© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

It's not about any person who's going to pick it up. No, these addresses fix on a much more glorious, worthy, and fascinating topic: the God, the Creator, the Redeemer as revealed in the Bible. The study of God is like a brilliant diamondwe should keep holding it up to the light to see new details ofits beauty. Before the awe of such a God, what room is there to focus on man? Our only place is to respond to himand (...) even our response does not depend on us! We must not only worship him, but alsoif our worship is to be meaningful and not cheapenedlearn how he is to be worshiped. The Princeton Regional Conference on Reformed Theology presents the following pastor-scholars, who delve into the glory of God and into his grace in making sinners into worshipers: Bryan Chapell - God's Glory Revealed Charles D. Drew - Called by God to Worship Richard D. Phillips - Sought by Christ to Worship Joseph "Skip" Ryan - Guided by God's Sovereign Providence Philip Graham Ryken - Redeemed by God's Sovereign Mercy Michael S. Horton - Sanctifying Grace Richard D. Phillips - Our Holy Redeemer Michael A. G. Haykin - The Spirit of Holiness R. Albert Mohler - Know the Truth D. A. Carson -I Am the Truth Learn from these teachers about the glory of, the providential work of, and our proper response to the amazing God we worship. (shrink)

En 1938-1939, le centenaire de la mort de Johann Adam Möhler provoque en France un retour à l’école théologique de Tübingen piloté par le dominicain Yves Congar, professeur au Saulchoir, et par le jésuite Pierre Chaillet, professeur à Fourvière. Ils y trouvent un recours contre l’ecclésiologie intransigeante, un appui à l’œcuménisme naissant et un rempart contre la menace totalitaire. Au contraire, les théologiens romains voient dans l’œuvre de Möhler une préfiguration du modernisme condamné en 1907. Aussi son livre L’Unité dans (...) l’Église est-il brièvement retiré du commerce en 1939 par le Saint-Office, avant d’inspirer après-guerre l’ecclésiologie du P. Congar. L’épisode est significatif des débats théologiques entre modernisme et Vatican II. (shrink)

Heft 1. Der Laie über die Weishelt, von E. Bohnenstädt.--Heft 2. Über den Beryll. von K. Fleischmann.--Heft 3. Drei Schriften vom verborgenen Gott. De Deo abscondito. De quaerendo Deum. De filiatione Dei. Hrsg. von E. Bohnenstaedt.--Heft. 5. Von Gottes Sehen. De visione Dei. Von E. Bohnenstaedt.--Heft 4. Der Laie über Versuche mit der Waage. Idiota de staticis experimentis. Von H. Menzel-Rogner.--Heft 6-7. Sichtung des Alkorans. Cribratio Alkoran. 1. Buch von P. Naumann. 2.-3. Buch von G. Hölscher.--Heft 8. Über den Frieden (...) im Glauben. De pace fidei. Von L. Mohler.--Heft 9. Vom Können-Sein. De possest. Vom Gipfel der Betrachtung. De apice theoriae. Von E. Bohnenstaedt.--Heft 10. Der Laie über den Geist. Idiota de mente. Von M. Honecker und H. Menzel-Rogner.--Heft 11. Die manthematischen Schriften, übers. von J. Hofmann, mit einer Einführung und Anmerkungen versehen von J.E. Hofmann.-- --Heft 13. Vom Globusspiel. De ludo globi, übers. und mit Einführung und Anmerkungen versehen, von G. von Bredow. --Heft. 15. De docta ignorantia. Die belehrte Unwissenheit. Übers. und mit Vorwort und Anmerkungen von P. Wilpert. (2 v.)--Heft. 16. Compendium. Kompendium. Übers. und mit Einleitung und Anmerkungen hrsg. von B. Decker und K. Bormann.--Heft 17. De coniecturis. Mutmassungen. Übers. und mit Einführung und Anmerkungen hrsg. von J. Koch und W. Happ.--[18] Über den Ursprung. De principio. Deutsch mit Einführung von Maria Feigl.--Heft 19. Die höchste Stufe der Betrachtung. Herausgegeben von Hans Gerhard Senger. (shrink)

jild-i 1. Āzādī va marzʹhāyash -- jild-i 2. Istiqlāl (farhangī).

The struggle over legal abortion access in the United States is a religious controversy, not a scientific debate. Religious activists who believe that meaningful individual life (i.e., “personhood”) begins at a specific “moment-of-conception” are attempting to pass laws that force this view upon all pregnant persons, irrespective of their medical circumstances, individual preferences, or personal religious beliefs. This paper argues that such actions promote a constitutionally prohibited “establishment of religion.” Abortion policy in a secular state must be based upon scientifically (...) accurate biology, not unprovable theological presuppositions. The scientific facts regarding human pregnancy do not support the position that personhood begins with fertilization—at which point a pregnancy does not yet even exist. Abortion policy should regard the embryo/fetus as part of the pregnant individual’s body until delivery. We argue that individual “personhood” only begins when the _latent_ potentialities of the fetal nervous system are _actualized_ in the newborn after delivery. The paper argues that instantiating non-scientific beliefs concerning embryonic/fetal “personhood” into the law as the basis for abortion policy establishes a state-sponsored religion. The protection of religious liberty requires that abortion be decriminalized. Abortion should be treated like any other medical procedure and regulated similarly. To protect both religious freedom and sound medical practice, individual legal personhood should be recognized as beginning only at birth. (shrink)

This book presents three of the works of Abdu'l-Bahá, son of the founder of the Bahá'i Faith, dealing with social and political issues.00In 'The Secret of Divine Civilization' (1875) Abdu'l-Bahá supports the administrative and broader social reforms of Mirzá Hosayn Khán, but looks mainly for organic reform through the efforts of Iranian intellectuals to waken and educate the masses. In this work, Abdu'l-Bahá gives virtuous and progressive Islamic clerics a leading role among these intellectuals, indeed most of his appeals are (...) directed specifically to them. 'A Traveller's Narrative' (1889/90) is an authoritative statement of the broad lines of Bahá'i social and political thinking. 'The Art of Governance' (1892/93) was written as Iran entered a pre-revolutionary phase, and ideas that we recognise today as the precursors of political Islam were spreading. It sets out the principles underlying the ideal relationship between religion and politics and between the government and the people.00In addition to presenting the first parallel text translations of these works, the Persian texts incorporate notes on variants in the early published sources. An introduction outlines the intellectual and political landscape from which Abdu'l-Bahá wrote, and in which his expected readers lived. (shrink)

Bioethicists have recently expressed concern over a lack of quality control within the field. This apprehension focuses on bioethics expanding in ways that obscure its distinctive ethical remit and the specialist reasoning skills it requires. This thesis about the quality and conduct of bioethics may have particular relevance for clinical ethics. As one of the youngest offshoots of bioethics, the field focuses on the ethical issues that arise specifically in a clinical context. However, non-ethics specialists are increasingly involved in this (...) field. This means that clinical ethics could be especially vulnerable to the quality control concerns articulated within bioethics. The growing public profile of clinical ethics means that concerns over quality in this area warrant specific attention by those concerned with declining standards in bioethics and those working in clinical ethics. (shrink)

In addition to the transmission of the science of hadith from the Eastern Islamic world to the west, particularly to Andalusia, a rich literature also developed in Andalusia. Therefore, the development of the science of hadith and hadith methodology in the Andalusian region and the impact of scholars from that region on these sciences is an important issue that deserves attention. This article examines how the intellectual atmosphere of Andalusia was enriched by the hadith works that came from the East (...) and the scholarly activity these works generated. It also addresses the hadith methodology literature that emerged in the Andalusian region and the reflections of this literature in the hadith methodology works of the From this perspective, the study first briefly highlights the hadith and hadith methodology literature that reached Andalusia from the Mashriq region, followed by the works written by Andalusian scholars that contributed to the hadith methodology literature. Subsequently, the influence of hadith methodology works by hadith scholars from the Eastern Islamic world on Andalusian literature is examined. Furthermore, the study evaluates how Andalusian scholars were referenced in the Mashriq hadith methodology literature and their influence on these works. Through this analysis, the interaction between the Mashriq and Andalusian regions within the context of hadith methodology is demonstrated. The contribution of Andalusian scholars to the hadith literature by enriching the knowledge and expertise they received from the East with their interpretations and original works increased the importance of the region in the Islamic world. Additionally, the influence of the hadith methodology works written in Andalusia on Eastern literature reveals the reciprocal nature of cultural interaction. (shrink)

What is the identity of the best regime in Aristotle's Politics? Although there are a few references to the best regime in Book III, the obvious answer is the regime discussed in Books VII and VIII. Aristotle calls it the best regime on numerous occasions and discusses it at great length. Yet, this is not the complete answer. In Book IV Aristotle makes certain curious remarks on the best regime that, on examination, do not fit the best regime of Books (...) VII and VIII. They lead, instead, to the discovery of a systematic, though quiet, teaching on a very different best regime in Book III. The Politics actually contains a complicated yet coherent teaching on two best regimes. Grasping this teaching is key to arriving at a proper understanding of the distinctive character of Aristotle's political thought. (shrink)

Elwyn Richardson’s experimental approach to teaching and learning and Oruaiti was officially sanctioned, but the history of education in Aotearoa/new Zealand shows that teachers have been typically conformist. In this article, I suggest that positivist paradigms from the industrial age continue to shape classroom teaching, partly because of norms of individualism, and partly because neoliberal understandings have become central in the functioning of our schools and society. Teaching is an activity that promotes the ethics of a community or society by (...) promulgating some ideas and marginalising others. In Aotearoa/new Zealand, many of our students struggle with the collective orientation of their community traditions and the societal emphasis on individualism. Modernist beliefs in social progress through technology still permeate education policy. Promoting communitarian understandings requires more open-ended approaches to teaching such as Richardson demonstrated. With digital technologies gaining progressively greater influence in schools, the opportunities for social connectedness have been enhanced alongside an increasing emphasis on individual devices. This article briefly explores interconnections between experimentation, context and community. (shrink)

We prove linear and polynomial growth properties of sets and functions that are existentially definable in the ordered group of integers with divisibility. We determine the laws of addition with order and divisibility.

"(...) Felsefeye ilişkin Arapça ve Fransızca bazı eserleri mütalaa ettiğim sırada felsefi terimlerin bu iki dilde tesadüf ettiğim karşılıklarını bir mecmuaya kaydetmiştim. Bunların perişan bir halde kalmasına ve sarfettiğim emeğin bu şekilde heder olmasına gönlüm razı olmadı. Gerçekten de bu konuda sarfedilen mesai öyle pek kolay feda edilecek bir şey değildi. Çünkü bu işe en evvel, felsefeyi İbn Bâcce'nin en seçkin öğrencilerinden tahsil etmiş olan meşhur Musevi hakîm Ebû İmrân Musa bin Meymun'un Delâletü'l-Hâirîn başlıklı eserinden başlamış idim. Bu kitap İbrani (...) harfleriyle, Arap dili üzere yazılmış olduğundan felsefeye ait fasıllarının Fransızca tercümesiyle tatbikinde pek ziyade güçlük çekmiş idim. Bu eser Avrupaca Guide des Égarés başlığıyla tanınıp, mütekellimlerin mezhebi hakkında en önemli bilgi kaynağı sayılmıştır. Bunu müteakiben, bir taraftan Aristoteles'in bazı eserlerini ve diğer taraftan İbn Rüşd'ün bunlardan iktibâsen yazdığı Telhîsât'ı, Kütübhâne-i Hidivî'den istinsâh ettirerek mütalaa ettim. Sonra da Şehristânî'nin Kitâbü'l-Milel ve'n-Nihal'i, Zevzenî'nin Muhtasar Târîh-i Hukemâ'sı, Fârâbî ile İbn Sînâ'nın bazı eserleri, Ebû Abdullâh el-Kâtib'in Mefâtîhu'l-Ulûm'u, İbnu'n-Nedîm Bağdâdî'nin Kitâbü'l-Fihrist'i gibi Avrupa'da basılmış birtakım nadir kitapları ve diğer birçok mantık kitaplarını gözden geçirerek, bunlardan her ne buldumsa aldım. Bu şekilde cem ettiğim kelimeler ve tabirler büyücek bir mecmua teşkil etmiş ise de bunlar mantık ve eski felsefeye ait olduğundan yeni terimlerin de karşılıklarını bulmak lazım geldi. Bu noksanı da âcizâne kütüphanemde mevcut lûgat kitaplarından Fransız ve İngiliz ve Arap ve Fars dillerine ait olan kamuslara müracaat ederek ve bunlarla maksadın temini mümkün olamadığı halde kelimelerin etimolojik anlamlarına nazaran birer tabir bulmak suretiyle mümkün mertebe ikmal etmek üzere bu Lûgatçe'nin tertip ve tanzimine başladım. Ve Bulletin de la Société Française de Philosophie başlığıyla yayınlanmakta olan süreli yayının bazı numaralarında, 1904 senesinden beri yer almış ve bu kere son bulmuş ise de henüz ayrıca kitap şeklinde toplanmamış olan Yeni Felsefe Lûgatçesi'ni başlıca kaynak kabul ederek, buna dâhil edilmiş olan yeni terimlerin hemen hepsini aldım. E. Goblot'nun Felsefe Lûgatçesi'yle diğer lûgatçelerde mananın açıklık kazanmasına hizmet ediyor gördüğüm özet bilgileri de ait oldukları kelimelere ilave ettim. Kısacası bu naçiz eser, diğer lûgatlerin hiçbirine henüz geçmemiş olan yeni felsefe terimlerinden başka felsefeyle ilgili olan tıp bilimine ve sosyal ve ekonomik bilimlere ait bir hayli kelimeleri de içermektedir. Bununla beraber âcizâne eserimin pek noksan olduğunu ve ancak ilim ve irfan erbabının tashih kalemleri için hazırlanmış bir müsveddecik teşkil edebileceğini itiraf ederim. Yegâne emelim mütalaa erbabına naçizâne bir hizmette bulunarak hayır ile yâd olunmaya hak kazanmaktan ibaret olduğundan görülecek hataların iyi niyetime bağışlanacağı ümidindeyim". İsmail Fenni Ertuğrul. (shrink)