Since its original identification as a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, K protein has been found not only in the nucleus but also in the cytoplasm and mitochondria and is implicated in chromatin remodeling, transcription, splicing and translation processes. K protein contains multiple modules that, on one hand, bind kinases while, on the other hand, recruit chromatin, transcription, splicing and translation factors. Moreover, the K‐ protein‐mediated interactions are regulated by signaling cascades. These observations are consistent with K (...) protein acting as a docking platform to integrate signaling cascades by facilitating cross‐talk between kinases and factors that mediate nucleic‐acid‐directed processes. Comparison of K across species reveals that it is an essential factor in metazoans, but not in yeast. Although some of the K protein interactions and functions are conserved in eukaryotes from yeast to man, the mammalian protein seems to play a wider role. The greater diversity of mammalian K protein interactions and function may reflect gain of novel docking sites and expansion evolutionary of gene expression networks. BioEssays 26:629–638, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Jerzy Perzanowski s ideas were based on an original blend of logic and ontology in what he called onto/logic, where the slash is meant to suggest a quotient of ontology by logic. Perzanowski began as a logician, his early works being on modal logic, then gradually shifted his interest to logical philosophy, meaning not so much philosophy of logic as philosophy informed by logic. Perzanowski was a rare breed of analytical philosopher who thought that a philosophical theory of everything (...) was worthwhile. In this systematic spirit, he began with method. He presented his method of total analysis and synthesis quite simply: reduce the object of research to its simplest possible constituents, and then combine them in some way. Better still, combine them in every possible way, thereby producing a space of possibilities analogous to (and in certain cases identical with) the logical space. Thus, analysis and synthesis differ from a trivial disassembly and reassembly.". (shrink)

Chciałem Go pożegnać. Kilkakrotnie próbowałem napisać choć parę słów. O Nim samym. Okazało się, że nie potrafię. Udało mi się tylko przedstawić Jego poglądy na reizm Tadeusza Kotarbińskiego, ale uczyniłem to gdzie indziej. Muszę tu poprzestać na ofiarowaniu Mu tego, co napisałem na Jego dziewięćdziesiąte urodziny, w osiemdziesięciolecie naszej przyjaźni.

A gap exists between the philosophers of history and the practitioners. Both groups proudly encourage their splendid isolation from the other. The philosophers tend to consider the practitioners incompetent to philosophize about historical study; the practitioners tend to think that the philosophers engage only in “flimflam.” Insofar as one can judge from the practitioners’ attempts to formulate theories of historical study and the philosophers’ attempts to explain historical practice, each group is right about the other. As a result, the practitioners (...) of history rarely ponder theoretical issues because they tend to feel that there are more worthwhile pursuits, such as studying the past. The philosophers rarely examine how historical study is actually done because they tend to feel that the practice is not important for their exquisitely designed theoretical models. (shrink)

The narration in the music video to Celine Dion’s song All By Myself is a linearly organised construct or composition equipped with features of logicality, which organises specific linguistic or image-based material. It constructs a fiction based on the principles of dramatism. If one assumes that a music video can be analysed as a system which produces meaning, then the production occurs mainly within two dimensions. Firstly, as fiction, and secondly, as narration. The sequential editing adds significance to the entire (...) film. The specific connection points of individual scenes influence the interpretation of the images by viewers – they extract the significance of a portion of the music video. Surely this phenomenon could be defined as a production of sense. (shrink)

The paper defends a dynamic view of reality which is founded on the assumption of the existence of the flow of time. This vindication makes use of a metaphysical theory of the flow of time developed by the author which is based on the notion of dynamic existence. It is shown that such a conception allows one to explain the fundamental phenomena connected with the flow of time, namely the continuous changing of the present, the endurance of things, and the (...) asymmetry of time. It is also argued that the proposed approach may be of some virtue for the empirical sciences because it explains the ubiquitous interest of scientists in the evolution of dynamic systems of different kinds, and provides us with an arrow of time which is lacking in theories describing fundamental physical interactions. The argument is advanced which aims to show that physics is unable to provide us with a theory of the flow of time and that we should look for such a theory in metaphysics. Thus, an approach to the relation between metaphysics and physics is vindicated that may help to overcome the difficulties blocking our understanding of reality as a dynamic one. (shrink)

In times of erosion and dissolution of social structures and institutions, described by Bauman as the interregnum, there arises both a need and a possibility of developing alternative approaches to the most fundamental organizational practices. Marketing, a simultaneously tremendously successful and much criticized sub-discipline and practice, is a prime candidate for such a redefinition. Potential prefigurations of future processes of organizing and institutionalizing can be found within dissenting organizations, the alternative organizations built at the fringes of, and in opposition to, (...) the mainstream businesses as reported by Parker et al.. In this paper, we present an exploration of the alternative yet already enacted practice we call earnest marketing. Drawing on an ethnographic study of a number of dissenting organizations in the United Kingdom and Poland, we focus on the radical reconstitution of marketing evidenced in their practice, defined by an attitude of earnestness and dedication to the dissemination and demonstration of their self-defined goodness: ideas and values. As organizations engage in earnest marketing, they also become receptive to reciprocal messages from their environments. We conclude by reflecting on the possibilities of a dissenting management model developing the principles of earnest marketing beyond disciplinary confines. (shrink)

The old-fashioned concept of state is shown to be inadequate and misleading. Replacing it by a concept of information and taking advantage of the invariance of the mechanical description under time reversal puts the problems of the interpretation of quantum mechanics in a new light. A more realistic interpretation appears to be possible. Moreover, a new explanation of the Einstein-Podolsky-Rosen paradox is presented, too.

Jerzy Franczak comprehensively presents Jacques Rancière's thought by emphasizing the relations between politics and literature. The detailed analysis considers the context of modern aesthetics and political philosophy, which is why the book introduces further protagonists, such as Louis Althusser, Michel Foucault, Pierre Bourdieu, or Jean-François Lyotard. Franczak first reconstructs Rancière's original philosophy of literature so as to then immediately apply it in readings of select world literature masterpieces by Gustav Flaubert, Max Jacob, Bertold Brecht, Vladimir Nabokov, and Philip Roth.

The aim of this paper is to make presentism a dynamic view of reality by basing it on a notion of dynamic existence, that is, on a notion of existence which has a dynamic character. The paper shows that both of the notions of existence which are used in metaphysical theories of time have a static character and, while such a notion is useful for eternalists, it is useless for presentists if they want to make their view able to remain (...) in agreement with our everyday experience and self-consistent. It is demonstrated that both empirical and theoretical arguments indicate that the presentist should replace the notion of this static existence with the notion of a dynamic existence and that this maneuver allows the presentist to treat his/her existential thesis as equivalent to the thesis that time flows. Not only does this strategy allow us to express presentism in a simple, homogenous way which remains in agreement with our experience, but also permits us to solve some of the difficult problems which presentism faces, such as, for example, the objection of triviality and the question about the rate of time passage. Moreover, such an approach to presentism allows us to solve fundamental metaphysical problems concerning time such as the problem of the openness of the future and the fixity of the past, direction of causation, and relations between presentism and persistence through time by endurance. (shrink)

The paper examines the relations between presentism and the thesis concerning the existence of the flow of time. It tries to show that the presentist has to admit the existence of the passage of time and that the standard formulation of presentism as a singular thesis saying that only the present exists is insufficient because it does not allow the inference of the existence of the passage of time. Instead of this, the paper proposes a formulation of presentism with the (...) aid of the notion of becoming; not only does a formulation state the existence of the flow of time in such a way as to avoid the question of the rate of the passage of time, it also allows the inference of the existence of only present things and events. The paper demonstrates that the proposed conception of presentism also has other virtues, such as homogeneity, non-triviality, and ability to express dynamicity of presentists’ image of the world which testify for it. (shrink)

The paper analyzes the philosophical consequences of the recent discovery of direct violations of the time–reversal symmetry of weak interactions. It shows that although we have here an important case of the time asymmetry of one of the fundamental physical forces which could have had a great impact on the form of our world with an excess of matter over antimatter, this asymmetry cannot be treated as the asymmetry of time itself but rather as an asymmetry of some specific physical (...) process in time. The paper also analyzes the consequences of the new discovery for the general problem of the possible connections between direction of time and time-asymmetric laws of nature. These problems are analyzed in the context of Horwich’s Asymmetries in time: problems in the philosophy of science argumentation, trying to show that existence of a time–asymmetric law of nature is a sufficient condition for time to be anisotropic. Instead of Horwich’s sufficient condition for anisotropy of time, it is stressed that for a theory of asymmetry of time to be acceptable it should explain all fundamental time asymmetries: the asymmetry of traces, the asymmetry of causation, and the asymmetry between the fixed past and open future. It is so because the problem of the direction of time has originated from our attempts to understand these asymmetries and every plausible theory of the direction of time should explain them. (shrink)

The idea of rejection of some sentences on the basis of others comes from Aristotle, as Jan Łukasiewicz states in his studies on Aristotle's syllogistic [1939, 1951], concerning rejection of the false syllogistic form and those on certain calculus of propositions. Short historical remarks on the origin and development of the notion of a rejected sentence, introduced into logic by Jan Łukasiewicz, are contained in the Introduction of this paper. This paper is to a considerable extent a summary of papers (...) which are not easily available, even to the Polish reader: (1) J. Słupecki, Funkcja Łukasiewicza (Łukasiewicz’s function), Zeszyty Naukowe Uniwersytetu Wrocławskiego, Seria B, nr 3 (1959), 33-40; (2) U. Wybraniec-Skardowska, Teoria zdań odrzuconych (Theory of Rejected Sentences), (doctoral dissertation under the supervision of Jerzy Słupecki, published as a monograph), Zeszyty Naukowe Wyższej Szkoły Pedagogicznej w Opolu, Studia i Monografie, Nr 22 (1969), 5-131; (3) G. Bryll, Kilka uzupełnień teorii zdań odrzuconych (Some supplements to the theory of rejcted sentences), Zeszyty Naukowe Wyższej Szkoły Pedagogicznej w Opolu, Studia i Mnografie, Nr 22 (1969), 153-154. The paper also contains a good number of results which have not been published yet. Chapter I contains results presented in the papers (1)-(3). It provides an extension of Alfred Tarski’s theory of deductive systems presented by him in the papers [1930]: Fundamentale Begriffe der Methodologie der deduktiven Wssenschaften, I and Über einige fundamentale Begriffe der Metamathematik. The enriched theory is marked with T. The most essential new concept in T is the function Cn-1, whose definition was given by Słupecki in (1) on the basis of the so-called Tarski’s general theory of deductive systems. It has the form: y e Cn-1X iff Ex e X (x e Cn {y}), where Cn is Tarski’s consequence operation. In accordance with the definition: A sentence y is rejected on the basis of the sentences of the set X iff at least one of sentences of X is a consequence of y (is deducible from y). The intuitive meaning of the rejection function Cn-1: on the basis of false sentences we can reject false sentences only (while by means of the consequence operation Cn on the basis of true sentences we can deduce true sentences only). The function Cn-1 is a generalization of the notion of rejected sentences which was introduced into logic by Łukasiewicz. The essential property of the rejection function Cn-1 is that it satisfies the axioms of general Tarski’s consequence Cn, so it is a consequence operation, called the rejection consequence. In addition, it is an additive and normal operation. In Chapter I, there are given notions analogous to those of the theory of deductive systems, but they are written down by means of the symbol ‘Cn-1’ and not ‘Cn’. There are established the properties of introduced notions and differences and analogies taking place between them and properties of respective notions of the theory T. There are also given generalizations of the notions of ‘decidable system’ and ‘consistent system’ used by Łukasiewicz. The short Chapter II contains axioms of the system T’ which is equivalent to the system T. The only difference between sets of primitive notions of these systems consists in the appearance of the function Cn-1 in the system T’ instead of the function Cn. This chapter reproduces the results given in (2), but they are partially simplified. (shrink)

This paper is a continuation of Part I under the same title. Its Chapter III contains results given in the following publications: U. Wybraniec-Skardowska, Teoria zdań odrzuconych (Theory of Rejected Sentences), (doctoral dissertation under the supervision of Jerzy Słupecki, published as a monograph), Zeszyty Naukowe Wyższej Szkoły Pedagogicznej w Opolu, Studia i Monografie, Nr 22 (1969), 5-131. G. Bryll, Związki logiczne pomiędzy zdaniami nauk empirycznych (Logical relations between sentences of empirical sciences). Zeszyty Naukowe Wyższej Szkoły Pedagogicznej w Opolu, Studia (...) i Monografie, Nr 22 (1969), 155-216. This chapter contains an attempt to formalize some questions of methodology of empirical sciences. The theory T is enriched here not only by new definitions but also by a new primitive term and new axioms. The most important notion defined in this chapter is the set IndX of all inductive conclusions obtained on the basis of sentences of the set X. The function CnI defined by the equality: CnI X = X u IndX, satisfies the axioms of the general theory of deductive systems. The set CnI X can be understood as a system of empirical sciences in a narrower sense. This paper is a development of the considerations of G. Bryll, included in the above-listed article by this author. (shrink)

The article is devoted to the evaluation of the ecological alternative in cognitive psychology. The theory of „extended minds” is discussed in this paper as a version of ecological psychology. The authors of the theory of extended mind advocate „active externalism”, based on the active role of the environment in driving cognitive processes. The environment, driving cognitive processes, comprises books, diagrams, language, and other culture products. Władysław Witwicki's psychology and his idea of real presence of persons in cultural products which (...) they create, provide a conceptual framework for the undertaken analysis and evaluation. (shrink)

The historical literature of the past two centuries testifies to disputes about what historical knowledge is and the relationship of the historian to it. The disputes have been fierce enough for each side to declare that any position other than its own is untenable. It would be futile to try to convince those who so staunchly defend their own ground that the other side might have a legitimate contribution to make. Yet, it might be worthwhile to classify the positions so (...) as to focus the arguments on legitimate issues, and, in some measure, to begin to resolve them. (shrink)

The article analyses the role of Church’s Thesis (hereinafter CT) in the context of the development of hypercomputation research. The text begins by presenting various views on the essence of computer science and the limitations of its methods. Then CT and its importance in determining the limits of methods used by computer science is presented. Basing on the above explanations, the work goes on to characterize various proposals of hypercomputation showing their relative power in relation to the arithmetic hierarchy. The (...) general theme of the article is the analysis of mutual relations between the content of CT and the theories of hypercomputation. In the main part of the paper the arguments for abolition of CT caused by the introduction of hypercomputable methods in computer science are presented and critique of these views is presented. The role of the efficiency condition contained in the formulation of CT is stressed. The discussion ends with a summary defending the current status of Church’s thesis within the framework of philosophy and computer science as an important point of reference for determining what the notion of effective calculability really is. The considerations included in this article seem to be quite up-to-date relative to the current state of affairs in computer science.1. (shrink)

The present note is intended to draw the reader's attention to the analysis of the relation between Newtonian Mechanics and Special Relativity Mechanics (henceforth to be referred to as NM and SRM), given by Philipp Frank, one of the classics of Logical Empiricism (in Frank [1938]). Frank's analysis of the relation between NM and SRM is interesting in many ways. Firstly, it shows clearly that problems of disruptive changes and of conceptual disparity were known to and discussed by Logical Empiricists (...) and that, therefore, some of them at least were not at all blinded to 'dynamic' problems of changes in actual science by their view of physical theories as interpreted axiomatic systems and did not deal with those theories as 'static, frozen in logical mold'. Secondly, it reveals some of the reasons for the Logical Empiricist rejection of what came to be known later as the incommensurability claim. (shrink)

The axiom of canonicity was introduced by the famous Polish logician Roman Suszko in 1951 as an explication of Skolem's Paradox and a precise representation of the axiom of restriction in set theory proposed much earlier by Abraham Fraenkel. We discuss the main features of Suszko's contribution and hint at its possible further applications.

Resumo Este artigo analisa, as recentes versões, da objecção à existência de um fluxo do tempo, com base na pergunta: “Com que velocidade flui o tempo?”. O autor mostra que as soluções existentes para o problema não são plausíveis e, que em vez disso, a resolução deve ser encontrada numa nova concepção de fluxo temporal, que evite tais dificuldades. A teoria metafísica proposta desenvolve as ideias de Broad e Prior sob um novo enquadramento, que invalida a objecção resultante da questão (...) sobre o ritmo da passagem do tempo e das respostas “segundo a segundo”. Neste texto também se procura mostrar, que esta teoria metafísica, aqui proposta, possui outras virtudes que testemunham a seu favor. Palavras-chave : existência dinâmica, fluxo do tempo, presentismo, velocidade de passagem do tempoThe paper analyzes some recent versions of the objection to the existence of the flow of time based on the question: “How fast does time flow?”. It shows that the replies given to the problem are implausible and instead proposes a solution for the issue in the form of a conception of the flow of time which can avoid such a difficulty. The proposed metaphysical theory develops the ideas of Broad and Prior in a radical way and invalidates the objection resulting from the question about the rate of passage and answers “second per second”. The paper also tries to show that this metaphysical theory has other virtues which testify in favor of it. Keywords : flow of time; rate of time’s passage; presentism; dynamic existence. (shrink)