What is Life? This is the question asked by Denis Noble in this very personal and at times deeply lyrical book. Noble is a renowned physiologist and systems biologist, and he argues that the genome is not life itself: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider (...) environment, that is life. (shrink)

The Modern Synthesis has dominated biology for 80 years. It was formulated in 1942, a decade before the major achievements of molecular biology, including the Double Helix and the Central Dogma. When first formulated in the 1950s these discoveries and concepts seemed initially to completely justify the central genetic assumptions of the Modern Synthesis. The Double Helix provided the basis for highly accurate DNA replication, while the Central Dogma was viewed as supporting the Weismann Barrier, so excluding the inheritance of (...) acquired characteristics. This article examines the language of the Modern Synthesis and reveals that it is based on four important misinterpretations of what molecular biology had shown, so forming the basis of the four Illusions: 1. Natural Selection; 2. The Weismann Barrier; 3. The Rejection of Darwin’s Gemmules; 4. The Central Dogma. A multi-level organisation view of biology avoids these illusions through the principle of biological relativity. Molecular biology does not therefore confirm the assumptions of the Modern Synthesis. (shrink)

What is Life? To answer this question, Denis Noble argues that we must look beyond the gene's eye view. For modern 'systems biology' considers life on a variety of levels, as an intricate web of feedback between gene, cell, organ, body, and environment. He shows how it is both a biologically rigorous and richly rewarding way of understanding life.

The extensive range and depth of the twenty commentaries on my target article confirms that something has gone deeply wrong in biology. A wide range of biologists has more than met my invitation for “others to pitch in and develop or counter my arguments.” The commentaries greatly develop those arguments. Also remarkably, none raise issues I would seriously disagree with. I will focus first on the more critical comments, summarise the other comments, and then point the way forward on what (...) I view as a necessary and long-overdue transition in the foundations of biology. (shrink)

Conscious Agency is a major driver of evolution. Artificial Selection (i.e. Conscious Selection by human breeders) was the foil against which Charles Darwin defined Natural Selection. In later work, he extended Artificial Selection to other species. That ability for social (e.g. sexual) selection must have evolved. Jablonka and Ginsburg identify markers of conscious agency, such as Unlimited Associative Learning (UAL), and show that it must have existed at the time of the Cambrian Explosion. To their insights, my commentary argues that (...) the harnessing of stochasticity was also involved in the evolution of the faculty of choice in organisms. (shrink)

In Silence et langage Stephen A. Noble offers a new interpretation of the development of Merleau-Ponty’s phenomenology which analyses the central position of language within a philosophy of perception predicated upon the interdependence of seeing and speaking.

Plotinus maintains that there is a single first principle, the One (or the Good), from which all other things derive. He is usually thought to hold this view on the grounds that any other thing’s existence depends on its participation in a paradigm of unity. This paper argues that Plotinus has a further, independent argument for adopting a single first principle, according to which principle pluralism is committed (unacceptably) to attributing good cosmic states of affairs to chance. This argument exhibits (...) similarities to ancient design arguments, but is used to draw the more radical conclusion that there is only one non-derivative existent. (shrink)

In this paper I offer an analysis of Plotinus’ argument for the existence of a quasi-psychic entity, the so-called ‘trace of soul’, that functions as an immanent cause of life for an organism’s body. I argue that Plotinus posits this entity primarily in order to account for the body’s possession of certain quasi-psychic states that are instrumental in his account of soul-body interaction. Since these quasi-psychic states imply that an organism’s body has vitality of its own , and Platonic souls (...) are no part or aspect of any body, Plotinus draws the conclusion that the soul must be a cause of the body’s life by imparting a quasi-psychic qualification to it. In so doing, Plotinus introduces elements of hylomorphism into Platonist psychology, and addresses a problem for the animation of the body that Platonic soul-body dualism may plausibly be thought to face. (shrink)

This chapter describes the origin of the principle of biological relativity and its development since 2012. It was first formulated by distinguishing between the causal properties of initial and boundary conditions, regarded as a formal cause, compared to the dynamics of the differential functions themselves, regarded as an efficient cause. The concept of organisational level, and of boundaries between levels and environmental factors are also central to the principle. Work on the properties of boundaries reveals two important features: the nature (...) of causation differs significantly between different levels of organisation, and the top-down and bottom-up forms must act simultaneously. These developments of the principle are used to clarify the reasons why bottom-up causation alone is inadequate in multi-level biology. (shrink)

Life is definitively purposive and creative. Organisms use genes in controlling their destiny. This book presents a paradigm shift in understanding living systems. The genome is not a code, blueprint or set of instructions. It is a tool orchestrated by the system. This book shows that gene-centrism misrepresents what genes are and how they are used by living systems. It demonstrates how organisms make choices, influencing their behaviour, their development and evolution, and act as agents of natural selection. It presents (...) a novel approach to fundamental philosophical and cultural issues, such as free-will. Reading this book will make you see life in a new light, as a marvellous phenomenon, and in some sense a triumph of evolution. We are not in our genes, our genes are in us. (shrink)

During Advent we prayerfully consider how Jesus was born to save us from death through his incarnation, death, and resurrection. Remembering this in light of your own death can change your life. Mememto mori or "remember your death" is a phrase long associated with the practice of remembering the unpredictable and inevitable end of one's life. This book is the latest in a series of books by Sr. Theresa Alethia Noble, FSP, that explores the traditional Christian practice of meditation (...) on death in light of Christ. This book will help you to connsider the four Last Things: death, judgment, hell, and heaven in the context of Advent. -- Adapted from back cover. (shrink)

In Ennead 3.6, Plotinus maintains that the soul is unaffectable. This thesis is widely taken to imply that his soul is exempt from change and free from emotional ‘affections’. Yet these claims are difficult to reconcile with evidence that Plotinian souls acquire dispositional states, such as virtues, and are subjects of emotional ‘affections’, such as anger. This paper offers an alternative account that aims to address these difficulties. In denying affections to soul, Plotinus is offering a distinction between the soul’s (...) self-actuated motions (or "activities") and the passive motions (or "affections") of bodies. But this distinction does not imply the soul’s changelessness, since Plotinus regards psychic motions that culminate in the soul’s acquisition of new dispositional states as changes. As for emotional ‘affections’, these (as activities) are merely homonymous with the affections denied to soul, and so do not violate the ban on the soul’s affectability. (shrink)

We give anecdotal accounts from our own experience of scientific theories which have been generally accepted as the ruling opinion long after sufficient evidence has been collected for their disproof. This has led us to the opinion that the normal scientific process, of working hypothesis followed by experimental test aimed at disproof, is being replaced by the ruling opinion followed by experiment aimed at confirmation. The apparently widespread adoption of this procedure may be postulated to arise in part from the (...) need for workers entering a new field of study to obtain grants and to get their results published. (shrink)

According to a straightforward reading of Enn. 6.2.21, all principles (logoi) in nature have their origin in corresponding features of a divine Intellect. But interpreters have often advocated more restricted readings of Intellect’s contents. Restricted readings are based in part on other textual evidence, and in part on the grounds that a more expansive reading would seem to require Intellect to think objects of trivial value (‘the value problem’) or whose purposes depend upon facts about sensible reality to which it (...) has no access (‘the teleology problem’). This paper argues that restricted readings are not well founded, and that Plotinus is committed to a more expansive conception of Intellect’s contents by his understanding of Plato’s paradeigmatism. (shrink)

The Language of Symmetry is a re-assessment of the structure and reach of symmetry, by an interdisciplinary group of specialists from the arts, humanities, and sciences at Oxford University. It explores, amongst other topics order and chaos in the formation of planetary systems entropy and symmetry in particle physics group theory, fractals and self-similarity symmetrical structures in western classical music, and how biological systems harness disorder to create order. This book aims to open up the scope of interdisciplinary work in (...) the study of symmetry and is intended for scholars of any background - whether it be science, arts or philosophy. (shrink)

Leibniz standardly associates “mechanism” with extended material bodies and their aggregates. In this paper, I identify and analyze a further distinct sense of “mechanism” in Leibniz that extends, by analogy, beyond the domain of material bodies and applies to the operations of immaterial substances such as the monads that serve, for Leibniz, as the metaphysical foundations of physical reality. I argue that in this sense, Leibniz understands “mechanism” as an intelligible process that is capable of providing a sufficient reason for (...) a series of changes. I then apply these findings to enrich our understanding of Leibniz’s well-known mill argument in Monadology ¶17: although material machines and mechanisms cannot produce perceptions, the perceptual activity of immaterial monads is to be understood as “mechanical” according to this analogical sense. (shrink)

The Weismann Barrier and the Central Dogma do not protect the assumptions of The Modern Synthesis.

Numerous mediators are involved in both the control and the transmission of nociceptive messages, and several lines of research have been developed in the management of pain. Complete enkephalin- degrading enzyme inhibitors, which produce naloxone-reversible analgesia in all tests where morphine has been found to be active, remains the most promising way. CCK compounds, especially the CCKB antagonists also may be interesting drugs. Indeed, they are able to strongly potentiate the antinociceptive effects of the opioids. [dickenson, wiesenfeld-hallin et al.].

In this paper, I discuss how Plotinus seeks to reconcile (1) the transcendence of providential thought with its creation of an optimal cosmos, (2) providence's comprehensive oversight with the existence of evils, and (3) fate with human autonomy and moral responsibility.

The recent production of major treatises devoted to elaborating normative ethical theories and the eruption of lively debates concerning the merits of opposed normative systems have been greeted with applause. This reaction is an historical about-face, since for forty or fifty years “ethical” treatises had been attacking the pretensions of traditional moral philosophy, calling for its demise or at the least severely limiting its claims. These skeptical attacks had succeeded in seriously undermining the academic status of moral philosophy and consequently (...) moral philosophy was transformed into “metaethics,” a highly abstract and technical discipline considered much less necessary to the general education of students than what it replaced and with a diminished role in the curriculum. The recent resurgence of interest in normative ethics has generally been lauded as a sign that philosophy has rededicated itself to its proper and time-honored tasks. There is a widespread feeling that the overblown claims of twentieth century skepticism have been whittled down to innocuous proportions and thus that nothing stands in the way of proceeding to construct ethical theories. The study of normative ethical theory now enjoys such respectability and popularity that it is difficult to raise once more the uncomfortable ideas that the ideal of normative ethical theory is a false one, that vanquishing the spectre of noncognitivism is not sufficient for legitimizing it, and that the popular new justifications for the enterprise fail in mischievous ways. (shrink)

Research using the intermodal preferential looking paradigm (IPLP) has consistently shown that English‐learning children aged 2 can associate transitive argument structure with causal events. However, studies using the same methodology investigating 2‐year‐old children’s knowledge of the conjoined agent intransitive and semantic role assignment have reported inconsistent findings. The aim of the present study was to establish at what age English‐learning children have verb‐general knowledge of both transitive and intransitive argument structure using a new method: the forced‐choice pointing paradigm. The results (...) suggest that young 2‐year‐olds can associate transitive structures with causal (or externally caused) events and can use transitive structure to assign agent and patient roles correctly. However, the children were unable to associate the conjoined agent intransitive with noncausal events until aged 3;4. The results confirm the pattern from previous IPLP studies and indicate that children may develop the ability to comprehend different aspects of argument structure at different ages. The implications for theories of language acquisition and the nature of the language acquisition mechanism are discussed. (shrink)

Plotinus, following certain Platonic cues, maintains that ‘we’ and ‘the true human being’ correspond to the rational part of the embodied human soul. This view is counterintuitive because it is natural to see ourselves and our humanity as including parts of the human organism additional to reason. In this paper, I propose that Plotinus’ view that we are our rational part is best understood as expressing a teleological claim. Since our proper end is an activity of the rational part of (...) soul, it is appropriate to identify our nature with that part of the organism alone. (shrink)

Organismal death has long been considered the irreversible ending of an organism's integrated functioning as a whole. However, the persistence of functionality in organs, tissues, and cells postmortem, as seen in organ donation, raises questions about the mechanisms underlying this resilience. Recent research reveals that various factors, such as environmental conditions, metabolic activity, and inherent survival mechanisms, influence postmortem cellular functionality and transformation. These findings challenge our understanding of life and death, highlighting the potential for certain cells to grow and (...) form new multicellular entities. This opens new avenues in biology and medicine, expanding our comprehension of life's complexity. (shrink)

In this paper, I investigate the foundations of Plotinus’ innovative theory that prime matter is unaffectable. I begin by showing that Plotinus’ main arguments for this thesis (in Ennead 3.6) all rely upon the controversial assumption that the properties prime matter underlies are not properties of prime matter itself. It is then argued that prime matter’s privation of sensible qualities has its conceptual basis in an idiosyncratic understanding of form-matter composition generally, and its primary doctrinal basis in Aristotle’s critical reports (...) on the Platonists’ substratum in Physics 1.9. While Plotinus finds Platonic authority for unaffectible matter in the Receptacle passage of the Timaeus, it is Aristotle’s testimony that provides the crucial impetus for reading that text in this way. On this basis, Plotinus develops a Platonist conception of form’s inherence in matter with distinctively non-Aristotelian features. (shrink)