We propose for the first time to divide histone proteolysis into “histone degradation” and the epigenetically connoted “histone clipping”. Our initial observation is that these two different classes are very hard to distinguish both experimentally and biologically, because they can both be mediated by the same enzymes. Since the first report decades ago, proteolysis has been found in a broad spectrum of eukaryotic organisms. However, the authors often not clearly distinguish or determine whether degradation or clipping was studied. Given the (...) importance of histone modifications in epigenetic regulation we further elaborate on the different ways in which histone proteolysis could play a role in epigenetics. Finally, unanticipated histone proteolysis has probably left a mark on many studies of histones in the past. In conclusion, we emphasize the significance of reviving the study of histone proteolysis both from a biological and an experimental perspective.Also watch the Video Abstract. (shrink)

In this reply I further defend my claim that the transcendental should always remain a primary concern for philosophy of technology as a philosophical enterprise, contra the empirical turn’s rejection of it. Yet, instead of emphasizing the non-technological conditions of technology, as ‘classic’ thinkers of technology such as Heidegger did, it should recognize technology itself as the transcendental operator par excellence. Starting from Heidegger’s ontological understanding of transcendence I show that while technical artifacts may indeed always conform to a certain (...) horizon of understanding, they also constitute this horizon in specific ways. Following Stiegler I show that concrete technologies (technology with a small ‘t’) are not just empirical effects of an overarching movement of transcendence (Technology with a capital ‘T’) but are originally constitutive of it. In response to Romele’s critique that the social, language, images, imaginaries, symbols, etc. are also transcendentals, I argue that all these phenomena are always already conditioned by technical milieus. As for Besmer’s contention that I offer a reductive interpretation of postphenomenology’s notion of multistability, I argue that there are decisive systemic and organological limits to multistability offered by technical artefacts and that all variation in use and implementation is always constrained by inherent technical tendencies and processes of concretization. Agreeing with Besmer that the transcendental and the empirical should be understood not oppositional but compositional I argue that technology may be that which constantly ‘mediates’ between the two. (shrink)

In this important new study, Pieter Duvenage shows that Habermas’s work on aesthetics, far from being marginal to his core concerns, is central to understanding and evaluating Habermas's entire theoretical enterprise. This important new study shows that Habermas's work on aesthetics is central to understanding and evaluating his entire theoretical enterprise. Duvenage demonstrates that, in the first phase of his intellectual career, Habermas emphasizes the communicative and societal relevance of art; in the second phase, the idea of a communicative (...) aesthetics is worked out in terms of a theory of rationality. Reveals that Habermas’s later work offers a third, albeit undeveloped, alternative that suggests a convergence of the two. Offers a critical perspective on the role of aesthetics in Habermas's work and proposes possible alternatives. (shrink)

Introduction -- 1. The settling of a language -- 2. The Whorf hypothesis -- 3. Relativism or a universal theory? -- 4. What does language have to do with logic and mathematics? -- 5. A test bed for grammatical theories -- 6. The Chomsky hierarchy in perpsective -- 7. Reflexivity and identity in language and cognition -- 8. The generalized logic hierarchy and its cognitive implications -- 9. The intensionalization of extensions.

This article has two general aims. It first of all critically reconsiders the empirical turn’s dismissal of transcendentalism in the philosophy of technology, in particular through the work of Ihde and Verbeek, and defends the continuing relevance of the notion of the transcencental in thinking about technology today, illustrating this mainly through a reading of Stiegler’s understanding of the human condition as a technical condition and his view of human (noetic) evolution as proceeding from a process of technical exteriorization. The (...) crucial issue that is missed by postphenomenology and the empirical turn is that technology itself in its empiricity occupies the (periodically changing) place of the transcendental. It thus fails to consider the transcendental operativity of technical artifacts within its own empiricist stance. Secondly, it argues for the continuing importance and usefulness of the idea of Technology with a capital T, equally discarded by the representatives of the empirical turn, in particular against the emerging backdrop of the Anthropocene as the age of decisive anthropogenic forcing of the planet and the growing dominance of what has recently been called the technosphere in Earth system science. With Stiegler I show that a proper, inherent dynamic of technology must be acknowledged historically, anthropologically, techno-evolutionarily as well as (techno)phenomenologically. I conclude by demonstrating that our time of planetary crisis summons us to redirect our attention to technology from the empirical to the transcendental, and from the micro-level to the macro-level again. (shrink)

Dr Seuren's study deals with the problem of presenting an adequate model of grammatical description. The model he proposes conforms in its main outlines to the transformational generative grammar established by Chomsky, but differs in important respects. These mainly affect that part of Chomsky's syntactic component known as the 'base', which generates basic or 'deep' structures. In the model of the base proposed here two main constituents are distinguished for every deep structure representation of a sentence, vis-a-vis the operators and (...) the nucleus. The deep structure of a sentence is thus seen to be very similar to the logical structure of a proposition. The arguments given in support of this analysis are based on mainly on considerations of simplicity and semantic adequacy. (shrink)

Aristotle's philosophically most explicit and sophisticated account of the concept of a (primary-)universal proof is found, not in "Analytica Posteriora" 1.4, where he introduces the notion, but in 1.5. In 1.4 Aristotle merely says that a universal proof must be of something arbitrary as well as of something primary and seems to explain primacy in extensional terms, as concerning the largest possible domain. In 1.5 Aristotle improves upon this account after considering three ways in which we may delude ourselves into (...) thinking we have a primary-universal proof. These three sources of delusion are shown to concern situations in which our arguments do establish the desired conclusion for the largest possible domain, but still fail to be real primary-universal proofs. Presupposing the concept of what may be called an immediate proof, in which something is proved of an arbitrary individual, Aristotle in response now demands that a proof be immediate of the primary thing itself and goes on to sketch a framework in which an intensional criterion for primacy can be formulated. For the most part this article is a comprehensive and detailed commentary on Aristotle's very concise exposition in 1.5. One important result is that the famous passage 74a17-25 referring to two ways of proving the alternation of proportions cannot be used as evidence for the development of pre-Euclidean mathematics. (shrink)

In this dialogue with Yuk Hui, Pieter Lemmens explains the discipline called philosophy of technology and gives a concise overview of the most important contemporary approaches within this field. He also offers a critical evaluation of what are probably the two most salient characteristics of contemporary philosophy of technology, the so-called “empirical turn” and the “ethical turn,” which are deeply related and partly reflect the discipline’s on-going alignment with the global neoliberal agenda of exclusively profit-driven technological innovation. He also (...) critically reflects on recent developments in the molecular and informational life sciences such as genomics, metabolomics, bioinformatics and synthetic biology. (shrink)

In this reply I try to show that, contrary to Milberry’s apparent assertion, the general intellect of the multitude does not have the explanatory robustness she accredits to it. Digital network technologies are currently overwhelmingly effective in proletarianizing and disempowering the cognitariat and only an active technopolitics of deproletarianization could reverse this hegemonic situation. In my response to Verbeek, I attempt to correct his misinterpretation of the Stieglerian approach as being dialectical in nature and show that, far from reinstating the (...) humanist dichotomy between human beings and technologies, my analysis assumes their original, albeit fundamentally ambiguous and even ‘uncanny’ [unheimlich] interconnection. I conclude with pointing out some implications of this view for a ‘really realistic’ political theory of technology. (shrink)

‘The art of living with ICTs ’ today not only means finding new ways to cope, interact and create new lifestyles on the basis of the new digital technologies individually, as ‘consumer-citizens’. It also means inventing new modes of living, producing and, not in the least place, struggling collectively, as workers and producers. As the so-called digital revolution unfolds in the context of a neoliberal cognitive and consumerist capitalism, its ‘innovations’ are predominantly employed to modulate and control both production processes (...) and consumer behavior in view of the overall goal of extracting surplus value. Today, the digital networks overwhelmingly destroy social autonomy, instead engendering increasing social heteronomy and proletarianization. Yet it is these very networks themselves, as technical pharmaka in the sense of French ‘technophilosopher’ Bernard Stiegler, that can be employed as no other to struggle against this tendency. This paper briefly explores this possibility by reflecting upon current diagnoses of our ‘technological situation’ by some exemplary post-operaist Marxists from a Stieglerian, pharmacological perspective. (shrink)

Since Aristotle and the Stoa, there has been a clash, worsened by modern predicate logic, between logically defined operator meanings and natural intuitions. Pragmatics has tried to neutralize the clash by an appeal to the Gricean conversational maxims. The present study argues that the pragmatic attempt has been unsuccessful. The “softness” of the Gricean explanation fails to do justice to the robustness of the intuitions concerned, leaving the relation between the principles evoked and the observed facts opaque. Moreover, there are (...) cases where the Gricean maxims fail to apply. A more adequate solution consists in the devising of a sound natural logic, part of the innate cognitive equipment of mankind. This account has proved successful in conjunction with a postulated cognitive mechanism in virtue of which the universe of discourse is stepwise and recursively restricted, so that the negation selects different complements according to the degree of restrictedness of Un. This mechanism explains not only the discrepancies between natural logical intuitions and known logical systems; it also accounts for certain systematic lexicalization gaps in the languages of the world. Finally, it is shown how stepwise restriction of Un produces the ontogenesis of natural predicate logic, while at the same time resolving the intuitive clashes with established logical systems that the Gricean maxims sought to explain. (shrink)

This paper investigates the impact of negative screening on the investment universe as well as on financial performance. We come up with a novel identification process and as such depart from mainstream socially responsible investing literature by concentrating on individual firms’ conduct and by studying a much wider range of issues. Firstly, we study the size and financial performance of fourteen potentially controversial issues: abortion, adult entertainment, alcohol, animal testing, contraceptives, controversial weapons, fur, gambling, genetic engineering, meat, nuclear power, pork, (...) stem cells, and tobacco. We investigate an international sample of more than 1,600 stocks for more than twenty years. We then analyze the impact of applying negative screens to a market portfolio. Our findings suggest that the choice for negative screening strategies does matter for the size of the investment universe as well as for risk-adjusted return performance. Investing in controversial stocks in many cases results in additional risk-adjusted returns, whereas excluding them may reduce financial performance. These findings suggest that there are opportunity costs to negative screening. (shrink)

Starting from a perspective of democratic politics, this essay argues that the problem lies not in any “unjustified” politicization of risk controversies; quite to the contrary, it lies in their depoliticization or their capture in a postpolitical consensus. To this end, the prevailing storylines in public discourse on risk controversies are shown to be based on invalid assumptions regarding nature and science and on exclusionary mechanisms. In response, the risk conflicts perspective is put forward as an analytical framework, which allows (...) us to evaluate mediated public discourse on the extent to which democratic debate and citizenship are facilitated. For the fields of science and environment communication, this entails a shift in emphasis from a focus on the epistemic level to the level of the political. We conclude by discussing the potential transformative impacts of this perspective for academic research, public discourse, as well as the directly involved social actors, in relation to the controversies in question. (shrink)

We generalize the modal interpretation of quantum mechanics so that it may be applied to composite systems represented by arbitrary density operators. We discuss the interpretation these density operators receive and relate this to the discussion about the interpretation of proper and improper mixtures in the standard interpretation.

This book is about how to understand quantum mechanics by means of a modal interpretation. Modal interpretations provide a general framework within which quantum mechanics can be considered as a theory that describes reality in terms of physical systems possessing definite properties. Quantum mechanics is standardly understood to be a theory about probabilities with which measurements have outcomes. Modal interpretations are relatively new attempts to present quantum mechanics as a theory which, like other physical theories, describes an observer-independent reality. In (...) this book, Pieter Vermaas summarises the results of this work. The book will be of great value to undergraduates, graduate students and researchers in philosophy of science, and physics departments with an interest in learning about modal interpretations of quantum mechanics. (shrink)

Contrary to received opinion, the Aristotelian Square of Opposition (square) is logically sound, differing from standard modern predicate logic (SMPL) only in that it restricts the universe U of cognitively constructible situations by banning null predicates, making it less unnatural than SMPL. U-restriction strengthens the logic without making it unsound. It also invites a cognitive approach to logic. Humans are endowed with a cognitive predicate logic (CPL), which checks the process of cognitive modelling (world construal) for consistency. The square is (...) considered a first approximation to CPL, with a cognitive set-theoretic semantics. Not being cognitively real, the null set Ø is eliminated from the semantics of CPL. Still rudimentary in Aristotle’s On Interpretation (Int), the square was implicitly completed in his Prior Analytics (PrAn), thereby introducing U-restriction. Abelard’s reconstruction of the logic of Int is logically and historically correct; the loca (Leaking O-Corner Analysis) interpretation of the square, defended by some modern logicians, is logically faulty and historically untenable. Generally, U-restriction, not redefining the universal quantifier, as in Abelard and loca, is the correct path to a reconstruction of CPL. Valuation Space modelling is used to compute the effects of U-restriction. (shrink)

The aim of this paper is to evaluate etiological accounts of functions for the domain of technical artefacts. Etiological theories ascribe functions to items on the basis of the causal histories of those items; they apply relatively straightforwardly to the biological domain, in which neo-Darwinian evolutionary theory provides a well-developed and generally accepted background for describing the causal histories of biological items. Yet there is no well-developed and generally accepted theory for describing the causal history of artefacts, so the application (...) of etiological theories to the technical domain is hardly straightforward. In this paper we consider the transposition of etiological theories in general from the biological to the technical domain. We argue that a number of etiological theories that appear defensible for biology become untenable for technology. We illustrate our argument by showing that the standard etiological accounts of Neander and Millikan, and some recent attempts to improve on them, provide examples of such untenable theories. 1 Introduction 2 Desiderata for theories of functions 3 Etiological theories in general 3.1 Common core and divergent aims 3.2 Reproduction versus non-reproduction etiological theories 3.3 Intentionalist versus non-intentionalist etiological theories 4 Problems for etiological theories in the technical domain 5 The failure of existing reproduction theories 6 The failure of existing non-reproduction theories 7 Improving reproduction by hybridisation 8 Conclusions. (shrink)

: This article focuses on cognitive enhancement technologies and their possible anthropological implications, and argues for a reconsideration of the human-technology relation so as to be able to better understand and assess these implications. Current debates on cognitive enhancement consistently disregard the intimate intertwinement of humans and technology as well as the fundamentally technogenic nature of anthropogenesis. Yet, an adequate assessment of CET requires an in-depth and up-to-date re-conceptualization of both. Employing insights from the work of Bernard Stiegler, this article (...) proposes an organology and pharmacology of CE. What is typical about new CET is their interiorizing nature, which can be expected to fundamentally reshape organological configurations. Starting from the premise that CE is a phenomenon that predominantly unfolds within the current conjuncture of cognitive capitalism, I will present the issue of cognitive proletarianization as being of crucial importance for considering CE. I conclude by providing some methodological guidelines for the development of a positive pharmacology of CET and by suggesting that CET should be considered as technologies of the self sensu Michel Foucault. (shrink)

Since its inception in 1869, the periodic system — icon of modern chemistry — has suffered from the problematic accommodation of the rare-earth elements. The substance of this paper intends to retrace Mendeleev’s shifting attitudes with regard to the rare-earth crisis during the period 1869–1871. Based on a detailed examination of Mendeleev's research papers from that period, it will be argued that the rare-earth crisis played a key role in inducing a number of important changes in Mendeleev’s philosophical viewpoints with (...) regard to the epistemological concept of a chemical element and the nature of elementary groups. Many of Mendeleev's most cherished beliefs got endangered by the nature of these elements. Their mystifying properties forced him to revise his ideas about primary and secondary groups, the elements as basic and simple substances, and the use of short and long form tables. They made him question the validity and universality of the periodic law, and led him into hypothesizing about the internal structure of matter and constitution of atoms. (shrink)

To Bauman the incongruities of life are best reflected in an analytical effort that moves between perspectives without forcing them into a synthesis. He seems to arrogate the right to inconsistency when operating from points of view. This violates a curious requirement of scholarly discourse: an author is free to select his conceptual framework and method — but once they are selected, he must stick to them. This practically inviolable rule of consistency might come (as Bauman himself suggests) from the (...) juridical pretensions sociology had from its birth. Consistency gives an aura to academicians who feel called to legislate, judge and legitimize. To Bauman, however, truth in judgement, reality in empirical studies and responsibility in practical affairs are approached by a constant movement between incongruous points of view. These ambitions make heavy demands on the composition of his writing. In many stretches of linear argument, imagery is interjected, showing lateral connections and complications — conversely, in many pieces of interpretation causal explanations intrude. A discourse with all these boundary violations is rather suspect in modern eyes. When Bauman contaminates the purity of analytical lines with terminology from other branches, he is demonstrating in a stylistic way that our reality is multitudinous — be it premodern enchantment, ambivalence in modernity or liberated postmodern polyvalence. (shrink)

In the past two decades, individual explanations of scientific misconduct have increasingly given way to systemic explanations. Where did this interest in systemic factors come from? Given that research ethicists often present their interventions as responses to scientific misconduct, this article tests the hypothesis that these systemic explanations were triggered by high-visibility cases of scientific norm violation. It does so by examining why Dutch scientists in 2011 explained Diederik Stapel’s grand-scale data fabrication largely in systemic terms, whereas only fifteen years (...) earlier, in the René Diekstra affair, such explanations had been close to absent. Drawing on a wealth of historical sources, the article suggests that cases like Stapel’s as such do not explain why early 21st-century commentators exchanged individual explanations for systemic ones. Only against the background of an existing discourse of criticism of the science system, developed in the 1990s and 2000s in response to rapidly increasing competition for research funding, could the Stapel affair achieve notoriety as an example of how systemic factors provoke bad conduct. (shrink)

In this paper I consider the problem of interpreting quantum mechanics. I argue that this problem has evolved in part into the problem of selecting tenable interpretations from a set of available interpretations. We lack the means to make this selection. There is consensus that interpretations should be consistent and empirically adequate. But these conditions are not particularly discriminative. Other conditions may be discriminative but are not generally accepted. I propose two new conditions for selecting tenable interpretations, motivated by the (...) use of quantum mechanics in technology. The first requires that interpretations ascribe the physical properties to technical artefacts that are entailed by the ascription of technical functions to those artefacts. The second requires that they ascribe the physical properties represented by engineering sketches of those artefacts. I consider the example of quantum teleportation in some detail. Introduction The problem of interpreting quantum mechanics Technical functions Decoders in quantum teleportation Engineering sketches Conclusions Appendix: Quantum teleportation. (shrink)

In this article, I discuss manuscript material written by Petrus van Musschenbroek (1692–1761) related to his first experiments with the Leiden jar. Despite the importance of the discovery of the Leiden jar for the history of electricity and the questions that still surround its discovery, a detailed treatment of this manuscript material is lacking in the literature. The main aim of this paper is to provide an outline of the manuscript material and to contextualize van Musschenbroek’s first experiments with the (...) Leiden jar. I show how the experiment fits within his research program on electricity and I discuss van Musschenbroek’s initial reactions to and analysis of the phenomenon. Before doing so, I first provide a short overview of the treatment of the early history of the Leiden jar in the secondary literature. After that, I discuss van Musschenbroek’s treatment of the topic of electricity in the textbooks he published in the years before the discovery of the device. Van Musschenbroek repeatedly emphasized that not enough experimental results were available for an informed theoretical treatment of the phenomenon of electricity to be possible. I then turn to the manuscript material, where I give a general description of the contents of the manuscript and van Musschenbroek’s experimental practice. The manuscript material further confirms recent work on the Leiden jar by Silva and Heering, and provides new insights into the way van Musschenbroek himself reacted to the discovery. (shrink)

Are acids natural kinds? Or are they merely relevant kinds? Although acidity has been one of the oldest and most important concepts in chemistry, surprisingly little ink has been spilled on the natural kind question. I approach the question from the perspective of microstructural essentialism. After explaining why both Brønsted acids and Lewis acids are considered functional kinds, I address the challenges of multiple realization and multiple determination. Contra Manafu and Hendry, I argue that the stereotypical properties of acids are (...) not multiply realized. Instead, given the equivalence between the proton-donating and electron-accepting mechanisms of Brønsted and Lewis, respectively, I show that acidity as a property type can be identified with a unique microstructural property, namely the presence of a LUMO or other low energy empty orbital. In doing so, I defend the view that the Lewis theory encompasses Brønsted–Lowry, and that all Brønsted acids are also Lewis acids. Contra Hacking and Chang, I thus maintain that the different concepts of acidity do not crosscut, and that the hierarchy requirement is met. Finally, by characterizing natural kinds as powerful objects and by adopting a dispositional view of functions, I illustrate how the microessentialist can make sense of the latent and relational character of most acids. In sum, I contend that acids are genuine natural kinds, even for the microstructural essentialist. (shrink)

Stiegler understands the Anthropocene as the age in which planetary enframing engenders an avalanche of entropization, putting humanity’s survival at risk. To avoid catastrophe, the so-called technosphere should be transformed from an entropic-destructive into a negentropic-constructive assemblage, ushering in the Neganthropocene. Stiegler’s focus is on the noetic dimension, in particular as constituted and conditioned overwhelmingly today by the digital pharmakon. In this article I want to make a case for the importance of an entirely other noetic pharmakon not addressed by (...) Stiegler: the nontechnical pharmakon of psychedelics, which allows for the expansion of humanity’s noetic frontier beyond the digital, providing access to dimensions of experience—and possibly also of reality—that may support the emerging neganthropos to awaken on a postanthropocentric planet in which it is enabled to commune in a noosphere made up by many other, nonhuman intelligences, which may prove essential for the neganthropic transformation to succeed. (shrink)

This essay complements Roberto Esposito’s analysis of the political category of the person by outlining the role of literature, and especially the genre of the novel, in consolidating this category and allowing it to do its political and affective work. The essay shows how Ben Lerner’s 2014 novel 10:04 dismantles three central features of the traditional novel’s poetics of the person: its investment in the notion of literary character, its use of fictionality, and its structural reliance on the narrative future. (...) Lerner’s novel, like Esposito’s biopolitical work, aims to overcome the hierarchical divisions within human life that are endemic to the category of the person and that have historically fostered biopolitical violence. Both projects intimate a less destructive politics—what Lerner calls “the transpersonal” and Esposito “the impersonal.”. (shrink)

In order to understand our thinking, we use all kinds of metaphors. Without them we would be blind to the process of thinking. One of the metaphors is the idea of a "map": the mind is conceived of as something spacial in which our thoughts are located and where connections of all different kinds are established. The process of thinking is conceived of as the travelling along these connections from one thought to another.

Cowan makes an intriguing case for a fundamental limit in the number of chunks that can be stored in short term memory. Chunks are collections of concepts that have strong associations to one another and much weaker associations to other chunks. A translation of this definition for the visual domain would be that a visual chunk is a collection of features that belong to the same perceptual group. Here, we will first address the neuronal mechanisms that may demarcate visual chunks. (...) Then we critically evaluate to what extent these mechanisms might be responsible for the limit on the number of chunks that can be held in STM. We conclude that the clarity with which the psychophysical data point to the number four is not matched by a similarly clear limit imposed by physiological mechanisms. (shrink)

In various publications over the past years, Floridi has developed a theory of semantic information as well-formed, meaningful, and truthful data. This theory is more or less orthogonal to the standard entropy-based notions of information known from physics, information theory, and computer science that all define the amount of information in a certain system as a scalar value without any direct semantic implication. In this context the question rises what the exact relation between these various conceptions of information is and (...) whether there is a real need to enrich these mathematically more or less rigid definitions with a less formal notion of semantic information. I investigate various philosophical aspects of the more formal definitions of information in the light of Floridi’s theory. The position I defend is that the formal treatment of the notion of information as a general theory of entropy is one of the fundamental achievements of modern science that in itself is a rich source for new philosophical reflection. This makes information theory a competitor of classical epistemology rather than a servant. In this light Floridi’s philosophy of information is more a reprise of classical epistemology that only pays lip service to information theory but fails to address the important central questions of philosophy of information. Specifically, I will defend the view that notions that are associated with truth, knowledge, and meaning all can adequately be reconstructed in the context of modern information theory and that consequently there is no need to introduce a concept of semantic information. (shrink)