than decolonial scholarship and relational autonomy – about the impact of AI on the human experience needs to be done to appreciate any other barriers that may exist. Future studies can take up this task. (shrink)

Every natural scientist, I should suppose, is an empiricist. But to say this is not to assert that he is consciously such. Very few scientists would presumably consider themselves qualified to state even what is involved in the term, and still fewer would be willing to admit that they are adherents of the position. One might say that natural scientists, in their general outlook, presuppose—in one of the many meanings of this term—the empirical point of view. This probably means that (...) if one could make clear to them what is meant by the term, and if one could convince them that it is proper for scientists to take sides on philosophical issues, they should probably be willing to call themselves empiricists. Expressed otherwise, the general temper and spirit of natural science are those which philosophers tend to identify with the empirical outlook. (shrink)

Carrying out research on brains is important for medical advances in various diseases. However, such research ought not be carried out on human brains because the benefits do not outweigh the potential risks. A possible alternative is the use of brain surrogates. Nevertheless, some scholars who uphold a threshold account of moral status suggest the possibility that, with technological advances in the near future, more advanced brain surrogates will have very similar features to humans. This may suffice for these having (...) the same moral status as humans, and as a result, the situation may have implications for brain research, indeed, leading to the implication that this ought also not to be carried out upon brain surrogates. In this article, we present a relational approach to moral status which upholds that brain surrogates do not have the same moral status as human beings. Hence, brain research ought not be rejected on the grounds of equality of moral status between humans and brain surrogates. (shrink)

Bridget Pratt and Jantina de Vries1 have made an insightful contribution to enhancing epistemic justice in global health ethics. Their elaboration details intellectual (external) exclusion—described as non-representation—across three levels, and at its core, proposes inclusion to rectify this. To extend this work, we contend that it is worth probing the nuances and challenges associated with inclusion as a response to epistemic injustice. These include (A) the meaning of inclusion outside binary vocabularies of north and south; (B) the possibility of forms (...) of inclusion that produce exclusion and (C) inclusion as a politics of belonging with intellectual confinement as a possible epistemic harm. How the problem of injustice is described influences the substantive meaning of inclusion. In describing epistemic injustice, north and south (centre and periphery) are used as relational markers of power, inclusion, authority and exclusion. While this binary vocabulary is seductive, it can appear to confer proprietary rights to the concepts, theories and values described as originating in the global north (and south). However, such inscriptions of ownership are not always a correct reading of the problem. Sometimes, the ostensible western-ness and non-western-ness of ideas are taken for granted, particularly …. (shrink)

Background: One of the ethical imperatives for a valid consent process in clinical medication trials is that the process be guided by and recorded in an informed consent document (ICD). Concerns have been expressed, however, about readability and participant understanding of ICDs, which are often 10–20 pages long. Objective measures of readability and understanding have been used to support these concerns in several articles, but surprisingly the voice of trial participants on ICDs has not been heard in previous studies. Hence, (...) this study compares participants' subjective views on readability and their understanding of ICDs with those ICDs' objective readability scores. It also evaluates whether family, friends, and additional aids would foster better understanding of the ICD. Methods: Sixty current trial participants rated the readability and their understanding of deidentified standard ICDs. These had been sourced from two multicenter international Phase III trials on medication for diabetes mellitus and cancer. Results: Less than 10% of participants considered the ICDs difficult to read or difficult to understand in spite of objective readability scores at levels of about 12th grade education, but about a quarter considered the ICDs to be too technical. Participants gave mixed responses about friends or family members helping or the need for videos, pictures, additional reading material, and frequently answered questions (FAQ) sheets as an aid to their understanding. Conclusions: These findings suggest individual clinical trial participants should be engaged on their views of an ICD, for doing so is part of informed consent as a process rather than consent being merely focused on written information. Such participant-specific engagement should guide whether family and friends, videos, pictures, additional reading material, and FAQ sheets would be of assistance in improving understanding. (shrink)