This article offers a contrast between European and US-American approaches to the convergence of enabling technologies and to associated issues. It identifies an apparently paradoxical situation in which regional differences produce conflicting claims to universality, each telling us what can and will happen to the benefit of humanity. Those who might mediate and negotiate these competing claims are themselves entangled in the various positions. A possible solution is offered, namely a universalizable strategy that aims to disentangle premature claims to unity (...) and universality as in the case of the greater "efficiency" of nanomedicine. This is the strategy by which Science and Technologies Studies (STS) can analytically tease apart what it has helped produce and sustain in the first place. The virtues and limits of this strategy are briefly presented, deliberation and decision-making under conditions of productive disillusionment recommended. (shrink)

Infra-experimentality. Traces ; Models ; Making visible ; Grafting ; Protocols -- Supra-experimentality. Shapes of time ; Experimental cultures ; Knowing and narrating ; Thinking wild ; Eulogy of the fragment -- Postscript.

This article argues that Badiou's account of subjects of truth-procedures requires the Lacanian subject in order to be intelligible. Without an account of the Lacanian subject as void and precarious with respect to all identifications, Badiou is unable to explain how the subject of truth procedures is able to throw off its identifications and symbolic roles that characterize its existence as an individual or body in the situation, taking on, instead, fidelity to the truth that follows from an event.

In a class of quantum gravity approaches it is indicated that our observable world emerges out of a fundamental structure that appears highly resistant to any clear spatial or temporal interpretation. In this work we are examining an analogue quantum system that appears to simulate such an unintuitive structure: the emergence of the so called topological phase of matter depicted by the Chern–Simons gauge theory. By investigating the proposed analogy from the lens of category theory, we offer a clear interpretation (...) of the way in which space and time act at the fundamental level. (shrink)

Prior’s Tonk is a famously horrible connective. It is defined by its inference rules. My aim in this article is to compare Tonk with some hitherto unnoticed nasty connectives, which are defined in semantic terms. I first use many-valued truth-tables for classical sentential logic to define a nasty connective, Knot. I then argue that we should refuse to add Knot to our language. And I show that this reverses the standard dialectic surrounding Tonk, and yields a novel solution to the (...) problem of many-valued truth-tables for classical sentential logic. I close by outlining the technicalities surrounding nasty connectives on many-valued truth-tables. (shrink)

This paper assumes the success of arguments against the view that informal mathematical proofs secure rational conviction in virtue of their relations with corresponding formal derivations. This assumption entails a need for an alternative account of the logic of informal mathematical proofs. Following examination of case studies by Manders, De Toffoli and Giardino, Leitgeb, Feferman and others, this paper proposes a framework for analysing those informal proofs that appeal to the perception or modification of diagrams or to the inspection or (...) imaginative manipulation of mental models of mathematical phenomena. Proofs relying on diagrams can be rigorous if it is easy to draw a diagram that shares or otherwise indicates the structure of the mathematical object, the information thus displayed is not metrical and it is possible to put the inferences into systematic mathematical relation with other mathematical inferential practices. Proofs that appeal to mental models can be rigorous if the mental models can be externalised as diagrammatic practice that satisfies these three conditions. (shrink)

In 1926 and 1927, James W. Alexander and Kurt Reidemeister claimed to have made “the same” crucial breakthrough in a branch of modern topology which soon thereafter was called knot theory. A detailed comparison of the techniques and objects studied in these two roughly simultaneous episodes of mathematical research shows, however, that the two mathematicians worked in quite different mathematical traditions and that they drew on related, but distinctly different epistemic resources. These traditions and resources were local, not universal elements (...) of mathematical culture. Even certain common features of the main publications such as their modernist, formal style of exposition can be explained by reference to particular constellations in the intellectual and professional environments of Alexander and Reidemeister. In order to analyze the role of such elements and constellations of mathematical research practice, a historiographical perspective is developed which emphasizes parallels with the recent historiography of experiment. In particular, a notion characterizing those “working units of scientific knowledge production” which Hans-Jörg Rheinberger has termed “experimental systems” in the case of empirical sciences proves helpful in understanding research episodes such as those bringing about modern knot theory. (shrink)

The aim of this article is to explain why knot diagrams are an effective notation in topology. Their cognitive features and epistemic roles will be assessed. First, it will be argued that different interpretations of a figure give rise to different diagrams and as a consequence various levels of representation for knots will be identified. Second, it will be shown that knot diagrams are dynamic by pointing at the moves which are commonly applied to them. For this reason, experts (...) must develop a specific form of enhanced manipulative imagination, in order to draw inferences from knot diagrams by performing epistemic actions. Moreover, it will be argued that knot diagrams not only can promote discovery, but also provide evidence. This case study is an experimentation ground to evaluate the role of space and action in making inferences by reasoning diagrammatically. (shrink)

The present paper aims to shed light on some post-oedipal moments of the Freudian-Lacanian psychoanalysis. Going beyond the stereotypical opposition between the oedipal psychoanalysis and the anti-oedipal schizoanalysis, it endeavors to reinvestigate the semiotic nature of theknotenpunktand thesinthomeby applying some Deleuzian and Bakhtinian concepts. Thus, theknotenpunktis described as a grotesque knot bringing together some heterogeneous elements. The involved disparate components establish a rhizomatic multiplicity irreducible to a common determiner. As far as thesinthomeis concerned, it is also illustrated as a grotesque (...) knot quilting the disseminated heterogeneous orders. In contrast to the dominant conception of the symptom with a complex mode of signifying (that is mainly bound to the oedipal topography), theknotenpunktand thesinthomehold a kind of hyper-formative mode of signifying. As a result, the latter may be regarded as pure formators irreducible to a meaning or a certain interpretation. Finally, the paper sets out to analyze and evaluate the relationship between thesinthomeand the foreclosure from a semiotic perspective. Accordingly, thesinthomeis explained as a reply to foreclosure which is specifically a perceptive-imperative (retroactive) contemplation (in the light of law according to the Peircean phaneroscopy) on the rhizomatic multiplicity of psychosis (the case of schizophrenia). (shrink)

Alternative splicing allows for the production of many gene products from a single coding sequence. I introduce the concept of alternative splicing via some examples. I then discuss some current hypotheses about the explanatory role of alternative splicing, including the claim that splicing is a significant contributor to the difference in complexity between the human genome and proteosome. Hypotheses such as these bring into question our working concepts of the gene. I examine several gene concepts introduced to cope with processes (...) such as alternative splicing. Next I introduce some hypotheses about the evolution of mechanisms alternative splicing in higher organisms. I conclude that attention to alternative splicing reveals that we adopt an attitude that developmental theorizing must inform evolutionary theorizing and vice versa. (shrink)

While the independently conceived and executed essays making up Threads and Knots can be viewed as knotting and completing certain loose threads of argument left dangling in Skepticism and the Basis of Morality (Lang 1995), they also have a second unifying specific purpose all their own: to provide an account of the cognitive content and manner of operation of the innate (and, therefore, for us valid, or by us a priori assertably true) supreme structural principle of human moral reason (...) detailed enough for its linguistically self-conscious application to human conduct and affairs in a manner that will enable us eventually to realize the full human potential built into us by nature through the process of our evolution-by-natural-selection. (shrink)

The nomination of candidate genes underlying complex traits is often focused on genetic variations that alter mRNA abundance or result in non‐conservative changes in amino acids. Although inconspicuous in complex trait analysis, genetic variants that affect splicing or RNA editing can also generate proteomic diversity and impact genetic traits. Indeed, it is known that splicing and RNA editing modulate several traits in humans and model organisms. Using high‐throughput RNA sequencing (RNA‐seq) analysis, it is now possible to integrate the genetics of (...) transcript abundance, alternative splicing (AS) and editing with the analysis of complex traits. We recently demonstrated that both AS and mRNA editing are modulated by genetic and environmental factors, and potentially engender phenotypic diversity in a genetically segregating mouse population. Therefore, the analysis of splicing and RNA editing can expand not only the regulatory landscape of transcriptome and proteome complexity, but also the repertoire of candidate genes for complex traits. (shrink)

Alternative splicing is a critical post‐transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms.1 It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint. BioEssays 25:1031–1034, 2003. © 2003 Wiley (...) Periodicals, Inc. (shrink)

Normal 0 21 false false false ES-CO X-NONE X-NONE Este ensayo busca mostrar la relevancia de la perspectiva de la primera persona a través de un enfoque fenomenológico. Frente a la negativa de las distintas tendencias de la filosofía de la mente analítica, las ciencias cognitivas y las neurociencias de considerar la realidad de los estados mentales como fenómenos subjetivos, se esboza una revisión de la cuestión con la finalidad de señalar la relación entre la experiencia subjetiva y una ontología (...) de la primera persona. Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4. (shrink)

Splicing is an efficient and precise mechanism that removes noncoding regions from a single primary RNA transcript. Cutting and rejoining of the segments occurs on nascent RNA. Trans-splicing between small specialized RNAs and a primary transcript has been known in some organisms but recent papers show that trans-splicing between two RNA molecules containing different coding regions is the normal mode in a Drosophila gene.1-3 The mod(mdg4) gene produces 26 different mRNAs encoding as many protein isoforms. The differences lie in alternative (...) 3′ exons encoded by different transcriptional units and spliced to the 5′ common region by a surprising trans-splicing mechanism. BioEssays 24:988–991, 2002. © 2002 Wiley-Periodicals, Inc. (shrink)

Alternative splicing (AS) is a widespread mechanism with an important role in increasing transcriptome and proteome diversity by generating multiple different products from the same gene. Evolutionary studies of AS have focused primarily on the conservation of alternatively spliced sequences or of the AS pattern of those sequences itself. Less is known about the evolution of the regulation of AS, but several studies, working from different perspectives, have recently made significant progress. Here, we categorize the different levels of AS evolution, (...) and summarize the studies on evolution of AS regulation, which point to a high level of evolutionary conservation of the regulation of AS events conserved between related species. This suggests that the quantitative regulation of AS is an intrinsic part of AS function. We discuss the potential role of changes in developmental regulation of AS as an additional layer in complex gene regulatory networks and in the emergence of genetic novelties. (shrink)

Alternative pre‐mRNA splicing leads to distinct products of gene expression in development and disease. Antagonistic splice variants of genes involved in differentiation, apoptosis, invasion and metastasis often exist in a delicate equilibrium that is found to be perturbed in tumours. In several recent examples, splice variants that are overexpressed in cancer are expressed as hyper‐oncogenic proteins, which often correlate with poor prognosis, thus suggesting improved diagnosis and follow up treatment. Global gene expression technologies are just beginning to decipher the interplay (...) between alternatively spliced isoforms and protein‐splicing factors that will lead to identification of the mutations in these trans‐acting factors responsible for pathogenic alternative splicing in cancer. BioEssays 28: 378–386, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Abstract One perspective in contemporary linguistic theory defends the idea that the language faculty may result from the combinations of diverse systems and principles. As a case study, I critique a recent proposal by Juan Uriagereka and colleagues according to which the evolutionary emergence of the language faculty can be identified through studying the computational structure of knots as present within the fossil record. I here argue that the ability to conceptualize and, thereby, create knots is not parasitic (...) on the ability to conceptualize and create language. On the contrary, these two domains are entirely distinct, unrelatable in terms of their computational complexity, expressive power or, most importantly, in terms of their requisite mental operations and principles. The overall approach defended here can profitably be employed in the study of the relationship between language and thought, as I briefly discuss in the case of the role of language in spatial reorientation. (shrink)

The splicing of pre‐mRNAs in vitro is accomplished by formation of RNA intermediates in a lariat form. Lariat RNAs have been recently identified in vivo supporting the validity of the proposed pathway for processing pre‐mRNAs in vitro.We have recently reported20 a partial purification scheme for a pre‐mRNA splicing activity. Purification of the individual components and eventually reconstitution of the reaction with purified activities will firmly establish the pathways for pre‐mRNA splicing and help to elucidate the detailed biochemical mechanism of the (...) several reactions involved in mRNA splicing. (shrink)

Hypotrichous ciliates extensively process genomic DNA during their life cycle. Processing occurs after cell mating, beginning with multiple rounds of DNA replication to form polytene chromosomes. Thousands of transposonlike elements are then excised from the chromosomes and destroyed, and thousands of short, internal eliminated sequences (IESs) are excised from coding and noncoding parts of genes and destroyed. IES removal from a gene is accompanied by splicing of the remaining chromosomal DNA segments to form a transcriptionally competent gene. For some genes (...) these DNA segments are in a scrambled order and are ligated into a genetically correct order at the time of IES removal. Next the polytene chromosomes are cut up band‐by‐band and all genes are excised from the chromosomes as short, linear molecules averaging 2.2 kbp (in Oxytricha nova). Gene excision is accompanied by destruction of all nongenic DNA, which, together with the transposonlike elements and IESs, accounts for ∼95% of the total sequence complexity of the genome in O. nova. Telomeric sequences are added to the excised gene‐sized DNA molecules. Finally, the gene‐sized molecules are replicated several times to form the macronucleus of the organism. (shrink)

Over the last decade, Hugo Mercier and Dan Sperber have elaborated an influential naturalistic account of human reasoning. Their distinctive hypothesis is that its adaptive rationale – and primary function – is to produce and assess reasons in interpersonal justification and argumentation. In this paper I argue, first, that their characterisation of reasoning as based on metarepresentations threatens to oversophisticate reasoning and faces the problem of vicious regress. Second, I argue that they owe us a coherent account of the cognitive (...) role of reasons in reasoning. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Untying Foucauldian Knots of Power/Knowledge and Tying Better Relationships with the Confucian PersuasionJoseph Harroff (bio)Reconsidering the Life of Power: Ritual, Body, and Art in Critical Theory and Chinese Philosophy. By James Garrison. Albany: SUNY Press, 2021.Life is a self-renewing process through action upon the environment.—Dewey, Democracy and Education (2)There is no pure self to be redeemed here, but perhaps some kind of rehabilitation beyond the problematic trappings of (...) subject life might be possible.—Garrison, Reconsidering the Life of Power (54)The problem of critiquing power by untangling and retangling ourselves more creatively and intelligently in webs of habit and flows of somaesthetic information and value-laden ethical-political imaginative horizons of futurity is taken up by James Garrison in Reconsidering the Life of Power: Ritual, Body and Art in Critical Theory and Chinese Philosophy (2021). By asking a series of ethically sustained and interculturally hermeneutically sensitive questions surrounding the critical problematic as to the conditions for the possibility of how "it is possible to use the sign chains of power to chain power," or how it is possible to "tie power up in its own knots" (p. 18), Garrison makes creative use of "subjectality theory" that foregrounds somaesthetic practices seeking to be in many ways recasting rather than simply reconsidering the life of power. It is through a methodological sounding of the depths of somaesthetic experience and a creative-critical inquiry into the ways in which the complex of social arts understood in the broadest possible conception, including at all ethical and political intersections, that this book enters into the domain of Confucian theorizing of persons as part of never-simply-located root-body-persons (shenti 身體)—that is, as offering a theory of relational persons that is simultaneously and intersectionally caught up in a manifold of social practices of aesthetic, ethical, political, and religious signification. It is by critically interrogating the historical a priori that condition the possibility for any specific knowledge-power discursive interpellation by drawing attention to the complex interplay and entanglement of forces and signification involved in tool-making and tool-using practices as a "sedimentation" (jidian 積澱) of [End Page 809] somaesthetic arts that straddle a polarity of natural-cultural form-functioning, that Garrison makes creative advances in pushing critical theory past a problematic pessimism and/or nihilism that stems from any brute recognition of the "skintight prison" houses we inhabit as a result of Foucauldian power knots.Using the idea of "sedimentation" to better articulate the complex strata of social experience as mediated by aesthetic culture Garrison draws heavily from Li Zehou. Li is suspicious of a Maoist model of conflating theory and practice, subject and object, especially when the treatment is part of a civic and political religiosity that renders the Great Helmsman a supreme leader and unilateral decision-maker in a Marxist-Leninist vanguard of the historico-teleological revolution. For Li, aesthetic sensibility is the "manifestation of the sedimentation of society in nature, and the sedimentation of humankind as a species in the individual."1 And moreover, the "animal structure and quality of psychology" is "transformed into something that has a human nature, in which sensation and rationality are dissolved and combined."2 This complex process of dissolution and combination is more like a Hegelian dialectic of spirit than it is a linear-totalitarian realization of Maoist voluntarism. However, this is what I want to begin challenging by asking what degree Garrison draws upon this aspect of Li. I would suggest that Maoist voluntarism can be read as part of a traditional Chinese philosophical problematic that prioritizes practice in order to realize the truth of nature (gongfu jishi benti 功夫即是本體).This way of approaching the Maoist dynamic of voluntarism seems much closer to the Expansive Learning 《大學》 dynamic of "from the King to the commoners, everyone takes self-cultivation as the root," but would avoid any problematic Maoist hubris regarding the limits, methods and confines of class "struggle." The post-linguistic turn and then return to a Deweyan process metaphysical and creatively democratic inquiry into experience to garner more intelligent methods for critiquing and cultivating embodied and relationally configured habits of perception, speech, and thought via the vocabulary of... (shrink)

While many scholars join in the call for an experiential shift in thinking and living, it is not always clear how it could be done. Recent environmental philosophy has illuminated the significance of re-animating human–environment relations on an experiential level for endeavouring a new (or renewed) ethical, experiential, and, indeed, existential stance of the human as part of the environed embodiment. In relation to this call, I explore embodied critical thinking (ECT) as a tool for recognising, revitalising, and reflecting embodied, (...) enactive, and embedded thinking that comes from a felt sense. Thus, this chapter employs some of the TAE (Thinking at the Edge) steps for ECT research as a practical approach to facilitating and embracing a new way of thinking that is crucial for reconnecting humans with their lived environments, but also for emancipating research practices to enable research that goes out from such a renewed connectivity. In particular, the chapter traces the application of Eugene Gendlin’s move of instancing to showcase the use of embodied knowing and felt sense in environmental contexts. Thus, it showcases how, in fundamental ways that speak directly to and from our embodied embeddedness, ECT has an emancipatory impact in ways that resonate with lived experiences. (shrink)

How tight is the conceptual connection between imagination and perception? A number of philosophers, from the early moderns to present-day predictive processing theorists, tie the knot as tightly as they can, claiming that states of the imagination, i.e. mental imagery, are a proper subset of perceptual experience. This paper labels such a view ‘perceptualism’ about the imagination and supplies new arguments against it. The arguments are based on high-level perceptual content and, distinctly, cognitive penetration. The paper also defuses a recent, (...) influential argument for perceptualism based on the ‘discovery’ that visual perception and mental imagery share a significant neural substrate: circuitry in V1, the brain’s primary visual cortex. Current neuropsychology is shown to be equivocal at best on this matter. While experiments conducted on healthy, neurotypical subjects indicate substantial neural overlap, there is extensive clinical evidence of dissociations between imagery and perception in the brain, most notably in the case of aphantasia. (shrink)

Neuronal signalling involves multiple neuropeptides that are diverse in structure and function. Complex patterns of tissue‐specific expression arise from alternate RNA splicing of neuropeptide‐encoding gene transcripts. The pattern of expression and its role in cell signalling is diffecult to study at the level of single neurons in the complex vertebrate brain. However, in the model molluscan system, Lymnaea, it is possible to show that alternate mRNA expression of the FMRFamide gene is specific to single identified neurons. Two different transcripts are (...) expressed in a mutually exclusive manner in different neurons. Post‐translational processing of the two precursor proteins leads to completely distinct sets of neuropeptide transmitters. The function of these transmitter cocktails, resulting from alternate mRNA splicing, was studied physiologically in identified neurons forming part of a behaviourally important network regulating heartbeat. (shrink)

Untying the Gordian Knot shows how the fundamental notions of process, logic and relations, woven with triads of input-output-context, can be combined with quantum distinctions associated with actuality and potentiality, enabling the leveraging of many advances in philosophy and physics to unravel several long-standing philosophical problems.

A novel "dream splicing" technique allows the objective evaluation of thematic coherence in dreams. In this study, dream reports were cut into segments and segments randomly recombined to form spliced reports. Judges then attempted to distinguish spliced reports from intact ones. Five judges correctly scored 22 spliced and intact reports 82% of the time ; 13 of the 22 reports were correctly scored by all five judges . We conclude that most dream reports contain sufficient coherence to allow judges to (...) distinguish intact from spliced reports. In contrast, abridged reports, which had all but their first and last five lines removed, were correctly identified in only 10 of 38 reports, suggesting that thematic continuity does not normally extend from the beginning to the end of dreams. The continuity identified in this minority of the reports depended on easily identifiable features, such as specific characters, objects, locations, and emotions, rather than on "latent" themes. (shrink)

Recent ethical misconduct in American business has resulted in volumes of written commentary, various legislative responses, as well as litigation by those identified as victims. While legislators, judges, juries, and the Securities and Exchange Commission (SEC) pursue an increasing number of cases, there is little attention devoted to understanding what drives executives and other leaders to behave in ways that violate the ethical and legal standards of business in the United States. This understanding is a prerequisite to selecting leaders and (...) designing interventions that prevent future misconduct. Understanding leadership’s nature and functioning is one key to understanding the ethical behavior of an organization as a system and of the people who lead the organization. Two models or frameworks provide the foundation for this paper. The first is a model of leadership competencies. This model identifies five key areas of competence related to overall, long-term leadership success. The second model targets leadership effectiveness. This model has three components – motivational patterns, decision criteria, and competencies. Using the Leadership Effectiveness Model to frame the discussion, the authors describe the nature and importance of the models, with particular focus on motivational patterns. Research suggests these patterns often account for 40–60% of overall leadership effectiveness. This article defines motivational patterns and describes key patterns that may impact ethical behavior of leaders. The article concludes with a discussion of how to use data on motivational patterns in leadership selection, development, and evaluation processes. (shrink)

Colours and consciousness both present us with metaphysical problems. But what exactly are the problems? According to standard accounts, they are roughly the following. On the one hand, we have reason to believe, about both colour and consciousness, that they are identical with some familiar natural phenomena. But on the other hand, it is hard to see how these identities could obtain. I argue that this is an adequate characterisation of our metaphysical problem of colour, but a mischaracterisation of the (...) problem of consciousness. It mischaracterises the problem by presenting consciousness as more 'colour-like' than we have reason to take it to be. The real problem of consciousness is, I suggest, that almost nothing theoretically useful is known about this phenomenon at present. I also explore some implications of this perspective on the problem of consciousness. Given the shape of the problem, I argue that we can't rule out all forms of eliminativism about consciousness. Nor can we rule out that future research will close the ' explanatory gap' that consciousness gives rise to. (shrink)

In this paper I explore a series of fertile ambiguities that Merleau-Ponty’s work is premised upon. These ambiguities concern some of the central methodological commitments of his work, in particular his commitment to transcendental phenomenology and how he transforms that tradition, and his relationship to science and philosophical naturalism and what they suggest about his philosophical methodology. Many engagements with Merleau-Ponty’s work that are more ‘analytic’ in orientation either deflate it of its transcendental heritage, or offer a “modest” rendering of (...) its transcendental dimensions. This is also true, albeit perhaps to a lesser extent, of the work of the more empirically-minded phenomenological philosophers who engage very seriously with Merleau-Ponty—e.g. Hubert Dreyfus, Shaun Gallagher, Evan Thompson, Alva Noë, and others. At the same time, many other scholars contest these proto-scientific and more naturalistic uses of Merleau-Ponty’s work on hermeneutical and exegetical grounds, and they likewise criticise the deflated reading of his transcendental phenomenology that tends to support them. By working through some of the key passages and ideas, this paper establishes that the former view captures something pivotal to Merleau-Ponty’s philosophy. I also extend these interpretations by arguing that, at least around the time of Phenomenology of Perception, his philosophy might be reasonably regarded as a form of minimal methodological naturalism. (shrink)

Technological progress may eventually produce sophisticated robots with human-like traits that result in humans forming meaningful relationships with them. Such relationships would likely lead to a demand for human–artificial intelligence matrimony. U.S. Supreme Court decisions that expanded the definition of marriage to include interracial and same-sex couples, as well as those that have not extended marriage to polygamous relationships, provide guidance regarding the criteria that human–AI would have to meet to successfully assert a right to marry. Ultimately, robots will have (...) to possess certain characteristics of personhood to marry, including the capacity to contract and to engage in an intimate relationship. Alternatively, if AIs can simulate these abilities sufficiently, we may believe that they have these capacities. Even if AIs genuinely possess the capabilities necessary to enter into a marriage, it is social acceptance of intelligent non-humans as life partners that will likely influence legal development is this realm rather than personhood criteria. However, AIs are likely to face bias due to their “artificial” rather than biological nature. Yet, Peter Singer’s influential argument regarding speciesism in the context of animal rights implies that AIs with specific human-like qualities cannot be justifiably denied certain rights. (shrink)

In eukaryotes, RNA trans‐splicing is an important RNA‐processing form for the end‐to‐end ligation of primary transcripts that are derived from separately transcribed exons. So far, three different categories of RNA trans‐splicing have been found in organisms as diverse as algae to man. Here, we review one of these categories: the trans‐splicing of discontinuous group II introns, which occurs in chloroplasts and mitochondria of lower eukaryotes and plants. Trans‐spliced exons can be predicted from DNA sequences derived from a large number of (...) sequenced organelle genomes. Further molecular genetic analysis of mutants has unravelled proteins, some of which being part of high‐molecular‐weight complexes that promote the splicing process. Based on data derived from the alga Chlamydomonas reinhardtii, a model is provided which defines the composition of an organelle spliceosome. This will have a general relevance for understanding the function of RNA‐processing machineries in eukaryotic organelles. (shrink)

Death narratives, nurturance, and transitive crossings within species and between species open pathways into entanglements of life of earth. This paper engages with time in both sequential and synchronous modes, investigating interfaces where time, species, and nourishment become densely knotted up in ethics of gift, motion, death, life, and desire. The further aim is to consider the dynamic ripples generated by anthropogenic mass death in multispecies knots of ethical time, and to gesture toward a practice of writing as witness.

This article discusses some current research claims on gender and state socialism in Eastern Europe from 1945 to 1989. It raises questions about claims by Revisionist Feminist Scholars that official state socialist women’s organizations were ‘agents’ on behalf of women, or women’s movements, perhaps feminist, and not ‘transmission belts’ of communist parties. State socialist policies are described as ‘friendly towards women’ and ‘pro-women’. In contrast, the author claims that these organizations both were and were not agents on behalf of women, (...) and also prevented women’s agency. Meaningful women’s agency is not actually shown to occur intermittently throughout their history, but in two contexts – before 1955 or in moments of political rupture. Scholars do not distinguish the who, when, and what – Who could be agents? When could they be agents? And what kind of agents could they be? State policies, the author claims, were also at one and the same time ‘friendly’ and ‘unfriendly’ towards women, sometimes harming women. The author explores why this research is happening now, discussing research on Bulgaria, Czechoslovakia, the Democratic Women’s Organization of Germany, the Democratic Association of Hungarian Women, later renamed MNOT, the Romanian National Council of Women and the Yugoslav Anti-Fascist Women’s Organization. (shrink)

David Ray Griffin develops a third form of realism, one that resolves the basic problem (common to dualism and materialism) of the continued acceptance of the Cartesian view of matter.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Horace and the Rhetoric of AuthorityKenneth J. ReckfordEllen Oliensis. Horace and the Rhetoric of Authority. Cambridge: Cambridge University Press, 1998. xii 1 241 pp. Cloth, $64.95.In a gratifying book, crafted with unusual care, Ellen Oliensis investigates Horace’s self-fashioning in his poetry. “Horace is present,” she argues, “in his personae... not because these personae are authentic and accurate impressions of his true self, but because they effectively construct that (...) self—for Horace’s contemporary readers, for us, and also for Horace himself” (2). As she carefully observes the “faces” Horace makes from early satires and epodes to late epistles, she never assumes that they simply screen a “real” Horace, ambitious and/or subservient, from the public gaze. Horace’s strategies are unmasked, and [End Page 313] his tact (together with some rudeness), and what Oliensis characterizes as a fine, shifting blend of authority and deference; but “the final sum of Horace’s calculations is the making of good poetry, by which I mean poetry that is not exhausted in or fundamentally compromised by the social exchanges in which it participates” (14). This is (as I see it) a rescue operation that succeeds most admirably.Chapter 1 is titled “Face-saving and Self-defacement in the Satires.” In book 1, Horace distinguishes himself from his satiric targets as a discriminating poet and person, worthy of his equally discriminating patron. While his defensive maneuvers ward off envious outsiders, they also and more importantly appeal to Maecenas’ judgment as “overreader.” Oliensis often argues negatively, in terms of what Horace does not do. (Cf. Sherlock Holmes and the dog that didn’t bark.) There is, for example, no mention in Satires 1.6 of the part played by Horace’s poetry in winning Maecenas’ approval, no suggestion that Horace’s father was eager to see him advance socially. So too, in 2.6, Horace’s travails are not attributed to Maecenas; his villa is not connected with Maecenas; there is no self-incriminating “thank you”; the city day does not end with dinner at Maecenas’ house. Horace’s tact, his self-effacement here, are remarkable. Yet even as his satires decry the pursuit of wealth and status, they mark and promote “the poet’s own progress from the obscure margins to the shining center of Roman society” (17). Satires 1.10 proclaims Horace’s newfound authority together with his acceptance into an aesthetic and social elite.In book 2, Oliensis argues, Horace retreats from the role of satirist, giving it (ostensibly) to others, displacing upon them (Ofellus in 2.2, Damasippus in 2.3, Ulysses in 2.5, Davus in 2.7, Nasidienus in 2.8) the attempt to “mend misfortune with art” (51–63). Only later, in Epistles 2.2.49–52, will he admit to his early ambitiousness. For now, “by displacing these autobiographical ‘facts’ onto a series of surrogates in Satires 2, he retroactively exposes the satirist of Book 1” (54). The picture is convincing. We see Horace growing in subtlety and assurance as he moves away from satire—or moves satire in a new direction? I would only ask: did the process begin earlier, with the partial rejection of diatribe satire in 1.3 and Lucilian satire in 1.4? How and where should we draw the line between Horace’s half-ironic denials of aggressive intent and his genuine self-education through satire writing?Chapter 2, on the Epodes, is distinguished by Oliensis’ regard for diversity, the ugly and low stuff along with the bright and lofty. To simplify a complex, intuitive argument: Horace associates himself deferentially with the new center of Octavian and Maecenas, and repels outsiders, but his project fails: because he is forced to recognize too much of himself in scapegoated figures like the upstart slave-tribune of Epodes 4; because attack breeds attack in an unending cycle of vengeance; and because Horace is finally impotent before the dark, irrational forces represented by Canidia. He fails signally to achieve closure in the expected ten-poem book, turning instead (mainly) to erotic subjects, [End Page 314] unsubdued passions. Dactyls compete symbolically with iambs. Finally Horace lets Canidia win—and triumphs... (shrink)

The notion of “intentionality” is much invoked in various foundational theories of meaning, being very often equated with “meaning”, “content” and “reference”. In this paper, I propose and develop a basic distinction between two concepts and, more fundamentally, properties of intentionality: intentionality-T and intentionality-C. Representationalism is then defined as the position according to which intentionality-T can be reduced to intentionality-C, in the form of representational states. Nonrepresentationalism is rejecting this reduction, and argues that intentionality-T is more fundamental than intentionality-C. Non-representationalism (...) allows for a new layered view of the relations between cognitive intentionality and linguistic intentionality; this view is presented at the end of the paper. (shrink)

Recent feminist theory has attempted to bring considerations of women’s agency into analyses of the meaning and consequence of beauty norms in women’s lives. This article argues that these works have often been limited by their use of individualist frameworks or by their neglect of considerations of race and class. In this article I draw upon examples of African-American utilization of beauty discourse and practices in collective efforts to resist racism. I argue that there is no singular beauty standard enforced (...) by a unified male gaze. Instead, we should conceive of fields in which differently located individuals and groups invest in and promote particular ways of seeing beauty, producing both penalties and pleasures in women’s lives. (shrink)