Purified nuclei are being used as a test system to study the regulation of nuclear enzymes in plants. Regulatory agents such as light, hormones and polyamines can stimulate kinases or phosphatases that control nuclear protein phosphorylation and they can modulate the activity of as yet unidentified enzymes required for transcript synthesis and/or stabilization. This essay summarizes current findings and discusses the advantages and pitfalls of using isolated nuclei to investigate how nuclear functions are controlled.

1. Premadharma o Rāsalīlā.-- 2. Bedānta o bijñāna ebaṃ Jagadgurura ābirbhāba.-- 3. Upanishad-brahmatattva ebaṃ yājñabalkyera advaitabāda.-- 4. Upanishad-jaṛa o jībatattva.-- 5. Karmabāda o janmāntara, abatāratattva ebaṃ prakr̥ta yoga ki? -- v. 6. Sāṃkhya paricaẏa, Buddhadebera 'nāstikatā' ebaṃ buddhi o bodhi. -- v. 7. Gītāẏa Īśvarabāda, Raṅgamatī, ebaṃ Meghadūta (mūla o padyānubāda).

Celebrated yogi Reema Datta adapts her world-renowned 12-week course into a book format that combines the ancient practice of yoga with modern science. The result is a practical method for attaining emotional well-being, physical health, and spiritual nourishment.

Reproductive autonomy is an integral aspect of female reproduction, but this autonomy is endangered by the control and surveillance of pregnant bodies by institutional structures, laws, and cultural norms. These restrictions deprive women of the freedom to make informed choices, ranging from decisions concerning prenatal care and reproductive procedures to abortion, violating fundamental human rights and bodily autonomy. This article examines how Kalki Koechlin’s graphic memoir _The Elephant in the Womb_ (2021) advances and nuances the discourses surrounding reproductive autonomy and (...) offers insights into how graphic reproduction narratives contribute to developing reproductive rights discourse. (shrink)

Articles chiefly on the Bratachāri Movement, founded and popularised by Gurusadaẏa Datta, 1882-1941; includes articles on nationalism with special reference to Bengal, India.

Transcript of speeches by a Hindu philosopher, chiefly on Hindu philosophy and Hinduism.

Wittgenstein in his early work viz. Tractatus argued that there is a common, essential, underlying structure that links logic, language and the world. He also argued about the need for an analysis of ordinary language in terms of a perspicuous symbolism that would display a one to one relationship between a proposition and a fact – when both of them are broken down to their simplest components – viz. to atomic propositions and atomic states of affairs. All propositions are ultimately (...) truth-functional combinations of atomic propositions – thus all language is resolvable to a unique constant. So for early Wittgenstein, though there is an apparent complexity and diversity of propositions still there lies a uniform, essential structure of truthfunctional propositions and that can be reduced to a single constant. And language to have a determinate sense must be ultimately based on objects – the absolutely simple logical atoms of the world. These objects imbibe their range of combination with other objects, which implies that any genuine propositions – however unusual and unconventional it may seem to be – must ultimately be constrained by the permissible range of combination of the objects. In this way early Wittgenstein sought to secure an essential metaphysics via an essential structure of language. However in Philosophical Investigations Wittgenstein attacked essentialism by rejecting the picture theory, and the search for commonality and uniformity. He denied essence, the universal, the common element present in all the objects of a class and accepted only an indeterminate and incomplete flow of the criss-crossing, the overlapping features. For him language is constituted by an ever expanding flow of uses, which he called language-games. The significance of the term ‘language-game’ lies in the fact that like games language too is not based on any ontology that would confer a common essence across all the widely divergent uses. Nor did Wittgenstein accept any hidden essence behind appearance. In PI the later Wittgenstein denied both analysis and essence and propagated description of usage and behaviours as the only method of philosophy. Later Wittgenstein will neither commit himself to ontological necessity, nor to necessity being a matter of scheme-relative propositions in the Quinean sense. For later Wittgenstein all attempts to establish essences, or the contrary exercises to relativise them to a particular set of presumptions, are themselves language-games – they boil down to usage and practices that do not rest on any foundation. (shrink)

Purpose– The purpose of this paper is to create a conceptual framework, based on a structured literature review, to analyze the digital disability divide and help find solutions for it. A digital disability divide exists between people with impairments and those without impairments. Multiple studies have shown that people without impairments are less likely to own a computer or have an Internet connection than are people with impairments. However, the digital disability divide is seen in relation not only to access (...) but also to accessibility and use. For people with impairments, new technological innovations offer solutions for everyday challenges, such as finding information, communicating with others and using electronic services.Design/methodology/approach– For this study, 4,778 conference and journal publications were systematically analyzed.Findings– A number of key findings emerged. This field is relatively new, and the literature is highly focused on the technological and social aspects of the digital disability divide, with technology and societal attributes being the core sub-attributes for a comprehensive model. The previous literature did not significantly study the consequences of the financial situation of individuals; rather, the predominant focus was on the have-nots and countries with low income potentials. Furthermore, motivation reveals a compelling case within the digital disability divide subset.Originality/value– The review provides a consolidated view of past research on the general topic of the digital disability divide and the attributes that affect it. (shrink)

This work presents a blueprint or set of guidelines for the planning and development of sustainable national centers dealing with the safety of nanomaterials and nanotechnologies toward public health and environment. The blueprint was developed following a methodological approach of EU-wide online survey and workshop with several stakeholders. The purpose was to identify the key elements and challenges in the development and sustainability of a national nanosafety center. The responses were received from representatives of 16 national nanosafety centers across Europe (...) and 44 people from 18 EU member states who represented the stakeholder groups of researchers, academics, industry, regulators, civil society, and consultants. By providing an overview of the organizational design of existing national nanosafety centers across EU and converging demands in the field of nanosafety, the blueprint principally benefits those EU member states who do not have a national nanosafety center, but intend to develop an entity to manage the human health, environmental, ethical, and social concerns/risks toward the growing nationwide activities on engineered nanomaterials, e.g., their production, use or disposal, at national level. (shrink)

In their analysis Childress et al. (2023) suggest that withdrawal of extracorporeal membrane oxygenation (ECMO) over a patient’s dissent is not justified by existing ethical arguments. The alternat...

How does one decolonize and reclaim the meanings of research and researcher, particularly in the context of Western research? Indigenous communities have long experienced oppression by Western researchers. Is it possible to build a collaborative research knowledge that is culturally appropriate, respectful, honoring, and careful of the Indigenous community? What are the challenges in Western research, researchers, and Western university methodology research training? How have ‘studies’ – critical anti-racist theory and practice, cross-cultural research methodology, critical perspectives on environmental justice, and (...) land-based education – been incorporated into the university to disallow dissent? What can be done against this disallowance? According to Eve Tuck and K Wayne Yang’s suggestion, this article did not use the concept of decolonization as a substitute for ‘human rights’ or ‘social justice’, but as a demand of an Indigenous framework and a centering of Indigenous land, Indigenous sovereign... (shrink)

Study of Yogasūtra of Patañjali and Vyāsabhāṣya, commentary on Yogasūtra by Vyāsa.

New research and a government investigation have shed light on an anticompetitive practice called “Product Hopping” and specifically how it was employed in the case of the multiple sclerosis treatment glatiramer acetate beginning in 2014, which cost payers billions of dollars. We examine this case as well as a separate, impending instance of product hopping.

The governments of China, India, and the United Kingdom are unanimous in their belief that bioinformatics should supply the link between basic life sciences research and its translation into health benefits for the population and the economy. Yet at the same time, as ambitious states vying for position in the future global bioeconomy they differ considerably in the strategies adopted in pursuit of this goal. At the heart of these differences lies the interaction between epistemic change within the scientific community (...) itself and the apparatus of the state. Drawing on desk-based research and thirty-two interviews with scientists and policy makers in the three countries, this article analyzes the politics that shape this interaction. From this analysis emerges an understanding of the variable capacities of different kinds of states and political systems to work with science in harnessing the potential of new epistemic territories in global life sciences innovation. (shrink)

The analysis of the measurement of gravitational fields leads to the Rosenfeld inequalities. They say that, as an implication of the equivalence of the inertial and passive gravitational masses of the test body, the metric cannot be attributed to an operator that is defined in the frame of a local canonical quantum field theory. This is true for any theory containing a metric, independently of the geometric framework under consideration and the way one introduces the metric in it. Thus, to (...) establish a local quantum field theory of gravity one has to transit to non-Riemann geometry that contains (beside or instead of the metric) other geometric quantities. From this view, we discuss a Riemann–Cartan and an affine model of gravity and show them to be promising candidates of a theory of canonical quantum gravity. (shrink)

On 27 February 1998, the Indian Institute of Management, Calcutta and the office of the Fulbright binational educational exchanges (US Educational Foundation in India) in Calcutta jointly hosted a seminar on 'The Tradition of Non Violence: The American Experience and the Gandhian' at the Management Centre for Human Values (MCHV). There were two keynote presentations. The one on the American experience was by Michael True, Professor of English Literature at Assumption College, Massachusetts, who was teaching as Fulbright visiting lecturer at (...) Utkal University, Bhubaneswar. The Gandhian case was presented by Profes sor Amlan Datta, economist and writer, also former Vice-Chancellor of Visva-Bharati University, Santiniketan. The session was chaired by Professor Amitava Bose, Director, Indian Institute of Management. To close the discussions, a summing up was presented by Professor S.K. Chakraborty, Convenor, Management Centre for Human Values. The importance of discussions on the subject of non-violence and the Gandhian alterna tive cannot be overestimated in this year of the 50th anniversary of Indian independence and a nationwide soul-searching over these five decades. The US Educational Foundation in India contributed to the national discussion through this bilateral seminar and its comparative perspective. (shrink)

The analysis of the measurement of gravitational fields leads to the Rosenfeld inequalities. They say that, as an implication of the equivalence of the inertial and passive gravitational masses of the test body, the metric cannot be attributed to an operator that is defined in the frame of a local canonical quantum field theory. This is true for any theory containing a metric, independently of the geometric framework under consideration and the way one introduces the metric in it. Thus, to (...) establish a local quantum field theory of gravity one has to transit to non-Riemann geometry that contains (beside or instead of the metric) other geometric quantities. From this view, we discuss a Riemann–Cartan and an affine model of gravity and show them to be promising candidates of a theory of canonical quantum gravity. (shrink)

The age old conflict between logical analysis and phenomenological study revealed by different philosophical treatments of our experience of temporal passage are discussed in the present paper. Temporal passage is found to be problematic because philosophers entertain conflicting views regarding the status of the passage of time. As logical analyses prove temporal passage as unreal or illusory and phenomenological study of our experience of temporal passage considers it to be a fundamental structure of our life, the conflict regarding the status (...) of the passage of time emerges. In this paper our aim will be to explore gradually different logical analyses of our experience of temporal passage provided by philosophers of both classical India and the West on the one hand and also to discuss some of the phenomenological treatments of our experience of temporal passage provided by some continental philosophers to show the conflict between the results of these two philosophical treatments. Finally, we would like to state that since this conflict culminates into the conflict between reason and experience, it is not possible to resolve the conflict in the present life form in which both these categories have their distinctive roles to play. (shrink)

Vaiśeşikas are realist philosophers of classical India. They admit time (kāla) as a ubiquitous real substance. In this paper, our aim is to discuss such a determination of time following sixth century Vaiśeşika scholar Praśastapāda and a few of his interpreters, Vyomaśivācārya and Udayanācārya. This paper is an effort to state realist philosophers’ understanding of time and also to highlight how in classical Indian tradition, interpretations paved the way for proving the reality of time. The application of logical methods by (...) the Vaiśeşika interpreters is also worth studying. These methods show the internal development occurring in the system of Vaiśeşika. Praśastapāda stated different notions like priority etc. (paratvādi) as the linga or hetu of kāla. Vyomaśiva and Udayana have established this statement of Praśastapāda as the lakşaņa of kāla by virtue of different forms of inference. (shrink)

This book presents in brief, yet systematic way the philosophy of the great Indian thinker. The author's purpose in this book is "to present in English to the Western world the life and the philosophy of Gandhi and to show the importance of his ideals of truth, love, and non-violence for the solution of the social and political problems of the present age".

A study was undertaken of the views of users of two genitourinary medicine (GUM) clinics in England on unlinked anonymous testing (UAT) for HIV. The UAT programme measures the prevalence of HIV in the population, including undiagnosed prevalence, by testing residual blood (from samples taken for clinical purposes) which is anonymised and irreversibly unlinked from the source. 424 clinic users completed an anonymous questionnaire about their knowledge of, and attitudes towards, UAT. Only 1/7 (14%) were aware that blood left over (...) from clinical testing may be tested anonymously for HIV. A large majority (89%) said they would agree to their blood being tested, although 74% wanted the opportunity to consent. These findings indicate broad support for UAT of blood in a group of patients whose samples are included in the HIV surveillance programme. The findings suggest the need for greater attention to be given to the provision of information and, if replicated in a larger survey, may justify a reappraisal of UK policy on UAT. (shrink)

Hereditary breast and ovarian cancers are frequently attributed to germline mutations in the tumor suppressor genes BRCA1 and BRCA2. BRCA1/2 act to repair double‐strand breaks (DSBs) and suppress the demise of unstable replication forks. Our work elucidated a dynamic interplay between BRCA2 and the WRN DNA helicase/exonuclease defective in the premature aging disorder Werner syndrome. WRN and BRCA2 participate in complementary pathways to stabilize replication forks in cancer cells, allowing them to proliferate. Whether the functional overlap of WRN and BRCA2 (...) is relevant to replication at gaps between newly synthesized DNA fragments, protection of telomeres, and/or metabolism of secondary DNA structures remain to be determined. Advances in understanding the mechanisms elicited during replication stress have prompted the community to reconsider avenues for cancer therapy. Insights from studies of PARP or topoisomerase inhibitors provide working models for the investigation of WRN's mechanism of action. We discuss these topics, focusing on the implications of the WRN‐BRCA2 genetic interaction under conditions of replication stress. (shrink)