BackgroundInnovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accommodate these innovations and comply with ethical, legal and regulatory requirements. This paper explores how Dynamic Consent may provide solutions to address challenges encountered when researchers invite individuals to participate in research and follow them up over time in a continuously changing environment.MethodsAn interdisciplinary workshop jointly organised by the University of Oxford (...) and the COST Action CHIP ME gathered clinicians, researchers, ethicists, lawyers, research participants and patient representatives to discuss experiences of using Dynamic Consent, and how such use may facilitate the conduct of specific research tasks. The data collected during the workshop were analysed using a content analysis approach.ResultsDynamic Consent can provide practical, sustainable and future-proof solutions to challenges related to participant recruitment, the attainment of informed consent, participant retention and consent management, and may bring economic efficiencies.ConclusionsDynamic Consent offers opportunities for ongoing communication between researchers and research participants that can positively impact research. Dynamic Consent supports inter-sector, cross-border approaches and large scale data-sharing. Whilst it is relatively easy to set up and maintain, its implementation will require that researchers re-consider their relationship with research participants and adopt new procedures. (shrink)

Personalized medicine aims to tailor disease prevention, diagnosis, and treatment to individuals on the basis of their genes, lifestyle and environments. Patient and interest organizations may potentially play an important role in the realization of PM. This paper investigates the views and perspectives on PM of a variety of PIOs. Semi-structured telephone interviews were conducted among leading representatives of 13 PIOs located in Europe and North-America. The data collected were analysed using a conventional content analysis approach. The PIO representatives supported (...) the realization of PM but feared that many financial, structural and organizational challenges may delay its realization. They encouraged strategies to modernize drug licencing mechanisms, develop research and data sharing infrastructures, and educate patients and health care professionals in PM. Notably, they emphasized the importance of developing PM in an equitable way and taking into consideration the patients’ needs, values and personal situation. Despite varying levels of awareness regarding PM, the PIO representatives expressed willingness to engage in the PM agenda and recommended that PIOs work closely with policy-makers to design PM in a way that truly addresses the needs and concerns of patients. PIOs have the potential to become central drivers of the PM agenda. Collaborations should be further developed between PIOs, researchers, drug developers and health care authorities. (shrink)

The pressures that led to the evolution of episodic memory have recently seen much discussion, but a fully satisfactory account of them is still lacking. We seek to make progress in this debate by taking a step backward, identifying four possible ways that episodic memory could evolve in relation to simulationist future planning—a similar and seemingly related ability. After distinguishing each of these possibilities, the paper critically discusses existing accounts of the evolution of episodic memory. It then presents a novel (...) argument in favor of the view that episodic memory is a by-product of the evolution of simulationist future planning. The paper ends by showing that this position allows for the maintenance of the traditional view that episodic memory operates on stored memory traces, as well as explaining a number of key features of episodic memory: its being subject to frequent and systematic errors, its neural co-location with the capacity for simulationist future planning, and the potential existence of non-human episodic memory. (shrink)

Moritz Schulz explores counterfactual thought and language: what would have happened if things had gone a different way. Counterfactual questions may concern large scale derivations or small scale evaluations of minor derivations. A common impression, which receives a thorough defence in the book, is that oftentimes we find it impossible to know what would have happened. However, this does not mean that we are completely at a loss: we are typically capable of evaluating counterfactual questions probabilistically: we can say (...) what would have been likely or unlikely to happen. Schulz describes these probabilistic ways of evaluating counterfactual questions and turns the data into a novel account of the workings of counterfactual thought. (shrink)

Most epistemologists hold that knowledge entails belief. However, proponents of this claim rarely offer a positive argument in support of it. Rather, they tend to treat the view as obvious and assert that there are no convincing counterexamples. We find this strategy to be problematic. We do not find the standard view obvious, and moreover, we think there are cases in which it is intuitively plausible that a subject knows some proposition P without—or at least without determinately—believing that P. Accordingly, (...) we present five plausible examples of knowledge without (determinate) belief, and we present empirical evidence suggesting that our intuitions about these scenarios are not atypical. (shrink)

The present paper is the third and final piece of an ongoing and as of yet unfinished dialog on normative issues about rationality and the self. After specifying the differences, yet also the actual – and to some extent: unexpected – agreements between myself and Menachem Fisch, I argue that the latter are more substantial and far-reaching. This is an assumption I seek to justify by unpacking the implications of Fisch’s core idea, according to which being rational in the fullest (...) human sense goes hand in hand with and in fact depends on being (able to be) a self. However, I also argue that some remaining shortcomings in Fisch’s account are mainly due to the latter’s all too liberal notion of rationality (“acting for a reason”) – shortcomings, which in my view can easily be remedied by a more restricted account, according to which acting for a reason only counts as rational, if and to the extent that the agent is “responsive to reasons,” i. e. willing to call his claim to being and acting rationally into question, whenever that claim is (expected to be) challenged by his peers. This notwithstanding, the entire conversation between Fisch and myself is arguably itself an instance of what it is about: a dialog concerning issues of rationality in the environment and spirit of a rationality conceived of as irreducibly dialogical. (shrink)

In terms of Groenendijk and Stokhofs (1984) formalization of exhaustive interpretation, many conversational implicatures can be accounted for. In this paper we justify and generalize this approach. Our justification proceeds by relating their account via Halpern and Moses (1984) non-monotonic theory of only knowing to the Gricean maxims of Quality and the first sub-maxim of Quantity. The approach of Groenendijk and Stokhof (1984) is generalized such that it can also account for implicatures that are triggered in subclauses not entailed by (...) the whole complex sentence. (shrink)

This paper argues that the exclusion problem for mental causation can be solved by a variant of non-reductive physicalism that takes the mental not merely to supervene on, but to be grounded in, the physical. A grounding relation between events can be used to establish a principle that links the causal relations of grounded events to those of grounding events. Given this principle, mental events and their physical grounds either do not count as overdetermining physical effects, or they do so (...) in a way that is not objectionable. (shrink)

This paper deals with the recent policies introduced in Brazil in order to foster a public interest towards science. Persuasive messages and strategies aiming at increasing a public awareness of the importance of scientific literacy for the development of the country are introduced at different levels and targeting different kinds of publics. These policies are analysed in view of classical models of social influence and persuasion.

In this paper an approach to the exhaustive interpretation of answers is developed. It builds on a proposal brought forward by Groenendijk and Stokhof (1984). We will use the close connection between their approach and McCarthy's (1980, 1986) predicate circumscription and describe exhaustive interpretation as an instance of interpretation in minimal models, well-known from work on counterfactuals (see for instance Lewis (1973)). It is shown that by combining this approach with independent developments in semantics/pragmatics one can overcome certain limitations of (...) Groenenedijk and Stokhof's (1984) proposal. In the last part of the paper we will provide a Gricean motivation for exhaustive interpretation building on work of Schulz (to appear) and van Rooij and Schulz (2004). (shrink)

A knowledge-based decision theory faces what has been called the prodigality problem : given that many propositions are assigned probability 1, agents will be inclined to risk everything when betting on propositions which are known. In order to undo probability 1 assignments in high risk situations, the paper develops a theory which systematically connects higher level goods with higher-order knowledge.

Many philosophers appeal to intuitions to support some philosophical views. However, there is reason to be concerned about this practice as scientific evidence has documented systematic bias in philosophically relevant intuitions as a function of seemingly irrelevant features (e.g., personality). One popular defense used to insulate philosophers from these concerns holds that philosophical expertise eliminates the influence of these extraneous factors. Here, we test this assumption. We present data suggesting that verifiable philosophical expertise in the free will debate-as measured by (...) a reliable and validated test of expert knowledge-does not eliminate the influence of one important extraneous feature (i.e., the heritable personality trait extraversion) on judgments concerning freedom and moral responsibility. These results suggest that, in at least some important cases, the expertise defense fails. Implications for the practice of philosophy, experimental philosophy, and applied ethics are discussed. (shrink)

SNOMED CT is a clinical terminology that uses logical axioms to provide terms with meaning. This enforces precise agreements about the ontological nature of the entities denoted by the terms, commo...