Classically, an osculating circle at a point of a planar curve is introduced technically, often with formula giving its radius and the coordinates of its center. In this note, we propose a new and intuitive definition of this concept: among all the circles which have, on the considered point, the same tangent as the studied curve and thus seem equal to the curve through a microscope, the osculating circle is this that seems equal to the curve through a (...) class='Hi'>microscope within microscope. (shrink)

Legendre transform between thermodynamic quantities such as the Helmholtz free energy and entropy plays a key role in the formulation of the canonical ensemble. In the standard treatment, the transform exchanges the independent variable from the system’s internal energy to its conjugate variable—the inverse temperature of the heat reservoir. In this article, we formulate a microscopic version of the transform between the free energy and Shannon entropy of the system, where the conjugate variables are the microstate probabilities and the energies (...) (scaled by the inverse temperature). The present approach gives a non-conventional perspective on the connection between information-theoretic measure of entropy and thermodynamic entropy. We focus on the exact differential property of Shannon entropy, utilizing it to derive central relations within the canonical ensemble. Thermodynamics of a system in contact with the heat reservoir is discussed in this framework. Other approaches, in particular, Jaynes’ maximum entropy principle is compared with the present approach. (shrink)

In this commentary, the microscopic animals of the genus Rotifera, or “rotifers,” emerge as a theory-provoking nonhuman animal. Rotifers embody otherness in ways that may intrigue scholars within both Human-Animal Studies and feminist science studies. In their encounter with rotifers, such fields of research might also engage each other in new, unexpected, and fruitful ways, as is here argued.

ArgumentFilm scholars have long posed the question of the specificity of the film medium and the apparatus of cinema, asking what is unique to cinema, how it constrains and enables filmmakers and audiences in particular ways that other media do not. This question has rarely been considered in relation to scientific film, and here it is posed within the specific context of cell biology: What does the use of time-based media such as film coupled with the microscope allow (...) scientists to experience that other visualization practices do not? Examining three episodes in the twentieth-century study of the cell, this article argues that the apparatus of microcinematography constitutes what might be thought of as a technical portal to another world, a door that determines the experience of the world that lies on the other side of it. In this case, the design of apparatuses to capture time-lapsed images enabled the acceleration of cellular time, bringing it into the realm of human perception and experience. Further, the experience of the cellular temporal world was part of a distinct kind of cell biology, one that was focused on behavior rather than structure, focused on the relation between cells, and between the cell and its milieu rather than on cell-intrinsic features such as chromosomes or organelles. As such, the instruments and technical design of the microcinematographic apparatus may be understood as a kind of materialized epistemology, the history of which can elucidate how cinema was and is used to produce scientific knowledge. (shrink)

There is some complementarity of models for the origin of the electroencephalogram (EEG) and neural network models for information storage in brainlike systems. From the EEG models of Freeman, of Nunez, and of the authors' group we argue that the wavelike processes revealed in the EEG exhibit linear and near-equilibrium dynamics at macroscopic scale, despite extremely nonlinear – probably chaotic – dynamics at microscopic scale. Simulations of cortical neuronal interactions at global and microscopic scales are then presented. The simulations depend (...) on anatomical and physiological estimates of synaptic densities, coupling symmetries, synaptic gain, dendritic time constants, and axonal delays. It is shown that the frequency content, wave velocities, frequency/wavenumber spectra and response to cortical activation of the electrocorticogram (ECoG) can be reproduced by a “lumped” simulation treating small cortical areas as single-function units. The corresponding cellular neural network simulation has properties that include those of attractor neural networks proposed by Amit and by Parisi. Within the simulations at both scales, sharp transitions occur between low and high cell firing rates. These transitions may form a basis for neural interactions across scale. To maintain overall cortical dynamics in the normal low firing-rate range, interactions between the cortex and the subcortical systems are required to prevent runaway global excitation. Thus, the interaction of cortex and subcortex via corticostriatal and related pathways may partly regulate global dynamics by a principle analogous to adiabatic control of artificial neural networks. (shrink)

Summary We offer a novel historical-philosophical framework for discussing experimental practice which we call ‘Generating Experimental Knowledge’. It combines three different perspectives: experimental systems, concept formation, and the pivotal role of error. We then present an historical account of the invention of the Scanning Tunnelling Microscope (STM), or Raster-Tunnelmikroskop, and interpret it within the proposed framework. We show that at the outset of the STM project, Binnig and Rohrer—the inventors of the machine—filed two patent disclosures; the first is (...) dated 22 December 1978 (Switzerland), and the second, two years later, 12 September 1980 (US). By studying closely these patent disclosures, the attempts to realize them, and the subsequent development of the machine, we present, within the framework of generating experimental knowledge, a new account of the invention of the STM. While the realization of the STM was still a long way off, the patent disclosures served as blueprints, marking the changes that had to be introduced on the way from the initial idea to its realization. (shrink)

This paper discusses some philosophical and historical connections between, and within, nineteenth century evolutionism and microscopical research. The principal actors are mainly Darwin, Schleiden, Whewell and the “London Doctors,” Arthur Henfrey and Edwin Lankester. I demonstrate that the apparent alliances—particularly Darwin/Schleiden (through evolutionism) and Schleiden/Whewell (through Kantian philosophy of science)—obscure the deep methodological differences between evolutionist and microscopical biology that lingered on until the mid-twentieth century. Through an understanding of the little known significance of Schleiden’s programme of microscopical research (...) and by comparing certain features of his methodology to the activities of the “London Doctors,” we can identify the origin of this state of affairs. In addition, the outcome provides an insight into a critique of Buchdahl’s view on Schleiden’s philosophical conception. (shrink)

Many important concepts of the calculus are difficult to grasp, and they may appear epistemologically unjustified. For example, how does a real function appear in “small” neighborhoods of its points? How does it appear at infinity? Diagrams allow us to overcome the difficulty in constructing representations of mathematical critical situations and objects. For example, they actually reveal the behavior of a real function not “close to” a point (as in the standard limit theory) but “in” the point. We are interested (...) in our research in the diagrams which play an optical role –microscopes and “microscopes within microscopes”, telescopes, windows, a mirror role (to externalize rough mental models), and an unveiling role (to help create new and interesting mathematical concepts, theories, and structures). In this paper we describe some examples of optical diagrams as a particular kind of epistemic mediator able to perform the explanatory abductive task of providing a better understanding of the calculus, through a non-standard model of analysis. We also maintain they can be used in many other different epistemological and cognitive situations. (shrink)

Electron microscopic examination of the non‐granulated cells of the adenohypophysis of several species has evidenced a unity of structure amongst vertebrates. Efforts to correlate structure and function have been made, but they have often been hampered by the scarcity or absence of direct experimental methods for the investigation of their function. Yet often the evidence in favor of a given role has been circumstantial, relying on coincidences between changes in the secretory activity of the gland and changes in the ultrastructure (...) of the non‐granulated cells or in colloid production. At the present time, the prevailing hypothesis is that, in addition to a possible role in mechanical support within the gland, the non‐granulated cells seem to be important with respect to the secretory process of the endocrine cells and/or to the metabolism of the adenohypophysis. (shrink)

Nature's simplest atom and mother of all matter, hydrogen feeds the stars as well as interlaces the molecules of their biological descendants – to whom it ultimately whispers the secrets of quantum reality. Hydrogen’s most prevalent earthly guise lies within the composition of water. A slight electrical disturbance can split water into hydrogen and oxygen gas, resulting in diaphanous bubble clouds slowly rising towards the liquid’s surface. Though the founding fathers of electrochemistry posited that the mass of liberated bubbles (...) is directly proportional to the input voltage, certain modes of electrolysis release more energy than is spent. One such mode involves water’s Janus-faced capacity to react as either an acid or a base. Emanating from an array of electrodes at the bottom of a water-filled chamber, strings and strata of hydrogen bubbles meticulously trace their emergent surroundings. In addition to eddy formations incited by a bubble's rapid growth and subsequent detachment from the electrode surface, acoustic vibrations permeate the two-phase fluid. As the sonic frequency and amplitude rises, the hydrogen bubbles start to coalesce with one another. When the sound field reaches maximum intensity, it can trap bubbles within its antinodes. The vibrations are generated both by transducers and by the bubbles themselves, which emit frequencies ranging from the audible spectrum to as high as 800 kHz. A white laser sheet scans and illuminates the hydrogen bubble trajectories. Each quivering bubble-lens divides the white light into its constituent spectrum of colors. While scanning, the laser sheet also swiftly pulsates and thereby extends the perceivable resolution of micro-momentary bubble dynamics. Before it even begins to map out its vibratory environment, a bubble goes through various stages of spatio-temporal evolution. During the first phase of growth, a bubble nucleus inflates linearly with time. At the second stage, bubble growth is limited by the diffusion of gas within the liquid, causing its size to increase as the square root of time. The final phase before detachment is limited by the kinetics of dissolved gas production, causing the bubble to grow as the cube root of time.1 Beyond macroscopically observable bubbles, an expanse of nanobubbles hides within the water’s internal architecture. Some researchers presume that these nanobubbles of dissolved gas are the carriers of water’s magnetic ‘memory’, enabling electromagnetic fields to saturate its innards for hours and even days after their initial appearance. In the seas and oceans, the lingering presence of electromagnetic fields photonically imparted by sunlight, triggers the electrolysis responsible for most of the Earth’s hydrogen. An essential form of photosynthesis, solar water splitting is the cleanest and most efficient means imaginable for generating and storing energy. —Evelina Domnitch & Dmitry Gelfand *** Animals and plants are formed in earth and in water because there is water in earth, and there is pneuma in water, and there is soul heat in all pneuma ; so that in a way all things are full of soul. Hence plants and animals quickly form once this gets enclosed; and when this enclosing happens, when the corporeal liquids get heated, a sort of frothy bubble is formed. Now the difference between the various creatures which are produced in this way are due to the stuff which makes up the envelope around the soul-source.2 Throwing light into this pneumatic spray of perdurances, which would otherwise swarm below the threshold of human visibility, Evelina Domnitch and Dmitry Gelfand’s Hydrogeny saturates the viewer’s sensorial space with the nano-architectures of froth. Straddling the cell wall between scientific enquiry and artistic praxis, Hydrogeny , beckons a recasting of Lucretius' clinamen in tune with the technologies of the modern observer. For Lucretius it was the indeterminate swerving of an atomistic layer of reality which accounted for the unpredictability of change and the existence of free will. Taken up by Harold Bloom to describe the swerving of cultural production from that which has already been made, the idea has since been textually redressed by Lacan, Derrida, Serres, Deleuze, Nancy, and Badiou. Here we have been given a kaleidoscopic technique for refining and expanding awareness of our enmeshment with so many nested, atomistic layers of object-bubbles—of things—as Aristotle might say,“full of soul.” The gravitational pull of Hydrogeny ushers a de-centered human spectatorship to the ever more intimate recesses of what media philosopher N. Katherine Hayles calls our capacity for “deep attention.”3 Vaporous attention suspended and re-oriented. Microscopic as these diaphanous waves are, the calling they produce is anything but inconsequential. Evelina Domnitch and Dmitry Gelfand are two-thirds of the Amsterdam-based Art–Science Labratory, Optofonica , an atelier initiated by the Italian interdisciplinary artist TeZ in 2006. Follow more of their work at www.portablepalace.com —Isaac Linder NOTES (1) cf. Brandon, Kelsall, Levine, & Smith. “Interfacial Electrical Properties of Electrogenerated Bubbles.” Journal of Applied Electrochemistry 15 (1985):485-493. (2)Aristotle, On the Generation of Animals, 762a18, tr. A. L. Peck (Cambridge, MA: Loeb Classical Library, 1942). (3)“ My article on hyper and deep attention ,” N. Katherine Hayles, accessed on September 14, 2011. (shrink)

According to classical molecular chemistry, molecules have a structure, that is, they are sets of atoms with a definite arrangements in space and held together by chemical bonds. The concept of molecular structure is central to modern chemical thought given its impressive predictive power. It is also a very useful concept in chemistry education, due to its role in the rationalization and visualization of microscopic phenomena. However, such a concept seems to find no place in the ontology described by quantum (...) mechanics, since it appeals to classical notions such as the position of the atomic nuclei or the individuality of electrons. Although this problem has attracted the attention of several authors, the discussion is far from settled. Some authors adopt an explicitly reductionist position and advocate to reconstruct the concept of molecular structure within the framework of the quantum theory. Others, although acknowledging the conceptual discontinuity between quantum mechanics and molecular chemistry, keep the hope of future reduction alive. From an explicitly non-reductionist position, on the contrary, others authors conceive molecular structure as an emergent phenomenon. The purpose of this article is to propose a different line of argumentation to address this problem. By contrast to reduction and emergence, the admission of a multiplicity of ontologies, not necessarily linked by hierarchical connections, cancels the need of finding a relation of dependence between the molecular level and the quantum level. This ontologically pluralist position can be applied to the issue of molecular structure, in order to argue that it is possible to admit the existence of structure in the ontology of molecular chemistry, in spite of the fact that it does not exist in the quantum world. (shrink)

The nature of physical measurements performed on microscopic systems is discussed, and it is suggested that the procedures which are conventionally referred to as “measurements” fall into at least three different categories. The connection between observation processes and irreversible processes is stressed. The customary quantum mechanical treatment of irreversible processes is discussed, and its deficiencies from the philosophical point of view are criticized. The standpoint that quantum mechanics should not be considered as a basic philosophical system but rather as an (...) immensely useful “tool” is defended. Some attempts at developing a more “basic” theory are discussed, and a hypothesis is put forward concerning the role of entropy within some possible future nonlocal hidden-variable theory. (shrink)

The Received View of particles in quantum mechanics is that they are indistinguishable entities within their kinds and that, as a consequence, they are not individuals in the metaphysical sense and self-identity does not meaningfully apply to them. Nevertheless cardinality does apply, in that one can have n> 1 such particles. A number of authors have recently argued that this cluster of claims is internally contradictory: roughly, that having more than one such particle requires that the concepts of distinctness (...) and identity must apply after all. A common thread here is that the notion of identity is too fundamental to forego in any metaphysical account. I argue that this argument fails. I then argue that the failure of individuality and identity applies also to macroscopic physical objects, that the problems cannot be constrained to apply only within the microscopic realm. (shrink)

The standard argument for the Lorentz invariance of the thermodynamic entropy in equilibrium is based on the assumption that it is possible to perform an adiabatic transformation whose only outcome is to accelerate a macroscopic body, keeping its rest mass unchanged. The validity of this assumption constitutes the very foundation of relativistic thermodynamics and needs to be tested in greater detail. We show that, indeed, such a transformation is always possible, at least in principle. The only two assumptions invoked in (...) the proof are that there is at least one inertial reference frame in which the second law of thermodynamics is valid and that the microscopic theory describing the internal dynamics of the body is a field theory, with Lorentz invariant Lagrangian density. The proof makes no reference to the connection between entropy and probabilities and is valid both within classical and quantum physics. To avoid any risk of circular reasoning, we do not postulate that the laws of thermodynamics are the same in every reference frame, but we obtain this fact as a direct consequence of the Lorentz invariance of the entropy. (shrink)

The effects of the vacuum electromagnetic fluctuations and the radiation reaction fields on the time development of a simple microscopic system are identified using a new mathematical method. This is done by studying a charged mechanical oscillator (frequency Ω 0)within the realm of stochastic electrodynamics, where the vacuum plays the role of an energy reservoir. According to our approach, which may be regarded as a simple mathematical exercise, we show how the oscillator Liouville equation is transformed into a Schrödinger-like (...) stochastic equation with a free parameter h′ with dimensions of action. The role of the physical Planck's constant h is introduced only through the zero-point vacuum electromagnetic fields. The perturbative and the exact solutions of the stochastic Schrödinger-like equation are presented for h′>0. The exact solutions for which h′within the realm of quantum electrodynamics is also presented. We suggest some other applications of the classical non-Heisenberg states introduced in this paper and we also indicate experiments which might give concrete evidence of these states. (shrink)

What does it mean to be an individual and how can an individual exist within society? Serious Leisure and Individuality examines the circumstances in the modern world that make for individual distinctiveness, and the role of these conditions in personal and social life. "The individual," said Friedrich Nietzsche, "has always had to struggle to keep from being overwhelmed by the tribe. If you try it, you will be lonely often, and sometimes frightened. But no price is too high to (...) pay for the privilege of owning yourself." Elie Cohen-Gewerc and Robert Stebbins explore the road to finding that privilege. They approach individuality by examining its relationship to freedom and being free, and by defining and elaborating on the concept of leisure space. They also look at individuality's place in community, citizenship, and globalization. The complex relationship between individuality and alienation is put under the microscope to highlight the negative side of being distinctive, which has adverse consequences for the individual and society. There are many studies on the modern individual that centre almost entirely on the person facing his local community and broader society. What is missing in the literature - and what Serious Leisure and Individuality provides - is a broad, comprehensive examination of individuality, particularly as it is rooted in leisure and the leisure-like areas of work. (shrink)

DNA–protein interactions are fundamental to many biological processes, including the regulation of gene expression. Determining the binding affinities of transcription factors (TFs) to different DNA sequences allows the quantitative modeling of transcriptional regulatory networks and has been a significant technical challenge in molecular biology for many years. A recent paper by Maerkl and Quake1 demonstrated the use of microfluidic technology for the analysis of DNA–protein interactions. An array of short DNA sequences was spotted onto a glass slide, which was then (...) covered with a microfluidic device allowing each spot to be within a chamber into which the flow of materials was controlled by valves. By trapping the DNA–protein complexes on the surface and measuring their concentrations microscopically, they could determine the binding affinity to a large number of DNA sequences that were varied systematically. They studied four TFs from the basic helix–loop–helix family of proteins, all of which bind to E‐box sites with the consensus CAnnTG (where “n” can be any base), and showed that variations in affinity for different sites allows each TF to regulate different genes. BioEssays 29:717–721, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

It is shown how to identify potential signatures of noncommutative geometry within the decay spectrum of a muon in orbit near the event horizon of a microscopic Schwarzschild black hole. This possibility follows from a re-interpretation of Moffat’s nonsymmetric theory of gravity, first published in Phys. Rev. D 19:3554, 1979, where the antisymmetric part of the metric tensor manifests the hypothesized noncommutative geometric structure throughout the manifold. It is further shown that for a given sign convention, the predicted signatures (...) counteract the effects of curvature-induced muon stabilization predicted by Singh and Mobed in Phys. Rev. D 79:024026, 2009. While it is unclear whether evidence for noncommutative geometry may become observable anytime soon, this approach at least provides a useful direction for future quantum gravity research based on the ideas presented here. (shrink)

Extending the approach to a ‘theology of science’ developed in Faith and Wisdom in Science, I expand its theme of the tension between chaos and emergent order, within the arc of the Biblical story of creation, towards a theology of evolutionary science. In addition to the material in Job, the book of Wisdom provides a remarkable account of transmutation of species, within a recapitulation of the Exodus theme, that I juxtapose with a modern genotype-phenotype theory of evolutionary dynamics, (...) exploiting analogies with statistical mechanics. The dual and connected structures of microscopic and macroscopic provide a locus for the Joban tensions of chaos and emergent order, and provide an interpretative narrative for the emergent directionality of evolution, and a theology that situates within a creation of freedom to explore the potential of the created order. (shrink)

Have humans always had the desire to inhabit other worlds? From the microscopic scale to the vastness of outer space, it seems our capacity for occupying uninhabitable spaces with our intellect, our bodies, our sensorium, our desire, is fundamental to our being. What are these spaces and how do we come to ‘know’ them? Whether mythological, religious or scientific, these minute or vast worlds are spaces that we unfold, narrate and dwell in. In his short story ‘The Stone Sky’ the (...) novelist Italo Calvino writes of the inhabitants who live in a world that exists beneath the earth’s crust. These inhabitants who occupy the underworld exist in a mutable form that allows them to travel through the dense, dark inner landscape of the earth, through the crystal structures, the nickel sea to the earth’s core, an intricate viscous landscape quite other than the formation of matter on the earth’s surface. Calvino’s narration tells us of what is it to inhabit the interstices of the underworld, to be in a space with little intervening air, to live within the deep time scale of crystal formation. The neuroscientist Christof Koch states that ‘we live in a universe where organised bits of matter give rise to consciousness’ and that we need to extend our understanding of what consciousness really is. Could it be that these other worlds, whether planets only just glimpsed through early telescopes, or nano-landscapes at the scale of the atom are still integrated with our own fundamental make-up? Are they the product of a vastly developed pre-frontal cortex or are they a result of ideas, knowledge and experiences accumulated over billions of years? In this article I will look at the concepts of matter as a carrier of consciousness and of panpsychism as a tool with which to understand our habitation of other worlds. (shrink)

It is beyond the scope of this paper to describe in detail the rise to popularity of the emboîtement theories during the last decades of the seventeenth century.51 Eventually the theories did gain great influence, but some points emerging from the above discussion indicate that the rise to popularity was not, perhaps, quite as rapid as has sometimes been assumed.52 Although the earlier preformation theories were sometimes regarded as the ancestors of the later ideas,53 there was little intellectual continuity between (...) the two movements, based as they were upon such divergent motivations. Nor can the preformation theories be regarded as the origin of the belief that a miniature can actually be seen within the egg, since the existence of metamorphosis as a perfectly valid alternative to epigenesis meant that the work of Malpighi and others, usually described as “preformationist,” was not always taken in this latter sense at the time it was published. The pre-existence theories developed in response to particular philosophical problems, and were themselves responsible for the reinterpretation of the observations. In France, the thoughts of Malebranche and Perrault were probably already exerting influence before their written support for pre-existence appeared, but elsewhere the idea was not taken up so rapidly, and ovism, for instance, could develop without associating itself with emboîtement. Malpighi always seems to have remained opposed to pre-existence,54 but by the last decade of the century, the idea had become sufficiently powerful to influence Ray and Garden in Britain, and was receiving support from as influential a thinker as Leibniz.55 But Garden and Hartsoeker were responsible for dividing emboîtement between two schools, just as the concept itself was becoming popular. The work of both Malpighi and Leeuwenhoek served as the basis of the animalculist version, illustrating how the microscopic discoveries served as much to disrupt the intellectual development of the emboîtement concept as they did to promote it. *** DIRECT SUPPORT *** A8402051 00002. (shrink)

The human genome is not a uniform structure but, instead, is a mosaic of bands. Some of these bands can be seen by the eye. Stained with Giemsa and viewed under the microscope each human chromosome has a prototypical pattern of light and dark bands (G and R bands respectively). Other bands are not so easily viewed. The human genome is, for example, a mosaic of isochores, blocks of DNA within which the proportion of the bases G and (...) C at silent sites (introns, third positions in codons, intergene spacer) is fairly uniform. Recent work by Matassi and colleagues(1) has revealed what might be a new and unexpected banding pattern. They have found that the genes which are close together on the chromosome have similar rates of evolution. BioEssays 22:105–107, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

The effects of the vacuum electromagnetic fluctuations and the radiation reaction fields on the time development of a simple microscopic system are identified using a new mathematical method. This is done by studying a charged mechanical oscillator (frequency Ω 0)within the realm of stochastic electrodynamics, where the vacuum plays the role of an energy reservoir. According to our approach, which may be regarded as a simple mathematical exercise, we show how the oscillator Liouville equation is transformed into a Schrödinger-like (...) stochastic equation with a free parameter h′ with dimensions of action. The role of the physical Planck's constant h is introduced only through the zero-point vacuum electromagnetic fields. The perturbative and the exact solutions of the stochastic Schrödinger-like equation are presented for h′>0. The exact solutions for which h′<h are called sub-Heisenberg states. These nonperturbative solutions appear in the form of Gaussian, non-Heisenberg states for which the initial classical uncertainty relation takes the form 〈(δx 2)〉〈(δp) 2 〉=(h′/2) 2,which includes the limit of zero indeterminacy (h → 0). We show how the radiation reaction and the vacuum fields govern the evolution of these non-Heisenberg states in phase space, guaranteeing their decay to the stationary state with average energy hΩ 0 /2 and 〈(δx) 2 〉〈(δp) 2 〉=h 2 /4 at zero temperature. Environmental and thermal effects-are briefly discussed and the connection with similar works within the realm of quantum electrodynamics is also presented. We suggest some other applications of the classical non-Heisenberg states introduced in this paper and we also indicate experiments which might give concrete evidence of these states. (shrink)

Every process studied in any science other than physics defines an arrow of time – to say nothing for the directedness of the processes of causation, inference, memory, control, and counterfactual dependence that occur in everyday life. The discussion in this chapter is confined to the arrow of time as it occurs in physics. The chapter briefly discusses those features of microscopic physics, which seem to conflict with time asymmetry. It explains just how this conflict plays out in the important (...) context of thermodynamics and statistical mechanics. The chapter then reviews the main strategies available for resolving the conflict between reversible microdynamics and irreversible macrodynamics, working within the context of the quantitative, time‐irreversible evolution laws that seem to apply to large‐scale phenomena. Finally, it offers a broad the discussion covering other arrows of time within physics. (shrink)

Although quantum theory is applicable, in principle, to both the microscopic and macroscopic realms, the strategy of practically applying quantum theory by retaining a classical conception of the macroscopic world has had tremendous success. This has nevertheless rendered the task of interpretation daunting. We argue the need for recognizing and solving the ‘observation problem', namely constructing a ‘quantum-compatible’ view of the properties and states of macroscopic objects in everyday thinking to realistically interpret quantum theory consistently at both the microscopic and (...) macroscopic levels. Toward a solution to this problem, we point out a category of properties called ‘relational properties’ that we regularly associate with everyday objects. We see them as being potentially quantum-compatible. Some possible physical implications are discussed. We conclude by touching upon the nexus between the relational property view within quantum physics and some neurobiological issues underlying cognition. (shrink)

This article examines the early modern household's importance for producing experimental knowledge through an examination of the Halifax household of Margery and Henry Power. While Henry Power has been studied as a natural philosopher within the male-dominated intellectual circles of Cambridge and London, the epistemic labour of his wife, Margery Power, has hitherto been overlooked. From the 1650s, this couple worked in tandem to enhance their understanding of the vegetable world through various paper technologies, from books, paper slips and (...) recipe notebooks to Margery's drawing album and Henry's published Experimental Philosophy. Focusing on Margery's practice of hand-colouring flower books, her copied and original drawings of flowers and her experimental production of ink, we argue that Margery's sensibility towards colour was crucial to Henry's microscopic observations of plants. Even if Margery's sophisticated knowledge of plants never left the household, we argue that her contribution was nevertheless crucial to the observation and representation of plants within the community of experimental philosophy. In this way, our article highlights the importance of female artists within the history of scientific observation, the use of books and paperwork in the botanical disciplines, and the relationship between household science and experimental philosophy. (shrink)

In attempting to derive irreversible macroscopic thermodynamics from reversible microscopic dynamics, Boltzmann inadvertently smuggled in a premise that assumed the very irreversibility he was trying to prove: ‘molecular chaos.’ The program of ‘Einselection’ within Everettian approaches faces a similar ‘Loschmidt’s Paradox’: the universe, according to the Everettian picture, is a closed system obeying only unitary dynamics, and it therefore contains no distinguishable environmental subsystems with the necessary ‘phase randomness’ to effect einselection of a pointer observable. The theoretically unjustified assumption (...) of distinguishable environmental subsystems is the hidden premise that makes the derivation of einselection circular. In effect, it presupposes the ‘emergent’ structures from the beginning. Thus the problem of basis ambiguity remains unsolved in Everettian interpretations. (shrink)

Ever since Big Data became a mot du jour across social fields, optical metaphors such as the microscope began to surface in popular discourse to describe and qualify its epistemological impact. While the persistence of optics seems to be at odds with the datafication of vision, this article suggests that the optical metaphor offers an opportunity to reflect about the material consequences of the modes of seeing and knowing that currently shape datafied worlds. Drawing on feminist new materialism, the (...) article investigates the optical metaphor as a material-discursive practice that actively constitutes the world, as metaphors imply modes of thinking, knowing and doing that have material enactions. Expanding visual culture theories, the notion of ‘optical unconscious’ is taken up to discuss the tensions between displacement and persistence of optics within datafied worlds, that is, how optical vision is displaced but also mobilised and repurposed by data-driven knowledge. In dialogue with feminist science and technology studies and speculative ethics, I suggest that the datafication of vision offers a chance to reconceptualize the sense of sight towards a sensorial engagement with Big Data premised on responsibility, care, and an ethics of unknowability. Within this framework, vision may be conceived differently, perhaps not only as enhancement and control, but as generator of new possibilities. Ultimately, the article proposes that the visual theories after which Big Data is being imagined matter not only for our understanding of Big Data's epistemic potential, but also for the possibility of shaping emerging data worlds. (shrink)

This article sets forward a new concept of reflection, to be contrasted with more usual reading of the concept for which we use the term `reflectivity'. The contrast is related to a distinction between normalizing education and counter-education. We claim that within the framework of normalizing education there is no room for reflection, but only for reflectivity. In contrast to reflectivity, reflection manifests a struggle of the subject against the effects of power which govern the constitution of her conceptual (...) apparatus, her knowledge, her consciousness and her limitations and possibilities for successful functioning. Reflectivity re-presents the hegemonic realm of self-evidence and the productive violence of social and cultural order. Reflection, by contrast, aims to challenge the supposedly self-evident and the present order of things. Reflection aims at transcendence and represents a moral commitment in respect of the otherness of the Other, which power relations in every realm of self-evidence oblige us to neglect, to destroy or consume. Transcendence is a concrete utopia, and so is the subject in her nonrepressive communication with the Other: they are part and parcel of our present possibilities, sometimes in microscopic arenas, struggled for, and from time to time even realized. (shrink)

In 1905 two different etiologic agents for syphilis were proposed in Berlin, one, the Cytorrhyctes luis, by John Siegel, the other, Spirochaete pallida, by Fritz Schaudinn. Both scientists were pupils of Franz Eilhard Schulze, and were outsiders to the Berlin medical establishment. Both belonged to the same thought collective, used the same thought style, and started from the same supposition that the etiologic agent of syphilis must be a protist. Both used the same morphological approach, the same microscopes and the (...) same stains. Both presented their findings in the same societies, used the same rhetoric, published in the same journals, used the same arguments to criticise each other's shortcomings. Both were backed by powerful institutions and enlisted the support of prestigious patrons. Within half a year, the scientific community at large had in its overwhelming majority accepted Schaudinn's results and rejected those of Siegel. Social forces thus cannot be shown to have played any role in deciding the issue. Ludwik Fleck's suggestion that 'appropriate influence' and a 'proper measure of publicity throughout the thought collective' would have been sufficient for Siegel's ideas to win the day is untenable. (shrink)

The Tang Dynasty is renowned for its cultural richness and openness to external influences, which significantly impacted the aesthetics of its costume designs, as depicted in contemporary murals. This paper explores the intricate clothing patterns and shapes featured in Tang Dynasty murals, utilizing high-definition microscopic analysis to uncover the profound artistic and symbolic significance embedded within these garments. The study reveals that the clothing patterns are predominantly linear and elongated, with wide cuffs and streamers, while the shapes primarily encompass (...) triangular, rectangular, and oval forms. These elements are executed in a palette of predominantly white, red, blue, and brown, using predominantly lightweight materials like silk, indicative of both aesthetic appeal and functional design. This research delves deeper into the philosophical and religious symbolism of these designs, examining how these ancient motifs influence modern fashion clusters and contribute to contemporary clothing design. The findings suggest that Tang Dynasty apparel exhibits a sophisticated interplay of form and function, enriched with philosophical and religious connotations that resonate with modern design principles. This historical continuity not only deepens the cultural and symbolic dimensions of contemporary fashion but also enhances brand identity and competitive edge in today's global fashion markets. By tracing the lineage of these artistic characteristics from ancient murals to modern clothing collections, this paper highlights the enduring influence of Tang Dynasty aesthetics on modern fashion, suggesting that ancient art forms can provide significant insights into contemporary design practices, especially in the context of enhancing philosophical and religious expressions within the fashion industry. (shrink)

A possible way out of the conundrum of quantum gravity is the proposal that general relativity (GR) emerges from an underlying microscopic description. Despite recent interest in the emergent gravity program within the physics as well as the philosophy community, an assessment of the general motivation for this idea is lacking at the moment. We intend to fill this gap in the literature by discussing the main arguments in favour of the hypothesis that the metric field and its dynamics (...) are emergent. First, we distinguish between microstructure inspired from GR, such as through quantization or discretization, and microstructure that is not directly motivated from GR, such as strings, quantum bits or condensed matter fields. The emergent gravity approach can then be defined as the view that the metric field and its dynamics are derivable from the latter type of microstructure. Subsequently, we assess in how far the following properties of (semi-classical) GR are suggestive of underlying microstructure: (1) the metric's universal coupling to matter fields, (2) perturbative non-renormalizability, (3) black hole thermodynamics, and (4) the holographic principle. In the conclusion we formalize the general structure of the plausibility arguments put forward. (shrink)

The evolution of microstructure upon partial crystallization and its influence on the mechanical properties such as hardness, elastic modulus and viscosity in a La 55 Al 25 Cu 10 Ni 5 Co 5 bulk metallic glass alloy are studied. Specimens with various volume fractions of crystalline phases were obtained by annealing the as-cast amorphous alloy above its glass transition temperature and were characterized by transmission electron microscopy. Microscopic examination of the heat-treated samples shows short-range-ordered domains prior to nanocrystallization within (...) the amorphous matrix, followed by the growth and impingement of the crystallites. Whereas the hardness of the annealed samples increases linearly with increasing crystallinity, the elastic modulus and the viscosity both increase abruptly when the crystalline volume fraction is about 40 vol.%, with a only minor variation on either side of this range. The sudden rises in the modulus and viscosity are similar to those in the literature data on the fracture strength of partially crystallized bulk amorphous alloys that shows a steep drop in strength at 30-50 vol.% crystallinity. On the basis of the microscopic observations, it is suggested that the interaction and formation of rigid networks of crystalline phases upon the attainment of a critical second-phase volume fraction may be the possible reason for the sudden change in mechanical properties. Percolation theory is utilized in further substantiating this hypothesis. (shrink)

Mammalian neural cells contain at least two forms of brain spectrin: brain spectrin (240/235) which is located primarily in the axons and presynaptic terminals of neurons, and brain spectrin (240/235E) which is found in the cell bodies, dendrites and postsynaptic terminals of neurones. Brain spectrin (240/235E) is also found in certain glial cell types. Antibodies against red blood cell spectrin detect only brain spectrin (240/235E), while antibodies against brain spectrin isolated from axonal and synaptic membranes detect brain spectrin (240/235). Previous (...) apparent discrepancies in the literature concerning brain spectrin localization at the light microscope level were undoubtedly due to different laboratories detecting distinct brain spectrin subtypes, based on the particular antibody being utilized for immunohistochemistry. In this review we (1) discuss the data supporting the presence of at least two distinct subtypes of mammalian brain spectrin, (2) explain how these results reconcile previous discrepancies concerning the localization of spectrin within neural cells, and (3) suggest the future implications of these findings. (shrink)

Had more philosophers of science come from chemistry, their thinking would have been different. I begin by looking at a typical chemical paper, in which making something is the leitmotif, and conjecture/refutation is pretty much irrelevant. What in fact might have been, might be, different? The realism of chemists is reinforced by their remarkable ability to transform matter; they buy into reductionism where it serves them, but make no real use of it. Incommensurability is taken without a blink, and actually (...) serves. The preeminence of synthesis in chemistry could have led philosophers of science to take more seriously questions of aesthetics within science, and to find a place in aesthetics for utility. The necessary motion twixt macroscopic and microscopic views of matter in modern chemistry leads to the coexistence of symbolic and iconic representations. And in another way to the deliberate, creative violation of categories. (shrink)

That endogenous retrovirus (ERV) is present within the placenta of humans and other mammals has been known for the past 25 years, but the significance of this observation is still not fully understood. Much molecular biological data have emerged in recent years to support the earlier electron microscopic data on the presence of placental ERV. The evidence for ERV in animal and human placental tissue is presented, then integrated with data on the the presence of ERV in a range (...) of other tissues, in particular teratocarcinoma cells. Placental invasiveness and maternal immunosuppression are then discussed in relation to metalloproteinase secretion, the immunosuppressive potential of retroviruses, and placental growth factors, while the evidence for a functional link between placental proto‐oncogenes and trophoblast malignancy is reviewed. Finally, placental development, structure, and life span are discussed within an evolutionary context. The hypothesis that one or more ancient trophoblastic ERVs could have played a role in the evolution and divergence of all placental mammals is evaluated. BioEssays 20:307‐316, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Ecological innovation is an inevitable trend for firms to enhance competitiveness and sustainably operate in the context of green economy. The previous literature has rarely discussed the influence of ambidextrous learning on the eco-innovation performance of startups and ignored the moderating effect of top management’s environmental awareness from the perspective of microscopic psychology. We have conducted a questionnaire survey on 212 firms established within 4 years in the Pearl River Delta of China, using the structure mode and the PROCESS (...) by Hayes (2013) to analyze the influence of ambidextrous learning, such as exploratory learning and exploitative learning, by startups on eco-innovation performance and verify the moderating effect of top management’s environmental awareness. The results show that: exploratory learning and exploitative learning have a positive and significant influence on eco-innovation performance, indicating that the organizational learning of startups is conducive to improving eco-innovation performance; under the moderating effect of top management’s environmental awareness, the influence of exploratory learning and exploitative learning on eco-innovation performance may differ. The results also show that in the process of organizing ambidextrous learning, startups should help raise the environmental awareness of top management to improve the eco-innovation performance, thus providing guidance for startups to carry out eco-innovation activities and for local governments to make decisions on green economy. (shrink)

This paper argues that humans possess unique cognitive abilities due to the presence of a functional system that exists in the human brain that is absent in the non-human brain. This system, the frontal feedback system, was born in the hominin brain when the great phylogenetic expansion of the prefrontal cortex relative to posterior sensory regions surpassed a critical threshold. Surpassing that threshold effectively reversed the preferred direction of information flow in the highest association regions of the neocortex, producing the (...) frontal feedback system. This reversal was from the caudo-rostral bias characteristic of non-human, or pre-human, brain dynamics to a rostro-caudal bias characteristic of modern human brain dynamics. The frontal feedback system works through frontal motor routines, or action schemes, manipulating the release and reconstruction of stored sensory memories in posterior sensory areas. As an obligatory feature of frontal feedback, a central character, or self, emerges within this cortical network that manifests itself as agent in these reconstructions as well as in the experience of sensory perceptions. Dynamical-systems modeling of cortical interactions is combined in the paper with recent neuroimaging studies of “resting-state” brain activity to bridge the gap between microscopic and macroscopic levels of cortical behavior. This synthesis is used to support the proposal of an information flow reversal occurring in the hominin brain and also to explain how such a reversal generates the wide variety of cognitive and experiential phenomena that many consider to be uniquely human. (shrink)

A new ensemble interpretation of quantum mechanics is proposed according to which the ensemble associated to a quantum state really exists: it is the ensemble of all the systems in the same quantum state in the universe. Individual systems within the ensemble have microscopic states, described by beables. The probabilities of quantum theory turn out to be just ordinary relative frequencies probabilities in these ensembles. Laws for the evolution of the beables of individual systems are given such that their (...) ensemble relative frequencies evolve in a way that reproduces the predictions of quantum mechanics.These laws are highly non-local and involve a new kind of interaction between the members of an ensemble that define a quantum state. These include a stochastic process by which individual systems copy the beables of other systems in the ensembles of which they are a member. The probabilities for these copy processes do not depend on where the systems are in space, but do depend on the distribution of beables in the ensemble.Macroscopic systems then are distinguished by being large and complex enough that they have no copies in the universe. They then cannot evolve by the copy law, and hence do not evolve stochastically according to quantum dynamics. This implies novel departures from quantum mechanics for systems in quantum states that can be expected to have few copies in the universe. At the same time, we are able to argue that the center of masses of large macroscopic systems do satisfy Newton’s laws. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Comme Elle Respire:Memory of Breath, Breath of MemoryFrédérique Berthet (bio)Translated by David F. Bell (bio)La poésie est un système de respiration, c'est fait pour mieux respirer.[Poetry is a respiration system, it's made for breathing better.]—Erri De Luca- Stop!- What?- I can hear you breathing!...- Stop!- Breathing?- Yes!—Paul Thomas AndersonLittle paper-fish cutouts have been placed on the ground, on the carpet.We're in the reassuring '70s stylishness of a doctor's office. (...) The carpet is soft and glistens like in interior decoration magazines, it's with it, in. We couldn't care less about what Dyson vacuum cleaners and "purifiers" boast they can eliminate several decades later: acarids, those microscopic domestic arthropods, human parasites (notably), and airborne vectors of infectious disease (colds, coughs, respiratory distress). No, in the spring of 1975, innocently and self-satisfyingly, the urbane doctor flaunts the opulent carpet with curly pile in his luxury apartment with its state-of-the-art waiting room.In this grand interior of a medical office, a man in a white coat plies his important trade. For example, that day a little girl is re-learning how to breathe. One might think that exhaling and inhaling is learned for life—je t'aime comme je respire, elle parle comme elle respire, il ment comme il respire1—from the very first cry at birth. But in fact, sometimes in life breathing gets stuck between the nasal cavity and the bronchial tubes, between the respiratory tract and the lungs. Progressively, imperceptibly, the organism is short of air, a malicious infection spreads and impairs [End Page 92] alveolar diffusion to the point of respiratory exhaustion: Is it serious, doctor? We must act quickly, very quickly. How to liquify what stopped up the system one day to the point of blocking it—the doctors know what to do.This doctor undertook long, arduous and learned studies. He knows functionally how a living being breathes, how a child lives organically. He can also re-teach the little girl what she no longer knows how to do: inhale, exhale using the full volume of the thoracic cage, regulating the ventilatory flow, solidifying the invisible membranes. In the child's family, everyone knows (and knows how to do) important things, but no one undertook extensive studies, much less studies of the aerial exchanges in the human body. This special knowledge possessed by the doctor (unless special means something else unspoken that would explain why this specific doctor was chosen rather than any other) surrounds him with a padding of respect that creates (and the little girl feels this) a sort of protective continuum between him and the walls within which he sees her, where he practices his kind of calm and slow urbane medicine. It's far from the formidable hospital she has just left, with its spherical apparatus next to the bed aspirating the red and yellow pleural liquid, the "treatment room" where the surgeon, the "butcher" as the nurses call him among themselves, manipulated the drain without anesthesia, with no regard for the child's suffering. The doctor, and his place in the elevated tower, even though they are not to be confused, make for a cozy reception space in which one is comfortable, even in passing.This doctor—who is, in truth, a massage-physiotherapist—is located in a designer high-rise building with a façade decorated by white, pointed features that manifest a will toward an architectural act. On the ground floor, the entrance hall is finished in dark-veined, clear brown marble, and the entry threshold between the exterior and interior is marked by large transparent glass panes that must be manipulated with care. The entrance hall has an intimidating sonority and a useless cold nudity from which one escapes in an elevator where one is surrounded by mirrors and gold buttons and in which one speeds upward silently toward floors, clouds.The designer high-rise is located at the outskirts, the outskirts of a city of recent Olympic stature, where several years earlier Olympic athletes were welcomed and trained to increase their respiratory capacity and... (shrink)

In this chapter, we will take a trip around several hot-spots where Bohmian mechanics and its capacity to describe the microscopic reality, even in the absence of measurements, can be harnessed as computational tools, in order to help in the prediction of phenomenologically accessible information (also useful for the followers of the Copenhagen theory). As a first example, we will see how a Stochastic Schrödinger Equation, when used to compute the reduced density matrix of a non-Markovian open quantum system, necessarily (...) seems to employ the Bohmian concept of a conditional wavefunction. We will see that by dressing these conditional wavefunctions with an interpretation, the Bohmian theory can prove to be a useful tool to build general quantum simulation frameworks, such as a high-frequency electron transport model. As a second example, we will explain how a Copenhagen “observable operator” can be related to numerical properties of the Bohmian trajectories, which within Bohmian mechanics, are well-defined even for an “unmeasured” system. Most importantly in practice, even if these numbers are given no ontological meaning, not only we will be able to simulate (thus, predict and talk about) them, but we will see that they can be operationally determined in a weak value experiment. Therefore, they will be practical numbers to characterize a quantum system irrespective of the followed quantum theory. (shrink)

This paper analyzes the investigation of the distribution of the protein tenascin-C in canine mammary tumors. The method involved immunohistochemistry of tissue slices, performed by the application of an antibody to tenascin-C that specifically can be made visible for microscopic inspection. The first phase of the project is the making of the protocol, the second the deduction of a pattern of tenascin-C distribution in tumors and the third the writing of a paper. Each of the phases is analyzed separately, using (...) the concept of resistance and accommodation. My purpose is to show that in each phase of the process of producing knowledge, the scientist meets resistances which force him to accommodate by changing his conceptual, technical and methodological approaches. In reverse, the details of the non-human agent have to be accommodated to the wishes and expectations of the scientist. Through this interaction a situation of stability of knowledge is reached at the end of each phase.In the protocol phase, resistance is found in the antibody and tissue slices. In the phase of pattern deduction the resistance is in the pathological diagnosis of the tumors and the expectations and hypothesis with which the scientist had entered the project; in the criteria to be used for assigning the slices to a tenascin-C pattern; and in the responses of colleagues and supervisor. In the paper-writing phase the interaction is between the scientist and the scientific community which should take on board the knowledge from the research project.When stabilization of knowledge is obtained in one of the phases, the agents of resistance turn into allies in the next phase, giving support to accommodating the resistances in this later phase. Second, the stabilization of knowledge of the protocol is further enhanced when stabilization of the pattern is achieved; in addition, knowledge of the pattern is more definite when it has become stabilized and closed knowledge within the science community. (shrink)

Arguments pertaining to the mind-brain connection and to the physical effectiveness of our conscious choices have been presented in two recent books, one by John Searle, the other by Jaegwon Kim. These arguments are examined, and it is explained how the encountered difficulties arise from a defective understanding and application of a pertinent part of contemporary science, namely quantum mechanics. The principled quantum uncertainties entering at the microscopic levels of brain processing cannot be confined to the micro level, but percolate (...) up to the macroscopic regime. To cope with the conflict between the resulting macroscopic indefiniteness and the definiteness of our conscious experiences, orthodox quantum mechanics introduces the idea of agent-generated probing actions, each of which specifies a definite set of alternative possible empirically/experientially distinguishable outcomes. Quantum theory then introduces the mathematical concept of randomness to describe the probabilities of the various alternative possible outcomes of the chosen probing action. But the agent-generated choice of which probing action to perform is not governed by any known law or rule, statistical or otherwise. This causal gap provides a logical opening, and indeed a logical need, for the entry into the dynamical structure of nature of a process that goes beyond the currently understood quantum mechanical statistical generalization of the deterministic laws of classical physics. The well-known quantum Zeno effect can then be exploited to provide a natural process that establishes a causal psychophysical link within the complex structure consisting of a stream of conscious experiences and certain macroscopic classical features of a quantum mechanically described brain. This naturally created causal link effectively allows consciously felt intentions to affect brain activity in a way that tends to produce the intended feedback. This quantum mechanism provides an eminently satisfactory alternative to the classical physics conclusion that the physical present is 1 completely determined by the physical past, and hence provides a physicsbased way out of the dilemma that Searle and Kim tried to resolve by philosophical analysis.. (shrink)

Interdisciplinarity has been a key term in the ecological debate ever since its advent in the early 1960s. The paper addresses these historical links and how the two terms ‘interdisciplinary’ and ‘ecology’ have influenced each other. The later concept ‘sustainable development’ is also truly interdisciplinary, including physical, biological, socio-economic and cultural, as well as normative, mechanisms, contexts and effects operating at scales ranging from the microscopic to the macroscopic. Policies to promote sustainable development need to be based on the type (...) of interdisciplinary thinking that has been advocated for several decades within the ecological debate. This applies not least to research into the sustainability aspects of urban development, the case discussed in this paper. Despite longstanding requests for interdisciplinarity, the development within the academic world has proceeded in the opposite direction. Many of the most influential metatheoretical perspectives virtually prohibit, or at best strongly discourage, the inclusion of insights about certain parts of reality. Here, critical realism could play a very important role as an underlabourer of interdisciplinarity. (shrink)

The success of a few theories in statistical thermodynamics can be correlated with their selectivity to reality. These are the theories of Boltzmann, Gibbs, end Einstein. The starting point is Carnot’s theory, which defines implicitly the general selection of reality relevant to thermodynamics. The three other theories share this selection, but specify it further in detail. Each of them separates a few main aspects within the scope of the implicit thermodynamic reality. Their success grounds on that selection. Those aspects (...) can be represented by corresponding oppositions. These are: macroscopic – microscopic; elements – states; relational – non-relational; and observable – theoretical. They can be interpreted as axes of independent qualities constituting a common qualitative reference frame shared by those theories. Each of them can be situated in this reference frame occupying a different place. This reference frame can be interpreted as an additional selection of reality within Carnot’s initial selection describable as macroscopic and both observable and theoretical. The deduced reference frame refers implicitly to many scientific theories independent of their subject therefore defining a general and common space or subspace for scientific theories (not for all). The immediate conclusion is: The examples of a few statistical thermodynamic theories demonstrate that the concept of “reality” is changed or generalized, or even exemplified (i.e. “de-generalized”) from a theory to another. Still a few more general suggestions referring the scientific realism debate can be added: One can admit that reality in scientific theories is some partially shared common qualitative space or subspace describable by relevant oppositions and rather independent of their subject quite different in general. Many or maybe all theories can be situated in that space of reality, which should develop adding new dimensions in it for still newer and newer theories. Its division of independent subspaces can represent the many-realities conception. The subject of a theory determines some relevant subspace of reality. This represents a selection within reality, relevant to the theory in question. The success of that theory correlates essentially with the selection within reality, relevant to its subject. (shrink)

Leeuwenhoek's observations relating to animal population, though scattered through many letters written during a period of over forty years, when seen in toto, were important contributions to the subject now known as animal demography. He maintained enough contact with other scientists to have received encouragement and some helpful suggestions, but the language barrier and the novelty of doing microscopic work forced him to be resourceful, inventive, and original. His multifarious investigations impinged upon population biology before he discovered a direct interest (...) in it. He devised methods for estimating numbers of animalcules, and then he went on to estimate the population of the world. His interest in reproduction was an important avenue by which he approached the subject of reproductive capacity. Other important approaches were his studies of growth, longevity, and life histories. He discovered relationships between aspects of the life history, longevity, and reproductive capacity of several species of insects, notably calanders, scavenger flies, crane flies, aphids, and lice. An important feature of these investigations were the arithmetical calculations which he made of reproductive potentials. In spite of several limitations, these calculations were an important innovation to the study of animal population. In his later years, his investigations came more and more within the sphere of ecology. He made the first significant observations on food chains. It is especially interesting that fish were the subject of these observations, because it was not until the latter half of the nineteenth century that scientists realized that fish ultimately depend upon phytoplankton.These accomplishments did not pass unnoticed. Although Leeuwenhoek never synthesized his scattered observations concerning population, his originality and perception were appreciated by outstanding biologists of the eighteenth century. The important discussions of population biology by Réaumur, Buffon, and Bonnet all derived inspiration and assistance from the writings of Leeuwenhoek.73 This ingenious Fellow of the Royal Society, “by detecting through diligent application and scrutiny the mysteries of Nature and the secrets of natural philosophy,”74 became one of the founders of animal demography. (shrink)

Development-oriented funding schemes such as the UK Global Challenges Research Fund (GCRF) have opened up opportunities for collaborations between low-middle income countries (LMICs) and high-income country (HIC) researchers. In particular, funding for medical technology research has seen a rise in previously under-represented disciplines such as physics and engineering. These collaborations have considerable potential to advance healthcare in LMICs, yet can pose challenges experienced to researchers undertaking these collaborations. Key challenges include a lack of tradition of HIC/LMIC collaborations within participating (...) departments, lack of experience with development agendas, designing contextually-appropriate technologies and ensuring long-term viability of research outputs. This paper reflects on these key challenges, using the experiences of the authors on the Open Laboratory Instrumentation (OLI) project as a focalizing lens. This project was a GCRF-funded collaboration between physicists in the UK and engineers in Tanzania to develop an open-source, 3D-printed, fully-automated laboratory microscope. The paper highlights key ethics lessons learnt. (shrink)

Perception is a first-person internal sensation induced within the nervous system at the time of arrival of sensory stimuli from objects in the environment. Lack of access to the first-person properties has limited viewing perception as an emergent property and it is currently being studied using third-person observed findings from various levels. One feasible approach to understand its mechanism is to build a hypothesis for the specific conditions and required circuit features of the nodal points where the mechanistic operation (...) of perception take place for one type of sensation in one species and to verify it for the presence of comparable circuit properties for perceiving a different sensation in a different species. The present work explains visual perception in mammalian nervous system from a first-person frame of reference and provides explanations for the homogeneity of perception of visual stimuli above flicker fusion frequency, the perception of objects at locations different from their actual position, the smooth pursuit and saccadic eye movements, the perception of object borders, and perception of pressure phosphenes. Using results from temporal resolution studies and the known details of visual cortical circuitry, explanations are provided for (a) the perception of rapidly changing visual stimuli, (b) how the perception of objects occurs in the correct orientation even though, according to the third-person view, activity from the visual stimulus reaches the cortices in an inverted manner and (c) the functional significance of well-conserved columnar organization of the visual cortex. A comparable circuitry detected in a different nervous system in a remote species-the olfactory circuitry of the fruit fly Drosophila melanogaster-provides an opportunity to explore circuit functions using genetic manipulations, which, along with high-resolution microscopic techniques and lipid membrane interaction studies, will be able to verify the structure-function details of the presented mechanism of perception. (shrink)

The hydrodynamical formalism for the quantum theory of a nonrelativistic particle is considered, together with a reformulation of it which makes use of the methods of kinetic theory and is based on the existence of the Wigner phase-space distribution. It is argued that this reformulation provides strong evidence in favor of the statistical interpretation of quantum mechanics, and it is suggested that this latter could be better understood as an almost classical statistical theory. Moreover, it is shown how, within (...) this context, the Wigner and the Margenau-Hill functions are not equivalent, and that the latter is essentially unsatisfactory, as well as the associated symmetrization rule. Arguments in favor of a stochastic picture of the phenomena at the microscopic level are also presented. (shrink)

The presence of asymmetry in the human cerebral hemispheres is detectable at both the macroscopic and microscopic scales. The horizontal expansion of cortical surface during development (within individual brains), and across evolutionary time (between species), is largely due to the proliferation and spacing of the microscopic vertical columns of cells that form the cortex. In the asymmetric planum temporale (PT), minicolumn width asymmetry is associated with surface area asymmetry. Although the human minicolumn asymmetry is not large, it is estimated (...) to account for a surface area asymmetry of approximately 9% of the region’s size. Critically, this asymmetry of minicolumns is absent in the equivalent areas of the brains of other apes. The left-hemisphere dominance for processing speech is thought to depend, partly, on a bias for higher resolution processing across widely spaced minicolumns with less overlapping dendritic fields, whereas dense minicolumn spacing in the right hemisphere is associated with more overlapping, lower resolution, holistic processing. This concept refines the simple notion that a larger brain area is associated with dominance for a function and offers an alternative explanation associated with “processing type.” This account is mechanistic in the sense that it offers a mechanism whereby asymmetrical components of structure are related to specific functional biases yielding testable predictions, rather than the generalization that “bigger is better” for any given function. Face processing provides a test case – it is the opposite of language, being dominant in the right hemisphere. Consistent with the bias for holistic, configural processing of faces, the minicolumns in the right-hemisphere fusiform gyrus are thinner than in the left hemisphere, which is associated with featural processing. Again, this asymmetry is not found in chimpanzees. The difference between hemispheres may also be seen in terms of processing speed, facilitated by asymmetric myelination of white matter tracts ( Anderson et al., 1999 found that axons of the left posterior superior temporal lobe were more thickly myelinated). By cross-referencing the differences between the active fields of the two hemispheres, via tracts such as the corpus callosum, the relationship of local features to global features may be encoded. The emergent hierarchy of features within features is a recursive structure that may functionally contribute to generativity – the ability to perceive and express layers of structure and their relations to each other. The inference is that recursive generativity, an essential component of language, reflects an interaction between processing biases that may be traceable in the microstructure of the cerebral cortex. Minicolumn organization in the PT and the prefrontal cortex has been found to correlate with cognitive scores in humans. Altered minicolumn organization is also observed in neuropsychiatric disorders including autism and schizophrenia. Indeed, altered interhemispheric connections correlated with minicolumn asymmetry in schizophrenia may relate to language-processing anomalies that occur in the disorder. Schizophrenia is associated with over-interpretation of word meaning at the semantic level and over-interpretation of relevance at the level of pragmatic competence, whereas autism is associated with overly literal interpretation of word meaning and under-interpretation of social relevance at the pragmatic level. Both appear to emerge from a disruption of the ability to interpret layers of meaning and their relations to each other. This may be a consequence of disequilibrium in the processing of local and global features related to disorganization of minicolumnar units of processing. (shrink)