Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

All states of human life are limited by time. Human personality, but also interpersonal justice therefore have a temporal dimension. Is time thus a source of normativity: a factor that every ethic must take into account? Does it make any demands on the design of our personal way of life? And must norms and rules that aim to bring about, maintain, change or end certain states of human life always have to take into account the passage of time? In this (...) book, seventeen philosophers discuss the significance of the temporal dimension of human personality and interpersonal justice for ethics and law. It becomes clear that hardly any problem applied ethics face today does not refer to the normative meaning of the temporality of our existence and the passing of time. With contributions by Dieter Birnbacher, Frank Dietrich, Michael Grossheim, Martin Hoffmann, Jan C. Joerden, Sebastian Knell, Andrea Klonschinski, Walter Mesch, Lukas H. Meyer, Andreas Mueller, Johannes Mueller Salo, Michael Quante, Michael Schefczyk, Reinold Schmücker , Niko Strobach, Timothy Waligore, Ulla Wessels. (shrink)

„On 23rd February 2022, when the editors had worked out topical issues of dispute relating to politics, ethics, technology and religion for a Hans Jonas Centre conference on responsibility for the future and discourse ethics, it was suddenly foreseeable that Russia would invade the core area of Ukraine the next night. We immediately informed our Ukrainian colleagues that we would allow them asylum, if desired, and invite them to the conference in Bad Kissingen as keynote speakers. In no time at (...) all, the new programme for the confer-ence was ready: After commemorating Hans Jonas' honorary doctorate in Berlin under the motto ‘Fatalism would be a mortal sin’ exactly 30 years ago, we now focus on ‘Discourse despite war’. After that, we discuss digitalisation as well as theology, philosophy and commitment". With contributions by Prof. Dr. Claus Altmayer; Harald Asel, M.A.; Dorothee Bär, MdB; Dr. Thomas Bausch; Prof. Dr. Dietrich Böhler; Prof. Dr. Michael Bongardt; Wolfgang Freese; Bernadette Herrmann, M.A.; Sebastian Höpfl; Bischof em. Prof. Dr. Dr. h.c. mult. Wolfgang Huber; Dr. Grigori Katsakoulis; Pfarrer Wolfgang Klein; Wolfgang Korb; Dr. Lena Kornyeyeva; Prof. Dr. Dr. h.c. Klaus Leisinger; Prof. Dr. Dr. h.c. Hans Lenk; Prof. Dr. Ulf Liedke; Prof. Dr. Alfons Matheis; Dr. Olaf Meyer; Dr. Jürgen Naeher-Zeiffer; Stephanie von Dallwitz; Dr. Marianne Rabe; Dr. Manuela Rottmann, MdB; PD Dr. Dr. Thomas Rusche; Prof. Dr. Johann Michael Schmidt; Dr. Eva-Maria Schwickert; Maritta Strasser, M.A.; OB Dr. Dirk Vogel and Prof. Dr. Anatoliy Yermolenko. (shrink)

Analyzes the meaning expressed in music, the social and psychological sources of meaning, and the methods of musical communication This is a book meant for ...

Based on a survey of editors, publishers and staff members of 300 newspapers, this work documents the ethical confusion in the American press in the wake of the Watergate scandal and the Pentagon Papers controversy. It provides an analytical and historical framework to show how the press reached this point and argues for an ethical audit to give publications an independent check on their moral condition.

Climate change can be interpreted as a unique case of historical injustice involving issues of both intergenerational and global justice. We split the issue into two separate questions. First, how should emission rights be distributed? Second, who should come up for the costs of coping with climate change? We regard the first question as being an issue of pure distributive justice and argue on prioritarian grounds that the developing world should receive higher per capita emission rights than the developed world. (...) This is justified by the fact that the latter already owns a larger share of benefits associated with emission generating activities because of its past record of industrialisation. The second question appears to be an issue of compensatory justice. After defining what we mean by compensation, we show that different kinds of compensatory principles run into problems when used to justify payments by historical emitters of the North to people suffering from climate change in the South. As an alternative, we propose to view payments from wealthy countries for adaptation to climate change in vulnerable countries rather as a measure based on concerns of global distributive justice. (shrink)

There is a prevalent notion among cognitive scientists and philosophers of mind that computers are merely formal symbol manipulators, performing the actions they do solely on the basis of the syntactic properties of the symbols they manipulate. This view of computers has allowed some philosophers to divorce semantics from computational explanations. Semantic content, then, becomes something one adds to computational explanations to get psychological explanations. Other philosophers, such as Stephen Stich, have taken a stronger view, advocating doing away with semantics (...) entirely. This paper argues that a correct account of computation requires us to attribute content to computational processes in order to explain which functions are being computed. This entails that computational psychology must countenance mental representations. Since anti-semantic positions are incompatible with computational psychology thus construed, they ought to be rejected. Lastly, I argue that in an important sense, computers are not formal symbol manipulators. (shrink)

Discusses the beliefs of Judaism and their application to life in today's world.

Much social theory takes for granted the core conceit of modern culture, that modern actors-individuals, organizations, nation states-are autochthonous and natural entities, no longer really embedded in culture. Accordingly, while there is much abstract metatheory about "actors" and their "agency," there is arguably little theory about the topic. This article offers direct arguments about how the modern (European, now global) cultural system constructs the modern actor as an authorized agent for various interests via an ongoing relocation into society of agency (...) originally located in transcendental authority or in natural forces environing the social system. We see this authorized agentic capability as an essential feature of what modern theory and culture call an "actor," and one that, when analyzed, helps greatly in explaining a number of otherwise anomalous or little analyzed features of modern individuals, organizations, and states. These features include their isomorphism and standardization, their internal decoupling, their extraordinarily complex structuration, and their capacity for prolific collective action. (shrink)

Die Münchener Texte und Untersuchungen zur deutschen Literatur des Mittelalters (MTU), seit Band 102 beim Max Niemeyer Verlag, machen bisher nicht oder ungenügend erschlossene Texte, Stoffe und Gattungen zugänglich. Neben höfischem und Heldenepos und der Lieddichtung des Hohen und Späten Mittelalters sind vor allem auch Prosaschriften des weltlichen und geistlichen Bereichs, vom theologischen Traktat über die Mystik bis zum Spiel und zur Sachliteratur aus der mittelalterlichen Alltagswelt vertreten. Die Auswahl der publizierten Werke besorgt ein internationales Gremium von Mediävisten verschiedener Disziplinen.

Die Sprache weiß, wovon sie spricht. Das zeigt sich im Kompositum "ef?μe ", von dem das deutsche "ephemer" abgeleitet wurde. Während das Präfix "epi" u.a. die Bedeutungen "darauf, während, bis zu" umfasst, bedeutet "hemära" nicht nur "Tag", sondern auch "Zeit" und "Leben". Das Ephemere spricht existenziell die Daseinsweise des Menschen an. Ephemeroi, Menschen, sind "Eintagswesen", "eines Schattens Traum". Ohne das Ephemere als Kennzeichen der Moderne und Postmoderne zu vernachlässigen, unter Berücksichtigung der Wechselwirkungen mit Medienumbrüchen und Künsten stehen Fragen nach der (...) Zeitlichkeit als Bedingung der Möglichkeit allen Existierens, aber auch nach den Weisen der Zeitigung von Zeit, die die konkrete Lebenszeit prägen, im Zentrum. Mit Beiträgen von: Gabriele Brandstetter, Danica Darkic, Martina Dobbe, Martin Dornberg, Hinderk M. Emmrich, Daniel Fetzner, Angela Melitopoulos, Petra Maria Meyer, Jürgen Partenheimer, Claus-Arthur Scheier, Michael Schirner, Annette Stahmer, Georg Christoph Tholen, Michael Wetzel, Martin Zenck. (shrink)

This Introduction tells the story of intergerational justice and how it has influenced philosophers and political thinkers throughout history. The Introduction goes on to discuss the aims of the book, which is to offer a sustained discussion of intergenerational justice as seen by practical philosophers. The first part of the book focuses on the way in which various schools of thought in moral and political philosophy approach the domain of intergenerational justice, while the second part focuses on more specific aspects, (...) such as how these theories address the question of motivation, how they deal with demographic fluctuations, or how they can be applied to real-world issues such as climate change. (shrink)

In the theory of judgment aggregation, it is known for which agendas of propositions it is possible to aggregate individual judgments into collective ones in accordance with the Arrow-inspired requirements of universal domain, collective rationality, unanimity preservation, non-dictatorship and propositionwise independence. But it is only partially known (e.g., only in the monotonic case) for which agendas it is possible to respect additional requirements, notably non-oligarchy, anonymity, no individual veto power, or implication preservation. We fully characterize the agendas for which there (...) are such possibilities, thereby answering the most salient open questions about propositionwise judgment aggregation. Our results build on earlier results by Nehring and Puppe (2002), Nehring (2006), Dietrich and List (2007a) and Dokow and Holzman (2010a). (shrink)

A perennial question in the philosophy of time concerns the relation between the objective “physical time” that features in empirical theories of motion and the subjective “human time” in which our own experiences unfold. This article is about one facet of this broader question: whether the phenomenon of consciousness allows us to make a principled distinction between the present and other times. A number of authors have argued that, without conscious observers, there would be no distinctions of past, present, and (...) future. This paper defends the opposing thesis that there is no interesting connection between consciousness and presentness. (shrink)

Inhabitants of low-lying islands flooded due to anthropogenic climate change will lose their territory and thereby their ability to exercise their right to political self-determination. This paper addresses the normative questions which arise when climate change threatens territorial rights. It explores whether the loss of statehood supports a claim to territorial compensation, and if so, how it can be satisfied. The paper concludes that such claims are well founded and that they should be met by providing compensatory territories. After introducing (...) a differentiation between land rights and territorial rights, previous theoretical responses to the problem of sinking islands are criticized. It is argued that states may be required to give up parts of their territory as compensation. The paper develops criteria of sufficiency for compensatory territories and proposes to base their selection process on a negative auction. Since it is unlikely that unsettled compensatory territories that meet the specified requirements are available, the rights of their original inhabitants are discussed. (shrink)

L'ONTOLOGIE comme question de l'Etre aura dominé le XXe siècle, avec L'Etre et le Temps de Heidegger et l'Etre et le Néant de Sartre. Mais que dire sur l'Etre sans le présupposer, sans dire qu'il est ceci ou cela alors que c'est ce dire même qui fait problème? L'Etre se présente ainsi comme la problématicité de la philosophie, et c'est du même coup cette problématicité qui pose question avant tel ou tel objet, aussi éminent soit-il. En se voulant interrogation sur (...) l'Etre, la philosophie néglige de prendre en compte l'être de sa propre interrogation, et de s'interroger non seulement sur son questionnement, mais sur le questionnement en général, qu'elle met cependant en œuvre comme une évidence. Le but de cet ouvrage est d'analyser, de Platon à Heidegger, en passant par Kant, Sartre, Bergson et Wittgenstein, les apories de l'ontologie et leur dépassement par la thématisation du questionnement, la problématologie. Car qu'est-ce que la philosophie sinon un questionnement radical, à questionner enfin comme tel, et non plus au travers de l'Etre ou du sujet? MICHEL MEYER. (shrink)

The prelims comprise: The Significance of Voluntariness Ordinary and Philosophical Notions of Voluntariness Constraint and Compulsion Force and Contrariety in the NE Knowledge and Ignorance The Platonic Asymmetry Thesis Responsibility for Character References Further reading.

Currently living people cannot be said to be wronged because of the wrongless emissons of greenhouse gases by past people. According to the usual subjunctive-historical understanding of harm, currently living people cannot be said to be harmed by the impact of greenhouse emissions on their well-being. By relying on a subjunctive-threshold notion of harm we can justify conclusions about both the present generation’s duties not to violate the rights of future generations, and the present generation’s duties to compensate currently living (...) people for the harms inflicted upon them through the lasting impact of wrongless past harms. This interpretation supports a forward-looking understanding of the grounds of our relating to wrongless past harms. The significance of past harms lies in their consequences for the well-being of currently living and future people. The subjunctive-threshold notion of harm lends support to a standard of minimal, general, and universal justice. Those actors who are in a position to fulfill its requirements are under a duty to do so. Especially the rich and powerful countries ought to counteract the harmful impact of past greenhouse emissions. (shrink)

The paper seeks to examine whether Roman emperors legitimized their political actions with a view towards the future achievement of social and political order. The heuristic point of departure is Koselleck’s concept of ‚futures past‘ (vergangene Zukunft) which has been widely discussed in early modern and medieval research while its applicability to prechristian antiquity is still unexplored. The example of the so-called reforms of Augustus and Diocletian reveals that even in response to severe crises in the Roman Empire the emperors (...) did not command any ideas of order in alternative to prevailing conditions. Neither did they have any ‚master plan‘ of coordinated reforms, but reacted in a situational manner with improvements of administrative practice which were mainly aimed at consolidating their power and authority. All ‚reforms‘ were pronounced retrotopically as a return to better days (restitutio) or as a preservation (conservatio) of ‚happier times‘ (felicitas temporum). Looking at the monarchical discourse of power and the messages exchanged in various media between the emperor and his subjects, it is evident that the dominant time regime of imperial chronopolitics lay in a ‚presentism‘ which extended the present, as ‚eutopia‘, into eternity and glorified it as a golden age, whereas the future was only envisaged in dynastic terms. The horizon of expectations of both the emperor and his subjects was restricted to present-day provision. Only Christians were able to imagine a worldly and transcendent horizon of the future. The political success and duration of the Roman Empire left no room for alternative horizons of possibilities, which also explains why the Roman Empire – in contrast to the Greek world – had no notion of utopia. (shrink)

Many Christian scholars have argued that standard versions of evolutionary theory and orthodox theological commitments can be reconciled. Some theistic evolutionists or “evolutionary creationists” have argued that evolutionary mechanisms such as random mutation and natural selection are nothing less than God’s way of creating. Though I dispute the logical coherence of these attempted reconciliations elsewhere, I argue here that there is little reason for Christians to attempt them, since an accumulating body of evidence from multiple subdisciplines of biology casts doubt (...) on the creative power of the main evolutionary mechanisms. Thus, rather than addressing the question, “Can a meaningful doctrine of divine providence or creation be reconciled with mainstream evolutionary theory?” this essay will address the question of whether Christians should, or need to, attempt such a reconciliation at all. (shrink)

Theodor Geiger (1891-1952) zählt zu den vernachlässigten Klassikern der deutschen Soziologie. Realismus und Ideologiekritik bilden die Klammer für ein Opus, das von der Schichtungs-, Rechts- und Erziehungssoziologie über Fragen zur Eugenik bis hin zur Erkenntnis-, Modernitäts- und Demokratietheorie reicht. Die vorliegende Studie ist der Versuch, trotz der zahlreichen Wechselfälle in Geigers Leben eine Gesamtwürdigung seines umfangreichen und heterogenen Werkes vorzulegen. Berücksichtigt werden die zum Teil schwer zugänglichen Schriften aus dem skandinavischen Exil sowie einige bislang unveröffentlichte Arbeiten aus dem Nachlass. Dies (...) erlaubt es, wissenschaftsbiographisch aufschlussreiche Aspekte aus der Zeit der nationalsozialistischen Machtergreifung zu erhellen. Der Vergleich mit alten und neuen Klassikern macht deutlich, dass dem "Querdenker" Geiger innerhalb der frühen deutschen Soziologie eine Ausnahmerolle zukommt. So ist er zum einen Pionier einer kritischen Problem- und Wirklichkeitswissenschaft, der danach strebt, die Soziologie mit den Mitteln der empirischen Sozialforschung und der Sozialstatistik auf eine methodisch kontrollierte Grundlage zu stellen. Zugleich ist Geiger aber auch Machtkritiker, Wertnihilist und Modernist. Als Ausdruck dieser Grundposition lässt sich nicht nur die entschiedene Gegnerschaft zu Kulturkritik, Gemeinschaftsschwärmerei und der NS-Ideologie verstehen, sondern auch sein Beitrag zur Entwicklung einer "realistischen" Demokratiekonzeption. (shrink)

Der vierbändige Titel Die Welt der Philosophin liefert eine anschauliche Darstellung vom Leben einzelnen Philosophinnen, die als Repräsentantinnen ihrer Zeit zu sehen sind. Mit Auszügen aus ihren Texten (zum Teil erstmals in deutscher Übersetzung), ausführlichen Einführungen in die historische Epoche mit besonderer Berücksichtigung der Lage der Frauen und einer ausführlichen Biografie bieten die Bände spannenden Einblicke in das Leben von Philosophinnen. The four-volume title The World of the Female Philosopher provides a vivid account of the lives of individual female philosophers (...) who are to be seen as representatives of their times. With excerpts from their texts (some of them in German translation for the first time), detailed introductions to the historical epoch with special attention to the situation of women and a detailed biography, the volumes offer exciting insights into the lives of women philosophers. (shrink)

Stanley Hauerwas argues that Christian ethics has lost its theological voice because it has accommodated itself to the secular assumptions of modern philosophical ethics. What has led to this fateful accommodation, he argues, is that theology has sought to translate its insights into a nontheological idiom in order to remain publicly intelligible and relevant. My thesis is that Hauerwas rightly recognizes that a fateful accommodation has occurred but wrongly identifies what it is. The real accommodation is found not in theology's (...) attempt to be publicly intelligible and credible but in its widespread acceptance of the modern denial of metaphysics. (shrink)

William James once suggested that the underlying difference between empiricists and rationalists is that empiricists explain wholes in terms of parts, while rationalists explain parts in relation to wholes.1 Whatever the merits of this description, it is fair to say that modern thought has predominantly followed the empiricist habit of emphasizing parts and particularity rather than wholes and totality. This essay explores the views of three philosophers who have challenged this dominant trend. In various ways, John Dewey, Thomas Nagel, and (...) Franklin Gamwell have argued that the meaning and value of human life are only properly understood in relation to the whole of reality. To be sure, Dewey embraced the empiricist... (shrink)

The purpose of this essay is to stimulate academic discussion about the ethical justification of using human primordial stem cells for tissue transplantation, cell replacement, and gene therapy. There are intriguing alternatives to using embryos obtained from elective abortions and in vitro fertilisation to reconstitute damaged or dysfunctional human organs. These include the expansion and transplantation of latent adult progenitor cells.

Constructivism claims to be a postepistemology that replaces 'traditional' concepts of knowledge. Supporters of constructivism have argued that progress requires that pre-service teachers be weaned off traditional approaches and that they should adopt constructivist views of knowledge. Constructivism appears to be gaining ground rapidly and should no longer be viewed as an exercise in radical thinking primarily aimed at generating innovative teaching. It has become an integral part of the pedagogic mainstream. Close examination of the theoretical foundations of constructivism, however, (...) reveals that the basic assumptions of constructivism are flawed. Far from being a postepistemology, constructivism simply regresses to a pre-Renaissance mindset with theology replaced with a psychologism. Constructivists should be aware that the implications of constructivism for future generations may be both profound and non-benign. (shrink)

These sixty contributions from researchers in ethology, ecology, cybernetics, artificial intelligence, robotics, and related fields delve into the behaviors and underlying mechanisms that allow animals and, potentially, robots to adapt and survive in uncertain environments. They focus in particular on simulation models in order to help characterize and compare various organizational principles or architectures capable of inducing adaptive behavior in real or artificial animals. Jean-Arcady Meyer is Director of Research at CNRS, Paris. Stewart W. Wilson is a Scientist at (...) The Rowland Institute for Science, Cambridge, Massachusetts. (shrink)

In this paper we present a brief overview of logic-based belief change, a research area concerned with the question of how a rational agent ought to change its mind in the face of new, possibly conflicting, information. Our intention is to provide the reader with a basic introduction to the work done in this area over the past 30 years. In doing so we hope to sketch the main historical results, provide appropriate pointers to further references, and discuss some current (...) developments. We trust that this will spur on the interested reader to learn more about the topic, and perhaps to join us in the further development of this exciting field of research. (shrink)