Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an ‘activating’ histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from genome‐wide studies is that actually (...) very little transcription changes upon removal of most H3K4me3 under steady‐state or dynamically changing conditions, including at mammalian CpG island promoters. Instead, rather than a major role in instructing transcription, time‐resolved experiments provide more evidence supporting the deposition of H3K4me3 into chromatin as a result of transcription, influencing processes such as memory of previous states, transcriptional consistency between cells in a population and transcription termination. -/- . (shrink)

The Routledge Classic Edition of Daniels’ influential 2001 text _Vygotsky and Pedagogy_ explores the growing interest in Vygotsky and the pedagogic implications of the body of work that is developing under the influence of his theories. With a new preface from Harry Daniels this book explores the growing interest in Vygotsky and the pedagogic implications of the body of work that is developing under the influence of his theories. It provides an overview of the ways in which the original (...) writing has been extended and identifies areas for future development. The author considers how these developments are creating new and important possibilities for the practices of teaching and learning in school and beyond, and illustrates how Vygotskian theory can be applied in the classroom. The book is intended for students and academics in education and the social sciences and will be of interest to all those who wish to develop an analysis of pedagogic practice within and beyond the field of education. (shrink)

The key to taking in Aristotle’s treatise on time is to approach it with the understanding that Aristotle was not a philosopher concerned with time—in questions about time or in delimiting the being of time.

In the reckoning of historian Enzo Traverso, the accumulative inventory of the past’s crimes has exceeded the ‘frontiers of historical research’ and colonised the public sphere to ‘interpellate our present’. The quarrel over the crisis of historicism before World War ii has been superseded by postwar debates that have now spilled over into everyday life that demand recognition as instances of the continuing collision of claims of a past that refuses to pass and the formation of a new historical consciousness (...) in which collective memory of the crimes occupies a central position. Traverso’s purpose has been to repair this emergent dichotomy between historical practice and memoration, event and experience, as well as to overcome attending binary couplings like subjective and objective, individual and group in order to avoid falling into an unbridgeable antinomy that risks collapsing into contradiction. (shrink)

We describe an Aldous–Hoover-type characterization of random relational structures that are exchangeable relative to a fixed structure which may have various equivalence relations. Our main theorem gives the common generalization of the results on relative exchangeability due to Ackerman \)-invariant measures: part I, 2015. arXiv:1509.06170) and Crane and Towsner and hierarchical exchangeability results due to Austin and Panchenko :809–823, 2014).

China, like a huge dragon, gobbles all in its path. Like a huge vat, dyes all the same color. Sun Jingxuan, A Spector Prowls Our Land (1980).

A. The Problem: Since A. Gercke's fundamental work, there has been no complete reappraisal of the manuscript tradition of the Natural Questions, yet a reappraisal is long overdue. Gercke divided the manuscripts into two branches, Δ and Φ but this division has been seriously undermined from two quarters. First, H. W. Garrod questioned the status which Gercke assigned to Δ, arguing, quite rightly, that in every case where Δ has the truth against Φ, Δ's reading can reasonably be attributed to (...) conjecture, which is known to be rife in Δ Certainly nothing is proved about Δ's integrity by the passages which Gercke adduced, such as the following :3. (shrink)

The Phenomenal Self (PS) is widely considered to be dependent on body representations, whereas the Narrative Self (NS) is generally thought to rely on abstract cognitive representations. The concept of the Bodily Social Self (BSS) might play an important role in explaining how the high level cognitive self-representations enabling the NS might emerge from the bodily basis of the PS. First, the phenomenal self (PS) and narrative self (NS), are briefly examined. Next, the BSS is defined and its potential for (...) explaining aspects of social cognition is explored. The minimal requirements for a BSS are considered, before reviewing empirical evidence regarding the development of the BSS over the first year of life. Finally, evidence on the involvement of the body in social distinctions between self and other is reviewed to illustrate how the BSS is affected by both the bottom up effects of multisensory stimulation and the top down effects of social identification. (shrink)

Defends "The New Men's Studies: From Feminist Theory to Gender Scholarship" (Hypatia 2:1, Winter 1987) against what is argued are Mary Libertin's misreadings. The argument for men's studies is logically independent of though related to the debate about essentialism in women's studies. Men's studies studies men in and as particular groups. Intellectual should not be equated with institutional autonomy. The feminist study of men should be supported by feminist scholars.