Book Information The Weight of Finitude: On the Philosophical Question of God. By Ludwig Heyde. State University of New York Press. Albany. 1999. Pp. 177 + xviii. Paperback, US$17.95.

At extreme altitude (>5,000 – 5,500 m), sustained hypoxia threatens human function and survival, and is associated with marked involuntary weight loss (cachexia). This seems to be a coordinated response: appetite and protein synthesis are suppressed, and muscle catabolism promoted. We hypothesise that, rather than simply being pathophysiological dysregulation, this cachexia is protective. Ketone bodies, synthesised during relative starvation, protect tissues such as the brain from reduced oxygen availability by mechanisms including the reduced generation of reactive oxygen species, improved (...) mitochondrial efficiency and activation of the ATP‐sensitive potassium (KATP) channel. Amino acids released from skeletal muscle also protect cells from hypoxia, and may interact synergistically with ketones to offer added protection. We thus propose that weight loss in hypoxia is an adaptive response: the amino acids and ketone bodies made available act not only as metabolic substrates, but as metabolic modulators, protecting cells from the hypoxic challenge.Also watch the Video Abstract. (shrink)

This article argues that commercial weight-loss organizations appropriate and debase the askeses—practices of care of the self—that Michel Foucault theorized, increasing members’ capacities at the same time as they encourage participation in ever-tightening webs of power. Weight Watchers, for example, claims to promote self-knowledge, cultivate new capacities and pleasures, foster self-care in face of gendered exploitation, and encourage wisdom and flexibility. The hupomnemata of these organizations thus use asketic language to conceal their implication in normalization.

In relative clause extraposition (RCE) in English, a noun is modified by a non-adjacent RC, resulting in a discontinuous dependency, as in: Three people arrived here yesterday who were from Chicago. Although discourse focus is known to influence the choice of RCE over truth-conditionally equivalent sentences with canonical structure (Rochemont and Culicover, English focus constructions and the theory of grammar, Cambridge University Press, 1990; Takami, A functional constraint on Extraposition from NP, John Benjamins, 1999), Hawkins (Efficiency and complexity in grammars, (...) Oxford University Press, 2004) and Wasow (Postverbal behavior, CSLI Publications, 2002) have proposed in addition that RCE should be preferred when the relative clause is long (or ‘heavy’) relative to the VP because such structures are processed more efficiently in comprehension and production. The current study tested this hypothesis based on Hawkins' (Efficiency and complexity in grammars, Oxford University Press, 2004) domain minimization principles. In an acceptability judgment task, canonical sentences were rated significantly higher than extraposition sentences when the RC was light, but this difference disappeared when the RC was heavy. In a self-paced reading task, extraposition sentences were read significantly faster than canonical sentences when the RC was heavy, but there was no difference when the RC was light. In an analysis of RCE in the ICE-GB corpus, extraposed RCs were significantly longer than the VP on average, whereas canonical RCs were significantly shorter, and the proportion of sentences with extraposition decreased as the ratio of VP-to-RC length increased. These findings support Hawkins' (Efficiency and complexity in grammars, Oxford University Press, 2004) domain minimization principles and help explain why a discontinuous dependency is allowed and sometimes preferred even in a language with relatively fixed word order. (shrink)

In this monograph the author presents the special and general theories of relativity from a geochronometrical viewpoint. The amount of mathematics demanded is not too great, and one can get quite far along on the material on vectors presented early in the book. The first three chapters especially derive from the work of A. A. Robb several decades ago: they treat foundations of geochronometry, one-plus-one geochronometry and its generalization to a one-plus-three system. Later chapters cover such staples as the Lorentz (...) transformation, the metric and dynamical tensors, dynamical relationships of particles, accelerating and curving events, geodesics, and applications to the red-shift of spectral lines and bending of light-rays. The best introduction to the study of the foundation of physics is physics itself; so those philosophers interested in the foundations of relativity theory will find here a lucid and logically respectable exposition of that theory, and in that way an understanding of its fundamentals and problems will be reached.—P. J. M. (shrink)

In the debate of epistemic peer disagreement the equal-weight view suggests to split the difference between one's own and one's peer's opinions. An argument in favour of this view---which is prominently held by Adam Elga---is that by such a difference-splitting one may make some use of a so-called wise-crowd effect. In this paper it is argued that such a view faces two main problems: First, the problem that the standards for making use of a wise-crowd effect are quite low. (...) And second, the problem that following the equal-weight view decreases such effects and by this the argument's own basis is defeated. We therefore come to the conclusion that an argument for the equal-weight view with the help of wise-crowd effects as provided more or less explicitly by Elga does not succeed. (shrink)

Postural instability in Parkinson’s disease (PD) is characterized by impaired postural responses to transient perturbations, increased postural sway in stance and difficulty transitioning between tasks. In addition, some studies suggest that loss of dopamine in the basal ganglia due to PD results in difficulty using proprioceptive information for motor control. Here, we quantify the ability of subjects with PD and age-matched control subjects to use and re-weight sensory information for postural control during steady-state conditions of continuous rotations of the (...) stance surface or visual surround. We measure the postural sway of subjects in response to a pseudorandom, surface-tilt stimulus with eyes closed, and in response to a pseudorandom, visual-tilt stimulus. We use a feedback control model of the postural control system to interpret our results, focusing on sensory weighting as a function of stimulus amplitude. We find that subjects with PD can re-weight their dependence upon sensory information in response to changes in surface- or visual-stimulus amplitude. Specifically, subjects with PD behaved like age-matched control subjects by decreasing proprioceptive contribution to stance control with increasing surface-tilt amplitude, and decreasing visual contribution with increasing visual-tilt amplitude. However, subjects with PD do not decrease their reliance on proprioception as much as age-matched controls for small increases in surface-stimulus amplitudes. Levodopa medication did not affect sensory re-weighting behaviors for postural control. The impairment in PD subject’s ability to respond differently to small changes in surface rotation amplitudes is consistent with an increased threshold for perceiving proprioceptive signals, which may result from decreased signal-to-noise in the dopaminergic pathways associated with sensory processing and/or sensory integration. (shrink)

The testimonia concerning weight in early Greek atomism appear to contradict one another. Some reports assert that the atoms do have weight, while others outright deny weight as a property of the atoms. A common solution to this apparent contradiction divides the testimonia into two groups. The first group describes the atoms within a κόσμος, where they have weight; the second group describes the atoms outside of a κόσμος, where they are weightless. A key testimonium for (...) proponents of this solution is Aëtius 1.3.18. It apparently denies weight as a property of the atoms, and supposedly describes the atoms when they are outside of a κόσμος. I argue against this interpretive solution by demonstrating, first, that Aëtius 1.3.18 does not deny that weight is a property of the atoms. Second, I argue that the report does not describe the atoms when they are outside of a κόσμος. Although these are largely negative conclusions, I contend that we are not left without a solution to the present interpretive difficulty. Once our testimonia concerning weight in early Greek atomism are examined thoroughly, it is clear that there is no conflict among them. (shrink)

There are several proposals to resolve the problem of epistemic peer disagreement which concentrate on the question of how to incorporate evidence of such a disagreement. The main positions in this field are the equal weight view, the steadfast view, and the total evidence view. In this paper we present a new argument in favour of the equal weight view. As we will show, this view results from a general approach of forming epistemic attitudes in an optimal way. (...) By this, the argument for equal weighting can be massively strengthened from reasoning via epistemic indifference to reasoning from optimality. (shrink)

Public health policies which involve active intervention to improve the health of the population are often criticized as paternalistic. This article argues that it is a mistake to frame our discussions of public health policies in terms of paternalism. First, it is deeply problematic to pick out which policies should count as paternalistic; at best, we can talk about paternalistic justifications for policies. Second, two of the elements that make paternalism problematic at an individual level—interference with liberty and lack of (...) individual consent—are endemic to public policy contexts in general and so cannot be used to support the claim that paternalism in particular is wrong. Instead of debating whether a given policy is paternalistic, we should ask whether the infringements of liberty it contains are justifiable, without placing any weight on whether or not those infringements of liberty are paternalistic. Once we do so, it becomes apparent that a wide range of interventionist public health policies are justifiable. (shrink)

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

Duncan Pritchard has, in the years following his (2005) defence of a safety-based account of knowledge in Epistemic Luck, abjured his (2005) view that knowledge can be analysed exclusively in terms of a modal safety condition. He has since (Pritchard in Synthese 158:277–297, 2007; J Philosophic Res 34:33–45, 2009a, 2010) opted for an account according to which two distinct conditions function with equal importance and weight within an analysis of knowledge: an anti-luck condition (safety) and an ability condition-the latter (...) being a condition aimed at preserving what Pritchard now takes to be a fundamental insight about knowledge: that it arises from cognitive ability (Greco 2010; Sosa 2007, 2009). Pritchard calls his new view anti-luck virtue epistemology (ALVE). A key premise in Pritchard’s argument for ALVE is what I call the independence thesis; the thesis that satisfying neither the anti-luck condition nor the ability condition entails that the other is satisfied. Pritchard’s argument for the independence thesis relies crucially upon the case he makes for thinking that cognitive achievements are compatible with knowledge-undermining environmental luck—that is, the sort of luck widely thought to undermine knowledge in standard barn facade cases. In the first part of this paper, I outline the key steps in Pritchard’s argument for anti-luck virtue epistemology and highlight how it is that the compatibility of cognitive achievement and knowledge- undermining environmental luck is indispensible to the argument’s success. The second part of this paper aims to show that this compatibility premise crucial to Pritchard’s argument is incorrect. (shrink)

When Gamurrini first published the Peregrinatio ad loca sancta, the narrative by an abbess of a pilgrimage undertaken to the Holy Land in the last quarter of the fourth century, he identified the authoress with Silvia, the sister of Arcadius' minister Rufinus. Heraeus, however, in his edition lends the weight of his authority to the view that the work was written by a certain Aetheria, and in his preface gives solid reasons for his preference. He also states that a (...) thirteenth-century catalogue of the Limoges Cathedral Library mentions the book under the title Itinevarium Egenae abbatissae, but he regards the form Egeria as a mere corruption. (shrink)

The Anderson-Friedman absolute objects program has been a favorite analysis of the substantive general covariance that supposedly characterizes Einstein's General Theory of Relativity (GTR). Absolute objects are the same locally in all models (modulo gauge freedom). Substantive general covariance is the lack of absolute objects. Several counterexamples have been proposed, however, including the Jones-Geroch dust and Torretti constant curvature spaces counterexamples. The Jones-Geroch dust case, ostensibly a false positive, is resolved by noting that holes in the dust in some models (...) ensure that no physically relevant nonvanishing timelike vector field exists there, so no absolute object exists. The Torretti constant curvature spaces case, allegedly a false negative, is resolved by testing an irreducible piece of the metric, the conformal metric density of weight -2/3, for absoluteness; this geometric object is absolute. A new counterexample is proposed involving the orthonormal tetrad said to be necessary to couple spinors to a curved metric. The threat of finding an absolute object in GTR + spinors is overcome by the use of an alternative spinor formalism that takes a symmetric square root of the metric (with the help of the matrix diag(-1,1,1,1)), eliminating 6 of the 16 tetrad components as irrelevant. The importance of eliminating irrelevant structures, as Anderson emphasized, is clear. The importance of the choice of physical fields is also evident. A new counterexample due to Robert Geroch and Domenico Giulini, however, finds an absolute object in vacuum GTR itself, namely the scalar density $g$ given by the metric components' determinant. Thus either the definition of absoluteness or its use to analyze GTR's substantive general covariance is flawed. Anderson's belief that all absolute objects are nonvariational (that is, not varied in a suitable action principle) and vice versa is also falsified by the Geroch-Giulini counterexample. However, it remains plausible that all nonvariational fields are absolute, so adding nonvariationality as a necessary condition for absoluteness, as Hiskes once suggested, would likely leave no useful work to the Anderson-Friedman condition of sameness in all models. Simply having only variational fields in an action principle (suitably free of irrelevant fields) might be a satisfactory analysis of substantive general covariance, if one exists. This proposal also resembles the suggestion that GTR is "already parameterized," if one decides to parameterize theories by defining the nonvariational fields in terms of preferred coordinates called clock fields. More questions need to be addressed. Which fields should be tested for absoluteness: only primitive fields (which ones?), or all or some (which?) of their concomitants also? Geroch observes that some kinds of geometric objects, such as tangent vectors, scalar densities, and tangent vector densities of non-unit weight, satisfy the condition of sameness in all models if they merely fail to vanish. If these "susceptible" geometric objects can hardly help being absolute, to what degree are they, or the theories harboring them, responsible for this absoluteness? The answer to this question helps to determine the significance of the Geroch-Giulini counterexample. (shrink)

Evidence suggests that one reason doctors provide certain interventions in assisted reproductive technologies (ART) is because of patient demand. This is particularly the case when it comes to unproven interventions such as ‘add‐ons’ to in vitro fertilisation (IVF) cycles, or providing IVF cycles that are highly unlikely to succeed. Doctors tend to accede to demands for such interventions because patients are willing to do and pay ‘whatever it takes’ to have a baby. However, there is uncertainty as to what moral (...) weight should be placed on patient‐led demands in ART, including whether it is acceptable for such demands to be invoked as a justification for intervention. We address this issue in this paper. We start by elucidating what we mean by ‘patient‐led demand’ and synthesise some of the evidence for this phenomenon. We then argue that a doctor's professional role morality (PRM) yields special responsibilities, particularly in commercialised healthcare settings such as ART, because of the nature of professions as social institutions that are distinct from markets. We argue on this basis that, while there may be reasons (consistent with PRM) for doctors to accede to patient demand, this is not always the case. There is often a gap in justification between acceding to patient‐led demands and providing contested interventions, particularly in commercial settings. As a result, acceding to demand in such settings needs a strong justification to be consistent with PRM. (shrink)

This chapter discusses Statistical Prediction Rules and provides an explanation for their success. SPRs are simple, formal rules that have been shown to be typically more reliable, than the predictions of human experts on a wide variety of problems. Based on testable results, psychology can make normative recommendations about how we ought to reason. The branches of psychology that provide normative recommendations are dubbed as ‘Ameliorative Psychology’. Two central lessons of Ameliorative Psychology are that when it comes to social judgment, (...) proper unit weight models outperform humans in terms of reliability and improper unit weight models often perform nearly as well as proper models and therefore better than humans. It is argued that the reason people resist this ‘practical conclusion’ is partly because the SPR results are noxious to our conception of ourselves as good reasoners. Further, they undermine our hope — so evident in the a priorism of so much contemporary epistemology — that we can be experts at recognizing good reasoning without massive empirical aid. (shrink)

Anachronistic values A value becomes anachronistic when it no longer fits current historical conditions (institutions, technology, culture, etc.). From an ‘idealist’ perspective, this fact does not tell against the old value (accepted as true), but rather against the new conditions. However, from a ‘naturalist’ perspective which takes values to be the product of human interests and (therefore) as interconnected with a given historical context, such a conflict seems to make a value obsolete. But this is neither an empirical law nor (...) a normative rule. A defence of anachronistic values might still be perfectly reasonable. It is argued that such reasonableness depends mainly on three criteria: (un)certainty, scope and weight. (shrink)

Rotating machinery produces vibrations depending upon the design of the rotor systems as well as any faults or uncertainties in the machine that can increase the vibrations of such systems. This study illustrates the effectiveness of using surrogate modeling based on kriging in order to predict the vibrational behavior of a complex flexible rotor in the presence of uncertainties. The basic idea of kriging is to predict unknown values of a function by using a small size set of known data. (...) The kriging estimation is based on a weighted average of the known values of the function in the neighborhood of the point for which the value of the function has to be calculated. The crucial dependence of a kriging predictor versus the correlation functions and different orders will be illustrated. This paper also shows that reducing the number of samples required to have predictive models can be achieved by performing an initial understanding of the mechanical system of interest and by considering certain characteristics directly deriving from the physics of the problem studied. (shrink)

This paper examines geometrical arguments from Galileo's Mechanics and Two New Sciences to discern the influence of the Aristotelian Mechanical Problems on Galileo's dynamics. A common scientific procedure is found in the Aristotelian author's treatment of the balance and lever and in Galileo's rules concerning motion along inclined planes. This scientific procedure is understood as a development of Eudoxan proportional reasoning, as it was used in Eudoxan astronomy rather than simply as it appears in Euclid's Elements. Topics treated include the (...) significance of the circle in Galileo's demonstrations, the substitution of rectilinear elements for heterogeneous factors like weight and curvilinear distance, and the way in which elements of a motion are used to measure other elements of the same motion. The indirectness of Galileo's proofs, his conception of speed as relative and comparative, and the meaning of his concept of moment all come into clearer focus. Conclusions are drawn about Galilean idealization, and also about the contrast of literal versus figural modes of explanation in Galileo's science. (shrink)

“I am still in despair over losing my identity,” said a blog comment in a discussion about post-menopause weight gain. Instead of recovering an identity, for some of us, as women age, our attitudes toward fitness may require forging new identities. But the challenge in coming to desire fitness, post-menopause, is a project of actually changing my desires. Habituating a good practice can lead to a change in our appetites, so that instead of losing our identities, we may become (...) the characters that we set goals to be. (shrink)