Isaac Levi is more interested in inquiry and how it progresses than he is in metaphysics. Questions concerning the role of disposition predicates in inquiry are more central to him than those concerning the nature and reality of dispositions. It has not stopped him from giving me and others very useful metaphysical advice. Currently, where empirical metaphysics is in vogue, there is every reason to see whether the two forms of philosophical interest might interlock substantially. Levi has stimulating ideas indeed (...) on the two forms of philosophical interest, and has recently summarized them in the slogan: “The reality of dispositions is a work in progress”. We can learn much about what kinds of dispositions are acceptable from tracing and comparing the histories of successful and less successful disposition predicates in scientific inquiry. Levi explores one route along which dispositions become real. His idea is that the introduction of dispositions facilitates covering law explanation by increasing the number of laws. The successful disposition predicate eventually becomes integrated in scientific theory, much like an ordinary theoretical term, whereas the unsuccessful does not. My impression is that Levi thinks that this is the only way a disposition can become real. To evaluate this claim, an alternative course suggested by Jon Elster is introduced. I then try to bring out the differences between Levi's and Elster's views on dispositions, partly by suggesting that they resemble two aspects of full explanations discussed by Wesley Salmon. But more about that below. (shrink)

Interdisciplinary research in the fields of forestry and sustainability studies often encounters seemingly incompatible ontological assumptions deriving from natural and social sciences. The perceived incompatibilities might emerge from the epistemological and ontological claims of the theories or models directly employed in the interdisciplinary collaboration, or they might be created by other epistemological and ontological assumptions that these interdisciplinary researchers find no reason to question. In this paper we discuss the benefits and risks of two possible approaches, Popperian optimism and Kuhnian (...) pessimism, to interdisciplinary knowledge integration where epistemological and ontological differences between the sciences involved can be expected. (shrink)

The thesis addresses the nature of causation. It is argued that causation exists and is as local as its causes and effects. As a consequence, the position advocated is contrary to the as yet prevailing view that no 'causal tie' between cause and effect exists. Moreover, it is suggested that this tie can be perceived. The essay attempts to elucidate the nature of causes, effects, and causal mechanisms. It is argued that they are facts rather than particulars or universals. Furthermore (...) it is suggested that these facts can be conceived of as tropes. Finally, in the light of this thesis a few traditional issues are discussed: what is the relation between causation and explanation? How should we conceive of causal laws? Does the idea of mechanisms with different degrees of reliability further our understanding of the determinism/indeterminism issue? (shrink)

Semmelweis’s work predates the discovery of the power of randomization in medicine by almost a century. Although Semmelweis would not have consciously used a randomized controlled trial (RCT), some features of his material—the allocation of patients to the first and second clinics—did involve what was in fact a randomization, though this was not realised at the time. This article begins by explaining why Semmelweis’s methodology, nevertheless, did not amount to the use of a RCT. It then shows why it is (...) descriptively and normatively interesting to compare what he did with the modern approach using RCTs. The argumentation centres on causal inferences and the contrast between Semmelweis’s causal concept and that deployed by many advocates of RCTs. It is argued that Semmelweis’s approach has implications for matters of explanation and medical practice. (shrink)

On a widely held view, the canonical way to make sense of intentional actions is to invoke the agent's ‘motivating reasons’, where the claim that X did A for some ‘motivating reason’ is taken to be neutral on whether X had a normative reason to do A. In this paper, I explore a challenge to this view, drawing on Anscombe's ‘second-personal’ approach to the nature of action explanation.

Recent controversy about the use of the vertebrate fossil record for external calibration of molecular clocks centers on two issues, the number of dates used for calibration and the reliability of the fossil calibration date. Viewing matters from a palaeontological perspective, we propose three qualitative, phylogenetic criteria that can be used within a comparative framework for the selection of well-constrained calibration dates from the vertebrate fossil record. On the basis of these criteria, we identify three highly suitable new fossil calibration (...) dates for molecular clock estimates: the lungfish–tetrapod split (between 419 and 408 Ma), the bird–crocodile split (between 251 and 243 Ma), and the alligator–caiman split (between 71 and 66 Ma). Together with our previously suggested bird–lizard split (between 252 and 257 Ma), these four fossil dates span a range of very different ages. They are, in our opinion, more suitable for molecular clock calibration than the traditionally used mammal–bird split, which is less well constrained. We plea for closer interactions between paleontologists and molecular biologists in studying the timescale of vertebrate evolution. BioEssays 27:1069–1075, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Anhand einer klinischen Vignette wird ausgeführt, dass das psychoanalytische Geschehen sich in mehreren Dimensionen entfaltet. Drei solcher Dimensionen – als Bedeutung (Erkenntnis), Berührung (Kontakt) und Bewegung (Ereignis) bezeichnet – werden beschrieben und deren dimensionale Charakteristik auf die Sinnesqualitäten des Sehens, des Berührungssinnes und des Hörens bezogen. Es wird gezeigt, dass sie Raum und Zeit auf je eigene Weise konstituieren und somit einander inkommensurable, durch keine logische oder dialektische Operation in eine Einheit überführbare Aprioritäten darstellen. Mit deren Unvereinbarkeit ist auch auf (...) Grenzen theoretisch-begrifflicher Bemächtigung verwiesen, womit die Frage nach der Reichweite metapsychologischer Begriffe, etwa des Begriffs des Unbewussten, aufgeworfen ist. Von hier aus wird in einem Ausblick nach der Begegnung als organisierendem Phantasma der analytischen Situation gefragt und – auf dem Weg einer Erörterung des Begegnungsbegriffs bei Martin Buber – versucht, Begegnung dimensional näher zu bestimmen. (shrink)

"Fritsche's book, which is closely researched, carefully argued, and philologically rigorous, will become an indispensable point of reference for further debates on Heidegger's ambiguous political and ethical legacy."—Richard Wolin, author of The Politics of Being "Unquestionably, Fritsche has a highly unusual command of the Heideggerian idiom, which he uses to very good effect."—Tom Rockmore, author of On Heidegger's Nazism and Philosophy.

The _Grundriss der Geschichte der Philosophie_ is the most comprehensive history of philosophy ever published in any language. Since the publication the initial volume in 1863 it has been the aim of this vast scholarly undertaking to elucidate philosophical systems and schools of thought as completely and objectively as possible. Thanks to these merits the _GGPh_ has become the standard work of reference on the history of philosophy for entire generations of scholars, teachers and students of all academic domains. While (...) the first editions had only three volumes, the completely revised new edition published by Schwabe Verlag in Basel, Switzerland, since 1988 is going to comprise of more than 30 volumes. Applying highest scholarly standards, the editors aim at balanced, well-informed presentations of of highest objectivity of individual philosophers, traditions of thought and of philosophical debates. (shrink)

The _Grundriss der Geschichte der Philosophie_ is the most comprehensive history of philosophy ever published in any language. Since the publication the initial volume in 1863 it has been the aim of this vast scholarly undertaking to elucidate philosophical systems and schools of thought as completely and objectively as possible. Thanks to these merits the _GGPh_ has become the standard work of reference on the history of philosophy for entire generations of scholars, teachers and students of all academic domains. While (...) the first editions had only three volumes, the completely revised new edition published by Schwabe Verlag in Basel, Switzerland, since 1988 is going to comprise of more than 30 volumes. Applying highest scholarly standards, the editors aim at balanced, well-informed presentations of of highest objectivity of individual philosophers, traditions of thought and of philosophical debates. (shrink)

The _Grundriss der Geschichte der Philosophie_ is the most comprehensive history of philosophy ever published in any language. Since the publication the initial volume in 1863 it has been the aim of this vast scholarly undertaking to elucidate philosophical systems and schools of thought as completely and objectively as possible. Thanks to these merits the _GGPh_ has become the standard work of reference on the history of philosophy for entire generations of scholars, teachers and students of all academic domains. While (...) the first editions had only three volumes, the completely revised new edition published by Schwabe Verlag in Basel, Switzerland, since 1988 is going to comprise of more than 30 volumes. Applying highest scholarly standards, the editors aim at balanced, well-informed presentations of of highest objectivity of individual philosophers, traditions of thought and of philosophical debates. (shrink)

The _Grundriss der Geschichte der Philosophie_ is the most comprehensive history of philosophy ever published in any language. Since the publication the initial volume in 1863 it has been the aim of this vast scholarly undertaking to elucidate philosophical systems and schools of thought as completely and objectively as possible. Thanks to these merits the _GGPh_ has become the standard work of reference on the history of philosophy for entire generations of scholars, teachers and students of all academic domains. While (...) the first editions had only three volumes, the completely revised new edition published by Schwabe Verlag in Basel, Switzerland, since 1988 is going to comprise of more than 30 volumes. Applying highest scholarly standards, the editors aim at balanced, well-informed presentations of of highest objectivity of individual philosophers, traditions of thought and of philosophical debates. (shrink)

The possibility of apparently negative causation has been discussed in a number of recent works on causation, but the discussion has suffered from beingscattered. In this paper, the problem of apparently negative causation and its attemptedsolutions are examined in more detail. I discuss and discard three attempts that have beensuggested in the literature. My conclusion is negative: Negative causation shows that thetraditional cause & effect view is inadequate. A more unified causal perspective is needed.

Both thought experiments and simulation experiments apparently belong to the family of experiments, though they are somewhat special members because they work without intervention into the natural world. Instead they explore hypothetical worlds. For this reason many have wondered whether referring to them as “experiments” is justified at all. While most authors are concerned with only one type of “imagined” experiment – either simulation or thought experiment – the present chapter hopes to gain new insight by considering what the two (...) types of experiment share, and what they do not. A close look reveals at least one fundamental methodological difference between thought and simulation experiments: while thought experiments are a cognitive process that employs intuition, simulation experiments rest on automated iterations of formal algorithms. It will be argued that this difference has important epistemological ramifications. (shrink)

There is evidence that bidders fall prey to the winner’s curse because they fail to extract information from hypothetical events—like winning an auction. This paper investigates experimentally whether bidders in a common value auction perform better when the requirements for this cognitive issue—also denoted by contingent reasoning—are relaxed, leaving all other parameters unchanged. For my underlying research question, I used a lab experiment with two stages. In stage I, the subjects participate in a non-standard common value auction, called the wallet (...) game, in which a naïve bidding strategy can lead to both winner’s curse and loser’s curse. In stage II, the subjects in the treatment group learn whether their initial bid was the winning bid or not and they get the opportunity to change this bid. In this sense, the bidders face the same decision problems as in stage I again, but the need for hypothetical thinking is reduced in stage II. The overall pattern of the data suggests that the problem of irrational over- and underbidding can be weakened by giving the subjects ex ante feedback about their bid, but unlike related studies I also find negative effects of additional information. (shrink)

After achieving sustained graft functioning in animal studies, the next step in the progression of xenotransplantation towards clinical application is the initiation of the first clinical trials. This raises the question according to which criteria patients shall be selected for these trials. While the discussion regarding medical criteria has already commenced, ethical considerations must also be taken into account. This is essential, first, to establish a procedure that is ethically reasonable and justified. Second, it is a prerequisite for a publicly (...) acceptable and comprehensible implementation. This paper outlines a multicriteria approach for the selection of patients in first-in-human clinical trials of cardiac xenotransplantation with four ethical criteria: medical need, capacity to benefit, patient choice and compliance (as an exclusion criterion). Consequently, these criteria identify a primary target group of patients who exhibit a high medical need for cardiac xenotransplantation, face a high risk of morbidity and mortality without an organ replcaement therapy, have a substantial chance of benefiting from xenotransplantation, thereby also enhancing the scientific value of the trial, and qualify for an allotransplant to have a real choice between participating in a first-in-human xenotransplantation trial and waiting for a human organ. A secondary group would include patients for whom only the first two criteria are met, that is, who have a high medical need and a good capacity to benefit from xenotransplantation but who have a restricted choice because they do not qualify for an allotransplant. (shrink)

Der Band gibt wichtige Impulse für die methodologische Reflexion der historischen Kulturwissenschaften. Er geht auf eine Tagung zurück, deren Thema "Dichtung und Wahrheit. Zum Verhältnis von Narration und Erklärung in den Kultur-, Geistes- und Sozialwissenschaften" war. Die Autoren greifen zum ersten Mal im kulturwissenschaftlichen Kontext Anregungen vor allem aus der Analytischen Philosophie auf und diskutieren ihren Wert für historisches und kulturwissenschaftliches Arbeiten. Im Fokus der Untersuchungen steht eine Begriffstrias, die für die Sozial-, Geistes- und Kulturwissenschaften gleichermaßen seit dem 19. Jahrhundert (...) eine große Herausforderung darstellt: Erklären, Verstehen und Erzählen. (shrink)

To address societal challenges, research and innovation approaches, involving a wide range of actors, are increasingly promoted by policy communities. This paper explores the practice of Quadruple Helix collaborations for responsible innovation and how these implement the theoretical ambition of including actors from different societal sectors in innovation, including actors from the fields of arts, media and civil society, which is conceptualized as the Fourth Helix in this concept. Referring to cross-sector collaboration literature and based on an empirical investigation, we (...) explore which actors, representing the Fourth Helix, actually engage in innovation collaborations, how this engagement plays out in practice, and the institutional and systemic dynamics involved in output and value creation. We rely on data from three Social Labs in Austria, Germany, and the Netherlands, which constitute qualitative, change-oriented research processes, where we researched and engaged with actors from cases constituting- or aiming for a Quadruple Helix collaboration. This was accompanied by a desktop study including qualitative interviews of 51 further cases. We find that the actual engagement of actors from civil society is fragile and that forces beyond Quadruple Helix cases impact these quite firmly in some cases. (shrink)