This article explores the nature and theoretical import of a hitherto neglected class of fictions which we term ‘self-involving interactive fictions’. SIIFs are interactive fictions, but they differ from standard examples of interactive fictions by being, in some important sense, about those who consume them. In order to better understand the nature of SIIFs, and the ways in which they differ from other fictions, we focus primarily on the most prominent example of the category: video-game fictions. We argue that appreciating (...) the self-involving nature of video-game fictions is key to understanding various otherwise puzzling phenomena concerning the ways in which consumers respond to them. Video-game fictions are, however, far from being the only extant example of this class; and we suggest that the recent philosophical interest in video games would be better focused on the wider class of self-involving interactive fictions. (shrink)

Ageism has unfortunately become a salient phenomenon during the COVID-19 pandemic. In particular, triage decisions based on age have been hotly discussed. In this article, I first defend that, although there are ethical reasons (founded on the principles of benefit and fairness) to consider the age of patients in triage dilemmas, using age as a categorical exclusion is an unjustifiable ageist practice. Then, I argue that ageism during the pandemic has been fueled by media narratives and unfair assumptions which have (...) led to an ethically problematic group homogenization of the older population. Finally, I conclude that an intersectional perspective can shed light on further controversies on ageism and triage in the post-pandemic future. (shrink)

Value change is a phenomenon that is gaining increasing attention in ethical analyses of technologies. However, a comprehensive study of how reprogenetic technologies and values coevolve is lacking. To remedy this gap, in this overview article, I address the relationship between reprogenetics and value change. This contribution thus argues for the importance of investigating the phenomenon of value change in relation to the technological controversies discussed in bioethics. To meet this goal, I begin by clarifying, first, how technologies shape reproductive (...) choice. I then clarify what “values” and “moral values” are, how reprogenetic technologies are value laden, and what values are often discussed in reprogenetics debates. Next, I show five types of value changes that have occurred in advance in reproductive and genetic technologies. Finally, I argue for the bioethical relevance of discussing future techno-value change, pointing out the descriptive and normative challenges of this philosophical endeavor. (shrink)

In this chapter we explore the process of extrapolating causal claims from model organisms to humans in pharmacology. We describe and compare four strategies of extrapolation: enumerative induction, comparative process tracing, phylogenetic reasoning, and robustness reasoning. We argue that evidence of mechanisms plays a crucial role in several strategies for extrapolation and in the underlying logic of extrapolation: the more directly a strategy establishes mechanistic similarities between a model and humans, the more reliable the extrapolation. We present case studies from (...) the research on atherosclerosis and the development of statins, that illustrate these strategies and the role of mechanistic evidence in extrapolation. (shrink)

L’articolo esamina le qualità della democrazia deliberativa a partire dal ri­ferimento a espressioni storiche di questa: nelle istituzioni ateniesi del quin­to-quarto secolo a. C., nella Convenzione Federale statunitense del 1788, negli Stati Generali della Rivoluzione francese, in varie esperienze lo­cali odierne. Stabiliti tre modelli di democrazia e tre criteri per la deliberazione , la questione da affrontare è se la forma deliberativa di democrazia sia un buon sistema politico. La risposta è sì, purché si verifichino tre con­dizioni: intensità della motivazione (...) nei partecipanti, orientamento al bene pubblico della motivazione stessa, corretta informazione dei partecipanti. Ma si tratta di una conclusione ipotetica, che tiene conto della complessità e molteplicità dei fattori in gioco, e dunque del fatto che nessuna proprietà dei processi decisionali collettivi è desiderabile incondizionatamente.The article reflects upon strengths of deliberative democracy from an historical point of view: beginning with Athens’ institutions , pas­sing through States-General during French Revolution and U. S. Federal Con­vention , finally reaching today’s experience. Having established three different models of democracy and three criteria for the deliberative process , the issue is whether deliberative democracy works well as a po­litical system. We can surely say it does, although under some con­ditions: level of participants’ motivation, actions directed towards well-being and good information. Nevertheless, this is only a hypothetical con­clu­sion: there’s no perfect deliberative process, because of the complexity and plurality of the factors at play. (shrink)

This article uses concepts from sociology, history, and philosophy to explore the shifting relationship between moral values and business in the Western world. We examine the historical roots and intellectual underpinnings of two major business-society paradigms in ideal-type terms. In pre-industrial Western society, we argue that business activity was linked to society’s values of morality (the moral unity paradigm}-for good or for ill. With the rise of industrialism, we contend that business was freed from moral constraints by the alleged “invisible (...) hand” of efficient markets (the amoral theory of business). Armed with this understanding of the intellectual history of the moral unity and amoral business-society paradigms, we suggest that some variant of the moral unity paradigm may be recurring in post-industrial society. (shrink)

As demonstrated repeatedly in the press, unethical decisions lead to damaged reputations and financial loss in business. This practical briefing provides board members and executives with advice on handling key business areas where ethics are essential.

Jon Erling Litland’s “Meta-Ground” is concerned with the question: If A grounds B, what grounds the fact that A grounds B? His chapter begins by discussing what turns on this question. The chapter then compares the two main existing solutions to the problem of meta-ground. It ends by discussing how the problem of meta-ground is connected to other issues in the theory of ground and what are the main issues for future research.

Jon Roffe shows how Empiricism and Subjectivity is the precursor for some of Deleuze's most well-known philosophical innovations. For those already familiar with Deleuze, he emphasises its novelty within his corpus. And, for all readers, he shows how it outlines Deleuze's powerful and striking theory of subjectivity, and of philosophy itself. Empiricism and Subjectivity is Gilles Deleuze's first book, and yet it is infrequently read and poorly understood. In fact, it constitutes a unique project in its own right, deserving of (...) the same close study that is now widely given to other, more well-known works. (shrink)

Chapter 1 Disordered Appetites: Addiction, Compulsion, and Dependence Gary Watson In both popular and technical discussion, addictive behavior is said to be ...

From the point of view of the philosophy of Gilles Deleuze, Raymond Ruyer's work appears to bear out two distinct tendencies of unequal appeal. On the one hand, Ruyer appears to be an anti-Aristotelian thinker of formation, rejecting any hylomorphic account of the production of reality. However, and notably despite his serious commitment to the work of the sciences of his day, he remains wedded to the ultimately conservative Leibnizian principle of closure. Nowhere is this dichotomy more striking than in (...) his account of human society. The aim of this paper is to show how his positive account of form finds a significant and convincing extension in Deleuze and Guattari's notion of social surface or socius in Anti-Oedipus. (shrink)

Søren Kierkegaard: Subjectivity, Irony, and the Crisis of Modernity examines the thought of Søren Kierkegaard, a unique figure, who has inspired, provoked, fascinated, and irritated people ever since he walked the streets of Copenhagen. At the end of his life, Kierkegaard said that the only model he had for his work was the Greek philosopher Socrates. This work takes this statement as its point of departure. Jon Stewart explores what Kierkegaard meant by this and to show how different aspects of (...) his writing and argumentative strategy can be traced back to Socrates. The main focus is The Concept of Irony, which is a key text at the beginning of Kierkegaard's literary career. Although it was an early work, it nevertheless played a determining role in his later development and writings. Indeed, it can be said that it laid the groundwork for much of what would appear in his later famous books such as Either/Or and Fear and Trembling. (shrink)

High atop cascading waterfalls and deep within the lush green depths of the valleys, Swiss photographer Ruedi Homberger has for more than twenty years captured in photographs the majestic beauty of eastern Alaska's Wrangell Mountain range. In addition to summiting some of the Wrangells' loftiest peaks, Homberger has in recent years incorporated a technically challenging new approach into his work. Flying above the mountains in a small plane, Homberger literally goes to new heights to reveal a series of stunning aerial (...) views. The first book-length collection of photographs focusing exclusively on the Wrangell-Saint Elias National Park and Preserve, My Wrangell Mountains offers readers a rare opportunity to “stand among the giants.” Included in this magnificent oversized volume are nearly three hundred full-color photographs and an accompanying selection of sketches by award-winning illustrator Jon Van Zyle. (shrink)

Journals are failing in their obligation to ensure that research is fairly represented to their readers, and must act decisively to retract fraudulent publications. Recent case reports have exposed how marketing objectives usurped scientific testing and compromised the credibility of academic medicine. But scant attention has been given to the role that journals play in this process, especially when evidence of research fraud fails to elicit corrective measures. Our experience with The Journal of the American Academy of Child and Adolescent (...) Psychiatry (JAACAP) illustrates the nature of the problem. The now-infamous Study 329 of paroxetine in adolescent depression was negative for efficacy on all eight protocol-specified outcomes and positive for harm, but JAACAP published a report of this study that concluded that “paroxetine is generally well tolerated and effective for major depression in adolescents.” The journal’s editors not only failed to exercise critical judgment in accepting the paper, but when shown evidence that the paper misrepresented the science, refused either to convey this information to the medical community or to retract the article. (shrink)

A 90-year-old man is diagnosed with early dementia. There are concerns about whether he is still fit to drive his car safely, but he is determined to continue driving. In this case, the clinician finds that this decision on fitness to drive is essentially evaluative and normative. Given the conflict of interests involved, how should the clinician attempt to manage this challenging ethical dilemma? This increasingly common clinical ethics scenario warrants further attention. After presenting the case, this analysis will consider (...) the relevant issues in three dimensions: an ethical dilemma, a clinician–patient interaction, and a broader context. This analysis provides a potential framework for clinicians making decisions on fitness to drive in early dementia. (shrink)