The recent interest in neuroscientific psychodynamic research ('neuropsychoanalysis') has meant that empirical findings are emerging which allow greater public scrutiny of psychodynamic concepts. However, Malcolm Macmillan has claimed that the psychoanalytic cornerstone, repression, is a circular explanatory concept and incapable of referring to a "real process." This paper discusses Macmillan's criticism and finds that repression is a coherent explanatory term and is not precluded from referring to real processes. Specifically, 'neural inhibition,' triggered by social factors, can account for (...) Freudian repression, without succumbing to circular explanation. Recent developments in neuroscience suggest that a plausible mechanism of inhibition exists, providing testable avenues for the 'cornerstone' of psychoanalysis. Evidence of the role of the frontal lobes, a brain area that appears to mediate the influence of social factors upon impulse control, demonstrates that repression is plausible within a dynamic neural framework. (shrink)

Purpose To examine process factors that either facilitate or inhibit learning medical ethics during case-based learning. Methods A qualitative research approach using microanalysis of transcribed videotaped discussions of three consecutive small-group learning sessions on medical ethics teaching for three groups, each with 10 students. Results This research effort revealed 12 themes of learning strategies, divided into 6 coping and 6 evasive strategies. Cognitive-based strategies were found to relate to Kamin's model of critical thinking in medical education, thereby supporting our distinction (...) between the themes of coping and evasive strategies. The findings also showed that cognitive efforts as well as emotional strategies are involved in discussions of ethical dilemmas. Based on Kamin's model and the constructivist learning theory, an examination of the different themes within the two learning strategies—coping and evasive—revealed that these strategies may be understood as corresponding to process factors either facilitating or inhibiting MET in SGL, respectively. Conclusions Our classification offers a more nuanced observation, specifically geared to pinpointing the desired and less desired process factors in the learning involved in MET in the SGL environment. Two key advantages of this observation are: it brings to the forefront process factors that may inhibit and not merely facilitate MET in SGL and it acknowledges the existence of emotional and not just cognitive process factors. Further enhancement of MET in SGL may thus be achieved based on these observations. (shrink)

During active vision, the eyes continually scan the visual environment using saccadic scanning movements. This target article presents an information processing model for the control of these movements, with some close parallels to established physiological processes in the oculomotor system. Two separate pathways are concerned with the spatial and the temporal programming of the movement. In the temporal pathway there is spatially distributed coding and the saccade target is selected from a Both pathways descend through a hierarchy of levels, (...) the lower ones operating automatically. Visual onsets have automatic access to the eye control system via the lower levels. Various centres in each pathway are interconnected via reciprocal inhibition. The model accounts for a number of well-established phenomena in target-elicited saccades: the gap effect, express saccades, the remote distractor effect, and the global effect. High-level control of the pathways in tasks such as visual search and reading is discussed; it operates through spatial selection and search selection, which generally combine in an automated way. The model is examined in relation to data from patients with unilateral neglect. (shrink)

The framework of Findlay & Walker's target article provides a first attempt to model the saccadic system at all levels. Their scheme is based on two main principles. These are “parallel processing of saccade timing and metrics” and “competitive inhibition through winner-take-all strategies.” In our opinion, however, both concepts are in their strictest sense at odds with the current knowledge of the saccadic system, and need to be refined to make the scheme more relevant.

ABSTRACT Social media is becoming increasingly embedded in people’s daily lives. These virtual spaces are now regularly used as a tool for information dissemination. Drawing on the moral intensity literature combined with uses and gratifications theory, this research explores how using social media to consume information can affect the ethical decision-making process. This study compares the influence of two online media dissemination formats – an online news article and social media discussion thread – on individuals’ ethical perceptions and decisions. Results (...) indicate that social media usage has an effect on perceptions of social consensus, problem recognition, and ethical sensemaking. Overall, Social media is shown to inhibit ethical decision-making when used as an information dissemination tool. (shrink)

Mindfulness is intentional focus of one’s attention on emotions, thoughts, or sensations occurring in the present moment with a nonjudgmental attitude. Recently there has been increased interest in the effects of mindfulness practice on psychological processes such as concentration, focus, and attention. In the present study, a prepulse inhibition/facilitation paradigm was employed to investigate the effect of brief mindfulness practice on automatic attention regulation processes. PPI occurs when a relatively weak prepulse is presented 30–500 ms before a (...) startle-inducing stimulus, and reduces the magnitude of the startle response. Prepulse facilitation is the increase in startle magnitude when the prepulse is presented 500 ms or more before the startle-eliciting stimulus. In the present study, the effect of engaging in a 23-min mindfulness exercise on PPI and PPF was investigated. Participants listened to either a mindfulness instruction or relaxing music. In a PPI/PPF pretest and posttest, a startle-eliciting noise was presented at lead intervals of 60, 120, and 2,000 ms. Results showed that engaging in brief mindfulness practice increased prepulse facilitation at the 2,000 ms lead interval in the posttest compared to the pretest. The amount of PPI did not differ between tests. (shrink)

When must a specific cognitive habit be called upon to solve a problem? In the subject’s learning process, “knowing-to” is connected with a conscious particular judgment of truth or “aha” moment enacting a new behavioral schema. This paper comments on recent experiments supporting the view that a shift from automatic to controlled forms of inhibition, involving conscious attention, is crucial for detecting errors and activating a new strategy in complex cognitive situations. The part that consciousness plays in this process (...) agrees with its philosophical description as “judge of truth”, and can thus be regarded as an essential precursor to the development of higher cognitive habits. In this regard, John Henry Newman’s explanation of human assent to truth, for which our consciousness of self is always prior, proves to be decisive. (shrink)

Background Previous reports have described that simple cognitive training using reading aloud and solving simple arithmetic calculations, so-called “learning therapy”, can improve executive functions and processing speed in the older adults. Nevertheless, it is not well-known whether learning therapy improve a wide range of cognitive functions or not. We investigated the beneficial effects of learning therapy on various cognitive functions in healthy older adults. Methods We used a single-blinded intervention with two groups (learning therapy group: LT and waiting list control (...) group: WL). Sixty-four elderly were randomly assigned to LT or WL. In LT, participants performed reading Japanese aloud and solving simple calculations training tasks for 6 months. WL did not participate in the intervention. We measured several cognitive functions before and after 6 months intervention periods. Results Compared to WL, results revealed that LT improved inhibition performance in executive functions (Stroop: LT (Mean = 3.88) vs. WL (Mean = 1.22), adjusted p =.013 and reverse Stroop LT (Mean = 3.22) vs. WL (Mean = 1.59), adjusted p =.015), verbal episodic memory (logical memory: LT (Mean = 4.59) vs. WL (Mean = 2.47), adjusted p =.015), focus attention(D-CAT: LT (Mean = 2.09) vs. WL (Mean = -0.59), adjusted p =.010) and processing speed compared to the waiting list control group (digit symbol coding: LT (Mean = 5.00) vs. WL (Mean = 1.13), adjusted p =.015 and symbol search: LT (Mean = 3.47) vs. WL (Mean = 1.81), adjusted p =.014). Discussion This RCT can showed the benefit of learning therapy on inhibition of executive functions, verbal episodic memory, focus attention, and processing speed in healthy elderly people. Our results were discussed under overlapping hypothesis. Trial registration “This trial was registered in The University Hospital Medical Information Network Clinical Trials Registry (UMIN000006998).”. (shrink)

The tendency for people to remember less as members of a group than they would be capable of were they to remember alone is a phenomenon known as collaborative inhibition. The article offers a phenomenological account of this highly counterintuitive effect of group remembering. It argues that the mutual failure to live up to one’s potential does not warrant the standard, strongly negative views about the role of others in recall. Rather, the phenomenon may imply that sharedness itself becomes (...) constitutive of the process in the sense that interaction partners co-determine what and how to remember. Drawing on phenomenological approaches to remembering and second-person engagement, the article argues that individuals participating in shared remembering co-construct their memories by reciprocally and dynamically incorporating each other’s perspectives, attitudes, and emotions about their shared past. (shrink)

Recent studies suggest that instrumental hypnosis is a useful experimental tool to investigate emotional and language processing effects. However, the capacity of hypnotic suggestions to intervene during the response inhibition of emotional words remains elusive. This study investigated whether hypnotic suggestion can improve the inhibition of prepotent negative word responses in an emotional Hayling sentence completion task. High-suggestible participants performed a computerised emotional Hayling task. They were first asked to select the appropriate words ending highly predictable sentences among (...) two propositions (initiation part), and then to select the filler words that did not end the sentences correctly (inhibition part). Half of the expected final words had a negative emotional valence, while the other half was neutral. The task was performed in a control condition (without suggestion) and with a hypnotic suggestion to decrease emotional reactivity. The results revealed that hypnotic suggestion (compared to the control condition) hastened response times on negative final words in the inhibition part, showing that hypnotic suggestion can enhance cognitive control over prepotent negative word responses in a sentence completion task. We suggest that this modulation stems from a reduction in the emotional relevance of the final words caused by the hypnotic suggestion. (shrink)

Pitch labeling in absolute pitch (AP), the ability to recognize the pitch class of a sound without an external reference, is effortless, fast, and presumably automatic. Previous studies have shown that pitch labeling in AP can interfere with task demands. In the current study, we used a cued auditory Go/Nogo task requiring same/different decisions to investigate both behavioral and electrophysiological correlates of increased inhibitory demands related to automatic pitch labeling. The task comprised two Nogo conditions: a Nogo condition with pitch (...) differences larger than one semitone, and a second Nogo condition with pitch differences of only a quarter semitone. The first Nogo condition tested if auditory-related inhibition processes are generally altered in AP musicians. The second Nogo condition tested the suppressibility of the pitch labeling using a Stroop-like effect: the two tones belonged to the same pitch class but were not identical in terms of tone frequency. If pitch labeling cannot be suppressed, the conflicting information would be expected to increase the inhibitory load in AP musicians. Our data provided no evidence for an increased difficulty to inhibit a prepotent response or to suppress conflicting pitch-labeling information in AP: AP musicians showed similar commission error rates as non-AP musicians in both Nogo conditions. N2d and P3d amplitudes of AP musicians were also comparable to those of non-AP musicians. The event-related potentials (ERPs) were, however, modulated by the Nogo condition, probably indicating an effect of stimulus similarity. It is possible that, depending on the context, pitch labeling in AP musicians is not entirely automatic and can be suppressed. (shrink)

Two lines of evidence indicate that there exists a reciprocal inhibitory relationship between opposed brain networks. First, most attention-demanding cognitive tasks activate a stereotypical set of brain areas, known as the task-positive network and simultaneously deactivate a different set of brain regions, commonly referred to as the task negative or defaultmode network. Second, functional connectivity analyses show that these same opposed networks are anti-correlated in the resting state. Wehypothesize that these reciprocally inhibitory effects reflect two incompatible cognitive modes, each of (...) which may be directed towards understanding the external world. Thus, engaging onemode activates one set of regions and suppresses activity in the other.Wetest this hypothesis by identifying two types of problem-solving task which, on the basis of prior work, have been consistently associated with the task positive and task negative regions: tasks requiring social cognition, i.e., reasoning about the mental states of other persons, and tasks requiring physical cognition, i.e., reasoning about the causal/mechanical properties of inanimate objects. Social and mechanical reasoning tasks were presented to neurologically normal participants during fMRI. Each task type was presented using both text and video clips. Regardless of presentation modality, we observed clear evidence of reciprocal suppression: social tasks deactivated regions associated with mechanical reasoning and mechanical tasks deactivated regions associated with social reasoning. These findings are not explained by self-referential processes, task engagement, mental simulation,mental time travel or external vs. internal attention, all factors previously hypothesized to explain default mode network activity. Analyses of resting state data revealed a close match between the regions our tasks identified as reciprocally inhibitory and regions of maximal anti-correlation in the resting state. These results indicate the reciprocal inhibition is not attributable to constraints inherent in the tasks, but is neural in origin. Hence, there is a physiological constraint on our ability to simultaneously engage two distinct cognitive modes. Furtherwork is needed tomore precisely characterize these opposing cognitive domains. (shrink)

Recent pain research has concentrated heavily on excitatory processes. However, noxious stimuli activate excitatory and inhibitory systems. As failure of inhibition could underlie some forms of pathological pain, it may be argued that a full understanding of the mechanisms underlying the development of pain states can only come from a consideration of all the central sequelae of injurious stimuli. [berkley; blumberg et al.; coderre & katz; dickenson; mcmahon; weisenfeld-hallin et al.].

Background: Recent research has demonstrated that depressed individuals show impairments in inhibiting irrelevant emotional material, and that these impairments are linked to rumination. Cognitive inhibition, however, is not a unitary construct but consists of several components which operate at different stages of information processing. The present study was designed to assess two components of inhibition and examine their relation to depression and rumination in a sample of clinically depressed and healthy control participants. Methods: Twenty-two individuals diagnosed with a (...) current depressive episode and 27 never-disordered control participants completed an Emotional Flanker Task to assess individual differences in interference control and a modification of the Working Memory Selection Task to assess individual differences in the ability to discard no longer relevant emotional material from working memory. Participants completed self-report measures to assess depressive symptoms and rumination. Results: Clinically depressed compared to control participants showed significantly reduced interference control of irrelevant negative information. The groups, however, did not differ in their ability to discard no longer relevant negative information from working memory. In contrast, rumination was associated with difficulty removing no longer relevant negative material from working memory but not with deficits in interference control. Conclusions: Results highlight the importance of differentiating among components of inhibition to gain a better understanding of cognitive mechanisms underlying depression and rumination. (shrink)

Depression is a disorder of impaired emotion regulation. Consequently, examining individual differences in the habitual use of emotion-regulation strategies has considerable potential to inform models of this debilitating disorder. The aim of the current study was to identify cognitive processes that may be associated with the use of emotion-regulation strategies and to elucidate their relation to depression. Depression has been found to be associated with difficulties in cognitive control and, more specifically, with difficulties inhibiting the processing of negative material. (...) We used a negative affective priming task to assess the relations among inhibition and individual differences in the habitual use of rumination, reappraisal, and expressive suppression in clinically depressed, formerly depressed, and never-depressed participants. We found that depressed participants exhibited the predicted lack of inhibition when processing negative material. Moreover, within the group of depressed participants, reduced inhibition of negative material was associated with greater rumination. Across the entire sample, reduced inhibition of negative material was related to less use of reappraisal and more use of expressive suppression. Finally, within the formerly depressed group, less use of reappraisal, more use of rumination, and greater expressive suppression were related to higher levels of depressive symptoms. These findings suggest that individual differences in the use of emotion-regulation strategies play an important role in depression, and that deficits in cognitive control are related to the use of maladaptive emotion-regulation strategies in this disorder. (shrink)

Inhibition, an executive function, is critical for achieving goals that require suppressing unwanted behaviours, thoughts, or distractions. One hypothesis of the emotion and goal compatibility theory is that emotions of sadness and fear enhance inhibitory control. Across Experiments 1–4, we tested this hypothesis by inducing a happy, sad, fearful, and neutral emotional state prior to completing an inhibition task that indexed a specific facet of inhibition (oculomotor, resisting interference, behavioural, and cognitive). In Experiment 4, we included an (...) anger induction to examine whether valence or motivational-orientation best-predicted performance. We found support that fear and sadness enhanced inhibition except when inhibition required resisting interference. We argue that sadness and fear enhance inhibitory control aiding the detection and analysis of problems (i.e. sadness) or threats (i.e. fear) within one’s environment. In sum, this work highlights the importance of identifying how negative emotions can be beneficial for and interact with specific executive functions influencing down-stream processing including attention, cognition, and memory. (shrink)

Using the Multiple Object Tracking (MOT) task, Pylyshyn & Leonard (VSS03) showed that a small brief probe dot was detected more poorly when it occurred on a nontarget than when it occurred either on a target or in the space between items, suggesting that moving nontarget items were inhibited. Here we generalize this finding by comparing probe detection performance against a baseline condition in which no tracking was required. We examined both a baseline condition in which objects did not move (...) and one in which they moved exactly as in the probe detection task, but without tracking. Detection in the nonmoving control was essentially error-free, but probe detection performance in the moving (non-tracking) control task did depend on the probe location. Nonetheless, the findings reported earlier (worse detection on nontargets than anywhere else) remained after we took account of the baseline performance (using several different baseline comparison methods). Using this new baseline-control method we also showed that inhibition does not spread more than about 1.3 degrees of visual angle from the nontargets as the latter move during a tracking trial. In the present report we also describe some preliminary studies of conditions under which enhancement of targets, as well as inhibition of nontargets, may be obtained. Increasing the number and type of nontargets appeared to improve the detection of probes on targets, relative to baseline. However, we failed to find evidence that potentially distracting nontarget objects were inhibited more than clearly task-irrelevant objects, as would be expected if inhibition were a top-down process applied in order to improve performance on the main tracking task. For example, using the comparison with its matching baseline, we showed that task-irrelevant stationary items (which are never confused with targets in the tracking task) appeared to be inhibited even more than nontargets. (shrink)

Cognitive-linguistic theories commonly model speakers’ grammatical knowledge as a network of constructions related by a variety of associative links. The present study proposes that structural priming can provide psycholinguistic evidence of such links, and crucially, that the method can be extended to non-alternating constructions. In a comprehension priming experiment using the “maze” variant of self-paced reading, English caused-motion sentences were found to have an inhibitory effect by slowing down participants’ subsequent processing of resultatives, and vice versa, providing evidence that speakers (...) store distinct but related representations for the constructions. Priming effects of a similar magnitude emerged in both directions, suggesting that the constructions are bidirectionally related, while not supporting previous claims about a metaphorical asymmetry between the patterns. Moreover, priming was only marginally affected when prime and target contained the same rather than different verbs, demonstrating that cross-constructional priming in comprehension can be observed in the absence of a “lexical boost”. The results raise questions for follow-up research on the role of inhibition in the grammatical network and the extension of structural priming to other types of constructional links. (shrink)

ObjectiveTo investigate the characteristics of response inhibition of overweight/obese people, using behavior experiments combine with neural electrophysiological technology and discussing the difference in impulse level between obesity/overweight and normal-weight people through EEG data, questionnaire, and behavior experiment.Method All participants completed the Go/Nogo task; meanwhile, behavior data and 64 channel EEG data were recorded. Participants completed the Stop-Signal task and behavior date was recorded.Results During Go/Nogo task, no significant differences were found in reaction time, omission errors of the Go task (...) between the two groups, while commission errors of the Nogo task of the control group were significantly greater than the overweight/obesity group. About SSRT during the Stop-Signal Task, the interaction of stimulus type and group was significant. No significant differences were found between the two groups in amplitude and latency of N2. About the amplitude of P3, the interaction of task type, electrode point, and groups were significant, the control group P3 amplitude was significantly greater than overweight/obesity group during the Nogo task. Regarding about latency of P3, the interaction of group and electrode point were not significant, but the main effect of task type was significant.Conclusion In terms of behavioral outcomes, overweight–obese subjects had lower dominant response inhibition and response cessation compared to normal-weight subjects. In terms of EEG results, overweight–obese subjects showed no difference in processing speed and level of conflict monitoring for early inhibitory processing compared to normal-weight subjects, but there was a deficit in behavioral control for late inhibitory processing. (shrink)

Perceptual load plays a critical role in identification and awareness of stimuli. Given the differences in emotion–attention interactions, we investigated the perception of distractor emotional faces in two different load conditions under divided attention with a task based on the inattentional blindness paradigm. Participants performed a low- or high-load task with a string of letters presented against a happy, sad or neutral face (in a circular form) as the background. Participants were asked to identify the face that appeared in the (...) critical trial. Results indicate an interaction between emotion and load. First, identification of faces with happy expression was better than chance and unaffected by load. Second, performance was worse than chance for faces with sad expression in the high-load condition, indicating inhibition of unattended sad distractor faces in the critical trial. This indicates that inhibitory processes during a difficult attentional task under divided attention influence subsequent perception of distractor stimuli especially sad faces. The results have implications for the theories of selective attention as well as the role of emotions in conscious perception. (shrink)

Palatable, unhealthy food stimuli can be devalued via Go/No-Go (GNG) training that consistently pairs such stimuli with motor inhibition. However, it remains unclear whether this devaluation is caused via learned associations with motor inhibition or via inferential learning based on the valence of emitted motor responses. The present research disentangles the effects of motor assignment and response valence in GNG training through task instructions. In two studies, chocolate stimuli were consistently paired with motor inhibition (“no-go”) or with (...) motor excitation (“go”). Task instructions indicated that no-go responses were negatively valenced (“do not take”) and that go responses were positively valenced (“take”), or identified no-go responses as positively valenced (“keep”) and go as negatively valenced (“throw away”). The results show an effect of response valence on chocolate evaluations, but no effect of motor assignment: Chocolate stimuli were consistently devalued following pairings with a negatively valenced response, regardless of whether this response entailed motor inhibition or excitation. These findings align best with an inferential account of GNG training, suggesting that devaluation effects critically depend on inferential processes regarding motor response valence. GNG training procedures may, therefore, be optimised by disambiguating the valence of go and no-go motor responses prior to training. (shrink)

Major contributions emanating from Sagvolden et al.'s theory include elucidation of the role in attention-deficit/hyperactivity disorder (ADHD) of temporal information processing, social learning, and response extinction learning. Key issues include a need for clearer explanation of the relative role of impulsivity versus response suppression/inhibition in the dual process model, and delineation of genotype-environment correlations versus interactions in the social and experiential mechanisms posited.

DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X‐ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of (...) DNA gyrase. (shrink)

ABSTRACTUsing faces as the priming stimuli, the present study explored the influence of facial expressions on the activation of gender stereotypes using a lexical decision paradigm. Experiment 1 explored the activation of gender stereotypes when the facial primes contained only gender information. The results showed that gender stereotypes were activated. In Experiment 2, the facial primes contained both gender category and expression information. The results indicated that gender stereotypes were not activated. Experiment 3 required the participants to make emotion, gender, (...) or impression decisions concerning the facial primes before the lexical decision task. The results showed that gender stereotypes were not activated in emotion and impression decisions conditions, whereas stereotypes were activated in gender decisions condition. These finding suggest that facial expressions can inhibit automatic activation of gender stereotypes, unless the perceivers perform gender categorization processing to prime f... (shrink)

Cognitive control enables people to adjust their thoughts and actions according to the current task demands. Response inhibition and response adjustment are two key aspects of cognitive control. Here, we examined how the implicit processing of emotional information influences these two functions with the help of the double-step saccade task. Each trial had either a single target or two sequential targets. Upon a single target onset, participants were required to make a quick saccade, but upon two target onsets, participants (...) were instructed to inhibit their initial saccades and redirect their gaze to the second target. In three experiments, we manipulated the emotional information of the first and second targets. We found that irrelevant emotional information of the first target impaired response inhibition compared to non-emotional information (geometric shapes) of the first target. When non-emotional information (geometric shape) came as the first target, irrelevant angry emotional faces as the second target interfered with both response inhibition and response adjustment compared to irrelevant happy and neutral faces. We explain these results with previous findings that processing faces with irrelevant angry facial expressions take up many attentional resources, leaving fewer resources available for ongoing activities such as response inhibition and response adjustment. (shrink)

Intra-individual variability (IIV) refers to within-person variability in behavioural task responses. Several factors can influence IIV, including aging and cognitive demands. The present study investigated effects of aging on IIV of response times during executive functioning tasks. Known age-related differences in cognitive control and emotion processing motivated evaluating how varying the design of emotional response inhibition tasks would influence IIV in older and younger adults. We also tested whether IIV predicted inhibitory control across task designs and age groups. Older (...) and younger adults (N = 237) completed one of three versions of a stop-signal task, which all displayed happy, fearful, or neutral faces in Stop trials. An independent group of older and younger adults (N = 80) completed a go/no-go task also employing happy, fearful and neutral faces. Results showed older adults had more consistent responses (lower IIV) than younger adults in the stop-signal task, but not the go/no-go task. Lower IIV predicted more efficient emotional response inhibition for fear faces in the stop-signal task, but only when attention to emotion was task-relevant. Collectively, this study clarifies effects of aging and task design on IIV and illustrates how task design impacts the relationship between IIV and emotional response inhibition in younger and older adults. (shrink)

Although it has been proposed that inhibition is related to individual differences in mathematical achievement, it is not clear how it is related to specific aspects of mathematical skills, such as arithmetic fact retrieval. The present study therefore investigated the association between inhibition and arithmetic fact retrieval and further examined the unique role of inhibition in individual differences in arithmetic fact retrieval, in addition to numerical magnitude processing. We administered measures of cognitive inhibition (i.e., numerical and (...) non-numerical stroop tasks) and a complementary, more ecologically valid measure of children’s inhibition in the classroom (i.e., teacher questionnaire), as well as numerical magnitude processing (i.e., symbolic and non-symbolic numerical magnitude comparison) and arithmetic fact retrieval (i.e., two verification tasks) in 86 typically developing third graders. We used a correlation, a regression and a Bayesian analysis. This study failed to observe a significant association between inhibition and arithmetic fact retrieval. Consequently, our results did not reveal a unique contribution of inhibition to arithmetic fact retrieval in addition to numerical magnitude processing. On the other hand, symbolic numerical magnitude processing turned out to be a very powerful predictor of arithmetic fact retrieval, as indicated by both frequentist and Bayesian approaches. (shrink)

We formulate a dynamic model of vascular tumor growth, in which the interdependence of vascular dynamics with tumor volume is considered. The model describes the angiogenic switch; thus the inhibition of the vascularization process by antiangiogenic drugs may be taken into account explicitly. We validate the model against volume measurement data originating from experiments on mice and analyze the model behavior assuming different inputs corresponding to different therapies. Furthermore, we show that a simple extension of the model is capable (...) of considering cytotoxic and antiangiogenic drugs as inputs simultaneously in qualitatively different ways. (shrink)

Our approach is based on a tri-partite method of integrating psychodynamic hypotheses, cognitive subliminal processes, and psychophysiological alpha power measures. We present ten social phobic subjects with three individually selected groups of words representing unconscious conflict, conscious symptom experience, and Osgood Semantic negative valence words used as a control word group. The unconscious conflict and conscious symptom words, presented subliminally and supraliminally, act as primes preceding the conscious symptom and control words presented as supraliminal targets. With alpha power as (...) a marker of inhibitory brain activity, we show that unconscious conflict primes, only when presented subliminally, have a unique inhibitory effect on conscious symptom targets. This effect is absent when the unconscious conflict primes are presented supraliminally, or when the target is the control words. Unconscious conflict prime effects were found to correlate with a measure of repressiveness in a similar previous study (Shevrin et al., 1992, 1996). Conscious symptom primes have no inhibitory effect when presented subliminally. Inhibitory effects with conscious symptom primes are present, but only when the primes are supraliminal, and they did not correlate with repressiveness in a previous study (Shevrin et al., 1992, 1996). We conclude that while the inhibition following supraliminal conscious symptom primes is due to conscious threat bias, the inhibition following subliminal unconscious conflict primes provides a neurological blueprint for dynamic repression: it is only activated subliminally by an individual's unconscious conflict and has an inhibitory effect specific only to the conscious symptom. These novel findings constitute neuroscientific evidence for the psychoanalytic concepts of unconscious conflict and repression, while extending neuroscience theory and methods into the realm of personal, psychological meaning. (shrink)

Performance Generating Systems (PGS) are rule- and task-based approaches to improvisation on stage in theatre, dance, and music. These systems require performers to draw on predefined source materials (texts, scores, memories) while working on complex tasks within limiting rules. An interdisciplinary research team at a large Western Canadian university hypothesized that learning to sustain this praxis over the duration of a performance places high demands on executive functions; demands that may improve the performers’ executive abilities. These performers need to continuously (...) shift attention while remaining responsive to embodied and environmental stimuli in the present, they are required to inhibit automated responses and impulses using the rules of the system, and they strive towards addressing multitasking challenges with fluidity and flexibility. This study set out to test the mentioned hypothesis deductively and identify mediating processes inductively, using mixed empirical methods. In a small sample experiment with a control group (28 participants; 15 in intervention group, 13 in control group), standardized quantitative tests of executive functions (D-KEFS) were administered before and after an eight-week intervention. Participant-reported qualitative observations from the praxis were also collected throughout the intervention for grounded analysis. Within the limitations of small sample data, we found both statistically significant and trending effects on inhibition, problem-solving initiation, fluidity, and cognitive flexibility. Examining the mediating process, we found that participants experienced significant challenges sustaining the practice halfway through the intervention. The participant-reported solutions to these challenges, which emerged as the strongest behavioural patterns when coding the qualitative data to saturation, were strategies of problem-solving and of re-directing attention. These strategies support and advance our understanding of the effects measured in the standardized tests. In terms of application, our results identify characteristics of PGS that could potentially maintain and strengthen executive functions over and above less demanding performing arts interventions. The results also deliver new insight into how PGS works, which may contribute to the development and teaching of this artistic practice. (shrink)

We present three studies examining whether multiple-object tracking (MOT) benefits from the active inhibition of nontargets, as proposed in (Pylyshyn, 2004). Using a probedot technique, the first study showed poorer probe detection on nontargets than on either the targets being tracked or in the empty space between objects. The second study used a matching nontracking task to control for possible masking of probes, independent of target tracking. The third study examined how localized the inhibition is to individual nontargets. (...) The result of these three studies led to the conclusion that nontargets are subject to a highly localized object-based inhibition. Implications of this finding for the FINST visual index theory are discussed. We suggest that we need to distinguish between the differentiation (or individuation) of enduring token objects and the process of making the objects accessible through indexes, with only the latter being limited to 4 or 5 objects. (shrink)

"Three Ends of the Absolute" discusses Schelling's notion of inhibition in the philosophy of nature, Hölderlin's notion of separation in his "Seyn, Urtheil, Modalität," and Novalis' notion of the density of God in his late scientific notes. All three thinkers can be contrasted with Hegel on the basis of their attacks on philosophical absolutes. Schelling, in his First Projection of a Philosophy of Nature, reflects on the conundrum of absolute inhibition in nature, an inhibition of absolute freedom (...) that is necessary if there is to be a procession of natural products. Inhibition conditions all putative absolutes. Hölderlin argues that absolute separation is essential to consciousness of any kind. Whereas he advances no "doctrine" of the end of the absolute as such, he does emphasize the tragic separation and dissolution to which all intellectual intuition comes. The absolute "original" suffers from an irremediable "debility." Novalis, in his Universal Sketchbook, continues the work of his early Fichte Studies by resisting the notion of the absolute ego. "Everything pure is... a deception." For Novalis, the absolute can only be our absolute inability to think or act in conformity with an absolute. The article ends with a reflection on Goethe's opposition between "relative" and "absolute" death. (shrink)

One observes regulation at every biological level. Organisms, cells, and biochemical processes operate efficiently, normally wasting neither material nor energy, and adjusting their functions to external influences. Nature evidently has evolved mechanisms specifically dedicated to regulation at many levels. What is the molecular basis of this control?In the 1950s these molecular control mechanisms began to be explored seriously. The discoveries of feedback inhibition of enzyme activity were important because they gave an initial example of how regulation is achieved (...) at the molecular level. We showed that certain enzymes are composed of two parts, one for catalysis and another distinct part present only to regulate this catalysis. Catalytic activity can be either stimulated or inhibited when a small molecule in the environment combines with the enzyme's regulatory site. In particular, a final product of a metabolic pathway generates a feedback loop which automatically limits its own excessive production, by combining with the regulatory site of an early enzyme in that pathway. Later studies showed that catalytic and regulatory structures of some enzymes could be separated physically.The discovery of regulatory sites and their interaction with molecules unrelated to their substrates was the basis for the generalized allosteric concept. This concept extends the regulatory site idea to a wide variety of processes such as control of gene expression, hormone action, and cellular growth. (shrink)

The processing of time intervals in the sub- to supra-second range by the brain is critical for the interaction of primates with their surroundings in activities, such as foraging and hunting. For an accurate processing of time intervals by the brain, representation of physical time within neuronal circuits is necessary. I propose that time dimension of the physical surrounding is represented in the brain by different types of neuronal oscillators, generating spikes or spike bursts at regular intervals. The proposed oscillators (...) include the pacemaker neurons, tonic inputs, and synchronized excitation and inhibition of inter-connected neurons. Oscillators, which are built inside various circuits of brain, help to form modular clocks, processing time intervals or other temporal characteristics specific to functions of a circuit. Relative or absolute duration is represented within neuronal oscillators by “neural temporal unit,” defined as the interval between regularly occurring spikes or spike bursts. Oscillator output is processed to produce changes in activities of neurons, named frequency modulator neuron, wired within a separate module, represented by the rate of change in frequency, and frequency of activities, proposed to encode time intervals. Inbuilt oscillators are calibrated by (a) feedback processes, (b) input of time intervals resulting from rhythmic external sensory stimulation, and (c) synchronous effects of feedback processes and evoked sensory activity. A single active clock is proposed per circuit, which is calibrated by one or more mechanisms. Multiple calibration mechanisms, inbuilt oscillators, and the presence of modular connections prevent a complete loss of interval timing functions of the brain. (shrink)

Leonard B. Meyer has proposed that when musical tendencies or expectations are inhibited by musical ambiguity or the unexpected, those inhibitions and their subsequent resolutions are likely to be provocative or engaging. Music, Tendencies and Inhibitions will explore the relevance of this theory to music and various other disciplines, and to psychological and natural processes. Each chapter consists of two parts: a presentation and consideration of an aspect of Meyer's theory, and a more associative or rhapsodic section of "Reflections" (...) on this aspect. The book will focus on Meyer's aesthetic rather than his music-theoretical proclivities, and is intended for academics and students in various fields as well as educated non-academics. The music scene is fluctuating, Meyer suggests, in that new and original styles or techniques are continuously emerging or developing on a small scale; it is static in that many of these developments seem unrelated, and are not likely to be grasped or progress as a whole. It will be posited that this theory foreshadowed and reflects important ideologies of contemporary culture, including postmodernism. (shrink)