Between 1983 and 1990, at least 163 Western drugs were tested in the GDR. On the basis of archival documentation, relevant literature, and interviews we examined the clinical trials of five drugs more thoroughly; two of these individual case studies are introduced in this article. In the case of the clinical trials of the synthetic human growth hormone Saizen we found extensive trial and patient documentation, which allows for a detailed analysis of ethical aspects such as parent information and informed (...) patient consent. In the case of the clinical trials of the „abortion pill“ Mifepristone for the World Health Organization we uncovered irregularities with regard to the ethical evaluation. However, taken together, we could not find any serious violation of ethical norms in connection with our cases studies. (shrink)

Interpretation in science has gained little attention in the past because philosophers of science believed that interpretation belongs to the context of discovery or must be associated with meaning. But scientists often speak about interpretation when they report their findings. Elsewhere I have argue in favour of a pragmatic-rhetorical theory of explanation, and it is in light of this theory that I suggest we can understand interpretation in the natural sciences.

Despite its prominent role in cognitive psychology, its relevance for the research of consciousness, and some helpful clarification (e.g., Revonsuo 1999), the binding problem is still surrounded by considerable confusion. In this paper, I first give an informal but systematic overview on the diversity of forms the binding problem can assume, and then attempt to extract, on the basis of "working definitions" of various much-discussed types of binding, a common denominator. I propose that at the heart of the binding problem (...) lies the notion of representing an entity as having a certain property, and discuss several objections that could be raised against the proposed analysis, as well its usefulness and implications. (shrink)

According to a common opinion, the word ‘semantics’ , derived from the Greek word semantikos , appeared for the first time, at least in modern times, in the book Essai de semantique, science de significations by M. J. A. Bréal . However, Quine says in his lectures on Carnap:As used by C. S. Peirce, “semantic” is the study of the modes of denotation of signs: whether a sign denotes its object through causal or symptomatic connection, or through imagery, or through (...) arbitrary convention and so on. This sense of semantic, namely a theory of meaning, is used also in empirical philology: empirical semantic is the study of historical changes of meanings of words.1For Bréal, semantics was a branch of general linguistics. In particular, semantics was occupied with so-called lexical meaning and its changes through time. Thus, semantics in this sense belonged to what was called “the diachronic treatment of language”. This tradition is fairly alive in contemporary linguistic theory. Quine’s description of the word ‘semantic’ in Peirce corresponds, which Quine explicitly states, to its use in philology. However, some linguists ascribe a more theoretical role to lingustic semantics. Karl Bühler is an example. In his Sprachtheorie he says that a theory of semantic functions of language is a part of theory of language.2 This account is to be found also among philosophers. It is also rather obvious that Peirce did not limit his semantic only to empirical studies. Linguists also use the word ‘semasiology’ instead of ‘semantics’; Bühler proposed the term ‘sematology’ for a general theory of symbols. (shrink)

Western civilization is over. So begins Jan Zwicky’s trenchant exploration of the root of global cultural and ecological collapse: a way of thinking that is also linked to some of the West’s most noted achievements. The Renaissance merged imperial enterprise with Islamic algebra and recently recovered Greek mathematics to precipitate mechanized industry and resource extraction; these in turn made possible the growth of capitalism, the military-industrial complex, and Big Technology. Despite its self-image as objective, Zwicky argues, the West’s style of (...) thought is not politically neutral, but intensely anthropocentric. It has led those who adopt it to regard the more-than-human world as nothing more than timber licences and drilling sites, where value is not recognized unless it is monetized. Oblivious to context and blind to big-picture thinking, it analyzes, mechanizes, digitizes, and systematizes, while rejecting empathy and compassion as distorting influences. Lyric comprehension, in Zwicky’s view, offers an alternative to this way of thinking, and she provides a wide range of examples. Once upon a Time in the West documents how a narrow epistemological style has left Western thought blind to critical features of reality, and how the terrifying consequences of that blinkered vision are now beginning to unfold. (shrink)

The aim of this book is a recovery of interest in the experience of meaning. Jan Zwicky defends the claim that we experience meaning in the apprehension of wholes and their internal structural relations, providing examples of such insight in mathematics and physics, literature, music, and Plato's ancient theory of forms. Taken together, these essays constitute a powerful indictment of the aggressive reductionism and the reliance on calculative modes of thought that dominate our present conception of understanding. The Experience of (...) Meaning proposes a more just epistemology, arguing for a new grammar of thought, a new way of understanding the relationship of human intelligence to the world. Engaging with philosophy, psychology, literature, fine arts, music, and environmental studies in a profound way, The Experience of Meaning will interest any reader who ponders the question of meaning and its relation to true human expression. (shrink)

PurposeChildhood onset speech fluency disorder is possibly related to dopaminergic dysfunction. Mesencephalic hyperechogenicity detected by transcranial ultrasound might be seen as an indirect marker of dopaminergic dysfunction. We here determined whether adults who stutter since childhood show ME.MethodsWe performed TCS in ten AWS and ten matched adults who never stuttered. We also assessed motor performance in finger tapping and in the 25 Foot Walking test.ResultsCompared to controls, AWS showed enlarged ME on either side. Finger tapping was slower in AWS. Walking (...) cadence, i.e., the ratio of number of steps by time, tended to be higher in AWS than in control participants.DiscussionThe results demonstrate a motor deficit in AWS linked to dopaminergic dysfunction and extending beyond speech. Since iron deposits evolve in childhood and shrink thereafter, ME might serve as an easily quantifiable biomarker helping to predict the risk of persistency in children who stutter. (shrink)

Hermeneutics should take Gadamer’s claims about experience and reality seriously, the hermeneutic urgency, described in the following concise ways: aus der Wahrheit des Erinnerns etwas entgegensetzen: das immer noch und immer wieder Wirkliche. WuM, p. XXVIeine Erfahrung, die Wirklichkeit erfährt und selber wirklich ist. WuM, p. 329.Die Erfahrung lehrt, Wirkliches anzuerkennen. WuM, p. 339.preceded by a general remark about the aim of historical knowledge:eine Erkenntnis, die versteht, daß etwas so ist, weil sie versteht, daß es so gekommen ist. WuM, p. (...) 2This indicates an ontological primacy of history, which is a singular processual event with a certain narrative dimension which can also be called history. Through this essential and at the same time particular finitude, meaning is given to us – and all the general aspects of explained reality are possible only inside such an effective history which unites event and narration. The article will elaborate the special character of historical effects compared to the effects in the modern scheme of cause and effect and suggest a way of reading the classical distinction between understanding and explanation in a way which differs somewhat from Gadamer’s, but also from Georg Henrik von Wright’s similar concerns. It is also argued that Dilthey’s notion of lived experience remains relevant inside a very much needed hermeneutic effort to include nature in history. (shrink)

Intentionality is a key concept in the phenomenological tradition, but also figures in several other currents of contemporary thought, often as a criteria of consciousness. Husserl adopted the principle of intentionality from Franz Brentano, who was heavily influenced by Aristotle and medieval Aristotelian tradition. Considering that intentionality means a direction of thought or behaviour, it is quite evident that Aristotle remains a major reference in this context : through the idea of natural entelechies, the theory of life, perception and thinking (...) and through the ethical descriptions of dispositions, virtues and decisions. Whatever point of view chosen, it seems obvious that the equivalent of Husserlian intentionality must be something else in Aristotle than a principle of constitution of objects in the sense of modern (Cartesian and Kantian) tradition. What could be called intentionality in Aristotle seems rather to be something like a direction of behaviour, founded on natural tendencies. Such a «physiomorphic» intentionality can shed some light on the contemporary discussions concerning consciousness, knowledge and affectivity and similarly differentiate and situate the «modern» critique of teleology. The present article deals with these questions in relation to phantasia and orexis. (shrink)

In this study of Robert Boyle's epistemology, Jan W. Wojcik reveals the theological context within which Boyle developed his views on reason's limits. After arguing that a correct interpretation of his views on 'things above reason' depends upon reading his works in the context of theological controversies in seventeenth-century England, Professor Wojcik details exactly how Boyle's three specific categories of things which transcend reason - the incomprehensible, the inexplicable, and the unsociable - affected his conception of what a natural philosopher (...) could hope to know. Also covered in detail is Boyle's belief that God had deliberately limited the human intellect in order to reserve a full knowledge of both theology and natural philosophy for the afterlife. (shrink)

The paper examines the interplays between logic and politics in the Polish School of Logic starting from 1914. The Polish School of Logic flourished between 1920 and 1939. Philosophically, it was influenced by Kazimierz Twardowski (1866–1938). For Twardowski logic is fundamental for every kind of human activity, professional and private and this means that every argument should be formulated and proceed by correct inferential rules. These rules involve semiotics, formal logic and methodology of science. The paper shows how this position (...) was shared by Twardowski’s students, including Jan Łukasiewicz, Stanisław Leśniewski, Kazimierz Ajdukiewicz and Tadeusz Kotrabiński, as well as by the next generation of logicians and philosophers and especially by Alfred Tarski. These authors considered logic, philosophy and science as completely neutral with respect to politics and ideology but they also considered logical skills as indispensable in political activities. (shrink)

Many philosophers accept derivative blameworthiness for ignorant conduct – the idea that the blameworthiness for one’s ignorance can ‘transfer’ to blameworthiness for one’s subsequent ignorant conduct. In this chapter we ask the question what it actually means that blameworthiness would transfer, and explore four distinct views and their merits. On views (I) and (II), one’s overall degree of blameworthiness is determined by factors relevant to one’s ignorance and/or one’s subsequent conduct, and transfer only involves an increase in scope. On views (...) (III) and (IV), one’s overall degree of blameworthiness is determined by factors relevant to one’s ignorance as well as one’s subsequent conduct, and transfer might not only entail an increase in scope, but also in degree. (shrink)

Background The ownership status of individual-level health data affects the manner in which it is used. In this paper we analyze two competing models of the ownership status of the data discussed in the literature recently: private ownership and public ownership. Main body In this paper we describe the limitations of these two models of data ownership with respect to individual-level health data, in particular in terms of ethical principles of justice and autonomy, risk mitigation, as well as technological, economic, (...) and conceptual issues. We argue that undifferentiated application of neither private ownership nor public ownership will allow us to resolve all the problems associated with effective, equitable, and ethical use of data. We suggest that, instead of focusing on data ownership, we should focus on the institutional and procedural aspects of data governance, such as using Data Access Committees (DACs) or equivalent managed access processes, which can balance the elements of these two ownership frameworks. Conclusion Undifferentiated application of the ownership concept (private or public) is not helpful in resolving problems associated with sharing individual-level health data. DACs or equivalent managed access processes should be an integral part of data governance. They can approve or disapprove data access requests after considering the potential benefits and harms to data subjects, their communities, primary researchers, and the wider society. (shrink)

The mind–body problem is analyzed in a physicalist perspective. By combining the concepts of emergence and algorithmic information theory in a thought experiment, employing a basic nonlinear process, it is shown that epistemologically emergent properties may develop in a physical system. Turning to the significantly more complex neural network of the brain it is subsequently argued that consciousness is epistemologically emergent. Thus reductionist understanding of consciousness appears not possible; the mind–body problem does not have a reductionist solution. The ontologically emergent (...) character of consciousness is then identified from a combinatorial analysis relating to universal limits set by quantum mechanics, implying that consciousness is fundamentally irreducible to low-level phenomena. (shrink)

Biography of the Indian philosopher Aurobindo Ghose, 1872-1950.

Clinicians and administrators have a professional obligation to contribute (OTC) to improvement of healthcare quality. At the same time, participation in embedded research poses risks to healthcare institutions. Disclosure of an institution’s sensitive information could endanger relationships with patients and undermine its reputation. The existing ethical framework (EF) for learning healthcare systems (LHSs) does not address the conflict between the OTC and institutional interests. Ethical guidance and policy regulation are needed to create a safe environment for embedded research. In this (...) article we analyse the EF for LHSs and the concept of professionalism. We suggest that the EF should be supplemented with an obligation to protect provider’s legitimate interests. We define legitimate interests as those that enable providers to discharge their primary duties. We argue that both the OTC and the obligation to protect legitimate interests are grounded in the concept of medical professionalism and can be understood as a matter of contract between a democratic society and medical professionals. The proposed supplemented EF can be implemented into a regulatory system in three different ways: theself-regulating: where providers decide themselves how to balance the ethical claims, the centralised: where a governmental institution decides the right balance between providers’ interests and interests of a health system; and themediating: where medical professionals, the state and patients negotiate their interests. Our article contributes to the discussion on ethical relevance of providers’ interests and the regulatory model for weighing opposite interests in LHSs. (shrink)

This unusual introduction to political philosophy draws on its history and main theories_classic liberal, democratic, socialist, radical_with an eye to how each sees the place of the individual in the political order.

If neoliberal globalization was a regime of American economic unilateralism, has this been succeeded by or combined with political and military unilateralism? This discussion probes the emerging features of a hybrid formation of neoliberal empire; a mélange of political-military and economic unilateralism, an attempt to merge geopolitics with the aims and techniques of neoliberalism. This is examined in relation to government, privatization, trade, aid, marketing and the occupation of Iraq. A further question is what kind of wider strategy is taking (...) shape amid the turmoil of the new wars. (shrink)

For the Critical Theory tradition of the Frankfurt School, rationalisation is a central concept that refers to the socio-cultural closure of capitalist modernity due to the proliferation of technical, ‘instrumental’ rationality at the expense of some form of political reason. This picture of rationalisation, however, hinges on a separation of technology and politics that is both empirically and philosophically problematic. This article aims to re-conceptualise the rationalisation thesis through a survey of research from science and technology studies and the conceptual (...) framework of Niklas Luhmann's systems theory. It argues that rationalisation indeed exhibits a logic of closure, namely the ‘operational closure’ of sociotechnical systems of measurement, but that this closure in fact produces the historical logics of technical reason and, paradoxically, also generates spaces of critical-political openness. This opens up the theoretical and practical opportunity of connecting the politically just to the technically efficient. (shrink)

This paper outlines the history of logic in Poland in the years 1918–1939 . The disciplinary and social history of logical investigations in Poland is widely described. The author stresses topics characteristic for Polish logic, namely prepositional calculus, many-valued logic, Lezśniewski's systems, Chwistek's systems and the works in the history of logic.

Objectives To determine the frequencies and types of limitation of medical treatment performed by physician members of the German Society for Palliative Medicine and to analyse the findings with respect to clinical and ethical aspects of end-of-life practices. Design Cross-sectional postal survey. Setting Data collection via the secretary of the German Society for Palliative Medicine using the German language version of the EURELD survey instrument. Subjects All 1645 physician members of the German Society for Palliative Medicine. Main outcome measures Types (...) and frequencies of limitation of treatment and possible determinants. Results 901 physicians participated in the study (response rate 55.8%). Participants reported limitation of treatment in 69.1% of cases. These decisions most often affected artificial nutrition (19%), chemotherapy (14%), antibiotics (11%) and medication other than antibiotics (11%). In the majority of eligible cases, physicians estimated the life-shortening effect of limitation of treatment to be <7 days. However, estimations differ depending on the medical measures in question. Bivariate statistical analysis indicated that withholding of treatment was performed significantly more frequently for patients aged ≥65 years (p=0.019). In addition, there were significant associations between the incidence of limitation of treatment and the different diseases reported by respondents as the underlying cause of death. Conclusion The findings of this study provide information on the current state of an ethically and clinically challenging aspect of clinical practice and can serve as a starting point for further interdisciplinary research on normative and empirical aspects of treatment decision-making at the end of life. (shrink)

Justin Holt argues that the Rawlsian requirements for justice are, contrary to Rawls’ own pronouncements, better met by socialism than ‘property owning democracy’, both of them preferring both to just plain capitalism, even with a welfare state tacked on. I suggest that Rawls’s ‘requirements’ are far less clear than most think, and that the only clarified version prefers the capitalist welfare state.

Conçue et écrite dans le milieu des années soixante, cette Introduction à la phénoménologie de Husserl marque les retrouvailles de Patocka avec la phénoménologie après la césure de la guerre et des années cinquante. Ayant fait l'objet d'un cours à Prague et à Mayence, ce texte ne vaut pas seulement par ses vertus pédagogiques, mais surtout par la remise en perspective globale, historique et critique, qu'il propose de la problématique du fondateur de la phénoménologie. Exposé en forme de bilan, repartant (...) des origines dans la Philosophie de l'arithmétique et les Recherches logiques, et allant jusqu'à la réduction phénoménologique, la conscience intime du temps et la question de l'intersubjectivité, il est remarquable par son sens des nuances et des difficultés, le plus souvent inaperçues dans des présentations plus doctrinales : on y retrouve tout l'"esprit de finesse" si caractéristique de Patocka. Destiné à tous les publics intéressés par la phénoménologie, cet ouvrage, rédigé par un familier de Husserl, de Heidegger et de Fink, vaudra tant par la puissance que par la subtilité de sa remise au point. Le cours est suivi d'un manuscrit de travail, daté de 1976 par les Archives Patocka, et intitulé "la Phénoménologie transcendantale de Husserl après révision". C'est dire que Patocka ne s'est jamais estimé quitte de l'œuvre de Husserl, dans ses efforts pour en prolonger la portée. (shrink)

Rassemblant douze textes rédigés entre 1934 et 1976, ce recueil remet les Essais hérétiques en perspective en permettant de saisir quelques-unes des principales lignes de force qui font l'unité intime de l'œuvre de Patocka et communiquent à sa pensée la tonalité et la tension éthiques qui lui donnent son éclat particulier à l'intérieur du mouvement phénoménologique. Ligne de force de la liberté en tant qu'expérience fondamentale de l'être historique qu'est l'homme, transcendance qui, dans sa négativité, rejoint le " pas en (...) arrière " des analyses phénoménologiques. Ligne, négative là encore, de la problématisation socratique. Ligne du destin qui s'ensuit et qui, incarnation exemplaire du conflit de la philosophie avec le monde comme il va, renvoie en direction du " sacrifice radical " à travers lequel la liberté, reniée à force de trop se revendiquer, refait signe à l'époque moderne, poussant Patocka, dans un regard qui embrasse toute l'étendue de l'histoire spirituelle de l'Europe, à considérer le Gestell heideggérien à travers le prisme du polemos dont parlait Héraclite. Écrits " polémiques " donc et " pathétiques ", autant que " politiques ", qui nous parlent de l'humanisme, de la modernité et de ce qui ne prétend pas " sauver ", mais qui résiste dans l'expérience philosophique vécue en tant que " soin de l'âme " - à la fois ébranlement radical et mode fondamental de la responsabilité vis-à-vis d'un sens à jamais problématique. (shrink)