In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined “perioperative tumour growth” and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget1Sir James Paget (1814–1899) was a surgeon and physiologist who is widely held (along with Rudolph Virchow) to be the father of the science of pathology. Paget (...) described Paget's disease of the nipple as well as Paget's disease of bone. himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host–tumour interactions that may occur during the perioperative period. BioEssays 28: 433–437, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

How should Christians interact with historical violence in their own tradition? Faced with a barrage of arguments from the ‘New Atheists’ that this killing invalidates biblical truth claims, Christians might be tempted to ignore or excuse these darker episodes. This article argues that they should be willing to confess the failings of the past, place the violent acts in a careful reading of their historical context and re-examine these acts in light of scripture.

George F. Kennan's political realism defines the object of diplomacy as the pursuit of the national self-interest and renders legitimate any means which expediently serve that purpose.

This volume traces the evolution of Whig and Tory, Puritan and Anglican ideas across a tumultuous period of British history, from the mid-seventeenth century through to the Age of Enlightenment. This volume, a tribute to Mark Goldie, traces the evolution of Whig and Tory, Puritan and Anglican ideas across a tumultuous period of British history, from the mid-seventeenth century through to the Age of Enlightenment. Mark Goldie, Fellow of Churchill College and Professor of Intellectual History at Cambridge University, is one (...) of the most distinguished historians of later Stuart Britain of his generation and has written extensively about politics, religion and ideas in Britain from the Restoration through to the Hanoverian succession. Based on original research, the chapters collected here reflect the range of his scholarly interests: in Locke, Tory and Whig political thought, and Puritan, Anglican and Catholic political engagement, as well as the transformative impact of the Glorious Revolution. They examine events as well as ideas and deal not only with England but also with Scotland, France and the Atlantic world. Politics, Religion and Ideas in Seventeenth- and Eighteenth-Century Britain will be of interest to later Stuart political and religious historians, Locke scholars and intellectual historians more generally. JUSTIN CHAMPION is Professor of History at Royal Holloway, University of London. JOHN COFFEY is Professor of Early Modern History at the University of Leicester. TIM HARRIS is Professor of History at Brown University. JOHN MARSHALL is Professor of History at John Hopkins University. CONTRIBUTORS: Justin Champion, John Coffey, Conal Condren, Gabriel Glickman, Tim Harris, Sarah Irving-Stonebraker, Clare Jackson, Warren Johnston, Geoff Kemp, Dmitri Levitin, John Marshall, Jacqueline Rose, S.-J. Savonius-Wroth, Hannah Smith, Delphine Soulard. (shrink)