Children’s intentions should be respected. Parents are the key persons involved in decision-making related to their children. In Japan, the appropriate ages and standards for a child’s consent and assent, approval, and decision-making are not clearly defined, which makes the process of obtaining consent and assent for clinical research complex. The purpose of this paper is as follows: to understand the attitudes and motives of parents concerning children’s participation in medical research and the factors influencing their decision-making. We also sought (...) to clarify who has the right to be involved in decisions regarding children’s participation in research. A semi-structured Internet survey on parents’ opinions and attitudes and preferences concerning medical research involvement was conducted. Children were divided into three age groups (6–10-year-olds, 11–14-year-olds, and 15–18-year-olds), with three illness severity categories. Possible correlations between the number of children, children’s ages, parents’ educational levels, and parents’ attitudes were examined. Among the participants, 42.3% recognized the term “informed consent.” The proportion of participants who understood “informed consent” increased with educational level. Four out of five participants did not know, or had not heard of, the term “informed assent.” Furthermore, the percentage of those who understood the term “informed assent” increased with academic level. Participants generally believed in prioritizing parents’ opinions over children’s, and that parents and children would ideally reach a joint decision. Although many parents favored collaborative decision-making, they also wanted their own will reflected in the decision and felt they should receive important information before their children do. Decision-making was affected by the condition’s severity and prognosis. This indicates that most Japanese parents believe that their children have the right to know their disease name and treatment; nonetheless, they should be protected. Parents’ values and judgments regarding medical intervention involving their children varied. Children’s ability to consent to treatment and research believed to be in their best interests should be assessed appropriately. They should be permitted to provide consent or assent, and their views should be respected. Involving children in decision-making fosters more open communication and transparency between medical professionals, parents, and children. (shrink)

The exocyst is a conserved octameric complex that physically tethers a vesicle to the plasma membrane, prior to membrane fusion. It is important not only for secretion and membrane delivery but also, in mammalian cells, for cytokinesis, ciliogenesis, autophagy, tumorigenesis, and host defense. The combination of genome editing and advanced light microscopy of exocyst subunits in living cells has recently shown the complex to be much more dynamic than previously appreciated, and exposed how little we still know about its function (...) and regulation. (shrink)

The Millennium Development Goals were criticised for failing to address the issue of governance, and the associated notions of responsibility and accountability. The Sustainable Development Goals, we argue, need to recognise the structural constraints facing poor countries – the power imbalances in the global economic system that limit their ability to promote the prosperity and well-being of their people, as was clearly brought out by the Commission on Global Governance for Health, of which we were both members [Ottersen, O. P., (...) J. Dasgupta, C. Blouin, Paulo Buss, Virasakdi Chongsuvivatwong, Julio Frenk, Sakiko Fukuda-Parr, et al. 2014. “The Political Origins of Health Inequality: Prospects for Change.” Lancet 383: 630–667]. This article is divided into three parts. We begin by making the case for a global justice perspective which emphasises the responsibility – and hence also accountability – of international organisations and rule-making bodies. We next demonstrate the limitations of accountabi.. (shrink)

The paper is concerned with the development of the paradoxical theme of Daoism. Based on Chad Hansen's interpretation of Daoism and Chinese philosophy in general, it traces the history of Daoism by following their treatment of the limit of language. The Daoists seem to have noticed that there is a limit to what language can do and that the limit of language is paradoxical. The 'theoretical' treatment of the paradox of the limit of language matures as Daoism develops. Yet the (...) Daoists seem to have noticed that the limit of language and its paradoxical nature cannot be overcome. At the end, we are left with the paradoxes of the Daoists. In this paper, we jump into the abyss of the Daoists' paradoxes from which there is no escape. But the Daoists' paradoxes are fun! (shrink)

Feinberg and Mallatt, in their presentation of neurobiological naturalism, have suggested that visual consciousness was acquired by early vertebrates and inherited by a wide range of descendants, and that its neural basis has shifted to nonhomologous nervous structures during evolution. However, their evolutionary scenario of visual consciousness relies on the assumption that visual consciousness is closely linked with survival, which is not commonly accepted in current consciousness research. We suggest an alternative idea that visual consciousness is linked to a specific (...) class of agency, consequently justifying their phylogenetic claim. We also examine the implication of their phylogenetic claim: visual consciousness is homologous across vertebrates, but its neural basis is not. This apparent incongruence illustrates a general phenomenon of homology, and that the resulting hierarchical view of visual consciousness and its neural basis can be straightforwardly accommodated by neurobiological naturalism. Throughout these discussions, we aim to address the potential theoretical issues in neurobiological naturalism and refine the picture illustrated by Feinberg and Mallatt regarding phylogenetic distribution and trajectories of visual consciousness. (shrink)

In the 1958-1959 Collège de France course, Merleau-Ponty expounds a detailed commentary on the last paragraphs of the Einleitung from Hegel’s Phenomenology of Spirit. We examine in what sense this course has developed the notions that he was in the process of defining, notions such as “chiasm,” “reversibility,” “depth,” and “flesh.” What seems crucial in this course is to clearly define good ambiguity as opposed to bad ambiguity, that is, to the simple mixture of finitude and universality, of interiority and (...) exteriority. It is a question then of revealing, even within Hegelian thought, the operation, although unstable, of good ambiguity and of instituting it beyond the distinction between anthropology and logic without a return to naturalism. It should first be noted that consciousness is for Hegel violence against itself, it gives itself its measure, such that the distinction between measuring and measured is internal to it. By insisting on this “reversibility” of the measuring and the measured, Merleau-Ponty comes to emphasize that the self-relation of consciousness is simultaneously its opening onto a transcendent – an opening whereby it learns something. This leads him to define “the new ontological milieu” which is the depth of the life of consciousness. It is within this depth that the interrogative experience winds on itself. Secondly, if there truly must be a moment where the Hegelian Zweideutigkeit becomes good ambiguity, it will not suffice to explore preobjective depth; it would still be necessary to discern “the hinge” which is “solid, unwavering” and which “remains irremediably hidden.” It is this unwavering hinge that supports phenomena and that, in simultaneously decentering and recentering the fields of appearances, opens a place where one can follow the genesis of sense. Finally, we note that this discovery of the new ontological milieu can be considered as the recovery of the notion of institution that Merleau-Ponty had proposed in 1954-1955: on the one hand, the notion of chiasm invites us to reveal the hinge which at once decenters and recenters the fields of appearances. This hinge is free from the alternative of nature and culture, of subjective and objective spirit; it is the rootedness of our interrogative experience in brute being, which is not object but starts an indefinite search of self. But, on the other hand, the notion of institution, which is essentially descriptive and factual, makes us better feel the weight of the instituted that is also irremediably hidden. It makes us feel the inertia of the instituting event, as well as its fecundity and its cumulativity. (shrink)

The Genesis of the Social and the Carnal Donation of the Non-Presentable. The Range of the Notion of Institution in Merleau-PontyThis article examines the range of the notion of institution that Merleau-Ponty proposes in his course at the Collège de France (1954-55), by notably insisting on the importance of the question of the genesis of the social for the deepening of his thought. By broadening his investigative domains in two complementary directions (that is, lateral passivity and socio-historical institution), Merleau-Ponty aims (...) in this course to grasp in a better way the lateral relations of our Urstiftung (originary institution) and the instituting subject who obliquely goes beyond the institution towards its sense. That leads him to introduce the perceptual field as being essentially lacunary, because it marks a place where the consciousness is present at the divergence in relation to consciousness. It is certain that the Phenomenology of Perception addressed this question by considering the social as a place where “I am given to myself”. However, the psychological starting point of this work, as well as the originary temporal and unilateral character of radical reflection, prevented one from really grasping the institutional junction of the concrete event and the symbolic matrix. One was not able to thematize an auto-articulation which appears suddenly between radical reflection and the unreflective. This is why Lévi-Strauss’ structuralist thought, by considering the social as symbolism, allows for a better understanding of this institutional nexus. But this idea does not lead to the dogmatic positing of the reality and the autonomy of the social. Instead, it encourages us to practice “the perception of history,” which consists in guessing, in the very process of sociological idealization, the carnal and wild donation of the non-presentable. Far from returning to psychologism, this perception aims at actively achieving the movement internal to the symbolic, that is, its incarnation.La genesi del sociale e la donazione carnale del non-presentabile. La portata della nozione di istituzione in Merleau-PontyQuesto articolo esamina la portata della nozione d’istituzione che Merleau-Ponty propone nel suo corso al Collège de France del 1954-1955, insistendo in particolare sull’importanza della questione della genesi del sociale per l’approfondimento del suo pensiero.Estendendo i propri domini di ricerca in due direzioni complementari (la passività laterale e l’istituzione socio-storica), Merleau-Ponty si propone in questo corso di cogliere meglio i rapporti laterali della nostra Urstiftung (l’istituzione originaria) e del soggetto istituente che la supera obliquamente in direzione del suo senso. Ciò induce a presentare il campo percettivo come essenzialmente lacunoso, poiché manca di un luogo dove la coscienza possa assistere allo scarto rispetto a se stessa.È certo che la Fenomenologia della percezione affrontava questa questione considerando il sociale come un luogo dove “io sono donato a me stesso”. I presupposti psicologici di quest’opera, così come il carattere originariamente temporale e unilaterale della riflessione radicale, impedivano tuttavia di cogliere in maniera adeguata il legame istituzionale dell’evento concreto e della matrice simbolica, e di tematizzare un’autoarticolazione che sorgesse tra la riflessione radicale e l’irriflesso.È per questo motivo che il pensiero strutturalista di Lévi-Strauss, che considerava il sociale come simbolismo, permette di comprendere meglio questo nesso istituzionale. Quest’idea non conduce però a porre dogmaticamente la realtà e l’autonomia del sociale, essa incita piuttosto a praticare “la percezione della storia” che consiste nell’individuare, nel processo stesso dell’idealizzazione sociologica, la donazione carnale e selvaggia del non-presentabile. Lungi dal rappresentare un ritorno allo psicologismo, questa nozione di percezione mira a completare attivamente il movimento interno al simbolico, ovvero la sua incarnazione. (shrink)

Contemplating one’s own death is a core aspect in the history of Western philosophy. In the modern era, existential philosophy has inherited this tradition and established unique discussions on the concept of “_my_ death,” resting on the premise that this concept is unapproachable via scientific inquiry. Conversely, biological research is essentially conducted within the scope of life phenomena, with death being referred to in the sense of lifespan; thus, death is not among its inherent themes, which automatically excludes the concept (...) of _my_ death from its scope. To establish a dialogue between the two fields, this study questions the widely held premise that _my_ death is unrelated to science and is best examined by philosophy. I consider the movement between continuity and discontinuity as foundational to scientific development, and integrate it with the relationship between the unknown and known. Furthermore, I extend this to the concepts of consciousness and body, and subsequently clarify and define the unknown divisions. Finally, I examine the kinds of unknowns that science confronts to interpret philosophically how an aspect of reproductive theory has unwittingly revealed a completely new dimension of life: _my_ death. Overall, I argue that _my_ death is an essential point of contact between philosophy and biology that reveals the scholarly significance of the unknown. (shrink)

Proof-theory has traditionally been developed based on linguistic (symbolic) representations of logical proofs. Recently, however, logical reasoning based on diagrammatic or graphical representations has been investigated by logicians. Euler diagrams were introduced in the eighteenth century. But it is quite recent (more precisely, in the 1990s) that logicians started to study them from a formal logical viewpoint. We propose a novel approach to the formalization of Euler diagrammatic reasoning, in which diagrams are defined not in terms of regions as in (...) the standard approach, but in terms of topological relations between diagrammatic objects. We formalize the unification rule, which plays a central role in Euler diagrammatic reasoning, in a style of natural deduction. We prove the soundness and completeness theorems with respect to a formal set-theoretical semantics. We also investigate structure of diagrammatic proofs and prove a normal form theorem. (shrink)

Recent neuroscience studies have reported that neurofeedback training with the use of functional magnetic resonance imaging enables the regulation of an individual’s cognitive, emotion-related, and behavioral states through a real-time representation of her brain activities. Since this technique has been applied not only to clinical research to, for example, mitigate mental or psychiatric symptoms but also to non-clinical research to, for example, change the cognition or preferences of a so-called healthy participant, neurofeedback-based cognitive and/or moral enhancements may be realized in (...) the future. However, neurofeedback-based human enhancement is not the only issue that requires neuroethical consideration. I examine why and to what extent the dual application of neurofeedback technique will blur the lines between the mental, the social, and the moral, threatening some social norms, such as individual freedom and diversity. First, I consider the link between the mental and the social in psychiatry. Examining the definition of “mental disorder” provided by the American Psychiatric Association, I show that the mental is partly defined through social performance. Second, I make explicit the link between the social and the moral and argue that moral evaluation of an activity is gently but positively correlated with its social evaluation. Third, I demonstrate the links between the mental, the social, and the moral. In spite of a great deal of effort to distinguish these notions, the possibility of the dual application of this technique blurs the lines between them. Fourth, I examine whether such blurred lines signal sociocultural evolution or dystopia and argue that it can be understood as a beginning of the second advent of ethical virtue. I conclude that further cautious consideration of neuroethics is required because the establishment of this technique may have unique influences on our society. (shrink)

This paper aims to examine the evolution of Japanese studies of international relations since the end of World War II. In so doing, in particular, this paper first looks at the dominant trends and characteristics of Japanese scholarship in this field, and, second, the correlations between the scholarship and Japan's experiences in real international relations. In discussing the evolution of Japanese studies of international relations, I shall divide the years since 1945 into three separate periods: (1) 194589, and (3) 1990 (...) and after. Then, taking the current US–Japan relationship as a case study, I will examine the contemporary characteristics of Japanese scholarship in this field. (shrink)

Sleep is a fundamental property conserved across species. The homeostatic induction of sleep indicates the presence of a mechanism that is progressively activated by the awake state and that induces sleep. Several lines of evidence support that such function, namely, sleep need, lies in the neuronal assemblies rather than specific brain regions and circuits. However, the molecular mechanism underlying the dynamics of sleep need is still unclear. This review aims to summarize recent studies mainly in rodents indicating that protein phosphorylation, (...) especially at the synapses, could be the molecular entity associated with sleep need. Genetic studies in rodents have identified a set of kinases that promote sleep. The activity of sleep-promoting kinases appears to be elevated during the awake phase and in sleep deprivation. Furthermore, the proteomic analysis demonstrated that the phosphorylation status of synaptic protein is controlled by the sleep-wake cycle. Therefore, a plausible scenario may be that the awake-dependent activation of kinases modifies the phosphorylation status of synaptic proteins to promote sleep. We also discuss the possible importance of multisite phosphorylation on macromolecular protein complexes to achieve the slow dynamics and physiological functions of sleep in mammals. (shrink)

The capacity of visual working memory (VWM) refers to the amount of visual information that can be maintained in mind at once, readily accessible for ongoing tasks. In healthy young adults, the capacity limit of VWM corresponds to about three simple objects. While some researchers argued that VWM capacity becomes adult-like in early years of life, others claimed that the capacity of VWM continues to develop beyond middle childhood. Here we assessed whether VWM capacity reaches adult levels in adolescence. Using (...) an adaptation of the visual change detection task, we measured visual working memory capacity estimates in 13 year-olds, 16-year-olds, and young adults. We tested whether the capacity estimates observed in early or later years of adolescence were comparable to the estimates obtained from adults. Our results demonstrated that the capacity of VWM continues to develop throughout adolescence, not reaching adult levels even in 16 year-olds. These findings suggest that VWM capacity displays a prolonged development, similar to the protracted trajectories observed in various other aspects of cognition. (shrink)

The moral status of human brain organoids (HBOs) has been debated in view of the future possibility that they may acquire phenomenal consciousness. This study empirically investigates the moral sensitivity in people’s intuitive judgments about actions toward conscious HBOs. The results showed that the presence/absence of pain experience in HBOs affected the judgment about the moral permissibility of actions such as creating and destroying the HBOs; however, the presence/absence of visual experience in HBOs also affected the judgment. These findings suggest (...) that people’s intuitive judgments about the moral status of HBOs are sensitive to the valence-independent value of phenomenal consciousness. We discuss how these observations can have normative implications; particularly, we argue that they put pressure on the theoretical view that the moral status of conscious HBOs is grounded solely in the valence-dependent value of consciousness. We also discuss how our findings can be informative even when such a theoretical view is finally justified or when the future possibility of conscious HBOs is implausible. (shrink)

CETTE THESE SE VEUT UNE CONTRIBUTION A LA COMPREHENSION DE LA DERNIERE PHILOSOPHIE DE MERLEAU-PONTY, EN PRENANT COMME FIL CONDUCTEUR LA NOTION D'INSTITUTION. NOUS ESSAYONS D'ABORD DE DELIMITER LE CHAMP D'INTERROGATION DE LA NOTION D'INSTITUTION, TELLE QU'ELLE EST PRESENTEE DANS SES DEUX PREMIERS OUVRAGES. DEUXIEMEMENT, LA DESCRIPTION DE QUATRE ORDRES DE L'INSTITUTION SYMBOLIQUE (ANIMALITE ET VIE; STYLE ARTISTIQUE; LANGUE ET IDEALITE; SYSTEME SOCIAL) QUE NOUS NOUS EFFORCONS DE RECONSTITUER A L'AIDE DES MANUSCRITS INEDITS CONDUIT A DEVOILER LES MOTIVATIONS DE LA (...) RADICALISATION DE LA QUESTION PHENOMENOLOGIQUE. ENFIN, NOTRE PROBLEMATIQUE SE PRESENTE DANS LE DERNIER OUVRAGE COMME UN PROJET DE L'INSTITUTION DE LA PHILOSOPHIE ELLE-MEME. CE PROJET A SA PORTEE HISTORIQUE, SE PROPOSANT DE METTRE EN EVIDENCE LES MOMENTS FECONDS DANS L'HISTOIRE DE LA PHILOSOPHIE, DE MANIERE A LEVER LES DIFFICULTES DE L'ONTOLOGIE ACTUELLE. (shrink)

Internet services, such as review sites, FAQ sites, online auction sites, online flea markets, and social networking services, are essential to our daily lives. Each Internet service aims to promote information exchange among people who share common interests, activities, or goods. Internet service providers aim to have users of their services actively communicate through their services. Without active interaction, the service falls into disuse. In this study, we consider that an Internet service has a network externality as its main feature, (...) and we model user behavior in the Internet service with network externality as a dynamic game. In particular, we model the diffusion process of users of an ISNE as an infinite-horizon extensive-form game of complete information in which: each user can choose whether or not to use the ISNE in her/his turn and the network effect of the ISNE depends on the history of each player’s actions. We then apply Markov perfect equilibrium to analyze how to increase the number of active users. We derive the necessary and sufficient condition under which the state in which every player is an active user is the unique Markov perfect equilibrium outcome. Moreover, we propose an incentive mechanism that enables the number of active users to increase steadily. (shrink)

Many functional glycoproteins are expressed on the lymphocyte cell surface. Some of them carry O-linked oligosaccharides (O-glycans), which are conjugated through serine or threonine residues. During various biological processes, including T-cell activation, a tetrasaccharide on the T-cell surface is dramatically converted to a branched hexasaccharide, called core2 O-glycan. The same structural change in O-glycans is also found on the lymphocytes from patients with immunodeficiency conditions such as Wiskott-Aldrich syndrome and AIDS. Several studies revealing the roles of core2 O-glycans in immune (...) responses show that this is a biologically significant change. In particular, core2 O-glycans expressed on the cell surface reduce cell–cell interactions, thereby regulating immune responses. Furthermore, core2 O-glycan is a key backbone structure in forming selectin ligands. Thus, O-linked oligosaccharides, in particular those containing core2 branches, play vital roles in immune responses and may play dual roles in certain situations. This review will summarize the results obtained from various studies investigating the roles of O-glycans in immunological processes. BioEssays 23:46–53, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

La figure du chat fait son apparition dans la littérature japonaise au ixe siècle, mais son image évoluera de manière inattendue à l’époque médiévale. Des témoignages littéraires du xie et du xiie siècle, tels que les Notes de chevet de Sei Shônagon et Le Dit du Genji de Murasaki Shikibu, montraient clairement l’intérêt porté aux chats par les dames de cour. Pourtant, à partir du xiiie siècle, le félidé fera au contraire l’objet d’une forme de « diabolisation », et c’est (...) cette dimension plus inquiétante du chat que nous aimerions évoquer ici, à travers trois exemples tirés du Kokon chomon-jû, vaste recueil de contes et légendes. Cette œuvre méconnue en Europe est attribuée à Tachibana no Narisue et achevée en 1254. The figure of the cat made its appearance in Japanese literature in the 9th century, but its image evolved unexpectedly in medieval times. Literary evidence from the 11th and 12th centuries, such as the Bedside Notes by Sei Shônagon and The Tale of Genji by Murasaki Shikibu clearly showed the interest of court women in cats. However, from the 13th century, the feline became the object of a form of “demonization”, and it is this more disturbing dimension of the cat that we would like to describe here, through three examples taken from Kokon chomon-Jû, a vast collection of tales and legends. This work, unknown in Europe, has been attributed to Tachibana no Narisue and was completed in 1254. (shrink)

This paper points out an error of Parigot's proof of strong normalization of second order classical natural deduction by the CPS-translation, discusses erasing-continuation of the CPS-translation, and corrects that proof by using the notion of augmentations.

Brain science research targeting neurodevelopmental disorders has rapidly advanced in recent years. Although findings from these studies could potentially serve as objective indicators for future screening and diagnosis, researchers may encounter ethical challenges when returning results to participants and their legal guardians, such as family members. Furthermore, no established guidelines exists for returning results in this field, either in Japan or internationally. This study aimed to identify the ethical considerations associated with returning results in brain science research on neurodevelopmental disorders (...) and to develop a protocol for doing so. The authors held regular meetings to discuss ethical issues and conducted a comprehensive search for relevant guidelines and literature. Databases such as PubMed, Igaku Chuo Zasshi, CiNii, and Google Scholar were searched for prior studies. Additionally, we referenced and manually searched genetic research literature and guidelines, as ethical considerations related to returning results in genetic and brain science research share commonalities, and the former has already advanced discussions on these issues. Key ethical concerns identified include the certainty of the results, the psychological burden of returning results, and the decision-making process. Researchers should verify the accuracy of results and, based on this, decide whether and how to return them. It is crucial to tailor explanations to the unique characteristics of neurodevelopmental disorders. Moreover, supporting participants in making autonomous decisions while respecting the authority of their legal guardians is essential. (shrink)