The neural crest is a transient population of multipotent progenitors arising at the lateral edge of the neural plate in vertebrate embryos. After delamination and migration from the neuroepithelium, these cells contribute to a diverse array of tissues including neurons, smooth muscle, craniofacial cartilage, bone cells, endocrine cells and pigment cells. Considerable progress in recent years has furthered our understanding at a molecular level of how this important group of cells is generated and how they are assigned to specific lineages. (...) Here we review a number of recent studies supporting a role for Wnt signaling in neural crest induction, differentiation, and apoptosis. We also summarize the timing of expression of a number of Wnt ligands and receptors with respect to neural crest induction. BioEssays 25:317–325, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

For a long time now there have been different interpretations of the philosophical category "one divides into two." The debate that took place in scholarly circles in 1964 over "one divides into two" and "two combine into one" began with the question of how to interpret this category. At first this was a very lively and widespread scholarly debate. But later, because those "authorities on theory" who had at that time taken over the reigns of intellectual leadership within the Party (...) created contemporary superstitions that inhibited thought, the tone and boundaries of this debate became arbitrarily fixed and circumscribed so that this scholarly question became a political issue resulting in the criticism and trial of comrades such as Yang Xianzhen and the premature death of this debate. Today, in accordance with the spirit of the Third Session of the Eleventh Congress of the Central Committee of the Party, with an attitude of really searching for the truth, we must undertake a new and correct evaluation of this debate. Politically, we must overturn the false charges which were wrongly leveled at Comrade Yang Xianzhen and others, and intellectually, we must uphold the policy of "let a hundred schools contend, let a hundred flowers bloom." We must encourage the free discussion of different points of view, and we must avoid issuing hasty conclusions. All of us comrades who participated in this debate should accept the valuable experience and lessons learned from it. We want the debate on this question to truly become a widespread intellectual debate which will once again develop and move forward healthily. In this article I would simply like to talk about a few of my own views concerning the problem of how to correctly interpret "one divides into two.". (shrink)

Compared with traditional technological innovation modes, green technology innovation is more targeted for low carbon development and critical support for countries worldwide to combat climate change. The impact of green technology innovation on carbon emissions is considered in terms of fixed effect and mediating effect models through industrial structure upgrading. For this purpose, the sample dataset of 30 provincial administrative areas in China from 2008 to 2020 is employed. The results demonstrate that green technology innovation exerts significantly inhibitory effects on (...) carbon emissions, whose conclusion still holds after removing municipalities and replacing the dependent variable. Industrial structure upgrading is vital for green technology innovation to diminish carbon emissions. There is significant regional heterogeneity in the effects of green technology innovation on carbon emissions, i.e., the direct and indirect impact of green technology innovation on carbon emission reduction is significant in the eastern-central area, but its effect is insignificant in the western region. Therefore, it is essential to realize carbon emission reduction by further bolstering green technology innovation and accelerating industrial structure upgrading to fulfill the synergy of technology and structure. (shrink)

The relationship between neuroticism and mobile phone use is a hot research topic in the academic community. The purpose of this study was to investigate the roles of self-emotional assessment and love status in the mechanism through which college students’ neuroticism influences mobile phone use.We construct a moderated mediation model, and taking 869 Chinese college students as the research object and testing the mediating role of self-emotional assessment and the moderating role of love status. The results show that: neuroticism was (...) significantly positively related to mobile phone use and significantly negatively related to self-emotional assessment; self-emotional assessment was significantly positively related to mobile phone use; self-emotional assessment had a masking effect on the relationship between neuroticism and mobile phone use; love status not only moderated the relationship between self-emotional assessment and mobile phone use but also moderated the process through which self-emotional assessment masked the effect of neuroticism on mobile phone use. Our research expands the literature on the mechanisms underlying the effects of neuroticism on mobile phone use, enriches the understanding of the pertinent boundary conditions, and provides a better explanatory basis for the mobile phone use of college students. (shrink)

Ingratiation is a common strategy for subordinates to deal with their supervisors in eastern and western societies. Based on the theory of impression management, this study focuses on the impact of upward ingratiation outside the workplace on supervisor’s human resource decisions in the Chinese context and the mechanism behind this impact. The data were collected from 252 supervisor-subordinate dyads in four manufacturing firms. The results demonstrate the following: first, supervisors hold a more favorable view of upward ingratiation outside the workplace; (...) second, upward ingratiation outside the workplace has a positive effect on the supervisor’s chance of promotion and bonus allocation decisions, and leader-member exchange plays a mediation role in this influence; third, Zhongyong thinking moderates the relationship between LMX and supervisor’s chance of promotion and bonus allocation decisions; and finally, ZYT moderates the indirect effect of ingratiation behavior outside the workplace on supervisor’s chance of promotion and bonus allocation decisions through LMX, and the mediated relationship is weakened when a supervisor has a higher level of ZYT. This is one of the first empirical studies, which examines the validity of subordinate’s upward ingratiation outside the workplace from the perspective of supervisor’s ZYT. This study plays an important role in highlighting the effect of ZYT on the ingratiation behavior. (shrink)

As one of the key technologies for accelerating the construction of the ubiquitous Internet of Things, demand response not only guides users to participate in power market operations but also increases the randomness of grid operations and the difficulty of load forecasting. In order to solve the problem of rough feature engineering processing and low prediction accuracy, a short-term load forecasting model of LSTM neural network considering demand response is proposed. First of all, in view of the strong randomness and (...) complexity of input features, the weighted method is used to process multiple input features to strengthen the contribution of effective features and tap the potential value of features. Secondly, an improved genetic algorithm is used to obtain the best LSTM parameters; finally, the special gate structure of the LSTM model is used to selectively control the influence of input variables on the model parameters and perform load forecasting. The experimental results show that the research has high prediction accuracy and application value and provides a new way for the development of power load forecasting. (shrink)

Internet addiction is a growing social problem with negative mental and social outcomes; the present study examined whether rejection sensitivity mediates the relationship between interparental conflict and adolescent IA and the moderating role of school connectedness. One thousand and seven adolescents anonymously completed questionnaires to assess interparental conflict, school connectedness, rejection sensitivity, IA, and demographic information. The model results showed that: the positive association between interparental conflict and adolescent IA was partially mediated by rejection sensitivity; this indirect link was moderated (...) by the school connectedness and was stronger for adolescents with high school connectedness. The results provide support for the attachment theory that high interparental conflict could increase adolescents’ rejection sensitivity, and high school connectedness plays a double-edged role that adolescents show more rejection sensitivity while reporting high interparental conflict and high school connectedness. (shrink)

As the autonomous vehicles technology gradually enters the public eye, understanding consumers' psychological motivations for accepting autonomous vehicles is critical for the development of autonomous vehicles and society. Previously, researchers have explored the determinants of fully autonomous vehicles but the relevant research is far from enough. Moreover, the relationship between anthropomorphism and users' behavior has been ignored to a large extent. Therefore, this study aim to fill the gap by using anthropomorphism and the unified theory of acceptance and use of (...) technology to explore how system attributes and UTAUT attributes influence consumers' acceptance behavior. The data were collected via questionnaire survey conducted in Beijing, China, which can be a promising early adopter of AVs. Structural equation modeling was used to analyze the data. The results reveal that perceived anthropomorphism and perceived intelligence have a direct positive influence on the adoption of AVs; performance expectancy, effort expectancy, and facilitating conditions have an indirect positive influence on intention to adopt AVs. Also, this research contributes to the literature by enriching studies on psychological determinants of autonomous vehicles' adoption by taking an initial step to highlight anthropomorphism perceptions. This can provide managerial implications for policy-makers and businesses on how to effectively allocate resources to enhance autonomous vehicle adoption. (shrink)

Patients requiring deep brain stimulation due to intracerebral metallic foreign substances have not been reported elsewhere in the world. Additionally, the long-term effects of metallic foreign bodies on deep brain stimulation are unknown. A 79-year-old man with a 5-year history of Parkinson's disease reported that, 40 years ago, while playing with a pistol, a metallic bullet was accidentally discharged into the left brain through the edge of the left eye, causing no discomfort other than blurry vision in the left eye. (...) DBS was performed due to the short duration of efficacy for oral medication. Because the bullet was on the left subthalamic nucleus electrode trajectory and the patient's right limb was primarily stiff, the patient received globus pallidus interna -DBS implantation in the left hemisphere and STN-DBS implantation in the right hemisphere. During a 6-month postoperative follow-up, the patient's PD symptoms were effectively managed with no noticeable discomfort. (shrink)

This study aimed to develop the Three-Dimensional Filial Piety Scale and explore its psychometric properties. Based on Wang’s Three-Dimensional Filial Piety Model, our study employed a review of the current literature, in-depth interviews, and feedback from experts and the target group. An initial 36-item scale using a bipolar Likert 6-point rating scale was developed. Then item analysis and exploratory factor analysis were conducted with sample 1 (n = 617) to explore the dimensions and final items, and a 15-item scale (...) with three factors was obtained. After that, confirmatory factor analysis was conducted to validate the 3-factor structure obtained through exploratory factor analysis with sample 2 (n = 585). Next, we tested criterion-related validity with sample 3 (n = 248) and test-retest reliability with sample 4 (n = 67). The results supported the model on which this scale was based and showed three dimensions of filial piety, namely the balance of interests, good affections, and family role norms. As a valid, reliable scale, the Three-Dimensional Filial Piety Scale can therefore be used in the Chinese context to measure filial piety for people of different genders, ages, and cohabitation situations. (shrink)

BackgroundVaccination has been considered one of the most effective public health interventions. In the context of the global epidemic of coronavirus disease 2019, it remains unclear what role general vaccination attitudes and perceptions have on the acceptance of COVID-19 vaccine.ObjectiveThis study aims to explore the impact of general attitudes and perceptions toward vaccination on the acceptance of a newly developed vaccine, taking COVID-19 vaccines as an example.MethodA cross-sectional survey was conducted among 2,013 Chinese adult participants. Generalized order logistic regression and (...) path analysis models were used to analyze impacts of general attitudes and perceptions toward vaccination on the acceptance of the COVID-19 vaccine.ResultsThe prevalence of hesitancy to vaccination in general is 49.9% among the Chinese adult population. General perceptions of vaccination were associated with corresponding perceptions of the COVID-19 vaccine. A “no hesitancy” attitude toward vaccination is a significant determinant of future COVID-19 vaccination compared to vaccine refusers, and perceptions of COVID-19 vaccine remain a significant determinant for the acceptance of the COVID-19 vaccine. Path analysis indicates that perceptions of the importance and safety of vaccination have a positive overall effect on the acceptance of the COVID-19 vaccine, and that general perceptions of vaccination as a whole on each measure indirectly influence the acceptance of the COVID-19 vaccine.ConclusionGeneral attitudes and perceptions toward vaccination were associated with those of the COVID-19 vaccine and future vaccination intention. To prepare for possible emergence of diseases in the future, routine health campaigns should be launched by relevant government departments and vaccination authorities to enhance the overall awareness and knowledge of vaccination among the public and to ensure optimal vaccination experience. In addition, targeted knowledge dissemination and mass mobilizations should be urged for newly developed vaccines when some specific infectious diseases emerge, such as COVID-19 at present. (shrink)

Emotion plays an essential role in the perception of time such that time is perceived to “fly” when events are enjoyable, while unenjoyable moments are perceived to “drag.” Previous studies have reported a time-drag effect when participants are presented with emotional facial expressions, regardless of the emotion presented. This effect can hardly be explained by induced emotion given the heterogeneous nature of emotional expressions. We conducted two experiments ( n = 44 and n = 39) to examine the cognitive mechanism (...) underlying this effect by presenting dynamic sequences of emotional expressions to participants. Each sequence started with a particular expression, then morphed to another. The presentation of dynamic facial expressions allows a comparison between the time-drag effect of homogeneous pairs of emotional expressions sharing similar valence and arousal to heterogeneous pairs. Sequences of seven durations (400, 600, 800, 1000, 1200, 1400, 1600 ms) were presented to participants, who were asked to judge whether the sequences were closer to 400 or 1600 ms in a two-alternative forced choice task. The data were then collated according to conditions and fit into cumulative Gaussian curves to estimate the point of subjective equivalence indicating the perceived duration of 1000 ms. Consistent with previous reports, a feeling of “time dragging” is induced regardless of the sequence presented, such that 1000 ms is perceived to be longer than 1000 ms. In addition, dynamic facial expressions exert a greater effect on perceived time drag than static expressions. The effect is most prominent when the dynamics involve an angry face or a change in valence. The significance of this sensitivity is discussed in terms of emotion perception and its evolutionary significance for our attention mechanism. (shrink)

How should insecure leaders deal with labor rights in the face of an economic downturn? Economic theory suggests that suppressing labor rights boosts the economy and that economic growth also dampens violent political opposition. As a result, the suppression of labor rights should contribute to more job security for leaders. However, some other scholars maintain that more repression actually increases the probability of opposition. As a result, the policy implication of this argument is that leaders would be better off if (...) they choose to improve the protection of labor rights. Our simple formal model demonstrates that the second argument is more likely to be the case. The probit analysis of 146 countries from 1984 to 2004 bears out this prediction. We also find that this relationship is stronger in non-democracies than in democracies. Our study appears to provide some support to Bueno de Mesquita et al.’s statement that policies that are good for political survival may not necessarily be good for the economy. (shrink)

The valence–arousal conflict theory assumes that both valence and arousal will trigger approaching or withdrawing tendencies. It also predicts that the speed of processing emotional stimuli will depend on whether valence and arousal trigger conflicting or congruent motivational tendencies. However, most previous studies have provided evidence of the interaction between valence and arousal only, and have not provided direct proof of the interactive links between valence, arousal and motivational tendencies. The present study provides direct evidence for the relationship between approach–withdrawal (...) tendencies and the valence–arousal conflict. In an empirical test, participants were instructed to judge the valence of emotional words after visual–spatial cues that appeared to be either approaching or withdrawing from participants. A three-way interaction was observed such that the response time was shorter if participants responded to a negative high-arousal stimulus after a withdrawing cue, or to a positive low-arousal stimulus after an approaching cue. These findings suggest that the approach–withdrawal tendency indeed plays a crucial role in valence–arousal conflict, and that the effect depends on the congruency of valence, arousal and tendency at an early stage of processing. (shrink)

Optimization for vertical vibration performance of a rail-train coupling system is investigated in this paper with the introduction of inerters for both primary and secondary suspensions. A model of a typical Chinese passenger train that travels on a traditional rail with track, sleepers, and ballast is simulated. The goal is to improve the ride quality for the train and vibration attenuation for the rail system in response to track irregularities. Optimizations for only inertance and all suspension parameters are carried out (...) by the particle swarm algorithm. Performance benefits for both the train and the rail system are demonstrated and suspension layouts with inerters connected in parallel and series are compared with the traditional one in both time domain and frequency domain. (shrink)

Knowledge of the patterns of location of retail stores in urban areas supports the development of effective urban planning and the reasonable allocation of commercial facilities. Using point of interest data and consumer survey data in three main commercial districts in Changchun, China, this study investigates the spatial structures of commercial districts and the patterns of distribution of retail stores to assess the determinants of the development of retail stores in commercial districts. Kernel density estimation, nearest neighbor index, and Pearson’s (...) correlation analysis were used for this study. The following conclusions are drawn. The spatial distribution of retail stores in Changchun commercial districts generates the coexistence of a concentration in the core area and diffusion in the peripheral area. The emergence of shopping malls has challenged the traditional single-center structure, resulting in the transformation of commercial districts from single-center to multicenter layouts, while also producing a hierarchical trend in development. The Chongqing Road and Hongqi Street commercial districts have a relatively high spatial concentration of retail stores. Retail stores in Guilin Road exhibit distinct characteristics, namely, stores selling textiles, clothing, and daily necessities show the highest concentration, and food, beverage, and tobacco outlets as well as integrated stores show the lowest concentration. The selected locations of the differing categories of stores on Chongqing Road strongly correlate, and textile, clothing, and daily necessity stores show a high correlation with other retail categories. Four main factors affect the development and spatial layout of retail in the commercial districts. First, the interaction between consumer behavior and location choice in retail stores promotes the evolution of retail formats and trends in the development of comprehensive, specialized, and hierarchical retail commercial spaces. Second, the retail format determines the spatial layouts and the historical inheritance of the format. Third, governmental planning and policies lead to the agglomeration and diffusion of commercial activities in different areas. Fourth, such spatial clustering effects are an external driving factor for integration and aggregation among retail formats. (shrink)

A striking feature of human female sexual reproduction is the high level of gametes that exhibit an aberrant number of chromosomes (aneuploidy). A high baseline observed in women of prime reproductive age is followed by a dramatic increase in older women. Proper chromosome segregation requires one or more DNA crossovers (COs) between homologous maternal and paternal chromosomes, in combination with cohesion between sister chromatid arms. In human females, CO designations occur normally, according to the dictates of CO interference, giving early (...) CO-fated intermediates. However, ≈25% of these intermediates fail to mature to final CO products. This effect explains the high baseline of aneuploidy and is predicted to synergize with age-dependent cohesion loss to explain the maternal age effect. Here, modern advances in the understanding of crossing over and CO interference are reviewed, the implications of human female CO maturation inefficiency are further discussed, and areas of interest for future studies are suggested. (shrink)

This paper mainly analyzes the current situation of e-commerce in domestic SMEs and points out that there are limited initial investment and difficulty in financing in China’s SMEs; e-commerce control is not scientific; e-commerce personnel of SMEs are not of high quality, in the case of improper setting of the e-commerce sector and shortage of talents, rigid management model, and outdated management concepts. By using the loss function and the value chain management theory of the deep learning in the stationary (...) wavelet domain residual learning model, the e-commerce model of SMEs is newly constructed, and the e-commerce department as the core department of the enterprise is proposed. By training the optimal parameters of the deep residual network and comparing the results with other models, the method of this paper has a good effect against the sample. The original loss function based on the residual learning model deep learning is modified to solve the original model fuzzy problem, which improves the effect and has good robustness. Finally, based on the wavelet residual depth residual evaluation method, this paper evaluates the application effect of this model and proposes relevant suggestions for improving this model, including rationalizing and perfecting the external value chain coordination mechanism, establishing the e-commerce value chain sharing center, and promoting integration of e-commerce business, strengthening measures and recommendations in various aspects of e-commerce information construction. At last, taking the business activities of a company as an example, applying the theory described in this paper to specific practice proves the feasibility and practical value of the theory. (shrink)