Inflamm‐aging is a relatively new terminology used to describe the age‐related increase in the systemic pro‐inflammatory status of humans. Here, we represent inflamm‐aging as a breakdown in the multi‐shell cytokine network, in which stem cells and stromal fibroblasts (referred to as the stem cell niche) become pro‐inflammatory cytokine over‐expressing cells due to the accumulation of DNA damage. Inflamm‐aging self‐propagates owing to the capability of pro‐inflammatory cytokines to ignite the DNA‐damage response in other cells surrounding DNA‐damaged cells. Macrophages, the major cellular (...) player in inflamm‐aging, amplify the phenomenon, by broadcasting pro‐inflammatory signals at both local and systemic levels. On the basis of this, we propose that inflamm‐aging is a major contributor to the increase in cancer incidence and progression in aged people. Breast cancer will be presented as a paradigmatic example for this relationship. (shrink)

Massimiliano Simons provides the first systematic study of Serres' work in the context of late 20th-century French philosophy of science. By proposing new readings of Serres' philosophy, Simons creates a synthesis between his predecessors, Gaston Bachelard, Georges Canguilhem, and Louis Althusser as well as contemporary Francophone philosophers of science such as Bruno Latour and Isabelle Stengers. Simons situates Serres' unique contribution through his notion of the quasi-object, a concept, he argues, organizes great parts of Serres' work into a promising (...) philosophy of science as well as a challenge to the narrower field of French epistemology, to which it has often been limited. Simons highlights how the concept encompasses Serres' commitment to positive relations between science and culture and his rejection of pleas to purify the scientific self from imaginative and cultural elements. It helps to situate Serres between the distinct traditions of Bachelard and Latour as well as progressing the innovative aspects of Serres' philosophy for current debates in the philosophy, history, and sociology of science. Showing how Serres' philosophy can serve as a normative approach to science and technology, Michel Serres and French Philosophy of Science takes in themes of materiality, religiosity, modernity and ecology to advance a timely alternative to philosophy of science for contemporary life. (shrink)

This article intends to summarise the content of my book Insurgent Universality: An Alternative Legacy of Modernity and expand the meaning of the term ‘universality’. Universality is not defined in abstract legal terms or by juxtaposition vis-à-vis a common enemy. Instead, I clarify the meaning of a more concrete and open practice of universality through historical examples and theories that I excavate from social practices.

The first systematic collaboration between cognitive scientists and sports psychologists considers the mind–body relationship from the perspective of athletic skill and sports practice. This landmark work is the first systematic collaboration between cognitive scientists and sports psychologists that considers the mind–body relationship from the perspective of athletic skill and sports practice. With twenty-six chapters by leading researchers, the book connects and integrates findings from fields that range from philosophy of mind to sociology of sports. The chapters show not only that (...) sports can tell scientists how the human mind works but also that the scientific study of the human mind can help athletes succeed. Sports psychology research has always focused on the themes, notions, and models of embodied cognition; embodied cognition, in turn, has found striking confirmation of its theoretical claims in the psychological accounts of sports performance and athletic skill. Athletic skill is a legitimate form of intelligence, involving cognitive faculties no less sophisticated and complex than those required by mathematical problem solving. After presenting the key concepts necessary for applying embodied cognition to sports psychology, the book discusses skill disruption ; sensorimotor skill acquisition and how training correlates to the development of cognitive faculties; the intersubjective and social dimension of sports skills, seen in team sports; sports practice in cultural and societal contexts; the notion of “affordance” and its significance for ecological psychology and embodied cognition theory; and the mind's predictive capabilities, which enable anticipation, creativity, improvisation, and imagination in sports performance. Contributors Ana Maria Abreu, Kenneth Aggerholm, Salvatore Maria Aglioti, Jesús Ilundáin-Agurruza, Duarte Araújo, Jürgen Beckmann, Kath Bicknell, Geoffrey P. Bingham, Jens E. Birch, Gunnar Breivik, Noel E. Brick, Massimiliano L. Cappuccio, Thomas H. Carr, Alberto Cei, Anthony Chemero, Wayne Christensen, Lincoln J. Colling, Cassie Comley, Keith Davids, Matt Dicks, Caren Diehl, Karl Erickson, Anna Esposito, Pedro Tiago Esteves, Mirko Farina, Giolo Fele, Denis Francesconi, Shaun Gallagher, Gowrishankar Ganesh, Raúl Sánchez-García, Rob Gray, Denise M. Hill, Daniel D. Hutto, Tsuyoshi Ikegami, Geir Jordet, Adam Kiefer, Michael Kirchhoff, Kevin Krein, Kenneth Liberman, Tadhg E. MacIntyre, Nelson Mauro Maldonato, David L. Mann, Richard S. W. Masters, Patrick McGivern, Doris McIlwain, Michele Merritt, Christopher Mesagno, Vegard Fusche Moe, Barbara Gail Montero, Aidan P. Moran, David Moreau, Hiroki Nakamoto, Alberto Oliverio, David Papineau, Gert-Jan Pepping, Miriam Reiner, Ian Renshaw, Michael A. Riley, Zuzanna Rucinska, Lawrence Shapiro, Paula Silva, Shannon Spaulding, John Sutton, Phillip D. Tomporowski, John Toner, Andrew D. Wilson, Audrey Yap, Qin Zhu, Christopher Madan. (shrink)

This study examines the implications of practical reason for entrepreneurial activities. Our study is based on Thomas Aquinas’ interpretation of such virtue, with a particular focus on the partition of practical reason in potential parts such as synesis, or common sense, and gnome, or perspicacity. Since entrepreneurial acts and actions deal with extremely uncertain situations, we argue that only this perspicacity, as the ability of correctly judging in exceptional cases, has the power to find wisdom under such blurred conditions. Perspicacity (...) frees entrepreneurs from their cognitive schemata rendering them able to be truly entrepreneurial. Based on this vision and thanks to a semantic analysis of the meaning of the Greek word gnome, we construct an interpretative model for entrepreneurial judgment composed of three dimensions, specifically, knowledge-cognitive, external-affective and personal-reflective. The model highlights how a ‘successful’ entrepreneurial judgment is also such from a holistic point of view. (shrink)

The foundation of statistical mechanics and the explanation of the success of its methods rest on the fact that the theoretical values of physical quantities (phase averages) may be compared with the results of experimental measurements (infinite time averages). In the 1930s, this problem, called the ergodic problem, was dealt with by ergodic theory that tried to resolve the problem by making reference above all to considerations of a dynamic nature. In the present paper, this solution will be analyzed first, (...) highlighting the fact that its very general nature does not duly consider the specificities of the systems of statistical mechanics. Second, Khinchin’s approach will be presented, that starting with more specific assumptions about the nature of systems, achieves an asymptotic version of the result obtained with ergodic theory. Third, the statistical meaning of Khinchin’s approach will be analyzed and a comparison between this and the point of view of ergodic theory is proposed. It will be demonstrated that the difference consists principally of two different perspectives on the ergodic problem: that of ergodic theory puts the state of equilibrium at the center, while Khinchin’s attempts to generalize the result to non-equilibrium states. (shrink)

According to Frege a proposition—or, in his terms, a thought—is an abstract structured entity constituted by senses which satisfies, at least, the three following properties: it can be semantically assessed as true or as false, it is the object of so called propositional attitudes and it can be grasped. What Frege meant by 'grasping' is the peculiar way in which we can have epistemic access to propositions. The possibility for propositions to be grasped is put by Frege as a warrant (...) for their existence: to challenge their graspability would amount to jeopardise their ontological reality. But is it true, as Frege uncritically maintained, that the "graspability requirement" is satisfied as far as propositions are concerned? This is the topic of the present work. A negative answer to the above mentioned question has been given in recent time by the representatives of what has come to be labelled the "cognitive turn" in analytical philosophy. People such as Fodor and Johnson-Laird patently denied the possibility for propositions, conceived Frege, to be accessed by the grasping relation. What grounds their position is, to put it roughly, the following train of thought: in order for something to be the target of the grasping relation it must enter the mind. Nothing which is different from a mental entity can enter the mind. Therefore, what can be grasped must be mental. The upshot of this move implies, among other things, the rejection of that radical anti-psychologism which was characteristic of the forefathers of the analytical tradition. In our work we shall try to resist their conclusion by showing that it is not necessary to zero the distinction between propositions and mental entities in order to provide an adequate account of the grasping relation. What one has to give up, instead, is only Frege's late Platonism of the "third realm" which, in our view, is a wholly unnecessary and dispensable accretion of his picture. For, as we shall show, if Platonism is in place it is difficult to provide an account of the grasping relation which makes no use of the "representationalist hypothesis" — i.e. of the hypothesis that mediate our access to whatever can be given to us. But representationalism, once in place, makes the theoretical role of the notion of sense dispensable or purely additional. (shrink)

Organizational identification has increasingly attracted scholarly attention as a key factor in understanding organizational processes and in fostering efficient human resource management. Available evidence shows that organizational ethical climate crucially predicts OI, a key determinant of both employees’ attitudes and behaviors. In the present paper, we examined the relationship between two specific ethical climates, distributed leadership, and employees’ attitudes and behaviors, incorporating OI as a core underlying mechanism driving these relationships. Three hundred and forty-two employees filled out questionnaires to examine (...) ethical climate, DL, OI, and a series of measures concerning attitudes and behaviors toward the organization. Structural equation modeling confirmed that a perception of an ethical climate of friendship fostered OI, which elicited higher commitment, perceived trust and recommendation, and lower turnover intention. Perception of DL further contributed to increasing OI. Our findings suggest that HR practices should carefully consider employee perceptions of a collectivistic ethical climate, together with perceptions of DL, as key determinants of positive organizational outcomes. We discuss results in light of the social identity approach and present practical implications for HR management. (shrink)

En este trabajo consideramos los discursos políticos y económicos actuales proponiendo el fenómeno start-up como el síntoma de un cambio profundo en la gubernamentalidad neoliberal y un nuevo episodio en la larga historia de las prácticas de organización de la fuerza de trabajo, de su gobierno y movilización. Nos basamos en los textos de Michel Foucault y en la literatura neomanagerial actual para analizar las recientes transformaciones de la racionalidad neoliberal. Con este punto de partida, proponemos que el emprendedor neoliberal (...) del yo, el empresario de sí mismo, tal y como lo concibió Foucault, se está transformando, además, en una especie de inversor de sí mismo administrando permanentemente sus activos personales y buscando constantemente la autoevaluación y la autovalorización en la lógica del rendimiento.In this paper we consider the political and economic discourses hyping the «start-up phenomenon» as the symptom of a deep change in neoliberal governmentality and a new episode in the long history of the practices of workforce government and mobilisation. After pointing out the recent transformations of neoliberal rationality of government, we concentrate on the forms of subjectification implied by what could be defined as the start-up subject: the typically neoliberal entrepreneur of the self is thus transforming into a sort of investor of the self permanently managing his personal assets and incessantly searching for self-evaluation and self-valorisation. (shrink)

In this brief paper I attempt to focus our attention on some of the main thematic lines concerning Karol Wojtyła’s meditation both on man’s personhood and man’s life. I especially wish to investigate the meaning of the term «life», such as it is used in the thought and the teachings of the man who became John Paul II.

Although implementation is ubiquitous in computer science, there is no systematic philosophical analysis of its metaphysical structure. In this article, I argue that the conceptual resources of analytical metaphysics can be very helpful in laying the foundations for a metaphysics of implementation and, by extension, of computer science. More specifically, I hold that implementation is a form of metaphysical grounding, and I show that, by combining the properties of grounding with the specific constraints of computer science, one can clarify what (...) a metaphysics of computer science could look like. In sections 2 and 3 of the article, I discuss various meanings of implementation, while in section 4, I submit my central claim that implementation is a form of metaphysical grounding. I substantiate this claim by showing that implementation and grounding share the same formal properties. If this is correct, then issues of ontological dependence, metaphysical explanation, hyperintensionality, and foundedness, typically associated with grounding, can be re-formulated in computer science using the concept of implementation. This is what I do in sections 5.1-5.4. I conclude with some general remarks about the future development of computer science's metaphysics. (shrink)

Skilful expertise is grounded in practical, performative knowledge-how, not in detached, spectatorial knowledge-that, and knowledge-how is embodied by habitual dispositions, not representation of facts and rules. Consequently, as action control is a key requirement for the intelligent selection, initiation, and regulation of skilful performance, habitual action control, i.e. the kind of action control based on habitual dispositions, is the true hallmark of skill and the only veridical criterion to evaluate expertise. Not only does this imply that knowledge-that does not make (...) your actions more skilful, but it also implies that it makes them less skilful. This thesis, that I call Radical Habitualism, finds a precursor in Hubert Dreyfus. His approach is considered extreme by most philosophers of skill & expertise: an agent –says Dreyfus– does not perform like an expert when they lack the embodied dispositions necessary to control their action habitually or when they stop relying on such dispositions to control their actions. Thus, one cannot perform skilfully if their actions are guided by representations (isomorphic schemas, explicit rules, and contentful instructions), as the know-that that they convey disrupts or diminishes the agent’s habitual engagement with the task at hand. In defence of Radical Habitualism, I will argue that only the contentless know-how embedded in habitual dispositions fulfils (i) the genetic, (ii) the normative, and (iii) the epistemic requirements of skilful performance. I will examine the phenomenological premises supporting Dreyfus’ approach, clarify their significance for a satisfactory normative and explanatory account of skilful expertise, and rebut the most common objections raised by both intellectualists and conciliatory habitualists, concerning hybrid actions guided by a mix of habitual and representational forms of control. In revisiting Dreyfus anti-representationalist approach, I will particularly focus on its epistemological implications, de-emphasizing other considerations related to conscious awareness. (shrink)

There is a widespread view that well-learned skills are automated, and that attention to the performance of these skills is damaging because it disrupts the automatic processes involved in their execution. This idea serves as the basis for an account of choking in high pressure situations. On this view, choking is the result of self-focused attention induced by anxiety. Recent research in sports psychology has produced a significant body of experimental evidence widely interpreted as supporting this account of choking in (...) certain kinds of complex sensorimotor skills. We argue against this interpretation, pointing to problems with both the empirical evidence and the underlying theory. The experimental research fails to provide direct support for the central claims of the self-focus approach, contains inconsistencies, and suffers from problems of ecological validity. In addition, qualitative studies of choking have yielded contrary results. We further argue that in their current forms the self-focus and rival distraction approaches both lack the theoretical resources to provide a good theory of choking, and we argue for an expanded approach. Some of the elements that should be in an expanded approach include accounts of the features of pressure situations that influence the psychological response, the processes of situation appraisal, and the ways that attentional control can be overwhelmed, leading to distraction in some cases, and in others, perhaps, to damaging attention to skill execution. We also suggest that choking may sometimes involve performance-impairing mechanisms other than distraction or self-focus. (shrink)

Excellent performance in sport involves specialized and refined skills within very narrow applications. Choking throws a wrench in the works of finely tuned performances. Functionally, and reduced to its simplest expression, choking is severe underperformance when engaging already mastered skills. Choking is a complex phenomenon with many intersecting facets: its dysfunctions result from the multifaceted interaction of cognitive and psychological processes, neurophysiological mechanisms, and phenomenological dynamics. This article develops a phenomenological model that, complementing empirical and theoretical research, helps understand and (...) redress choking. It aims at describing the experience of choking as experience, and to discuss strategies to palliate or prevent its onset at the pragmatic level at which athletes engage the phenomenon experientially. An overview of current empirical research and theoretical models highlights key ideas and points out contentious issues. The model describes the common structure of the choking experience. It identifies four core constitutive elements: A) disruptive proprioceptive and kinesthetic dynamics, B) a malfunctioning background or Jamesian fringe of consciousness, C) dislocated time dynamics, and D) emotional disturbances. The novelty of the remedy is that it is designed to cross disciplinary boundaries between phenomenology, historiography, and hermeneutics, and moreover connects theory to praxis as it looks at Japanese dō, practices of self-cultivation. It focuses on actual do-or-die situations, not putative ones such as important business deals or competing for a medal. To this effect, it examines medieval Japanese swordsmanship and training manuals and also engages risk sports, where death is indeed a real possibility. The manuals, which arise in the context of choke-inducing life or death duels, and risk sports, afford keen phenomenological observations and practical advice that prove invaluable for today’s sports world and beyond. (shrink)

The current status of Beilock and Carr's "execution focus" theory of choking under pressure in performance of a sensorimotor skill is reviewed and assessed, mainly from the perspective of cognitive psychology, and put into the context of a wider range of issues, attempting to take philosophical analysis into account. These issues include other kinds of skills, pre-performance practice, post-performance evaluation and repair, and integrating new and creative achievements into repertoires of heavily practiced routines. The focus is on variation in the (...) demand for reflection versus automaticity across the full gamut of learning and experience, not just game-time performance. Though automaticity remains important and there are many circumstances in which being "in the zone" is good whereas “execution focus” can do harm, it appears that reflective action deserves just as much a place at the performance table as does unreflective action. (shrink)

An intricate, long, and occasionally heated debate surrounds Boltzmann’s H-theorem (1872) and his combinatorial interpretation of the second law (1877). After almost a century of devoted and knowledgeable scholarship, there is still no agreement as to whether Boltzmann changed his view of the second law after Loschmidt’s 1876 reversibility argument or whether he had already been holding a probabilistic conception for some years at that point. In this paper, I argue that there was no abrupt statistical turn. In the first (...) part, I discuss the development of Boltzmann’s research from 1868 to the formulation of the H-theorem. This reconstruction shows that Boltzmann adopted a pluralistic strategy based on the interplay between a kinetic and a combinatorial approach. Moreover, it shows that the extensive use of asymptotic conditions allowed Boltzmann to bracket the problem of exceptions. In the second part I suggest that both Loschmidt’s challenge and Boltzmann’s response to it did not concern the H-theorem. The close relation between the theorem and the reversibility argument is a consequence of later investigations on the subject. (shrink)

I examine two explanatory models of choking: the representationalist model and the anti-representationalist model. The representationalist model is based largely on Anderson's ACT model of procedural knowledge and is developed by Masters, Beilock and Carr. The antirepresentationalist model is based on dynamical models of cognition and embodied action and is developed by Dreyfus who employs an antirepresentational view of know-how. I identify the models' similarities and differences. I then suggest that Dreyfus is wrong to believe representational activity requires reflection and (...) attention. I also argue that the representationalist model of choking is preferable, since some embodied actions require appeals to representations, something not available to Dreyfus's anti-representational model. (shrink)

The aim of this paper is not only to deal with the concept of infinity, but also to develop some considerations about the epistemological status of cosmology. These problems are connected because from an epistemological point of view, cosmology, meant as the study of the universe as a whole, is not merely a physical (or empirical) science. On the contrary it has an unavoidable metaphysical character which can be found in questions like “why is there this universe (or a universe (...) at all)?”. As a consequence, questions concerning the infinity of the universe in space and time can correctly arise only taking into account this metaphysical character of cosmology. Accordingly, in the following paper it will be shown that two different concepts of physical infinity of the universe (the relativistic one and the inflationary one) rely on two different ways of solution of a metaphysical problem. The difference between these concepts cannot be analysed using the classical distinctions between actual/potential infinity or numerable/continuum infinity, but the introduction of a new “modal” distinction will be necessary. Finally, it will be illustrated the role of a philosophical concept of infinity of the universe. (shrink)

This paper investigates the question of how we manage to single out the natural number structure as the intended interpretation of our arithmetical language. Horsten submits that the reference of our arithmetical vocabulary is determined by our knowledge of some principles of arithmetic on the one hand, and by our computational abilities on the other. We argue against such a view and we submit an alternative answer. We single out the structure of natural numbers through our intuition of the absolute (...) notion of finiteness. (shrink)

Michel Serres’s proposal to extend the social contract to a natural contract has been met with criticism and misunderstanding. In this article, I would like to respond to common criticisms by reconsidering two central related concepts. It is claimed that we cannot represent nature’s interests and therefore cannot come to an agreement, and thus a contract, with nature. However, I will suggest a way out by reinterpreting representation and agreement. I will start with the problem of representation: nature cannot be (...) represented. Specifically, I will present two counterarguments. The first argument is that political representation is always difficult, even in the case of human beings. Representing nature only seems more difficult because we have forgotten the difficulties associated with representing humans. The second argument aims to rethink representation. Representing nature only seems so hard because we tend to follow a cognitive understanding of representation, as if representation is about representing the ideas of the represented party. Instead, following Michael Saward, I propose an alternative understanding of representation as a game of representative claims and counterclaims: political representation is about claiming to speak on behalf of a referent and then allowing that referent to respond to that claim. Then I turn to the problem of agreement. A natural contract seems difficult because it is hard to imagine what it would mean for nature to agree to a particular proposal. To counter this, I turn to the notion of symbiosis, found in the work of Serres. A natural contract, I will argue, need not be a contract of consensus or synthesis. The alternative is a contract of symbiosis, which does not require all parties to have a common understanding of the situation. Instead, it allows for an agreement in which all parties have their own interests and definition of the situation. In this sense, a natural contract can make sense if it is understood as a contract in which symbiosis is achieved through political representation based on a game of claims and counterclaims. (shrink)

Contextualism, Pragmatics and Definite Descriptions Very few philosophers and linguists doubt that definite descriptions have attributive uses and referential uses. The point of disagreement concerns whether the difference in uses is grounded on a difference in meaning. The Ambiguity Theory holds while the Implicature Theory denies that definite descriptions are ambiguous expressions, having an attributive meaning and a referential meaning. Contextualists have attempted to steer between the Ambiguity Theory and the Implicature Theory. I claim that the early contextualist account provided (...) by Recanati and Bezuidehnout based on the idea that definite descriptions are semantically underdetermined and in need of a completion from the contextually available information through an optional top-down pragmatic process suffers from an explanatory gap. (shrink)

We speak of products in two senses: in one, we speak of types of products, in the other we speak of the particular objects that are instances of those types. I argue that types of products have the same ontological status as that of material stuffs, like water and gold, which have a non-particular level of existence. I also argue that the relationship between types of products and their instances is logically similar to the relation of constitution, which holds between, (...) say, gold and a ring made of gold. In my approach, types of products are concrete entities, having spatiotemporal properties. This picture fits our commonplace conception of types of products better than alternative approaches according to which types of products are universal, abstract, or mereological entities. (shrink)

The Knowability Paradox is a logical argument showing that if all truths are knowable in principle, then all truths are, in fact, known. Many strategies have been suggested in order to avoid the paradoxical conclusion. A family of solutions –ncalled logical revision – has been proposed to solve the paradox, revising the logic underneath, with an intuitionistic revision included. In this paper, we focus on so-called revisionary solutions to the paradox – solutions that put the blame on the underlying logic. (...) Specifically, we analyse a possibile translation of the paradox into a modified intuitionistic fragment of a logic for pragmatics inspired by Dalla Pozza and Garola in 1995. Our aim is to understand if KILP is a candidate for the logical revision of the paradox and to compare it with the standard intuitionistic solution to the paradox. (shrink)

Autonomous weapon systems could in principle release military personnel from the onus of killing during combat missions, reducing the related risk of suffering a moral injury and its debilita...

The essay starts from the singularization and temporalization of political concepts, that originate a self-representation of modernity as hierarchically superior to pre-modernity. Such self-representation, in Massimiliano Tomba’s words, must be now pluralized not only in relationship with the many extra-European temporalities, but also with the multiple temporal layers of European history. The author’s proposal of working on «time differentials», i.e. on the trajectories that turn from the dominant course of modern history, founded on Western emancipation, individual rights and modern (...) property relations, underlies that, in order to reconfigure the concept of modernity, it is necessary to reconfigure the concept of history itself. (shrink)

In Mathematics is megethology Lewis reconstructs set theory combining mereology with plural quantification. He introduces megethology, a powerful framework in which one can formulate strong assumptions about the size of the universe of individuals. Within this framework, Lewis develops a structuralist class theory, in which the role of classes is played by individuals. Thus, if mereology and plural quantification are ontologically innocent, as Lewis maintains, he achieves an ontological reduction of classes to individuals. Lewis’work is very attractive. However, the alleged (...) innocence of mereology and plural quantification is highly controversial and has been criticized by several authors. In the present paper we propose a new approach to megethology based on the theory of plural reference developed in To be is to be the object of a possible act of choice. Our approach shows how megethology can be grounded on plural reference without the help of mereology. (shrink)

In this paper we consider the emerging position in metaphysics that artifact functions characterize real kinds of artifacts. We analyze how it can circumvent an objection by David Wiggins (Sameness and substance renewed, 2001, 87) and then argue that this position, in comparison to expert judgments, amounts to an interesting fine-grained metaphysics: taking artifact functions as (part of the) essences of artifacts leads to distinctions between principles of activity of artifacts that experts in technology have not yet made. We show, (...) moreover, that our argument holds not only in the artifactual realm but also in biology: taking biological functions as (part of the) essences of organs leads to distinctions between principles of activity of organs that biological experts have not yet made. We run our argument on the basis of analyses of artifact and biological functions as developed in philosophy of technology and of biology, thus importing results obtained outside of metaphysics into the debate on ontological realism. In return, our argument shows that a position in metaphysics provides experts reason for trying to detect differences between principles of activities of artifacts and organs that have not been detected so far. (shrink)

In Parts of Classes (1991) and Mathematics Is Megethology (1993) David Lewis defends both the innocence of plural quantification and of mereology. However, he himself claims that the innocence of mereology is different from that of plural reference, where reference to some objects does not require the existence of a single entity picking them out as a whole. In the case of plural quantification . Instead, in the mereological case: (Lewis, 1991, p. 87). The aim of the paper is to (...) argue that one—an innocence thesis similar to that of plural reference is defensible. To give a precise account of plural reference, we use the idea of plural choice. We then propose a virtual theory of mereology in which the role of individuals is played by plural choices of atoms. (shrink)

Since Machery et al. _Cognition_ 92, B1-B12 ( 2004 ) attacked Kripke’s refutation of classical descriptivism, their experiment has been repeated several times, in its original version or in some revised ones, by theorists with contrasting intents. Some repeated the experiment for confirming its results, others for proving them unreliable. One striking characteristic of those surveys is that they mostly replicated the data collected in Machery et al.’s _Cognition_ 92, B1-B12, 2004 experiment: less than 60% of Westerners showed preference for (...) the causal-historical response. We side with the critics of Machery et al.’s experiment. In this paper, we present the results of a survey that tests some hypotheses for explaining that percentage of Westerners’ preferences without taking it as evidence that more than 40% of Westerners have descriptivist intuitions on semantic reference. The aim of our paper is not merely to question the reliability of Machery et al.’s experiment. In sections 4 and 5 we assess the impact of our survey on the current debate in experimental semantics. We provide a novel account of the nature of the epistemic ambiguity that affects experiments in theory of reference and explain the consequences that our account of the epistemic ambiguity has for subsequent works trying to avoid ambiguities. (shrink)

A recurrent theme in the characterization of synthetic biology is the role of engineering. This theme is widespread in the accounts of scholars studying this field and the biologists working in it, in those of the biologists themselves, as well as in policy documents. The aim of this article is to open this black-box of engineering that is supposed to influence and change contemporary life sciences. Too often, both synthetic biologists and their critics assume a very narrow understanding of what (...) engineering is about, resulting in an unfruitful debate about whether synthetic biology possesses genuine engineering methodologies or not. By looking in more detail to the diversity of engineering conceptions in debates concerning synthetic biology, a richer perspective can be developed. In this article, I will examine five influential ways in which engineering is understood in these debates, namely engineering as applied science, as rational methodology, context-sensitive practice, cunning activity or design. The claim is first of all thus to argue that engineering must not be seen as something stable or characterized by a fixed essence. It rather has multiple meanings and interpretations. Secondly, the claim is that most of the debates on synthetic biology cannot be indifferent towards the question which conception of engineering is at play, since the specific questions and concerns that pop up depend to a great extent on the precise conception of engineering one has in account. Many of the existing debates around synthetic biology can thus be reinterpreted and readdressed once one is aware of which conception of engineering is at play. (shrink)