This article critically examines the origins and evolution of China’s unique land institutions and situates land policy in the larger context of China’s reforms and pursuit of economic growth. It argues that the Chinese Communist Party has strengthened the institutions that permit land expropriation—namely, urban/rural dualism, decentralized land ownership, and hierarchical land management—in order to use land as a key instrument of macroeconomic regulation, helping the CCP respond to domestic and international economic trends and manage expansion and contraction. Key episodes (...) of macroeconomic policymaking are analyzed, with the use of local and central documents, to show how the CCP relied on the manipulation and distribution of the national land supply either to stimulate economic growth or to rein in an overheating economy. China’s land institutions, therefore, share “complementarities” with fiscal and financial institutions and benefit powerful political actors while imposing costs on marginal ones. (shrink)

As a normative concept, consent can perform the “moral magic” of transforming the moral relationship between two parties, rendering permissible otherwise impermissible actions. Yet, as a governance mechanism for achieving ethical data practices, consent has become strained—and AI has played no small part in its contentious state. In this chapter we will describe how consent has become such a controversial component of data protection as artificial intelligence systems have proliferated in our everyday lives, highlighting five distinct issues. We will then (...) lay out what we call consent’s “moral core,” which emphasizes five elements for meaningful consent. We next apply the moral core to AI systems, finding meaningful consent viable within a particular digital landscape. Finally, we discuss the forces driving some commentators away from individual consent and whether meaningful consent has a future in a smart world. (shrink)

J.M. Coetzee has unquestionably achieved the status of ‘international author’ within dominant conceptions of world literature: his works circulate widely in both English and translation and have been legitimated by the principal arbitrators of the global cultural industry. He has, however, recently positioned himself as ‘an international author, but in a different sense’; that is, as a writer whose internationalism is achieved through his location in ‘the South’. This article considers how Coetzee’s narratives thematize being ‘international’ in this ‘different sense’. (...) It focuses on the pivotal works of Youth: Scenes from Provincial Life (2002) and the opening chapters of Elizabeth Costello: Eight Lessons (2003) while tracking an orientation southward across his oeuvre in allusions to Joseph Conrad, Jorge Luis Borges and, in particular, Pablo Neruda as well as in Coetzee’s repeated turn to littoral settings. These settings open to what the article describes as the ‘blue southern hemisphere’, implicating narrative world-making in the geophysical properties and ‘troubled histories’ that constitute the South and recasting the act of writing from ‘the far edges’ into a planetary perspective that contends with the uncanny nature of settler societies in the southern temperate zone. (shrink)

As current events around the world have illustrated, epistemological issues are at the center of our political lives. It has become increasingly difficult to discern legitimate sources of evidence, misinformation spreads faster than ever, and the role of truth in politics has allegedly decayed in recent years. It is therefore no coincidence that political discourse is currently saturated with epistemic notions like ‘post-truth,’ ‘fake news,’ ‘truth decay,’ ‘echo chambers,’ and ‘alternative facts.’ This book brings together leading philosophers to explore ways (...) in which the analytic and conceptual tools of epistemology bear on political philosophy, and vice versa. It is organized around three broad themes: truth and knowledge in politics; epistemic problems for democracy; and disagreement and polarization. The authors provide new and rich insights on topics such as: propaganda, fake news, weaponized skepticism, belief polarization, political disagreement, the epistemic value of democracy, voter ignorance, irrationality in politics, political bullshit, and identity politics. (shrink)

Faith is a trusting commitment to someone or something. Faith helps us meet our goals, keeps our relationships secure, and enables us to retain our commitments over time. Faith is thus a central part of a flourishing life. -/- This article is about the philosophy of faith. There are many philosophical questions about faith, such as: What is faith? What are its main components or features? What are the different kinds of faith? What is the relationship between faith and other (...) similar states, such as belief, trust, knowledge, desire, doubt, and hope? Can faith be epistemically rational? Practically rational? Morally permissible? -/- This article addresses these questions. It is divided into three main parts. The first is about the nature of faith. This includes different kinds of faith and various features of faith. The second discusses the way that faith relates to other states. For example, what is the difference between faith and hope? Can someone have faith that something is true even if they do not believe it is true? The third discusses three ways we might evaluate faith: epistemically, practically, and morally. While faith is not always rational or permissible, this section covers when and how it can be. The idea of faith as a virtue is also discussed. (shrink)

Introduction: Depression, biology, aggression -- Underbelly -- The biological unconscious -- Bitter melancholy -- Chemical transference -- The bastard placebo -- The pharmakology of depression.

Introducing the work of three French feminists - Julia Kristeva, Luce Irigaray and Michele L Doeuff - "Sexual Subversions" provides access to the work of these writers. In doing so this book raises some key issues of relevance to feminist research, addressing debates around the nature of feminist theory; the relationship between feminist thinking theory; the relationship between feminist thinking and male-dominated areas of knowledge; the strategies appropriate for developing non-patriarchal or woman-centered knowledges. No book on French feminists would be (...) complete without including the contributions of Kristeva and Irigaray. The inclusion of Le Doeuff's work, which brings a different perspective to bear on the question of sexual difference, provides a counterbalance to literary appropriations of French feminism by Anglo-American readerships. Kristeva, Irigaray and Le Doeuff are the focal points of this study, precisely because each highlights the differences of the others, revealing the frameworks to which the others are committed. Nevertheless, while these writers do not present a common political or theoretical position or form a school, each does address the question of women's autonomy from male definition, affirms the sexual specificity of women, seeks out a femininity women can use to question the patriarchal norms and ideals of femininity and rejects the preordained positions patriarchy allots to woman. This book is intended for students and researchers in women's studies, philosophy and feminism. (shrink)

I propose that removed statues be placed in a monument graveyard. This would transfigure a monument, whose purpose is to honour a person or evoke a “glorious past,” into a memorial, whose purpose is to help us grieve. Thus, we dethrone the man who committed violent racists acts, like Edward Colson, and place the statue’s corpse in a graveyard. This repurposing will give old monuments new meanings more in line with our contemporary values.

Hearing the words of Deuteronomy, the preacher is called to make clear what it means to be God's covenant community and to live according to his will rather than the dictates of the surrounding culture.

Behind every sermon lies an understanding of the nature of the Bible; by its contribution to that understanding, biblical studies can make a crucial difference for preaching.

Understanding the form and content of the Bible's hymns allows the sermon to share their principal characteristic: praise to the honor and glory of God.

Recent scholarship in science, technology, and society has emphasized the neoliberal character of science today. This article draws on the history of US science and technology policy to argue against thinking of recent changes in science as fundamentally neoliberal, and for thinking of them instead as reflecting a process of “economization.” The policies that changed the organization of science in the United States included some that intervened in markets and others that expanded their reach, and were promoted by some groups (...) who were skeptical of free markets and others who embraced them. In both cases, however, new policies reflected growing political concern with “the economy” and related abstractions and a new understanding of S&T as inputs into a larger economic system that government could manipulate through policy. Understanding trends in US S&T policy as resulting from economization, not just neoliberalism, has implications for thinking about the present and likely future of science and S&T policy. (shrink)

A critical analysis of Diana Fuss's Essentially Speaking: Feminism, Nature, and Difference and Elizabeth Grosz's Sexual Subversions: Three French Feminists.

This paper raises three concerns regarding self-ownership rhetoric to describe autonomy within healthcare in general and reproductive justice in specific. First, private property and the notion of “ownership” embedded in “self-ownership,” rely on and replicate historical injustices related to the initial acquisition of property. Second, not all individuals are recognized as selves with equal access to self-ownership. Third, self-ownership only justifies negative liberties. To fully protect healthcare access and reproductive care in specific, we must also be able to make claims (...) on others to respect, protect, and fulfill our positive rights. As much as nondomination remains an urgent demand for reproductive rights, it does not go far enough to ensure reproductive justice. (shrink)

Unethical pro-organisational behaviour is an ongoing concern, prompting the need for more nuanced understanding of the workplace environment most likely to inhibit it. This study considers the role of risk climate, sometimes referred to as risk culture, as well as ethical climate, for reducing UPB. The study investigates whether four risk climate factors can, by focusing on the long-term consequences of UPB to the organisation, and providing guidance on behavioural norms, reduce UPB misconduct. Surveying employees in three financial institutions we (...) found that only one of the risk climate factors, avoidance, is consistently associated with UPB. On the other hand, a self-interested, ethical climate significantly increases UPB in all samples. In multi-climate analysis, we found that risk climate factors interacted with ethical climate to predict UPB. That is, when employees perceive that the workplace ethos is not self-interested, three factors of risk climate—avoidance, proactive and manager—significantly predict UPB. UPB is least likely when self-interest is low, avoidance risk climate is low, proactive risk climate is high and manager risk climate is high. Implications for leaders are discussed. (shrink)

This article addresses the question: “What follows from the claim that we have a certain kind of strong reason against animal cruelty?” It deals with the ethics of killing animals. It finds the following common assumption highly puzzling and problematic: despite our obligations not to commit animal cruelty, there is no comparably strong reason against painlessly killing animals in the prime of life. It argues that anyone who accepts this view is committed to the moral position that either we have (...) no reasons against such killings or we have only weak reasons. (shrink)

Many people who are vegetarians for moral reasons nevertheless accommodate the buying and eating of meat in many ways. They go to certain restaurants in deference to their friends’ meat eating preferences; they split restaurant checks, subsidizing the purchase of meat; and they allow money they share with their spouses to be spent on meat. This behavior is puzzling. If someone is a moral vegetarian—that is, a vegetarian for moral reasons—then it seems that the person must believe that buying and (...) eating meat is morally wrong. But if someone believes that a practice is morally wrong, it seems she should also believe that accommodating and supporting that practice is morally wrong; many moral vegetarians seem not to believe this. In this paper, I will offer a solution to this puzzle; I will offer a possible explanation of why people who are vegetarians for moral reasons nevertheless do accommodate the buying and eating of meat. I will offer an explanation of this accommodation behavior on which it is reasonable and it makes sense. I will argue that moral vegetarians may see the buying and eating of meat as a morally permissible moral mistake. They may see the practice as one that one should not engage in, for moral reasons, but that is not morally wrong. Thus, they may see their accommodation of the practice as accommodation of behavior that is not morally wrong, while it is still the case that they are moral vegetarians who see themselves as required to be vegetarians. (shrink)

The concept of vulnerability is widely used in bioethics, particularly in research ethics and public health ethics. The traditional approach construes vulnerability as inherent in individuals or the groups to which they belong and views vulnerability as requiring special protections. Florencia Luna and other bioethicists continue to challenge traditional ways of conceptualizing and applying the term. Luna began proposing a layered approach to this concept and recently extended this proposal to offer two new concepts to analyze the concept of vulnerability, (...) namely understanding external conditions that trigger vulnerability and layers of vulnerability with cascading effects. Luna's conception of vulnerability is useful, which we demonstrate by applying her layered view and the new analyses in multiple contexts. We begin by outlining Luna's view and we use vignettes from healthcare involving transgender patients, the care of patients in psychiatric contexts, and research involving prisoners to illustrate how each part of Luna's concept elucidates important moral issues. (shrink)

In this article, I argue that mass incarceration belongs to a category of social status interventions by which the modern state either withholds the ordinary protections and benefits of the law from outlawed groups or subjects them to private punishment based on their mere membership in those groups. In the US these groups include immigrants and resident Latinos, the homeless, the poor and poor blacks, sex workers, and ex-convicts. Outlawry is a fundamentally anti-democratic practice that cannot be justified in terms (...) of deterrence and is incompatible with public safety. (shrink)

This paper develops a form of realism about aesthetics that is stronger than typical versions of aesthetic realism. As I conceive of it, aesthetic realism is the view that there are some response-independent aesthetic facts. This kind of realism is unpopular in aesthetics and is often viewed as a non-starter. Against this pessimism, I argue that the prospects for this realist approach are more favorable than commonly supposed. I offer some reasons to prefer my brand of aesthetic realism to competing (...) realist and anti-realist positions. I also defend this aesthetic realism against what I call the ‘overly objective worry’ and correct misconceptions about what realism’s commitment to response-independence involves. (shrink)

Not only is deception commonplace in medical encounters, according to Christopher Meyers (2021), but the clinical ethicist might have moral obligations to support and even enact deception. Descriptively Meyers is right that there are “opportunistic, self-interested and benevolent reasons” for deception through omission and commission in clinical medicine. But it is possible to retain this premise while rejecting the normative conclusion that the clinical ethicist “should sometimes be an active participant in the deception of patients and families.” One reason to (...) reject the normative conclusion is its incompatibility with providing trauma informed ethics consultation (TIEC). In the TIEC framework I developed with Uchenna Anani, we defend the integration of trauma informed care (TIC) into ethics consultation (Lanphier and Anani 2021). While ethicists narrowly attend to the question and scope of the ethics consults made to them, doing so in alignment with trauma informed principles is tantamount to providing good ethics consultation. According to Meyers, the clinical ethicist is an “advocate for the best ethical choices.” The best ethical choices are also trauma informed ones. (shrink)

In their paper, ‘How to reach trustworthy decisions for caesarean sections on maternal request: a call for beneficial power’, Eide and Bærøe present maternal request caesarean sections (MRCS) as a site of conflict in obstetrics because birthing people are seeking access to a treatment ‘without any anticipated medical benefit’. While I agree with the conclusions of their paper -that there is a need to reform the approach to MRCS counselling to ensure that the structural vulnerability of pregnant people making birth (...) decisions is addressed—I disagree with the framing of MRCS as having ‘no anticipated medical benefit’. I argue that MRCS is often inappropriately presented as unduly risky,without supporting empirical evidence,and that MRCS is most often sought by birthing people on the basis of a clinical need. I argue that there needs to be open conversation and frank willingness to acknowledge the values that are currently underpinning the presentation of MRCS as ‘clinically unnecessary’; specifically there needs to be more discussion of where and why the benefits of MRCS that are recognised by individual birthing people are not recognised by clinicians. This is important to ensure access to MRCS for birthing people that need it. (shrink)

The GRW dynamics propose a novel, relevantly “observer”-independent replacement for orthodox “measurement”-induced collapse. Yet the tails problem shows that this dynamical innovation is not enough: a principled alternative to the orthodox account demands some corresponding ontological advancement as well. In fact, there are three rival fundamental ontologies on offer for the GRW dynamics. Debate about the relative merits of these candidates is a microcosm of broader disagreement about the role of ontology in our physical theorizing. According to imprimitivists, the GRW (...) dynamics directly describe (only) some (element’s) undulation in an unfamiliar high-dimensional physical field. Primitivists resist this GRW0 proposal on the grounds that it fails to secure comprehensible contact with our data about macroscopic objects in ordinary lowdimensional space-time. They expect an adequate fundamental ontology to include at least some spatiotemporally localized entities—intuitively, concrete constituents of our familiar macroscopic landscape. The most compelling case goes by way of distributional basing: minimally, primitivists expect a theory’s predictions immediately about spatiotemporal distributions of fundamental entities to provide a supervenience base for data about configurations of macroscopic objects. But while the background intuition is familiar, the distributional model is surprisingly subtle. Lack of clarity about its details generates serious confusion for both sides of our debate. (shrink)

I begin by examining the answer to a traditional puzzle concerning supererogatory acts: if they are good to do, why are they not required? The answer often given is that they are optional acts because they cost the agent too much. This view has parallels with the traditional view of religious sacrifice, which involves offering up something or someone valuable as a gift or victim and experiencing a ‘cost’ as part of the ritual. There are problems with the idea that (...) costs justify the optional nature of supererogatory acts, however, and I suggest that these problems mirror the tensions that are found in Christian theology when a traditional view of sacrifice is adopted. (shrink)

This paper argues for answers to two questions, and then identifies a tension between the two answers. First, regarding the implications of moral ignorance for moral responsibility: “Do false moral views exculpate?” Does believing that one is acting morally permissibly render one blameless? It does not. Second, in moral epistemology: “Can moral testimony provide moral knowledge?” It can (even granting some worries about moral deference). The tension: If moral testimony can provide moral knowledge, then surely it can provide justified false (...) moral belief. But surely there is no blameworthiness in a case in which a person acts on a justified false moral belief. So surely some false moral views do exculpate. This tension can be resolved by adoption of the view that moral testimony cannot provide justified false moral belief; this view relies on the fact that whether a belief is justified is sensitive to an agent’s total evidence. (shrink)

Earp et al. provide a robust justification for the decriminalization of drugs based on the systemic racism that fuels the “war on drugs” and the ongoing harms of drug policies to individuals...

Parmenides, mystery and contradiction -- The early theory of forms -- The new theory of forms -- Understanding proofs : Meno, 85d₉-86c₂, continued -- Aristotle and the sea battle -- The principle of individuation -- Thought and action in Aristotle -- Necessity and truth -- Hume and Julius Caesar -- "Whatever has a beginning of existence must have a cause" : Hume's argument exposed -- Will and emotion -- Retraction -- The question of linguistic idealism.

On Friday 17 August 2012, members of the feminist collective Pussy Riot were sentenced to two years in jail after their staging of a musical protest in a Russian Orthodox church. This article analyses Western news media responses to the Pussy Riot affair. It first examines how the event has resonated across various news media, activist, and social media networks. Focusing on the phrase, ‘We are all Pussy Riot’, which became a Twitter hashtag following the incarceration of Pussy Riot members, (...) I argue that narratives of feminist return (Hemmings, 2011) and of US exceptionalism have shaped the eventfulness of the Pussy Riot affair in the West. While not dismissing the activism of Pussy Riot, this article asserts that the discourses of transnational solidarity and feminist renewal that the arrests engendered rely on the perceived whiteness and non-Western identities of the members who were incarcerated. (shrink)

Feminist scholarship has increasingly turned towards the ocean as a conceptual apparatus in which to think through the complex philosophical and ethical dilemmas of the Anthropocene. Responding to the ebbs, flows and transformations of the oceanic turn, our article outlines our interactions with four decorator crabs. It begins by situating our experience of thinking-with these crabs as a feminist practice of care within the conceptual context of the ocean. Our article then draws on the knowledge that arose out of our (...) fertile entanglements with the crabs to propose that: 1) the aquarium, with its colonial histories of subjugation, is a fertile space to re-image human–aquatic relationalities, revealing the fallacy of human control over ‘nature’ and emphasising the agency of marine worlds; 2) Stacy Alaimo’s concept of trans-corporeality is a powerful way to think through the consequences of an acidifying ocean, both for ourselves and for our shelled companions; and 3) remediation is a radical approach to taking seriously the materiality of watery worlds. The objective of the article is to craft a practice of material feminism that entangles our more-than-human bodies to learn-with decorator crabs. In doing so, we show that the aquarium is a potent space of transformation that allows us to imagine new and distinctly feminist entanglements that dismantle hierarchies. We show that thinking-with the materiality of marine worlds is a series of remediations, both material and discursive, that dissolve the boundaries between entities, creating an embodied environmental ethics that is necessary as a feminist challenge to the Anthropocene. (shrink)

Astonishment that the things we are experiencing are "still" possible in the twentieth century is not philosophical. It is not the beginning of any insight, unless it is that the idea of history from which it comes is untenable.And so tyranny naturally arises out of democracy, and the most aggravated form of tyranny and slavery out of the most extreme form of liberty?In 1940 the exiled German critic and philosopher Walter Benjamin warned that fidelity to a vision of history as (...) progress risked normalizing the remy-thologization of politics.1 Recent events have underlined the urgency, both for thought and for action, of rejecting the same unphilosophical astonishment in our own time. In the face of political... (shrink)

Anne Conway produced only one short treatise – The Principles of the Most Ancient and Modern Philosophy – but addressed key problems in the philosophy of religion which are still much discussed today. The most significant of these are the problem of religious diversity and the problem of evil. Although the sources of her ideas may be found in the Kabbalah of Isaac Luria and the work of the Cambridge Platonists and the Quaker George Keith, among others, she offers her (...) own unorthodox solutions to these problems. The idea of Christ as an indwelling mediator of the divine who assists us in our moral endeavours is designed to appeal to those of all religions and none, while her claim that God created creatures knowing that they would eventually be redeemed, and that suffering promotes moral development which leads to redemption offers a novel response to the problem of evil. Conway's work is also important for its influence on the work of Gottfried Wilhelm Leibniz, and some have argued that it prefigures, at least in outline, the field theory of modern physics. (shrink)

Care ethics has a curious relationship to justice. Care theorists alternately portray justice as separate from yet at times intersecting with, parallel and distinct from, or falling within yet secondary to care. Theories of justice tend to imagine an ideal world, and reason about justice from an imagined universal position. Care ethics, on the other hand, respond to a philosophical history in which abstract universal reasoning occludes the particular needs and contributions of marginalized or oppressed groups. I argue that care (...) ethics is a kind of nonideal theory. I further argue that understanding care ethics as nonideal theory does two things. One, it draws care and justice into conversation with each other such that neither one is prior: both can be produced through practices of justice enacted through care, and care that responds to justice. Moreover, health care models the way in which care and justice must work in tandem. Two, care theory as nonideal theory invites an institutional ethic of care. An institutional ethic of care is modeled by, and at the same time can strengthen, existing health care practices. Such an ethic builds on the feminist scholarship deconstructing dichotomous binaries, including gendered dichotomies between justice and care. In conclusion, I raise the possibility that an institutional ethic of care might reveal a porous boundary between an ideal/nonideal theory binary. (shrink)

In “Obligations of the Gift” Sandra Lee (2021) suggests that social norms of reciprocity and the expectations and obligations associated with gift-giving afford a framework for addressing social justice considerations in precision medicine. Lee is particularly concerned with obligations to marginalized or oppressed racial and ethnic groups, which are also historically under-represented populations in precision medicine. Obligations arise, Lee argues, through the “gift” that research participants make when they contribute their data or biospecimens to precision medicine research. This conceptualization of (...) research participation is distinct from an altruistic donation model that explicitly precludes obligations of reciprocity. I agree with Lee’s overall project to support social justice aims by better recognizing responsibilities of researchers to their research participants, and increasing diverse participation in biomedical research. However, I am not convinced that the account of “the gift” she deploys can achieve the social justice goals she intends because it risks replicating rather than resisting problematic conceptions of labor, property, and ownership of selves and others. However, an alternate conceptualization of “the gift” found in the work of 20th century French philosopher Jacques Derrida recasts ethical obligations on the part of precision medicine to those who contribute their data and biospecimens for precision medicine research. (shrink)

Background The opioid epidemic has enabled rapid and unsurpassed use of big data on people with opioid use disorder to design initiatives to battle the public health crisis, generally without adequate input from impacted communities. Efforts informed by big data are saving lives, yielding significant benefits. Uses of big data may also undermine public trust in government and cause other unintended harms. Objectives We aimed to identify concerns and recommendations regarding how to use big data on opioid use in ethical (...) ways. Methods We conducted focus groups and interviews in 2019 with 39 big data stakeholders who had interest in or knowledge of the Public Health Data Warehouse maintained by the Massachusetts Department of Public Health. Results Concerns regarding big data on opioid use are rooted in potential privacy infringements due to linkage of previously distinct data systems, increased profiling and surveillance capabilities, limitless lifespan, and lack of explicit informed consent. Also problematic is the inability of affected groups to control how big data are used, the potential of big data to increase stigmatization and discrimination of those affected despite data anonymization, and uses that ignore or perpetuate biases. Participants support big data processes that protect and respect patients and society, ensure justice, and foster patient and public trust in public institutions. Recommendations for ethical big data governance offer ways to narrow the big data divide, enact shared data governance, cultivate public trust and earn social license for big data uses, and refocus ethical approaches. Conclusions Using big data to address the opioid epidemic poses ethical concerns which, if unaddressed, may undermine its benefits. Findings can inform guidelines on how to conduct ethical big data governance and in ways that protect and respect patients and society, ensure justice, and foster patient and public trust in public institutions. (shrink)

A variety of studies show that parental absence early in life leads to deleterious effects on the developing CNS. This is thought to be largely because evolutionary-dependent stimuli are necessary for the appropriate postnatal development of the young brain, an effect sometimes termed the “experience-expectant brain,” with parents providing the necessary input for normative synaptic connections to develop and appropriate neuronal survival to occur. Principal among CNS systems affected by parental input are the monoamine systems. In the present study,N= 434 (...) rhesus monkeys (233 males, 201 females) were reared in one of two conditions: as mother-reared controls (MR;n= 269) or without adults with 24-h access to same-aged peers (PR;n= 165). When subjects were six-months-old, they underwent a separation paradigm involving 4, sequential, four-day social separations from their mothers or peers, with each separation followed by three-day reunions with their mothers or their peers. Prior to the separation paradigm, baseline cisternal CSF samples were obtained, as well as at the end of each the four social separations, and after final separation, during a recovery period. CSF was assayed for concentrations of monoamine metabolites and a blood sample was genotyped for the serotonin transporter (5-HTT) genotype. Replicating earlier landmark findings, PR subjects with thesallele exhibited lower baseline concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), when compared to PR subjects homozygous for theLallele. MR subjects were undifferentiated by genotype. PR subjects exhibited lower CSF 5-HIAA concentrations during baseline, but higher CSF 5-HIAA during social separations, when compared to MR subjects. There were rearing effects for the dopamine metabolite homovanillic acid (HVA) and for the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), with PR subjects showing higher HVA and lower MHPG when compared to MR subjects. These findings indicate that there are long-term deficits in the response of monoamines following early maternal absence. The results of this study confirm and extend earlier findings that early parental absence has deleterious consequences for the development of the monoamine systems, and that these consequences are modulated by the 5-HTT genotype. (shrink)