Purified nuclei are being used as a test system to study the regulation of nuclear enzymes in plants. Regulatory agents such as light, hormones and polyamines can stimulate kinases or phosphatases that control nuclear protein phosphorylation and they can modulate the activity of as yet unidentified enzymes required for transcript synthesis and/or stabilization. This essay summarizes current findings and discusses the advantages and pitfalls of using isolated nuclei to investigate how nuclear functions are controlled.

1. Premadharma o Rāsalīlā.-- 2. Bedānta o bijñāna ebaṃ Jagadgurura ābirbhāba.-- 3. Upanishad-brahmatattva ebaṃ yājñabalkyera advaitabāda.-- 4. Upanishad-jaṛa o jībatattva.-- 5. Karmabāda o janmāntara, abatāratattva ebaṃ prakr̥ta yoga ki? -- v. 6. Sāṃkhya paricaẏa, Buddhadebera 'nāstikatā' ebaṃ buddhi o bodhi. -- v. 7. Gītāẏa Īśvarabāda, Raṅgamatī, ebaṃ Meghadūta (mūla o padyānubāda).

How does one decolonize and reclaim the meanings of research and researcher, particularly in the context of Western research? Indigenous communities have long experienced oppression by Western researchers. Is it possible to build a collaborative research knowledge that is culturally appropriate, respectful, honoring, and careful of the Indigenous community? What are the challenges in Western research, researchers, and Western university methodology research training? How have ‘studies’ – critical anti-racist theory and practice, cross-cultural research methodology, critical perspectives on environmental justice, and (...) land-based education – been incorporated into the university to disallow dissent? What can be done against this disallowance? According to Eve Tuck and K Wayne Yang’s suggestion, this article did not use the concept of decolonization as a substitute for ‘human rights’ or ‘social justice’, but as a demand of an Indigenous framework and a centering of Indigenous land, Indigenous sovereign... (shrink)

Purpose– The purpose of this paper is to create a conceptual framework, based on a structured literature review, to analyze the digital disability divide and help find solutions for it. A digital disability divide exists between people with impairments and those without impairments. Multiple studies have shown that people without impairments are less likely to own a computer or have an Internet connection than are people with impairments. However, the digital disability divide is seen in relation not only to access (...) but also to accessibility and use. For people with impairments, new technological innovations offer solutions for everyday challenges, such as finding information, communicating with others and using electronic services.Design/methodology/approach– For this study, 4,778 conference and journal publications were systematically analyzed.Findings– A number of key findings emerged. This field is relatively new, and the literature is highly focused on the technological and social aspects of the digital disability divide, with technology and societal attributes being the core sub-attributes for a comprehensive model. The previous literature did not significantly study the consequences of the financial situation of individuals; rather, the predominant focus was on the have-nots and countries with low income potentials. Furthermore, motivation reveals a compelling case within the digital disability divide subset.Originality/value– The review provides a consolidated view of past research on the general topic of the digital disability divide and the attributes that affect it. (shrink)

Reproductive autonomy is an integral aspect of female reproduction, but this autonomy is endangered by the control and surveillance of pregnant bodies by institutional structures, laws, and cultural norms. These restrictions deprive women of the freedom to make informed choices, ranging from decisions concerning prenatal care and reproductive procedures to abortion, violating fundamental human rights and bodily autonomy. This article examines how Kalki Koechlin’s graphic memoir _The Elephant in the Womb_ (2021) advances and nuances the discourses surrounding reproductive autonomy and (...) offers insights into how graphic reproduction narratives contribute to developing reproductive rights discourse. (shrink)

This work presents a blueprint or set of guidelines for the planning and development of sustainable national centers dealing with the safety of nanomaterials and nanotechnologies toward public health and environment. The blueprint was developed following a methodological approach of EU-wide online survey and workshop with several stakeholders. The purpose was to identify the key elements and challenges in the development and sustainability of a national nanosafety center. The responses were received from representatives of 16 national nanosafety centers across Europe (...) and 44 people from 18 EU member states who represented the stakeholder groups of researchers, academics, industry, regulators, civil society, and consultants. By providing an overview of the organizational design of existing national nanosafety centers across EU and converging demands in the field of nanosafety, the blueprint principally benefits those EU member states who do not have a national nanosafety center, but intend to develop an entity to manage the human health, environmental, ethical, and social concerns/risks toward the growing nationwide activities on engineered nanomaterials, e.g., their production, use or disposal, at national level. (shrink)

Articles chiefly on the Bratachāri Movement, founded and popularised by Gurusadaẏa Datta, 1882-1941; includes articles on nationalism with special reference to Bengal, India.

Articles on the life and work of Aurobindo Ghose, 1872-1950, philosopher and thinker from India, and his views on Ramakrishna, 1836-1886, Hindu saint, and his life.

Transcript of speeches by a Hindu philosopher, chiefly on Hindu philosophy and Hinduism.

In their analysis Childress et al. (2023) suggest that withdrawal of extracorporeal membrane oxygenation (ECMO) over a patient’s dissent is not justified by existing ethical arguments. The alternat...

In a deeper sense, quality of worklife (QWL) refers to the quality of life (QL) of individuals in their working organizations—commercial, educational, cultural, religious, philanthropic or whatever they are. Modern society is organizational society. Individuals spend much of their lives in organizations. Hence, the impor tance of QWL is unquestionable. It has an ideological core comprising the perceptual gap across individu als about the real connotation of QL as well as QWL. In addition to this ideological problem, the study of (...) QWL presents serious methodological problems too. A positivist attitude is always sceptical about the deeper meaning of life, maybe out of honest lack of knowledge, or maybe with some ulterior motives. The present paper therefore is an attempt to touch upon three aspects of QWL: (a) QWL from a human values approach; (b) some viewpoints for subjective observation of QWL; and (c) some ameliorative measures towards im proving QWL. (shrink)

The governments of China, India, and the United Kingdom are unanimous in their belief that bioinformatics should supply the link between basic life sciences research and its translation into health benefits for the population and the economy. Yet at the same time, as ambitious states vying for position in the future global bioeconomy they differ considerably in the strategies adopted in pursuit of this goal. At the heart of these differences lies the interaction between epistemic change within the scientific community (...) itself and the apparatus of the state. Drawing on desk-based research and thirty-two interviews with scientists and policy makers in the three countries, this article analyzes the politics that shape this interaction. From this analysis emerges an understanding of the variable capacities of different kinds of states and political systems to work with science in harnessing the potential of new epistemic territories in global life sciences innovation. (shrink)

Study of Yogasūtra of Patañjali and Vyāsabhāṣya, commentary on Yogasūtra by Vyāsa.

New research and a government investigation have shed light on an anticompetitive practice called “Product Hopping” and specifically how it was employed in the case of the multiple sclerosis treatment glatiramer acetate beginning in 2014, which cost payers billions of dollars. We examine this case as well as a separate, impending instance of product hopping.

The microfinance business model focuses largely on lending to the woman in the household, rather than the man. The belief is that women are more trustworthy borrowers than men, and that lending to women may have increased social impact. Yet in several cases, women do not have control over the loan backed business despite being the borrower of record. Such takeover of the business by the man constitutes an ethical violation. We find that high dependency ratios in the family are (...) correlates of such ethical violations. Further, we also find that ethical violations have a significant economic cost, consistent with prior scholarship in the family-business domain. While access to microfinance increases household welfare, this beneficial impact reduces by over 50% in the presence of an ethical violation. Our results suggest that microfinance lenders need to move beyond the traditional role of just being a lender to providing advice on issues like family planning, and money management, and enforcement, thus moving closer to the solidarity economy paradigm of integrating savings and credit into broader canvases of social relationships and social structures. (shrink)

Celebrated yogi Reema Datta adapts her world-renowned 12-week course into a book format that combines the ancient practice of yoga with modern science. The result is a practical method for attaining emotional well-being, physical health, and spiritual nourishment.

In this paper we introduce the concept of interval valued neutrosophic soft topological space together with interval valued neutrosophic soft finer and interval valued neutrosophic soft coarser topology. We also define interval valued neutrosophic interior and closer of an interval valued neutrosophic soft set. Some theorems and examples are cites. Interval valued neutrosophic soft subspace topology are studied. Some examples and theorems regarding this concept are presented.

On 27 February 1998, the Indian Institute of Management, Calcutta and the office of the Fulbright binational educational exchanges (US Educational Foundation in India) in Calcutta jointly hosted a seminar on 'The Tradition of Non Violence: The American Experience and the Gandhian' at the Management Centre for Human Values (MCHV). There were two keynote presentations. The one on the American experience was by Michael True, Professor of English Literature at Assumption College, Massachusetts, who was teaching as Fulbright visiting lecturer at (...) Utkal University, Bhubaneswar. The Gandhian case was presented by Profes sor Amlan Datta, economist and writer, also former Vice-Chancellor of Visva-Bharati University, Santiniketan. The session was chaired by Professor Amitava Bose, Director, Indian Institute of Management. To close the discussions, a summing up was presented by Professor S.K. Chakraborty, Convenor, Management Centre for Human Values. The importance of discussions on the subject of non-violence and the Gandhian alterna tive cannot be overestimated in this year of the 50th anniversary of Indian independence and a nationwide soul-searching over these five decades. The US Educational Foundation in India contributed to the national discussion through this bilateral seminar and its comparative perspective. (shrink)

Background: Informed consent in the modern era is a common and important topic both for the well-informed patient and to prevent unnecessary litigation. However, the effectiveness of informed consent in trauma patients is an under-researched area. This paper aims to assess the differences in patient recall of the consent process and desire for information by performing a comparative analysis between orthopaedic trauma and elective patients. Methods: Information from 41 consecutive elective operations and 40 consecutive trauma operations was collected on the (...) first post-operative day. Results: 100% of elective patients and 90% of trauma patients knew what operation they had received (p = 0.06). Overall recall of complications was poor, but was significantly lower in trauma patients compared with elective patients (62% vs 22%, p<0.001). 30% of trauma patients desired more information about their operation compared to 12% of elective patients (p = 0.049), although only 35% of trauma patients wanted written as well as verbal explanations, compared to 85% of elective patients p<0.001). Overall 100% of elective and 90% of trauma patients were happy with the consent process (p = 0.06). Subset analysis of neck of femur compared to other trauma patients showed that the above factors were not significantly different between the two groups. Conclusions: Recall of complications in the trauma patients is significantly lower than in elective patients, although both groups scored poorly overall. Repeated verbal explanations should be reinforced with the option of additional information leaflets for trauma operations. Further research into the usefulness of DVDs for commonly performed operations is warranted, although official internet resources may be more cost-effective. (shrink)

The 21st century is the time of complexity. We delineate it and its importance as necessary to solve ‘wicked problems.’ Inherently transdisciplinary, trans-scale, and interconnected to living systems, the solution to Heliophysics’ identity crisis and to unlock the next generation of scientific discovery may be to embrace complexity. With the right foresight, direction, and incentive over the next ten years, Heliophysics can become a beacon for how all of society thinks about and does complexity science.

Wittgenstein in his early work viz. Tractatus argued that there is a common, essential, underlying structure that links logic, language and the world. He also argued about the need for an analysis of ordinary language in terms of a perspicuous symbolism that would display a one to one relationship between a proposition and a fact – when both of them are broken down to their simplest components – viz. to atomic propositions and atomic states of affairs. All propositions are ultimately (...) truth-functional combinations of atomic propositions – thus all language is resolvable to a unique constant. So for early Wittgenstein, though there is an apparent complexity and diversity of propositions still there lies a uniform, essential structure of truthfunctional propositions and that can be reduced to a single constant. And language to have a determinate sense must be ultimately based on objects – the absolutely simple logical atoms of the world. These objects imbibe their range of combination with other objects, which implies that any genuine propositions – however unusual and unconventional it may seem to be – must ultimately be constrained by the permissible range of combination of the objects. In this way early Wittgenstein sought to secure an essential metaphysics via an essential structure of language. However in Philosophical Investigations Wittgenstein attacked essentialism by rejecting the picture theory, and the search for commonality and uniformity. He denied essence, the universal, the common element present in all the objects of a class and accepted only an indeterminate and incomplete flow of the criss-crossing, the overlapping features. For him language is constituted by an ever expanding flow of uses, which he called language-games. The significance of the term ‘language-game’ lies in the fact that like games language too is not based on any ontology that would confer a common essence across all the widely divergent uses. Nor did Wittgenstein accept any hidden essence behind appearance. In PI the later Wittgenstein denied both analysis and essence and propagated description of usage and behaviours as the only method of philosophy. Later Wittgenstein will neither commit himself to ontological necessity, nor to necessity being a matter of scheme-relative propositions in the Quinean sense. For later Wittgenstein all attempts to establish essences, or the contrary exercises to relativise them to a particular set of presumptions, are themselves language-games – they boil down to usage and practices that do not rest on any foundation. (shrink)

ABSTRACT This article explores Rabindranath Tagore’s vision of the future, continuously engaged with and drawing from the past, in relation to my own creative practice as theatre and film director, curator, and singer-performer, a practice that continuously engages with the resonances of Tagorean utopia. Through three case studies from the author’s creative engagement with Tagore’s utopia, the article explores the building of transcultural utopias in which Tagore and Leonard Elmhirst participated and how Dartington Hall rapidly became a magnet for artists, (...) writers, philosophers, and musicians; Tagore’s opera Tasher Desh, a powerful political satire on fascism/free will; and the author’s feature film Life Goes On and the Tagorean construct of the absent-present mother figure. (shrink)

The age old conflict between logical analysis and phenomenological study revealed by different philosophical treatments of our experience of temporal passage are discussed in the present paper. Temporal passage is found to be problematic because philosophers entertain conflicting views regarding the status of the passage of time. As logical analyses prove temporal passage as unreal or illusory and phenomenological study of our experience of temporal passage considers it to be a fundamental structure of our life, the conflict regarding the status (...) of the passage of time emerges. In this paper our aim will be to explore gradually different logical analyses of our experience of temporal passage provided by philosophers of both classical India and the West on the one hand and also to discuss some of the phenomenological treatments of our experience of temporal passage provided by some continental philosophers to show the conflict between the results of these two philosophical treatments. Finally, we would like to state that since this conflict culminates into the conflict between reason and experience, it is not possible to resolve the conflict in the present life form in which both these categories have their distinctive roles to play. (shrink)

Vaiśeşikas are realist philosophers of classical India. They admit time (kāla) as a ubiquitous real substance. In this paper, our aim is to discuss such a determination of time following sixth century Vaiśeşika scholar Praśastapāda and a few of his interpreters, Vyomaśivācārya and Udayanācārya. This paper is an effort to state realist philosophers’ understanding of time and also to highlight how in classical Indian tradition, interpretations paved the way for proving the reality of time. The application of logical methods by (...) the Vaiśeşika interpreters is also worth studying. These methods show the internal development occurring in the system of Vaiśeşika. Praśastapāda stated different notions like priority etc. (paratvādi) as the linga or hetu of kāla. Vyomaśiva and Udayana have established this statement of Praśastapāda as the lakşaņa of kāla by virtue of different forms of inference. (shrink)

Hereditary breast and ovarian cancers are frequently attributed to germline mutations in the tumor suppressor genes BRCA1 and BRCA2. BRCA1/2 act to repair double‐strand breaks (DSBs) and suppress the demise of unstable replication forks. Our work elucidated a dynamic interplay between BRCA2 and the WRN DNA helicase/exonuclease defective in the premature aging disorder Werner syndrome. WRN and BRCA2 participate in complementary pathways to stabilize replication forks in cancer cells, allowing them to proliferate. Whether the functional overlap of WRN and BRCA2 (...) is relevant to replication at gaps between newly synthesized DNA fragments, protection of telomeres, and/or metabolism of secondary DNA structures remain to be determined. Advances in understanding the mechanisms elicited during replication stress have prompted the community to reconsider avenues for cancer therapy. Insights from studies of PARP or topoisomerase inhibitors provide working models for the investigation of WRN's mechanism of action. We discuss these topics, focusing on the implications of the WRN‐BRCA2 genetic interaction under conditions of replication stress. (shrink)