In this volume, three aspects are examined: a) normal subjects, where new findings on spatial behavior are described. b) brain-lesioned subjects, where the ...

The excellent and highly interesting commentaries address the following concerns: (1) neuroanatomy and neurophysiology of catatonia; (2) cognitive-motor deficits in catatonia; (3) conceptual issues; (4) general methodology in neuropsychiatric research; and (5) neurophilosophical implications. The specific problems, issues, and aspects raised by the different commentators are grouped under these categories in Table R1 presented below. These five areas of concern are then discussed in the order listed in the five sections of the Response.

BackgroundPrenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder. In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers.MethodsChildren with FASD who were enrolled in a clinical trial of choline supplementation were followed for 9 months. Delayed (...) recall on a 9-step elicited imitation task served as the behavioral measure of recognition memory. Neurophysiological correlates of memory were assessed via event-related potentials.ResultsDelayed recall on EI was correlated with two ERP components commonly associated with recognition memory in young children: middle latency negative component and positive slow wave. No significant ERP differences were observed between the choline and placebo groups at the conclusion of the trial.ConclusionAlthough the small sample size limits the ability to draw clear conclusions about the treatment effect of choline on ERP, the results suggest a relationship between memory performance and underlying neurophysiological status in FASD. This trial was registered.1. (shrink)

Philosophers and neuroscientists often suggest that we perceptually represent objects and their properties. However, they start from very different background assumptions when they use the term “perceptual representation”. On the one hand, sometimes philosophers do not need to properly take into consideration the empirical evidence concerning the neural states subserving the representational perceptual processes they are talking about. On the other hand, neuroscientists do not rely on a meticulous definition of “perceptual representation” when they talk about this empirical evidence that (...) is supposed to show that we perceptually represent such and such properties. It seems that, on both sides, something is missed. My aim is to show that, in the light of empirical evidence from neuroscience, the case of action properties is a good candidate in order to properly talk of perceptually represented properties. My claim is that the neurophysiological states encoding action properties are perceptual processes and that these perceptual processes are representational processes. That is, in the case of those neurophysiological states involved in the detection of action properties, it is correct to speak of perceptual representational states, and hence, ipso facto, of perceptually represented properties. First, I describe a reasonable and widely agreed upon conception of perceptual representation in the philosophical literature. Then, I report evidence from vision and motor neuroscience concerning the perception of action properties, which is subserved by the ventro-dorsal stream, a portion of the dorsal visual system. Finally, I show that a strong connection can be found between the philosophical idea of perceptual representation I have reported before and the neuroscientific evidence concerning the activity of the ventro-dorsal stream, whose job is, as said, to detect action properties. (shrink)

In the first two sections of the paper, some basic terminological distinctions regarding “freedom of the will” as a philosophical problem are expounded and discussed. On this basis, the third section focuses on the examination of two neurophysiological experiments (one by Benjamin Libet and one by William Grey Walter), which in recent times are often interpreted as providing an empirical vindication of determinism and, accordingly, a refutation of positions maintaining freedom of the will. It will be argued that both experiments (...) fall short in this respect, and that in general—for methodical reasons—the prospects of ever deciding the dispute about freedom of the will through empirical research are rather poor. (shrink)

The aim of the paper is to reveal the main methodological problems of neuroethics in the course of its development as an interdisciplinary approach to the study of morality, as well as to propose a critical analysis of the results of cognitive science (neurophysiol­ogy) in the context of moral philosophy. For this purpose, the author analyzes the modern subject field of neuroethical research from the point of view of philosophical ethics and discusses the main conceptions in which the results of (...) neurophysiological studies of the moral decision-making process are summarized. The author describes a general divi­sion of the subject field in terms of “neuroethics No. 1” (a part of bioethics) and “neu­roethics No. 2” (a proclaimed part of moral philosophy). The object of research of this ar­ticle is neuroethics No. 2. It is argued that in neuroethics No. 2 the conceptualization of the moral decision-making process is carried out everywhere in accordance with the scheme of “double processes”: intuitive / quick / associative and discursive / slow / calculation-based. Even if the role of intuition is denied, duality is still preserved. This is so because emotions, as an extra-rational part of the psyche, are considered the basis of a quick decision. It is shown that a non-reflexive borrowing of concepts and concep­tions of moral philosophy is carried out both at the level of formation of the subject of re­search and at the level of method. The qualitatively meaningful meaning of concepts is blurred or substituted. Such a language transition outside the boundaries of the subject area of neurophysiology only simulates the presence of interdisciplinarity. The research remains in the frames of the study of cognitive processes, without their moral component. It is concluded that for the development of neuroethics as an interdisciplinary direction, we need to obtain a synthesis of the meanings developed in the course of cultural devel­opment and of the data on human biological development. Further, in accordance with such a synthetic subject we need to adjust the research method, also we must avoid sub­stituting the concepts of philosophical ethics. (shrink)

This article discusses neurophysiological correlates of those processes that mediate face recognition. Neurophysiological research in the past few years has been strongly focused on the N170, a putative correlate of the detection of a face-like visual configuration or structural encoding of faces. Neural correlates of recognition may be inferred from a difference between a repeated and an unrepeated presentation of a particular face. It focuses on effects related to face repetition and familiarity and correlates of face identification that involve retrieval (...) of semantic information or names. A debate around the face-selectivity of event-related potentials dominates underlying neural processes mediating face recognition. The main challenge is to investigate the functional significance of various neural responses in the context of cognitive models. (shrink)

Right-ear advantage refers to the observation that when two different speech stimuli are simultaneously presented to both ears, listeners report stimuli more correctly from the right ear than the left. It is assumed to result from prominent projection along the auditory pathways to the contralateral hemisphere and the dominance of the left auditory cortex for the perception of speech elements. Our study aimed to investigate the role of attention in the right-ear advantage. We recorded magnetoencephalography data while participants listened to (...) pairs of Japanese two-syllable words. The amplitudes of the stimuli were modulated at 35 Hz in one ear and 45 Hz in the other. Such frequency-tagging allowed the selective quantification of left and right auditory cortex responses to left and right ear stimuli. Behavioral tests confirmed the right-ear advantage, with higher accuracy for stimuli presented to the right ear than to the left. The amplitude of the auditory steady-state response was larger when attending to the stimuli compared to passive listening. We detected a correlation between the attention-related increase in the amplitude of the auditory steady-state response and the laterality index of behavioral accuracy. The right-ear advantage in the free-response dichotic listening was also found in neural activities in the left auditory cortex, suggesting that it was related to the allocation of attention to both ears. (shrink)

Short-term memory, nonattentional task effects and nonspatial extraretinal representations in the visual system are signs of cognitive penetration. All of these have been found physiologically, arguing against the cognitive impenetrability of vision as a whole. Instead, parallel subcircuits in the brain, each subserving a different competency including sensory and cognitive (and in some cases motor) aspects, may have cognitively impenetrable components.

Introduction: Evidence supporting the use of music interventions to maximize arousal and awareness in adults presenting with a disorder of consciousness continues to grow. However, the brain of a child is not simply a small adult brain, and therefore adult theories are not directly translatable to the pediatric population. The present study aims to synthesize brain imaging data about the neural processing of music in children aged 0-18 years, to form a theoretical basis for music interventions with children presenting with (...) a disorder of consciousness following acquired brain injury.Methods: We conducted a systematic review with narrative synthesis utilizing an adaptation of the methodology developed by Popay and colleagues. Following the development of the narrative that answered the central question “what does brain imaging data reveal about the receptive processing of music in children?”, discussion was centered around the clinical implications of music therapy with children following acquired brain injury.Results: The narrative synthesis included 46 studies that utilized EEG, MEG, fMRI, and fNIRS scanning techniques in children aged 0-18 years. From birth, musical stimuli elicit distinct but immature electrical responses, with components of the auditory evoked response having longer latencies and variable amplitudes compared to their adult counterparts. Hemodynamic responses are observed throughout cortical and subcortical structures however cortical immaturity impacts musical processing and the localization of function in infants and young children. The processing of complex musical stimuli continues to mature into late adolescence.Conclusion: While the ability to process fundamental musical elements is present from birth, infants and children process music more slowly and utilize different cortical areas compared to adults. Brain injury in childhood occurs in a period of rapid development and the ability to process music following brain injury will likely depend on pre-morbid musical processing. Further, a significant brain injury may disrupt the developmental trajectory of complex music processing. However, complex music processing may emerge earlier than comparative language processing, and occur throughout a more global circuitry. (shrink)

(1) Reaction time (RT) studies give only a partial picture of language processing, hence it may be risky to use the output of the computational model to inspire neurophysiological investigations instead of seeking further neurophysiological data to adjust the RT based theory. (2) There is neurophysiological evidence for differences in the cortical representation of different word categories; this could be integrated into a future version of the Levelt model. (3) EEG/MEG coherence analysis allows the monitoring of synchronous electrical activity in (...) large groups of neurons in the cortex; this is especially interesting for activation based network models. (shrink)

Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in every sleeping person. They show that the human brain, disconnected from the environment, can generate an entire world of conscious experiences by itself. Content analysis and developmental studies have promoted understanding of dream phenomenology. In parallel, brain lesion studies, functional imaging and neurophysiology have advanced current knowledge of the neural basis of dreaming. It is now possible to start integrating these two strands of research to address fundamental (...) questions that dreams pose for cognitive neuroscience: how conscious experiences in sleep relate to underlying brain activity; why the dreamer is largely disconnected from the environment; and whether dreaming is more closely related to mental imagery or to perception. (shrink)