This study examined how the level of meat consumption was related to two psychological factors, selfishness and animal-oriented empathy, and three motivations related to animal, health, and environmental issues. A sample of Australian adults between 18 and 80 (N = 497) was surveyed online via the Zoho Survey platform. Structural equation modelling was applied to the data, and the resulting models revealed that higher selfishness and lower empathy were associated with higher meat consumption for males but there was no association (...) between psychological factors and meat consumption for females. All three motivations were associated with both higher empathy and selfishness for males. For females, higher empathy was associated with higher health and animal motivations, while higher selfishness was associated with higher environmental motivation. Lastly, none of the three motivations were related to meat consumption for either gender. Thus, the results only partially supported the hypotheses that selfishness and empathy would influence meat consumption and motivations. Nevertheless, this study contributes to research on personality factors in relation to meat consumption and the link between masculinity and meat consumption. (shrink)

Increasing the willingness to reduce animal product consumption has the potential to contribute to ameliorating the impact of animal agriculture on the environment, as well as foster healthier diets and improve the lives of farmed and wild animals. Reduction of animal product consumption is a prosocial behaviour (PSB), and factors that are considered to influence it are empathy and selfishness. In this research, animal-oriented empathy examined empathy specifically for animals. Animal oriented empathy and three types of selfishness: adaptive, egoistic, and (...) pathological were measured to determine if they could predict willingness to reduce animal product consumption. PSB is also influenced by motivations and motivations can lead to willingness. The three most common motivations to reduce animal product consumption: animal welfare, the environment, and health were examined to determine whether they predict willingness. A sample of 492 Australian adults completed questionnaires via the Zoho survey platform, and the data underwent a hierarchical regression. Higher pathological selfishness predicted a greater willingness to reduce animal product consumption, as did environmental and animal welfare motivations. However, higher health motivation predicted a lower willingness to reduce animal product consumption. Interpretation of the perplexing results in relation to pathological selfishness suggested further research. The practical value of utilising environmental and animal motivations to increase willingness to reduce animal products whilst bringing attention to the health issues was also discussed. (shrink)

The price of Bitcoin is once more soaring. From early October 2020 to early January 2021, the price of a single Bitcoin token went from roughly $10,000 to nearly $65,000, reinspiring the hopes of the crypto-faithful in the inevitability of a future beyond centralized banking and leaving the rest to dread the jargon of computational libertarianism. The speculative betting driving this recent price action, however, belies a more rudimentary and overlooked shift in the digital economy signaled by cryptocurrencies and Bitcoin (...) in particular. Unlike an earlier industrial logic that sought to reduce heat loss and improve efficiency to maximize surplus value, Bitcoin’s proof-of-work system shifts the basis of value production from efficiency to inefficiency. Moreover, it does so by using a cryptographic algorithm whose purpose is to destroy the meaning of its inputs. Through an exploration of Bitcoin’s proof-of-work technics and its inversion of traditional models of value extraction, the text argues that Bitcoin reveals a profound transformation in the nature of surplus represented by computational capitalism. (shrink)

Philosophy, science, and common sense all refer to propositions--things we believe and say, and things which are true or false. But there is no consensus on what sorts of things these entities are. Jeffrey C. King, Scott Soames, and Jeff Speaks argue that commitment to propositions is indispensable, and each defend their own views on the debate.

There are two main ways in which things with minds, like us, differ from things without minds, like tables and chairs. First, we are conscious--there is something that it is like to be us. We instantiate phenomenal properties. Second, we represent, in various ways, our world as being certain ways. We instantiate representational properties. Jeff Speaks attempts to make progress on three questions: What are phenomenal properties? What are representational properties? How are the phenomenal and the representational related?

This volume of Social Philosophy Today contains a selection of papers presented at the 30th International Social Philosophy Conference (2013), an annual event sponsored by the North American Society for Social Philosophy. The theme of the conference was "Food". This volume invites wider discussion of the issues explored at the conference, including food production, distribution, and consumption. Contributors include Susan Dielman, Erinn Gilson, Joan McGregor, José Medina, Andrew Pierce, and Sally Scholz.

Levinas and the Philosophy of Religion Jeffrey L. Kosky Reveals the interplay of phenomenology and religion in Levinas’s thought. "Kosky examines Levinas’s thought from the perspective of the philosophy of religion and he does so in a way that is attentive to the philosophical nuances of Levinas’s argument.... an insightful, well written, and carefully documented study... that uniquely illuminates Levinas’s work." —John D. Caputo For readers who suspect there is no place for religion and morality in postmodern philosophy, (...) class='Hi'>Jeffrey L. Kosky suggests otherwise in this skillful interpretation of the ethical and religious dimensions of Emmanuel Levinas’s thought. Placing Levinas in relation to Hegel and Nietzsche, Husserl and Heidegger, Derrida and Marion, Kosky develops religious themes found in Levinas’s work and offers a way to think and speak about ethics and morality within the horizons of contemporary philosophy of religion. Kosky embraces the entire scope of Levinas’s writings, from Totality and Infinity to Otherwise than Being, contrasting Levinas’s early religious and moral thought with that of his later works while exploring the nature of phenomenological reduction, the relation of religion and philosophy, the question of whether Levinas can be considered a Jewish thinker, and the religious and theological import of Levinas’s phenomenology. Kosky stresses that Levinas is first and foremost a phenomenologist and that the relationship between religion and philosophy in his ethics should cast doubt on the assumption that a natural or inevitable link exists between deconstruction and atheism. Jeffrey L. Kosky is translator of On Descartes’ Metaphysical Prism: The Constitution and the Limits of Onto-theo-logy in Cartesian Thought by Jean-Luc Marion. He has taught at Williams College. Indiana Series in the Philosophy of Religion—Merold Westphal, general editor May 2001 272 pages, 6 1/8 x 9 1/4, bibl., index, append. cloth 0-253-33925-1 $39.95 s / £30.50. (shrink)

In this case study, I address the procedural ethics of conversation analysis (CA) and the collection of naturally occurring mundane interactions. I draw from the challenges that emerged from the institutional ethics review of the HIV, health and interaction study (the H2I Study), a CA project that sought to identify the practices through which normative assumptions of HIV and other health conditions are produced in conversations. Consistent with CA’s preference for naturally occurring interactions, the H2I Study collected and analysed everyday (...) telephone calls involving people living with HIV. This article offers practical strategies CA researchers might use to navigate two ethical concerns raised about the collection of naturally occurring mundane interactions. The first questions the merits of collecting naturally occurring mundane interactions. For those unfamiliar with CA, the specific advantages of analysing naturally occurring mundane interactions may not be self-evident. This places an evidentiary burden on CA researchers to warrant the collection of this type of data. To address this concern, I suggest demonstrating in ethics applications the analytic value of CA using publicly available interactions. The second concern questions the use of verbal consent necessary for the collection of naturally occurring mundane interactions. Like most CA research, the H2I Study required flexible informed consent protocols appropriate for spontaneous and unpredictable interactions. Drawing from within and outside the CA literature, I offer three rationales for the use of verbal consent. This article is written as a practical resource for conversation analysts seeking approval from their research ethics board (REB) and for REBs who might be unfamiliar with CA research. This article contributes to a small but growing body of literature that documents not only the kinds of challenges CA researchers encounter from institutional ethics review, but the specific procedural ethics they may employ to secure ethics approval. (shrink)

What can we know about God by reason alone? Philosophical theology is the attempt to obtain such knowledge. An ancient tradition, which is perhaps more influential now than ever, tries to derive the attributes of God from the principle that God is the greatest possible being. Jeff Speaks argues that that constructive project is a failure. He also argues that the related view that the concept of God is the concept of a greatest possible being is a mistake. In the (...) last chapter, he sketches an alternative path forward. (shrink)

A longstanding question at the intersection of science, philosophy, and theology is how God might act, or not, when governing the universe. Many believe that determinism would prevent God from acting at all, since to do so would require violating the laws of nature. However, when a robust view of these laws is coupled with the kind of determinism now used in dynamics, a new model of divine action emerges. This book presents a new approach to divine action beyond the (...) current focus on quantum mechanics and esoteric gaps in the causal order. It bases this approach on two general points. First, that there are laws of nature is not merely a metaphor. Second, laws and physical determinism are now understood in mathematically precise ways that have important implications for metaphysics. The explication of these two claims shows not only that nonviolationist divine action is possible, but there is considerably more freedom available for God to act than current models allow. By bringing a philosophical perspective to an issue often dominated by theologians and scientists, this text redresses an imbalance in the discussion around divine action. It will, therefore, be of keen interest to scholars of Philosophy and Religion, the Philosophy of Science, and Theology. (shrink)

To write a history “from antiquity to the present” of classical art or literature (or, worst of all, classicism) is the ultimate nightmare aspiration for a scholar whose colleagues are attentive methodologists. The product, when there is one (which I add because the aspiration can yield paralysis), is always in part an apologetic treatise on historical method. Professor Vout—of Christ's College, Cambridge—apologizes with the first word of her subtitle, A, which stresses that many differing histories may be as valid as (...) her own. The next two words, Life History, imply that her study is unauthorized, conjectural, a bit personal or informal, and reliant to an extent on unconfirmable stories. Her book, she tells readers, is of necessity an arrangement of “fragments” and “a mapping not of facts, but of ways in which Greek and Roman artifacts experience history.” She sets down, moreover, as a rule that “classical” is not “a self-standing category: it is always relational” (which historians of the novel have been telling us for many decades about “realism”).We might expect the result of Vout's axioms to be evenhanded diffidence when treating definitions of the classical, and indeed she entertains even the idea of Jeff Koons—maker of Balloon Venus (Orange) and Gazing Ball (Barberini Faun)—as a classical sculptor. There is, however, one approach that she dismisses out of hand: the obsession of classical humanism with authenticity and its renascence. She objects especially to research into the original conditions of objects and to the application of increasingly intrusive methods of restoring them. As she writes, “ ‘Real knowledge’ comes not from antiquities that have been ripped from their original context, cleaned and reconstituted for display in galleries and glass cabinets. ‘Real knowledge’ comes from antiquities that carry their dirt with them.”What Vout, as a critic of humanism, means by dirt is patina—the residue, interesting and sometimes beautiful in itself, of the use and misuse of objects. Dirt is a word that would occur to a humanist art historian when examining the patina of a Greek or Roman object. Vout's use of the word is a parodic expression of reverse snobbery. When studying changes, whether mistakes or enhancements, in a Greek or Roman document, a humanist literary historian would speak of corruption and edit the corrupt text by means of processes that humanist editors invented and perfected. Despite the humanists’ devotion to the recovery of classical learning, however, once a Renaissance edition of a manuscript was in print, the original, however rare, was often destroyed or lost. In effect, the work was reborn, better than new. Rebirth is not the same as preservation: though both are perhaps conservative (or better, in Ulysses's words, “rere regardant”), a renascence or a resurrection is cataclysmic.The humanist approach to the past can appear unlovable and is certainly arrogant, but it can also inspire awe and gratitude. The work of Michelangelo depended on it, and so (more to the point) did Martin Luther's. Vout's attitude toward dirt (patina, corruption, misprision, insertions, recontextualizations, bowdlerizations, misappropriations, translocations) resembles that of Catholic theologians to the depositum fidei. Restoring the original conditions of the Christian church involved methods of research learned from Renaissance humanists and the removal, often destructive, of the “deposit” or residue or patina that adhered to, distorted, discolored, and obscured the conditions of the “primitive church.” A Roman Catholic may well dislike the processes that Luther set in motion, but imagine a scholarly history of Christianity that mentioned Protestantism only to regret its existence.Still, Vout's reasoning, it seems to me, is more sophisticated in its defense of dirt and in its criticism of restoration than any offered against the Protestants’ reasoning during the Counter-Reformation. Consider, for instance, this inspiring passage: “When the curators at the Munich Glyptothek removed Thorwaldsen's restorations from the Aegina pediments, they did not so much take them back to a pristine state as out of the feedback loop, rendering them damaged goods. It was not a restriction of avenues or a change of direction that was being enacted here, but a refusal to speak the language, or rather an insistence that the only language worth speaking was an academic [humanist, restorationist] one.... In 2011, the Glyptothek marked the two hundredth year of the pediments’ discovery by putting new versions of Thorvaldsen's restored figures on display. They had relearned the lingo. For art to be ‘classical,’ it has to know its place in the discourse.” May lingo and feedback loop have successful careers in the lexicon of classical scholarship. “Far from producing a nostalgic narrative,” as Vout informs us, “the lessons learned from looking back ensure that we keep traveling.”. (shrink)

In early writings, stakeholder theorists supported giving all stakeholders formal, binding control over the corporation, in particular, over its board of directors. In recent writings, however, they claim that stakeholder theory does not require changing the current structure of corporate governance and further claim to be “agnostic” about the value of doing so. This article’s purpose is to highlight this shift and to argue that it is a mistake. It argues that, for instrumental reasons, stakeholder theorists should support giving all (...) stakeholders control over the corporation, in the form of control over its board. That is, stakeholder theorists should support stakeholder democracy over the status quo. A larger goal of this article is to steer the conversation about stakeholder theory toward questions of governance and control. Stakeholder theorists tend to sidestep these questions, but it is vital that they be addressed. (shrink)

"This book introduces Gottfried Wilhelm Leibniz's Principle of Optimality and argues that it plays a central role his physics and philosophy, with profound implications for both. Each chapter begins with an introduction to one of Leibniz's ground-breaking studies in natural philosophy, paying special attention to the role of optimal form in those investigations. Each chapter then goes on to explore the philosophical implications of optimal form for Leibniz's broader philosophical system. Individual chapters include discussions of Leibniz's understanding of teleology, the (...) nature of bodies, laws of nature, and free will. The final chapter explores the legacy of Leibniz's physics in light of his work on optimal form"--. (shrink)

This essay introduces the second installment of a symposium in Common Knowledge called “Apology for Quietism.” This introductory piece concerns the sociology of quietism and why, given the supposed quietude of quietists, there is such a thing at all. Dealing first with the “activist” Susan Sontag's attraction to the “quietist” Simone Weil, it then concentrates on the “activist” William Empson's attraction to the Buddha and to Buddhist quietism, with special reference to Empson's lost manuscript Asymmetry in Buddha Faces (and to (...) Sharon Cameron's work on the topic in her book Impersonality). The author, who is also editor of the journal, argues against the effort of some contributors to substitute new terms for quietism and emphasizes instead what he calls (quoting Sontag) “the need for repose.”. (shrink)

A simple tool is provided to assist researchers in assessing contributions to a scientific publication, for ease in evaluating which contributors qualify for authorship, and in what order the authors should be listed. The tool identifies four phases of activity leading to a publication—Conception and Design, Data Acquisition, Analysis and Interpretation, and Manuscript Preparation. By comparing a project participant’s contribution in a given phase to several specified thresholds, a score of up to five points can be assigned; the contributor’s scores (...) in all four phases are summed to yield a total “contribution score”, which is compared to a threshold to determine which contributors merit authorship. This tool may be useful in a variety of contexts in which a systematic approach to authorial credit is desired. (shrink)

Bianchi, Stanley, and Sutander argue in an insightful, cogent manner for the consideration of harm reduction as an ethically-defensible, non-paternal management approach for capable persons...

This chapter contains section titled: Introduction Chomsky's Challenge Methodological Physicalism.

This chapter contains sections titled: Introduction Investing in Science: Child Health and U.S. Medicine in the Twentieth Century The Impact of Specific Medical Interventions The Changing Definition of ID The “Flynn Effect” and the Impact of Improved Public Health Conclusion References.

There is an emerging consensus in recent literature that Nietzsche adheres to some form of “naturalism,” that his closest philosophical kin are Hume and Darwin rather than Derrida.1 Despite this consensus, however, scholars disagree as to the relationship between Nietzsche’s naturalism and his ethics.2 The most prominent interpretation is that Nietzsche is an ethical naturalist in the Aristotelian tradition. According to this interpretation, the good life for an individual is derived from natural “type-facts” about him.3 Each individual possesses certain natural (...) interests and capacities in virtue of being a member of a type, such that the satisfaction or fulfillment of these needs or capacities amounts to her.. (shrink)

ABSTRACT This article engages Frater Taciturnus’s ‘Letter to the Reader’ to argue for a religious aesthetics in Kierkegaard. This religious aesthetics is designed to purify the passions and help the believer ‘see’ the religious ideal, but also to confront the aesthetic spectator with the religious reality of her own situation. My claim for this revised reading of religious poetics in Kierkegaard derives from Taciturnus’s view of a superior form of religious ideality that comes ‘after actuality’. This ideality is not an (...) envisioned ideal that is untested by actuality and thus ‘illusory’ but an ideal that is graspable only after the self has acknowledged the actuality of their sinful condition, rather than any specific actual sin. To appreciate this form of ideality, Frater Taciturnus repeatedly resorts to visual metaphors and the power of imagination, suggesting that the religious ideal must be ‘seen’ with a sort of synoptic vision capable of looking past both comedy and tragedy and resulting in the purification of our typical affective responses to aesthetic objects. Seeing in this way, the individual imaginatively engages in religious aesthetics and grasps the religious ideality by affirming the actuality of their own sinfulness and receiving forgiveness for that sinfulness. (shrink)

_Post-Postmodernism_ begins with a simple premise: we no longer live in the world of "postmodernism," famously dubbed "the cultural logic of late capitalism" by Fredric Jameson in 1984. Far from charting any simple move "beyond" postmodernism since the 1980s, though, this book argues that we've experienced an _intensification_ of postmodern capitalism over the past decades, an increasing saturation of the economic sphere into formerly independent segments of everyday cultural life. If "fragmentation" was the preferred watchword of postmodern America, "intensification" is (...) the dominant cultural logic of our contemporary era. _Post-Postmodernism_ surveys a wide variety of cultural texts in pursuing its analyses—everything from the classic rock of Black Sabbath to the post-Marxism of Antonio Negri, from considerations of the corporate university to the fare at the cineplex, from reading experimental literature to gambling in Las Vegas, from Badiou to the undergraduate classroom. Insofar as cultural realms of all kinds have increasingly been overcoded by the languages and practices of economics, Nealon aims to construct a genealogy of the American present, and to build a vocabulary for understanding the relations between economic production and cultural production today—when American-style capitalism, despite its recent battering, seems nowhere near the point of obsolescence. Post-postmodern capitalism is seldom late but always just in time. As such, it requires an updated conceptual vocabulary for diagnosing and responding to our changed situation. (shrink)

Despite the current popularity of what is commonly referred to as an `ethics of care', no one has yet undertaken a systematic philosophical study of `care' itself. In this book, Jeffrey Blustein presents the first such study, offering a detailed exploration of human `care' in its various guises: concern for and commitment to individuals, ideals, and causes. Blustein focuses on the nature and value of personal integrity and intimacy, and on the questions they raise for traditional moral theory.

I argue that relations between non identical times, such as the relations, earlier than , later than , or 10 seconds apart , involve contraction, and only co temporal relations are non contradictory, which would leave presentism the only non contradictory theory of time. The arguments I present are arguments that I have not seen in the literature.

BackgroundResearch Ethics Boards, or Institutional Review Boards, protect the safety and welfare of human research participants. These bodies are responsible for providing an independent evaluation of proposed research studies, ultimately ensuring that the research does not proceed unless standards and regulations are met.Main bodyConcurrent with the growing volume of human participant research, the workload and responsibilities of Research Ethics Boards (REBs) have continued to increase. Dissatisfaction with the review process, particularly the time interval from submission to decision, is common within (...) the research community, but there has been little systematic effort to examine REB processes that may contribute to inefficiencies. We offer a model illustrating REB workflow, stakeholders, and accountabilities.ConclusionBetter understanding of the components of the research ethics review will allow performance targets to be set, problems identified, and solutions developed, ultimately improving the process. (shrink)

It is often challenging for mental health‐care providers and health organizations to perform their various roles and to meet their varied obligations. In complex mental health‐care circumstances the concurrent application of relevant ethical principles and values often leads to the emergence of completing obligations that need to be carefully weighed and balanced in the making of care‐related decisions. Although some clinical circumstances, such as those potentially triggering the duty to warn, are adequately guided by existing rules based on legal precedents, (...) there is a gap in decision‐making support in other mental health‐care domains. This article proposes that a set of targeted, decision‐making approaches be developed to assist in the handling of specific, challenging circumstances. By way of illustration, two novel approaches are introduced; that is, choosing to work within a moral relational space of optimal therapeutic engagement (at the micro level of clinical practice), and the use of a health policy development approach that instantiates deliberative engagement (at the meso and macro levels of health organization). (shrink)

In this introduction to Part 1 of “Contextualism—the Next Generation: Symposium on the Future of a Methodology,” the editor of Common Knowledge, a “journal of left-wing Kuhnian opinion,” reports that the new symposium responds to contextualist criticism of the previous CK symposium, which was on xenophilia. The content of the earlier symposium met with objections, from contextualists, on the grounds of methodology, and the new symposium questions the methodology of contextualism for the limits that it places on content as well (...) as on normative aims and degree of focus. Tracing the origins of contextualism to Kuhn and his theory that paradigms of scientific knowledge are incommensurable, this essay then argues that Kuhnian method is formal, with scant concern for content, and that Kuhn’s work was vatic, more than philosophical or historical. Kuhn’s depiction of his sudden, blinding realization that Aristotelian physics is correct in its own context is assessed as an ironic application of biblical scenes of revelation to what is, essentially, a process of scrupulous, piecemeal scholarship. What Kuhn unknowingly wanted, the essay concludes, was a combination of contextualism and phenomenology, as a means of knowing what it was like to believe in Aristotelian, as opposed to modern, concepts of matter, quality, space, void, position, change, and motion. The essay then introduces the first contribution to the new symposium: a monograph retrieving geometrical and taxonomic—Euclidean and Theophrastan—idioms of discourse about fictional characters and inquiring into their changing affective content. (shrink)

Many arguments have been advanced in favor of employee participation in firm decision-making. Two of the most influential are the "interest protection argument" and the "autonomy argument." I argue that the case for granting participation rights to some other stakeholders, such as suppliers and community members, is at least as strong, according to the reasons given in these arguments, as the case for granting them to certain employees. I then consider how proponents of these arguments might modify their arguments, or (...) views, in response to this conclusion. (shrink)

Discussions about resource allocation commonly invoke concerns of unfair and variable decisions when physicians ration at the bedside. This concern is no less germane in disaster medicine, in which physicians make triage and allocation decisions under duress, and patients and their families may be challenged to self-advocate. Unfortunately, a real-time mechanism to support a process for ethical decision making may not be available to medical relief workers. Yet, resources for ethics decision support can be important for the moral well-being of (...) the clinician, the ethical integrity of the relief effort, and to bolster the trust and confidence of the population receiving medical services. The need for clinical ethical support should be anticipated in disaster preparedness planning. (shrink)

What is secularity? Might it yield or define a distinctive form of reasoning? If so, would that form of reasoning belong essentially to our modern age, or would it instead have a considerably older lineage? And what might be the relation of that form of reasoning, whatever its lineage, to the Christian thinking that is often said to oppose it? In the present volume, these and related questions are addressed by a distinguished group of scholars working primarily within the Roman (...) Catholic theological tradition and from the perspectives of Continental philosophy. As a whole, the volume constitutes a conversation among thinkers who agree in their concerns but not necessarily their conclusions. Taken individually, each essay concentrates on a range of historical developments with close attention to their intellectual and sometimes pedagogical implications. Secular reason, they argue, is neither the antipode of Christian thought nor a stable and well-resolved component of it. Christian thinking may engage with secular reason as the site of profound difficulties, but on occasion will also learn from it as a source of new insight. _Christianity and Secular Reason_ contributes to the contemporary discussion of secularity prompted especially by Charles Taylor’s book _A Secular Age_. Unlike Taylor's work, however, this collection concentrates specifically on secular _reason_ and explicitly on its relation to Christianity. In this sense, it is closer to Michael J. Buckley’s _At the Origins of Modern Atheism_ or, to a lesser degree, Louis Dupré’s _Passage to Modernity_, which concern themselves with broad cultural developments. "This volume offers a variety of perspectives, some historical, some normative/constructive, on the questions of the relations between politics/culture/religion and the relations between selfhood/humanity/world. The essays are, without exception, of high quality in both scholarly-exegetical terms, and constructive-normative ones. The writers are learned, sometimes witty, and often interesting." —_Paul Griffiths, Duke Divinity School _ "This is no other volume I know of that covers just this ground. There is a substantial literature on, for example, the Habermas/Ratzinger exhange, and on Kant's view of the relation between philosophy and religion, and on the twelfth century background for thirteenth century reflection on this relation. The merit of _Christianity and Secular Reason_ is that it holds these threads together, and others besides, in a new and fruitful way." —_John E. Hare, Yale University_. (shrink)

Mitochondria are essential subcellular organelles containing an extranuclear genome (mtDNA). Mutations in mtDNA have recently been identified as causing a variety of human hereditary diseases. In most of these cases, the tissues of the affected individual contain a mixture of mutant and normal mtDNA, with this ratio determining the severity of symptoms. Stochastic factors alone have generally been believed to determine this ratio. Jenuth et al.(1), however, examining mice that contain a mixture of mtDNA types, show evidence of strong selective (...) forces at work in favoring one mtDNA variant over another in some tissues. (shrink)