GRAS is a recently discovered family of plant-specific proteins that play important regulatory roles in diverse aspects of plant development. Several of the motifs present in the GRAS proteins suggest that they function as transcription factors, although homology-searching programs have revealed no significant similarity to any non-plant proteins. Here we propose that the GRAS proteins are related to the Signal Transducers and Activators of Transcription (STAT) family of proteins. STATs are known in many non-plant species, and act as intracellular intermediaries (...) between extracellular ligands and the transcription and activation of genes. Our hypothesis is that the GRAS proteins perform this function in plants, with mechanisms similar to those of the animal STATs. If true, this hypothesis has important implications for the evolution of phosphotyrosine based signal transduction systems in eukaryotic organisms. BioEssays 22:573–577, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

The isolation requirements of the coronavirus epidemic and the intuitive display advantages of live-streaming have led to an increasing number of retailers shifting to social live-streaming platforms and e-commerce live-streaming platforms to promote and sell their products in real time. However, the provision of live-streaming services will also incur high live-streaming effort costs. In this paper, we develop two decision models for retailers to sell goods through a single online shop and both online shop and live-streaming room; we also present (...) the optimal decisions of pricing and live-streaming efforts. Furthermore, we identify the profitability conditions for retailers to determine when to provide live-streaming services. In addition, we examine the impact of the provision of live-streaming services on the optimal price and live-streaming effort. We obtain three findings. First, there is a unique optimal decision on the price and live-streaming effort under certain conditions. Second, when the effect coefficient of the live-streaming room reaches a certain threshold, there are enough customers who enter the live-streaming room to watch and buy and it is profitable for retailers to provide live-streaming service. Finally, the optimal price and live-streaming effort increase with the increase in average return loss, the effect coefficient of live-streaming effort, and the extra return rate and decrease with the increase in the proportion of customers who choose to buy in the online shop and the price discount coefficient in the live-streaming room. (shrink)

The Party school has always been an important bastion through which our Party trains and educates its cadres in Marxism-Leninism and Mao Zedong Thought. The Party Central Committee headed by Chairman Hua has laid great emphasis on the Party school since the smashing of the "gang of four" and has made special decisions on how successfully to run the Party schools on different levels. Chairman Hua and Vice Chairman Ye personally made important speeches at the opening ceremony of the Central (...) Party School and indicated the direction in which the Party school should be run during the new stage of historical development. Pursuant to the Central Committee's decision, the Shanghai Municipal Party Committee has restored its Party school which had been closed down for some ten years by the "gang of four." Since its reopening, the Municipal Party School has already run a one-term study class for the cadres and has achieved fairly good results. In the future, we will run the study class every term and strive to run the Party school better and better. (shrink)

The aim of this paper is to describe and analyze people's confidence in political institutions in the so-called BRICS countries, that is, Brazil, Russia, India, China, and South Africa. I argue that the quality of macroeconomic indicators cannot explain the variation in political confidence between the five most dynamic new emerging economies, and that there is no substantial difference among the young, middle-aged, and senior-aged groups. By combing data from the Asia Barometer Survey and the World Value Survey, I provide (...) two complementary approaches, one sociocultural and the other micropolitical, to reveal the factors that influence people's confidence in four major political institutions. The explanatory effects of these two approaches are mixed. Political identity and values, in most cases, have a significant impact on political confidence. On the other hand, high levels of interpersonal social trust, individual happiness, and satisfaction with living standards also show positive influences. (shrink)

Dujiangyan irrigation system of more than 2000 years history is a symbol of originality of Chinese ancestors both in its conception and project mode. It is still working well and benefit Chengdu Plain nowadays while other comparable water conservancy projects of the same or later age have vanished and been forgotten. More than just a world-famous cultural heritage, it shows the harmonious relationship between man and nature. And it also reveals us how to solve problems in the era of economic (...) globalization, such as the constantly silt up of the dams, the exhaustion of the energy and the crisis of the deterioration of ecosystem. The inspirations it gives us range from technology to humanities, from economy to various aspects in social life. In a word, Dujiangyan irrigation system demonstrates the wisdom and creativity of Chinese people and has a universal significance despite the change of time and space. (shrink)

This paper explores the often-overlooked role of teaching assistants (TAs) in engineering ethics courses, and a particular challenge that TAs face in these roles. TAs not only undertake tasks like instructors, which include teaching, guiding, and evaluating courses, but they also assume the roles of “intermediaries between instructors and students” and “learners becoming teachers.” These distinct roles present TAs with unique challenges, one of which we call the neutrality problem. This problem pertains to whether TAs can and should maintain a (...) neutral stance in the classroom, particularly when students articulate ideas that deviate from the values promoted in the course or held by the TAs. Using a real-life teaching experience as illustrative, we claim that it is challenging and, at times, undesirable for TAs to achieve pedagogical neutrality, primarily due to their pre-existing understanding of ethics and the actual situation of the students. Nevertheless, we posit that TAs should strive to foster an environment where students are encouraged to improve their ethical awareness. Through the underrepresented lens of TAs, we aim to initiate a multi-faceted dialogue on the teaching philosophy and goal of engineering ethics. (shrink)

Chinese drama was developed in the thirteenth century, but its roots can be traced back to music, one of the six arts, the main subjects in the Confucian curriculum. Yue is not only a synthesis of instrumental music, song, poetry, and dance as aspects of the fine arts, but also a method to promote moral education. In Confucianism, moral implications trump all other considerations in the discussion and evaluation of yue. This is what makes Confucianism the radical moralism that dominated (...) Chinese aesthetics before the Han dynasty. But Confucian moralism was attacked by Ji Kang 嵇康, a great scholar, musician, and Daoist philosopher who argued for the radical autonomism of music in his.. (shrink)

Under the influence of the linguistic turn in philosophy, contemporary Western philosophers typically limit their thinking on pluralism to the realm of language. This sort of pluralism can be named as pluralism of significance. I propose another version of pluralism in light of Confucianism, which extends the concerns from the realm of language to the realm of experience – I call it pluralism of presence. In this article, I first expound the aforementioned two versions of pluralism on the basis of (...) Hans-Georg Moeller’s semiotic trichotomy. I then argue that the conflict between multiculturalism and cultural identity in today’s globalized world and the failure of pluralism of significance in resolving this conflict can be overcome by pluralism of presence. Finally, I show a possibility of reconciliation between pluralism of significance and pluralism of presence. (shrink)

The relationships between age and the life-supporting treatments use, and between gender and the life-supporting treatments use are still controversial. Using extracorporeal membrane oxygenation as an example of life-supporting treatments, the objectives of this study were: to examine the relationship between age and the extracorporeal membrane oxygenation use; to examine the relationship between age and the extracorporeal membrane oxygenation use; and to deliberate the ethical and societal implications of age and gender disparities in the initiation of extracorporeal membrane oxygenation. This (...) is a population-based, retrospective cohort study. Taiwan’s extracorporeal membrane oxygenation cases from 2000 to 2010 were collected. The annual incidence rate of extracorporeal membrane oxygenation use adjusting for both age and gender distribution for each year from 2000 to 2010 was derived using the population of 2000 as the reference population. The trend of extracorporeal membrane oxygenation use was examined using time-series linear regression analysis. We conducted joinpoint regression for estimating the trend change of extracorporeal membrane oxygenation use. The trends of extracorporeal membrane oxygenation use both for different gender groups, and for different age groups have been significantly increasing over time. Men were more likely to be supported by extracorporeal membrane oxygenation than women. Women’s perspectives toward life and death, and women’s perception of well-being may be associated with the phenomenon. In addition, the patients at the age of 65 or older were more likely to be supported by extracorporeal membrane oxygenation than those younger than 65. Family autonomy/family-determination, and the Confucian tradition of filial piety and respecting elders may account for this phenomenon. This study showed gender and age disparities in the initiation of extracorporeal membrane oxygenation use in Taiwan, which may be accounted for by the cultural and societal values in Taiwan. For a healthcare professional who deals with patients’/family members’ medical decision-making to initiate life-supporting treatments, he/she should be sensitive not only to the legality, but also the societal and ethical issues involved. (shrink)

The topic of this issue of Contemporary Chinese Thought is the authorship, annotations, and philosophical interpretation of the Wuxing and evidence of the thought of Zisi and Mencius in the Wuxing. Four of the essays translated here are by Chen Lai, formerly professor of Chinese philosophy at Peking University and now dean of the School of Traditional Chinese Learning at Tsinghua University. An essay by Xing Wen, of Dartmouth College, provides context for a proper understanding of the Wuxing and Chen (...) Lai's scholarship on the Wuxing. (shrink)

The purpose of this study is to extend prior research on this topic by investigating whether the impact of ownership concentration moderates the link between corporate social performance and financial performance. This study uses a set of unique, hand-collected pollution control data to measure CSP, based on a sample of Taiwanese listed companies during the period from 1996 to 2006. The results of the empirical analysis provide firm support for the idea that the divergence between control rights and the cash (...) flow rights of controlling owners negatively moderates the link between social and short- and long-run FP. (shrink)

Strong Turing Determinacy, or ${\mathrm {sTD}}$, is the statement that for every set A of reals, if $\forall x\exists y\geq _T x (y\in A)$, then there is a pointed set $P\subseteq A$. We prove the following consequences of Turing Determinacy ( ${\mathrm {TD}}$ ) and ${\mathrm {sTD}}$ over ${\mathrm {ZF}}$ —the Zermelo–Fraenkel axiomatic set theory without the Axiom of Choice: (1) ${\mathrm {ZF}}+{\mathrm {TD}}$ implies $\mathrm {wDC}_{\mathbb {R}}$ —a weaker version of $\mathrm {DC}_{\mathbb {R}}$.(2) ${\mathrm {ZF}}+{\mathrm {sTD}}$ implies that every (...) set of reals is measurable and has Baire property.(3) ${\mathrm {ZF}}+{\mathrm {sTD}}$ implies that every uncountable set of reals has a perfect subset.(4) ${\mathrm {ZF}}+{\mathrm {sTD}}$ implies that for every set of reals A and every $\epsilon>0$ :(a)There is a closed set $F\subseteq A$ such that $\mathrm {Dim_H}(F)\geq \mathrm {Dim_H}(A)-\epsilon $, where $\mathrm {Dim_H}$ is the Hausdorff dimension.(b)There is a closed set $F\subseteq A$ such that $\mathrm {Dim_P}(F)\geq \mathrm {Dim_P}(A)-\epsilon $, where $\mathrm {Dim_P}$ is the packing dimension. (shrink)

Abstract:The most important themes of Wang Lü's painting theory are the "true self" and the "true thing." One reason this topic has not received sufficient attention is that the original text was altered. This article aims to correct and reinterpret the text. After textual research and interpretation, Wang Lü's paintings and painting theory have been reevaluated. This article also responds to some difficult topics such as the relationship between "form" (ᔶ) and "meaning" (ᛣ) and between "following" (ᕲ) and "not following" (...) (䘩) the rules in Chinese painting theory. (shrink)

This article explores the moral permissibility of sweatshop boycotts. We build explicitly on Tomhave and Vopat’s (2018) framework for evaluating the moral permissibility of boycotts in general for the specific case of sweatshop labor. We argue that sweatshop boycotts are more likely to be morally justified when targeting forced labor compared to free labor and we explore the relevant moral tradeoffs associated with boycotts of free labor sweatshops. We analyze the morality of three cases of sweatshop boycotts—Indonesia in the 1990s, (...) Bangladesh following the 2013 Rana Plaza disaster, and the Uyghur region in China—and then discuss how insights from these cases might provide a model to guide activists and business ethicists in analyzing the morality of other sweatshop boycotts. (shrink)

全书以灾异思想为切入点，以西汉经学灾异思想与思潮为中心，结合先秦至西汉间的时代背景与思想氛围，在细致考察与解读相关文本的基础上，对西汉经学灾异思想的观念来源与理论先导、创立过程与时代特色、理论形态与建 构方法，以及灾异思潮与现实政治的互动等问题，进行了全面深入的研究和探讨；对于经学灾异思想何以会在西汉建立、经学灾异思潮缘何会在西汉爆发、经学灾异论造成了怎样的历史影响，以及如何评价灾异论氛围中的西汉儒 学与儒生群体等问题，本书也进行了系统的反思，并提出了一系列见解。.

Xunzi’s philosophy of language was mainly unfolded through the discrimination of ming 名 (names) and shi 实 (realities) and the discrimination of yan 言 (words) and yi 意 (meanings). Particularly, the discrimination of names and realities was centered on the propositions that realities are realized when their names are heard and that names are given to point up realities, including the view on the essence of language such as names expect to indicate realities and conventions established by usage, the view (...) of development of language such as coming form the former usage and being newly established, and the view of functions of language such as discriminating superiority and inferiority and differentiating identities and differences ; while the discrimination of words and meanings mainly contained two aspects: One was that words could completely represent meanings while it could not do so on the other hand, and the other was that the Dao should be grasped through an unoccupied, concentrated and quiet mind. Xunzi’s philosophy of language stressed both language’s value attribute and its cognitive attribute, and it is the greatest achievement of pre-Qin dynasty’s philosophy of language. (shrink)

Der Autor hat sich die Aufgabe gestellt, Husserls Phänomemologie der Zeit systematisch zu interpretieren und das Differenzieren und Identifizieren zu problematisieren. Er untersucht Husserls Zeitphänomenologie mit rein phänomenologischem Blick, damit folgende Fragen beantwortet werden können: Worin liegt die Bedeutung von Husserls Zeitforschung? Beschränken sich seine Zeitgedanken noch auf die Denkweise der Metaphysik, wie Natorp und Heidegger behaupten. Wenn ja, worin verkörpert sich die metaphysische Denkweise und inwiefern bewegen sie sich im Rahmen der Tradition? Diese Untersuchung beginnt damit, Husserls Zeitphänomenologie systematisch (...) zu rekonstruieren, weil sich Husserls Gedanken und Forschungen zur Zeit uber zahlreiche Manuskripte und Werke verteilen. Nur anhand einer umfassenden, systematischen Rekonstruktion der Zeittheorie Husserls können die obigen Fragen angemessen beantwortet werden. Der Autor geht dann auf die Differenz- und Identitätsprobleme in Husserls Zeitphänomenologie ein. Er versucht Aporien, wie den unendlichen Regress, zu analysieren und zu beantworten. (shrink)

Journal of Mathematical Logic, Volume 24, Issue 03, December 2024. We construct a model in which MA[math] holds and [math] fails. This shows that MA[math] does not imply [math] and answers an old question of Larson and Todorcevic in [Katetov’s problem, Trans. Amer. Math. Soc. 354(5) (2002) 1783–1791]. We also investigate different strong colorings in models of MA[math].

This study aimed to explore the mediating effects of internet gaming disorder, social network use, and generalized pathological internet use on the association between loneliness and depression. A total of 2211 junior high school students completed questionnaires regarding loneliness, internet gaming disorder, social network use, GPIU, and depression. The results of a structural equation model revealed that the path coefficient of loneliness to depression was significantly positive, loneliness could not predict depression through GPIU directly, but loneliness could predict depression through (...) internet gaming disorder to GPIU, loneliness could predict depression through social network use to GPIU, and loneliness could not predict depression through internet gaming disorder to social network use to GPIU. These results provided significant implications for the prevention and reduction of depression in Chinese junior high school students. (shrink)

This study develops a short Creative Expression Interest Scale among Chinese freshmen based on the perspective of item response theory. Nine hundred fifty-nine valid Chinese freshmen participated in the Creative Expression Interest survey. Researchers applied the initial data for unidimensionality, item fit, discrimination parameter, and differential item functioning to obtain a short CEIS. The results show that the Short CEIS meets the psychometric requirements of the IRT. Pearson correlation coefficient of theta between the short and long CEIS is 0.922. The (...) marginal reliability of the short CEIS is 0.799. These indicate that the short CEIS developed in this study among Chinese freshmen, meets the psychometric requirements. Although the Short CEIS can eliminate redundant, uninformative items, save time, and improve the quality of data collection. However, the validity of this short scale needs further validation. (shrink)