Phage DNA packaging occurs by DNA translocation into a prohead. Terminases are enzymes which initiate DNA packaging by cutting the DNA concatemer, and they are closely fitted structurally to the portal vertex of the prohead to form a ‘packasome’. Analysis among a number of phages supports an active role of the terminases in coupling ATP hydrolysis to DNA translocation through the portal. In phage T4 the small terminase subunit promotes a sequence‐specific terminase gene amplification within the chromosome. This link between (...) recombination and packaging suggests a DNA synapsis mechanism by the terminase to control packaging initiation, formally homologous to eukaryotic chromosome segregation. (shrink)

The AMA Council on Ethical and Judicial Affairs (CEJA) has written a position paper on how social medical use challenges medical professionalism. The report offers persuasive ethical and practical guidelines for nonclinical internet use, specifically for social networking.This commentary provides a framework from which to apply these guidelines, but adds that there may be important situations in which physicians are not able to act in accordance. The guidelines call for professional reporting of questionable online portrayals or behaviors, but this commentary (...) argues that this may be not only cumbersome to implement, but may violate aspects of constitutional rights. While online social networking may in many ways be a new application of old challenges, there may be other aspects that require novel approaches to medical professionalism. (shrink)

In the Glossary-codex, Vat. Lat. 1469, written in the year 908, fol. 83 has been assigned to ‘glossae collectae.’ They begin : In Passione Apostolorum. Iussit eum inaumachia cathomis consumi. Cathomis: uirgis nodosis. Hie naumachia forum signat Romanorum quod Prorostris dicitur eo quod rostra, etc.. In Sancto Sebastiano. Saturnus apocatasticus : id est dispositor et destructor fatorum. Annus tuus ex diametro susceptus est. Diametrum est, etc. ‘Glossae collectae’ from the Bible and from Jerome's prefaces come next.

Charisivs, in his chapter on Adverbs, cites for Hispane a line of Ennius' Annals : Hispane, non Romane memoretis loqui me. Professor Norden , the apostle of Combinations-forschung, combines this fact with another fact mentioned by Livy , the celebre per Hispaniam responsum of a Spanish town to a Roman embassy. But why does he ignore a third fact which must be brought into any combination that can be convincing—the quotation of this line of Ennius by Festus in a paragraph (...) which apparently deals with Graeco-Roman affinities ? (shrink)

The line is preserved in a passage of Consentius ‘De Barbarismis et Metaplasmis’ : sicut Lucilius ‘ore corupto’; dempsit enim unam litteram per metaplasmum, r; et Ennius ‘huic statuam,’ etc.

Everyone interested in Latin Etymology knows the last word on mehercle, that the old vocative of meus is prefixed to the old Second Declension form Herclus, Voc. -lě. Without discussing whether this explanation is wholly true or partly wrong, I wish here to disqualify two pieces of evidence. Both originate from a marginal annotation on Rufinus' translation of Eusebius' Church History in, I think, a seventh-century English MS. These marginalia were used for the Leyden Glossary and for the common source (...) of the E E and Corpus Glossaries. The compiler of Leid. transferred them unaltered to his pages; and in the section devoted to Rufinus glosses we find Mehercule: mi fortis. The other compiler often recasts them for dictionary purposes. He gave this item the form Herculus: fortis . But of course the original annotation mi fortis was a mere lucky guess, and the substitution of ‘Herculus’ for Hercules was sheer ignorance. (shrink)

The narrow limits of the apparatus criticus in the new Clarendon Press edition have excluded these suggestions, which may find a place here:I xxix, 4 Quaedam etiam facta sunt ex nominum deriuatione, ut a prudentia ‘prudens ’; quaedam etiam ex uocibus, ut a garrulitate ‘garrulus.’ Although garrulus is the traditional reading, the derivation elsewhere of garrulus from graculus, ‘a jackdaw,’ suggests that we may read here ut a garrulitate ‘graulus.’ For the jackdaw's name in Late Latin developed from gragulus to (...) graulus. (shrink)

Egypt has not yet given us a Greek original of Plautus, unless the paltry Hibeh fragments belong to the original of the Aulularia. If they do, then Plautus departed widely from the Greek. And that is what one would expect. Read any ‘sermo’ in Plautus and see how recklessly he abandons himself to the vagaries of his humour. Clearly no ‘icily regular’ Greek is his guide there. Still a ray of light has come from Egypt that illumines one dark spot (...) in Plautus, the end of the first Scene of the Bacchides. The two sisters retreat into the house after a line which appears in our editions in this form. (shrink)

Professor Postgate speaks of ‘the regrettable silence of the principal editors of Plautus upon the subject.’ As a minor editor, I beg to defend my colleagues by pointing out that the scansions dĭŭtíus and dyūtius are subject of a note in Dziatzko's and Hauler's editions of the Phormio of Terence and in the Plautus Report in Bursian of 1879 . Also that a reference to the index of my larger edition of the Captiui will show that the word is discussed (...) in my section on Prosody : ‘The same doubt exists regarding the scansion of diutius , the by-form of the fuller form dĭūtĭŭs .’. (shrink)

Mrs. Dall, in her article A Seventh-Century English Edition of Virgil , shows that Virgil glosses taken from marginalia in the same MS. of the poems often preserve something of their original coherence in the two kindred glossaries, Affatim and the Second Amplonian, in spite of all the reshuffling of these two collections. Thus a small group of Virgil items appears in Affatim on p. 491 of Goetz's apograph : Carecta, Crateras, etc. The second last of this ‘Virgil cluster’ is (...) Cada: vasa vinaria. It appears also in Ampl. II. Ca[t]da: vas vinaria, and in Ampl. I. Cada: vasa vinaria, and is apparently taken , ultimately or immediately, from a marginal annotation on Aen. 1, 195 ‘uina bonus quae deinde cadis onerarat Acestes’ for in the Virgil Glossary printed by Goetz in C.G.L. IV. 427–470 we find Cadis: vasis vinariis. (shrink)

We use the format of a hypothetical case study to review issues related to pharmaceutical product approval and physician prescribing practices. In this case, a new FDA-approved drug is recommended for a patient who subsequently experiences an adverse event that may or may not be related to the prescription. This case raises a number of ethical and legal considerations physicians routinely face when deciding whether to recommend such drugs for their patients. Despite the need for ongoing observation by the regulatory (...) apparatus, physicians should be cognizant of the limitations of the drug approval system and the post-approval prescription drug surveillance system. We discuss physicians’ ethical obligations when faced with a newly approved drug, including seeking out independent sources of learning, reporting adverse effects, and notifying patients about limitations in available knowledge about therapeutic recommendations. (shrink)

The Oxford Classical Texts, or Scriptorum Classicorum Bibliotheca Oxoniensis, are renowned for their reliability and presentation. The series consists of a text without commentary but with a brief apparatus criticus at the front of each page. There are now over 100 volumes, representing the greater part of classical Greek and Latin literature. The aim of the series remains that of including the works of all the principal classical authors. Although this has been largely accomplished, new volumes are still being published (...) to fill the remaining gaps, and old editions are being revised in the light of recent research or replaced. (shrink)

Isidore Etymologiae Vol. II. Books XI-XX.

It has been pointed out above that Festus in his quotations cares more for the completion of the line than of the sense. His normal form is one complete line. So the probability is that Liu. Andr. com. is an Iambic Senarius, with a dactyl in the first foot and hiatus at the pause in the sense.

Amph. prol. 90–91. In the Amphitruo Plautus runs great risk of giving oflence by bringing Jupiter on the stage. In the prologue he conciliates the audience by saying that this Jupiter is no god but a mere actor. : 26 sqq. Etenim ille quois hue iussu uenio Iuppiter Non minu' quam uostrum quiuis formidat malum: Humana matre natus, humano patre, Mirari non est aequom sibi si praetimet.

Cicero defines gloria as frequens de aliquo fama cum laude, ‘much talk about a person to his praise.’ When the talk is by the person himself, the word takes the signification ‘boast’.

The Placidus Glossary was hailed in Ritschl's time as a new clue to Plautus' true text. And Buecheler, Ritschl's pupil, seized on its Alapari est alapas minari, etc., and foisted this verb on Plaut. True. 928. The great Latin Thesaurus quotes the line with this piece of new cloth put on an old garment: nil alapari satiust, miles, instead of the correct philippiari satiust, miles.