Purpose: Explore public attitudes towards the trade-offs between justice and medical outcome inherent in organ allocation decisions.Background: The US Task Force on Organ Transplantation recommended that considerations of justice, autonomy and medical outcome be part of all organ allocation decisions. Justice in this context may be modeled as a function of three types of need, related to age, clinical urgency, and quality of life.Methods: A web-based survey was conducted in which respondents were asked to choose between two hypothetical patients who (...) differed in clinical urgency , age, pretransplant and post-transplant quality of life, and life expectancy.Results: A pool of 1600 people were notified via email about the survey; 623 responded. Respondents preferred giving organs to younger people up to an age difference of <15.4 years and more clinically urgent people up to a difference in urgency of <2.54 months . Priority varied with the quality of life of the worst-off patient and the relative status of the patients. If both had worse than average quality of life, respondents preferred the better-off patient. When both had better than average quality of life, they preferred the worse-off patient. In analysis according to age versus clinical urgency, the older the patient, the more urgency needed to receive priority. In quality of life versus clinical urgency, the better the control’s quality of life, the more urgency the competing patient required. The worse the patient’s post-transplant outcome, the more urgency needed to receive priority.Conclusions: It appears that clinical urgency is only one of many factors influencing attitudes about allocation decisions and that respondents may invoke different principles of fairness depending the relative clinical status of patients. (shrink)

In this paper we address the interrelated questions of why and how certain features of an organism’s environment become meaningful to it. We make the case that knowing the biology is essential to understanding the foundation of meaning-making in organisms. We employ Miguel Nicolelis et al’s seminal research on the mammalian somatosensory system to enrich our own concept of brain-objects as the neurobiological intermediary between the environment and the consequent organismic behavior. In the final section, we explain how brain-objects advance (...) the ongoing discussion of what constitutes a biosemiotic system. In general, this paper acknowledges Marcello Barbieri’s call for biology to make room for meaning, and makes a contribution to that end. (shrink)

Abstract A unique aspect of human communication is the utilization of sets of well- delineated entities, the morphology of which is used to encode the letters of the alphabet. In this paper, we focus on Braille as an exemplar of this phenomenon. We take a Braille cell to be a physical artifact of the human environment, into the structure of which is encoded a representation of a letter of the alphabet. The specific issue we address in this paper concerns an (...) examination of how the code that is embedded in the structure of a Braille cell is transferred with fidelity from the environment through the body and into the Braille reader’s brain. We describe four distinct encoding steps that enable this transfer to occur. (shrink)

What reactions are legitimate when someone is pursuing an experiment in living that has, in your considered view, gone awry? This essay discusses how the way Mill expressed his concern over the cultivation of individuality places some stress on the harm principle and on the permissibility of making the sort of judgments about another person that seem fairly natural to make when someone is pursuing an experiment in living that has gone considerably awry. It is surprisingly difficult, but I argue (...) not impossible, to provide a representation of Mill’s view about such cases in a way that accommodates everything that Mill seems to commit himself to: the harm principle; antipathy towards conformism; and the permissibility of making some very negative appraisals of certain modes of living. (shrink)

Jaakko Hintikka (1998) has argued that clarifying the notion of abduction is the fundamental problem of contemporary epistemology. One traditional interpretation of Peirce on abduction sees it as a recipe for generating new theoretical discoveries . A second standard view sees abduction as a mode of reasoning that justifies beliefs about the probable truth of theories. While each reading has some grounding in Peirce's writings, each leaves out features that are crucial to Peirce's distinctive understanding of abduction. I develop and (...) defend a third interpretation, according to which Peirce takes abductive reasoning to lead to judgments about the relative pursuitworthiness of theories; conclusions that can be thoroughly disconnected from assessments of truth-value. Even if Peirce's use of "abduction" slides around among each of these three importantly different though potentially compatible senses, this neglected third understanding makes sense of a large number of Peirce's remarks and directs our attention to the cognitive structure of judgments that scientists face after the initial proposal of explanatory hypotheses but prior to their experimental testing; a topic which should be of interest to contemporary philosophers of science. (shrink)

Foundations of Economic Personalism is a series of three book-length monographs, each closely examining a significant dimension of the Center for Economic Personalism's unique synthesis of Christian personalism and free-economic market theory. In the aftermath of the momentous geo-political and economic changes of the late 1980s, a small group of Christian social ethicists began to converse with free-market economists over the morality of market activity. This interdisciplinary exchange eventually led to the founding of a new academic subdiscipline under the rubric (...) of economic personalism. These scholars attempt to integrate economic theory, history, and methodology with Christian personalism's stress upon human dignity, humane social structures, and social justice. This volume presents the methodological and theoretical foundations for economic personalism through a detailed investigation of human action from two different, yet complementary perspectives: from the personalist perspective of Karol Wojtyla in the Acting Person , and the free-market perspective of Ludwig von Mises in Human Action . By comparing and contrasting the viewpoints of Wojtyla and Mises, the authors develop a comprehensive praxeology capable of analyzing human action from moral and economic perspectives. Beyond Self-Interest illustrates how a unified praxeology could encourage more sustained analysis of the moral dimensions of economic activity while simultaneously softening the utilitarian prejudice of contemporary economic analysis. (shrink)

The central classical liberal insight is that private property appears both to protect personal liberty and to promote general productivity. By way of philosophically clarifying this insight, Escape from Leviathan (EfL) posits the extreme classical liberal, or libertarian, Compatibility Thesis: there is no long-term, systemic, practical conflict among economic rationality, interpersonal liberty, human welfare, and private-property anarchy (i.e., four plausible and relevant theories of these that are presupposed, or entailed, by libertarianism and consonant social science). The review (Liberty, November 2002) (...) holds that this extreme version is probably false and suggests that perhaps even EfL’s author would agree. He (still) does not, although he remains open to argument. But what anyone happens to believe at any particular moment is a piece of fleeting biography that is irrelevant to the truth of the thesis or the soundness of the arguments in EfL. (shrink)

Contra critical rationalism, the response begins by referring to “the variety of internalist and externalist versions of foundationalism” (Liberty, December 2002). But it makes no attempt to explain or defend any of them. Hence, no further criticism is due here. The response then argues that, “The critical rationalist method seems to suggest that Lester’s extreme compatibility thesis is probably false” because—quoting Escape from Leviathan (EfL)—“bold universal theories might be false, and probably are” and yet “he doesn’t think the thesis is (...) probably false”. And so this is, by implication, an inconsistent belief. But the Compatibility Thesis (CT) is not one of the “bold universal theories” of science. The review and the response appear, at times, to assume that the CT is a bold universal theory about the perfect compatibility of applying the relevant conceptions, or theories, of rationality, liberty, welfare, and anarchy. Then, at other times, they assert that it is not bold at all but merely about definitions designed to be compatible. In fact, the CT asserts both that there are no theoretical incompatibilities among relevant and plausible versions of the theories, and that there are no actual long-term, systemic, and practical conflicts among applying them. That is still a bold theory (perhaps even most libertarians would disagree with it), but it’s not a universal thesis of perfect compatibility. And if it were good practice to reject a theory just because of its boldness, then all scientific theories would be immediately rejected without even trying to produce a falsification. In any case, as stated in the reply to the review, anyone’s mere beliefs are irrelevant to the truth of objective theories and the soundness of objective arguments. (shrink)

Costly signalling theory has become a common explanation for honest communication when interests conflict. In this paper, we provide an alternative explanation for partially honest communication that does not require significant signal costs. We show that this alternative is at least as plausible as traditional costly signalling, and we suggest a number of experiments that might be used to distinguish the two theories.

It is widely believed that bringing parties with differing opinions together to discuss their differences will help both in securing consensus and also in ensuring that this consensus closely approximates the truth. This paper investigates this presumption using two mathematical and computer simulation models. Ultimately, these models show that increased contact can be useful in securing both consensus and truth, but it is not always beneficial in this way. This suggests one should not, without qualification, support policies which increase interpersonal (...) contact if one seeks to improve the epistemic performance of groups. (shrink)

This article presents the evolutionary dynamics of three games: the Nash bargaining game, the ultimatum game, and a hybrid of the two. One might expect that the probability that some behavior evolves in an environment with two games would be near the probability that the same behavior evolves in either game alone. This is not the case for the ultimatum and Nash bargaining games. Fair behavior is more likely to evolve in a combined game than in either game taken individually. (...) This result confirms a conjecture that the complexity of our actual environment provides an explanation for the evolution of fair behavior. Key Words: evolutionary game theory • Nash bargaining game • ultimatum game • fairness. (shrink)

In recent years, many scholars have suggested that the Baldwin effect may play an important role in the evolution of language. However, the Baldwin effect is a multifaceted and controversial process and the assessment of its connection with language is difficult without a formal model. This paper provides a first step in this direction. We examine a game-theoretic model of the interaction between plasticity and evolution in the context of a simple language game. Additionally, we describe three distinct aspects of (...) the Baldwin effect: the Simpson– Baldwin effect, the Baldwin expediting effect and the Baldwin optimizing effect. We find that a simple model of the evolution of language lends theoretical plausibility to the existence of the Simpson– Baldwin and the Baldwin optimizing effects in this arena, but not the Baldwin expediting effect. (shrink)

Soon after receiving Bouvet's interpretation of the hexagrams of the I ching as binary numbers, Leibniz communicated this application of his binary arithmetic to Hans Sloane in a letter published here for the first time. The letter also included a report on the observations of the variable star in the neck of the Swan by Gottfried Kirch. Sloane sent a copy of the scientific parts of the letter to Flamsteed.

It is widely believed that one should not become more confident that all swans are white and all lions are brave simply by observing white swans. Irrelevant conjunction or “tacking” of a theory onto another is often thought problematic for Bayesianism, especially given the ratio measure of confirmation considered here. It is recalled that the irrelevant conjunct is not confirmed at all. Using the ratio measure, the irrelevant conjunction is confirmed to the same degree as the relevant conjunct, which, it (...) is argued, is ideal: the irrelevant conjunct is irrelevant. Because the past’s really having been as it now appears to have been is an irrelevant conjunct, present evidence confirms theories about past events only insofar as irrelevant conjunctions are confirmed. Hence the ideal of not confirming irrelevant conjunctions would imply that historical claims are not confirmed. Confirmation measures partially realizing that ideal make the confirmation of historical claims by present evidence depend strongly on the (presumably subjective) degree of belief in the irrelevant conjunct. The unusually good behavior of the ratio measure has a bearing on the problem of measure sensitivity. For non-statistical hypotheses, Bayes’ theorem yields a fractional linear transformation in the prior probability, not a linear rescaling, so even the ratio measure arguably does not aptly measure confirmation in such cases. (shrink)

In On the Origin of Species, Charles Darwin put forward his theory of natural selection. Conventionally, Darwin's argument for this theory has been understood as based on an analogy with artificial selection. But there has been no consensus on how, exactly, this analogical argument is supposed to work – and some suspicion too that analogical arguments on the whole are embarrassingly weak. Drawing on new insights into the history of analogical argumentation from the ancient Greeks onward, as well as on (...) in-depth studies of Darwin's public and private writings, this book offers an original perspective on Darwin's argument, restoring to view the intellectual traditions which Darwin took for granted in arguing as he did. From this perspective come new appreciations not only of Darwin's argument but of the metaphors based on it, the range of wider traditions the argument touched upon, and its legacies for science after the Origin. (shrink)

This chapter contains sections titled: Notes.

We hypothesize that black women experience accelerated biological aging in response to repeated or prolonged adaptation to subjective and objective stressors. Drawing on stress physiology and ethnographic, social science, and public health literature, we lay out the rationale for this hypothesis. We also perform a first population-based test of its plausibility, focusing on telomere length, a biomeasure of aging that may be shortened by stressors. Analyzing data from the Study of Women’s Health Across the Nation (SWAN), we estimate that (...) at ages 49–55, black women are 7.5 years biologically “older” than white women. Indicators of perceived stress and poverty account for 27% of this difference. Data limitations preclude assessing objective stressors and also result in imprecise estimates, limiting our ability to draw firm inferences. Further investigation of black-white differences in telomere length using large-population-based samples of broad age range and with detailed measures of environmental stressors is merited. (shrink)

This comprehensive and important volume includes contributions by activists, journalists, lawyers and scholars from twenty-one countries. The essays map the directions the movement for women's rights is taking--and will take in the coming decades--and the concomittant transformation of prevailing notions of rights and issues. They address topics such as the rapes in former Yugoslavia and efforts to see that a War Crimes Tribunal responds; domestic violence; trafficking of women into the sex trade; the persecution of lesbians; female genital mutilation; and (...) reproductive rights. (shrink)

School liking is an important factor in student engagement, well-being, and academic achievement, but it is also potentially influenced by factors external to the individual, such as school culture, teacher support, and approaches to discipline. The present study employed a survey methodology to investigate the associations between school liking and disliking, teacher and school connectedness, and experiences of exclusionary discipline from the perspective of students themselves. Participants included 1,002 students from three secondary schools serving disadvantaged communities. Results indicated clear differences (...) between students who like and dislike school in terms of their preferred school activities and school disciplinary history, with students who disliked school experiencing overall lower school connectedness. Moreover, students who disliked school experienced less positive relationships with their teachers, and this was even more pronounced for students who had been previously suspended. The findings reveal key differences between students who do and do not like school, differences that may be masked by typical research approaches. This research indicates the need for more nuanced, student-informed approaches to inclusive school reform. (shrink)

Horace addresses Torquatus again in Carm. 4.7. There the poet distinguishes three cardinal qualities: Torquatus's genus, his facundia, and hispietas. Since Horace distinguishes them they were no doubt qualities on which Torquatus prided himself, but they are, in any case, the key by which Torquatus slips into Horace's lyric. I suggest that we can use the same key to open up the Epistle, and that by taking up these qualities we have ready access to the wit of the poem, carefully (...) predicated upon its addressee. (shrink)