Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an ‘activating’ histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from genome‐wide studies is that actually (...) very little transcription changes upon removal of most H3K4me3 under steady‐state or dynamically changing conditions, including at mammalian CpG island promoters. Instead, rather than a major role in instructing transcription, time‐resolved experiments provide more evidence supporting the deposition of H3K4me3 into chromatin as a result of transcription, influencing processes such as memory of previous states, transcriptional consistency between cells in a population and transcription termination. -/- . (shrink)

One of the most influential of contemporary philosophers, Harry Frankfurt has made major contributions to the philosophy of action, moral psychology, and the study of Descartes. This collection of essays complements an earlier collection published by Cambridge, The Importance of What We Care About. Some of the essays develop lines of thought found in the earlier volume. They deal in general with foundational metaphysical and epistemological issues concerning Descartes, moral philosophy, and philosophical anthropology. Some bear upon topics in political (...) philosophy and religion. (shrink)

In this book Harry Heft examines the historical and theoretical foundations of James J. Gibson's ecological psychology in 20th century thought, and in turn, integrates ecological psychology and analyses of sociocultural processes. A thesis of the book is that knowing is rooted in the direct experience of meaningful environmental objects and events present in individual-environment processes and at the level of collective, social settings. Ecological Psychology in Context: *traces the primary lineage of Gibson's ecological approach to William James's philosophy (...) of radical empiricism; *illuminates how the work of James's student and Gibson's mentor, E.B. Holt, served as a catalyst for the development of Gibson's framework and as a bridge to James's work; *reveals how ecological psychology reciprocally can advance Jamesian studies by resolving some of the theoretical difficulties that kept James from fully realizing a realist philosophy; *broadens the scope of Gibson's framework by proposing a synthesis between it and the ecological program of Roger Barker, who discovered complex systems operating at the level of collective, social processes; *demonstrates ways in which the psychological domain can be extended to properties of the environment rendering its features meaningful, publicly accessible, and distributed across person-environment processes; and *shows how Gibson's work points the way toward overcoming the gap between experimental psychology and the humanities. Intended for scholars and students in the areas of ecological and environmental psychology, theoretical and historical psychology, cognitive science, developmental psychology, anthropology, and philosophy. (shrink)

The key to taking in Aristotle’s treatise on time is to approach it with the understanding that Aristotle was not a philosopher concerned with time—in questions about time or in delimiting the being of time.

In the reckoning of historian Enzo Traverso, the accumulative inventory of the past’s crimes has exceeded the ‘frontiers of historical research’ and colonised the public sphere to ‘interpellate our present’. The quarrel over the crisis of historicism before World War ii has been superseded by postwar debates that have now spilled over into everyday life that demand recognition as instances of the continuing collision of claims of a past that refuses to pass and the formation of a new historical consciousness (...) in which collective memory of the crimes occupies a central position. Traverso’s purpose has been to repair this emergent dichotomy between historical practice and memoration, event and experience, as well as to overcome attending binary couplings like subjective and objective, individual and group in order to avoid falling into an unbridgeable antinomy that risks collapsing into contradiction. (shrink)

We describe an Aldous–Hoover-type characterization of random relational structures that are exchangeable relative to a fixed structure which may have various equivalence relations. Our main theorem gives the common generalization of the results on relative exchangeability due to Ackerman \)-invariant measures: part I, 2015. arXiv:1509.06170) and Crane and Towsner and hierarchical exchangeability results due to Austin and Panchenko :809–823, 2014).

China, like a huge dragon, gobbles all in its path. Like a huge vat, dyes all the same color. Sun Jingxuan, A Spector Prowls Our Land (1980).

A. The Problem: Since A. Gercke's fundamental work, there has been no complete reappraisal of the manuscript tradition of the Natural Questions, yet a reappraisal is long overdue. Gercke divided the manuscripts into two branches, Δ and Φ but this division has been seriously undermined from two quarters. First, H. W. Garrod questioned the status which Gercke assigned to Δ, arguing, quite rightly, that in every case where Δ has the truth against Φ, Δ's reading can reasonably be attributed to (...) conjecture, which is known to be rife in Δ Certainly nothing is proved about Δ's integrity by the passages which Gercke adduced, such as the following :3. (shrink)

The Phenomenal Self (PS) is widely considered to be dependent on body representations, whereas the Narrative Self (NS) is generally thought to rely on abstract cognitive representations. The concept of the Bodily Social Self (BSS) might play an important role in explaining how the high level cognitive self-representations enabling the NS might emerge from the bodily basis of the PS. First, the phenomenal self (PS) and narrative self (NS), are briefly examined. Next, the BSS is defined and its potential for (...) explaining aspects of social cognition is explored. The minimal requirements for a BSS are considered, before reviewing empirical evidence regarding the development of the BSS over the first year of life. Finally, evidence on the involvement of the body in social distinctions between self and other is reviewed to illustrate how the BSS is affected by both the bottom up effects of multisensory stimulation and the top down effects of social identification. (shrink)

Defends "The New Men's Studies: From Feminist Theory to Gender Scholarship" (Hypatia 2:1, Winter 1987) against what is argued are Mary Libertin's misreadings. The argument for men's studies is logically independent of though related to the debate about essentialism in women's studies. Men's studies studies men in and as particular groups. Intellectual should not be equated with institutional autonomy. The feminist study of men should be supported by feminist scholars.

Abstract:Work on stakeholder theory has proceeded on a variety of fronts; as Donaldson and Preston (1995) have noted, such work can be parsed into descriptive, instrumental, and normative research streams. In a normative vein, Phillips (1997) has made an argument for a principle of fairness as a means of identifying and adjudicating among stakeholders. In this essay, I propose that a reconstructed principle of fairness can be combined with the idea of consent as outlined in integrative social contract theory (ISCT) (...) to bring about a more normative stakeholder theory that also has ramifications for corporate governance. (shrink)