Allosteric and transmembrane signaling are among the major questions of structural biology. Here, we review and discuss signal transduction in four-helical TM bundles, focusing on histidine kinases and chemoreceptors found in two-component systems. Previously, piston, scissors, and helical rotation have been proposed as the mechanisms of TM signaling. We discuss theoretically possible conformational changes and examine the available experimental data, including the recent crystallographic structures of nitrate/nitrite sensor histidine kinase NarQ and phototaxis system NpSRII:NpHtrII. We show that TM helices can (...) flex at multiple points and argue that the various conformational changes are not mutually exclusive, and often are observed concomitantly, throughout the TM domain or in its part. The piston and scissoring motions are the most prominent motions in the structures, but more research is needed for definitive conclusions. Models of allosteric transmembrane signaling in microbial sensor histidine kinases and chemoreceptors are discussed in light of recent crystallographic structures. It is shown that the TM α-helices are flexible and various conformational changes are often observed concomitantly. The piston and scissoring motions are the most prominent in the structures. (shrink)

Contemplative and explanatory theories are distinguished. The corpus of European philosophy includes many sorts of texts. Only a few have explanatory value. Some are contemplative. But there are also therapeutic and sceptical texts. It was an old ideal of philosophy to lead a theoretical life. What could that mean? What does “life” mean in this context? We cannot choose forms of life, because all choices and preferences come up in life. Nevertheless a theoretical life is possible. What kind of life (...) is it – one spent in contemplation, in explanation, or a sceptical one? (shrink)

Spinoza has been interpreted as a rationalist and a monist. This article tries to show that these views are to be specified. The intuitive knowledge of God plays a constitutive role in Spinoza's "Ethics". To reach it, one has to run through long chains of inferences. But the inferential mode of cognition will not lead to an understanding of the definition of God given in the first part of the "Ethics". This understanding can only be gained in the fifth part. (...) Thus, there is circular epistemic structure hidden in Spinoza's opus magnum, which has not been sufficiently described in the literature yet. (shrink)

Complex-transitive argument structures have received a large amount of attention from syntacticians of both formalist and cognitive-functional orientations. To account for expressions with causative resultative meanings, construction grammar has postulated a family of argument-structure constructions whose core is constituted by the Caused-Motion Construction and the Resultative Construction, exhibiting a locative complement and a predicative complement in the form of an AjP, respectively. Argument structures with NP complements, however, have been largely neglected. The present study investigates these patterns in the International (...) Corpus of English (ICE-GB) by means “collostruction analysis”. It shows that the formal distinction between AjP and NP complements corresponds to a constructional distinction hitherto unrevealed, viz. that between the Resultative Construction and another argument-structure construction, here called the “Denominative Construction”. Apart from improving existing descriptions of the network of complex-transitive argument-structure constructions, this study demonstrates that collostruction analysis can be employed in an exploratory way to discover constructions. (shrink)

Selflessness can be considered on an epistemic, on a moral, and on a historical level. The article follows recent thoughts by Jay L. Garfield on the idea that conceiving of oneself as a substantive self means following an illusion. It investigates the different senses of “illusion” and asks what it could mean for individuals and societies tobe transformed in such a way that this illusion would not play a role anymore.

Metaphysik und Pragmatismus scheinen sich seit den Arbeiten von Richard Rorty auszuschließen. Deweys „Erfahrung und Natur“ ist der Versuch eines der bedeutendsten Pragmatisten, eine naturalistische und humanistische Metaphysik zu entwickeln, indem er die klassische europäische Metaphysik transformiert und ihr ihre Fixierung auf ewige Notwendigkeiten und absolute Gewissheiten austreibt. Er versucht, eine Metaphysik für eine in seinen Augen „gemischte“ Welt zu schreiben, in der es Zufall und Notwendigkeit, Gefahren und Ungewissheiten, aber auch für bestimmte Zeiträume verlässliche Ordnungen gibt. Dieser „Klassiker Auslegen“-Band (...) verfolgt dieses Projekt nach, indem die zehn Kapitel von Deweys Buch in zehn interpretierenden Essays historisch eingeordnet und systematisch analysiert werden. Dabei wird der ganze Themenhorizont der klassischen Metaphysik abgeschritten: Von dem Problem der Ordnung und Unordnung der Wirklichkeit über das Leib-Seele-Problem bis zu den Themen Wert und Kritik. Das Buch soll Studierenden den Zugang zu Deweys Metaphysik erleichtern und Forschenden in der Philosophie die Aktualität des Deweyschen Denkens wieder ins Gedächtnis zurückrufen. (shrink)

Till today Spinoza's "Ethics" is a standard for enlightened theoretical and practical reasoning.

Sterben und Tod werden aus unterschiedlichster Sicht (medizinisch, psychologisch, mystisch) beleuchtet und reflektiert. Die Sicht von Betroffenen, die Nahtod-Erlebnisse hatten, und die daraus resultierenden Konsequenzen für die betreuenden Personen werden ebenso wie der Umgang mit Sterben und Tod in unserer Gesellschaft kritisch dargestellt.

Preceding research in cognitive linguistics has advanced the claim that evaluative components form an integral part of image schemas (cf. Krzeszowski 1993, 1997; Cienki 1997: 3–6). This so-called “plus–minus” (or “axiological”) parameter has primarily been discussed with regard to opposing dimensions within a range of image-schematic contexts. In the paired particles in–out, up–down, and on–off, for instance, the meaning of which is based on the image-schematic notions of CONTAINMENT, VERTICALITY, and CONTACT, respectively, the second elements are assumed to carry negative (...) default evaluations. Additionally, the Axiological Invariance Principle (Krzeszowski 1997) claims that these evaluative components are generally retained in metaphorical extensions. This study applies the plus–minus hypothesis in image-schema theory to the analysis of semantically highly redundant verb-particle constructions in English. The hypotheses derived from this application are tested against the real usage of such constructions as documented in the British National Corpus and the Collins Online. Though the presentation of a full-blown alternative to the plus–minus assumption is beyond the scope of this empirical investigation, an important implication of this study is that the isolated, “primitive” (noncompound) image schemas traditionally dealt with in cognitive linguistic research should not be considered as the locus of evaluative defaults. It is suggested instead that axiological components are dimensions of richer, contextualized cognitive models, in which image schemas appear as complex superimpositions, i.e., image-schema groupings or compounds. (shrink)

Since Plato’s massive critique of the Sophists rhetoric’s ill repute runs through the history of western philosophy denunciating methods of rhetoric as in large part dishonest persuasion strategies which are at most marginally interested in dealing with truths. This judgement falls way too short insofar as it distorts the historically grown stock labeled “rhetoric” not only in the Aristotelian work. With reference to Olaf Müller’s philosophical book addressing the “controversy” between Goethe and Newton about the nature of light, I will (...) study the different rhetorical models and methods used by Newton and Goethe and also Müller himself. It becomes apparent that even works attempting to decide who was right in the long run do far more than trying to evoke true “representations” of facts or truths in the reader. The specific use of language patterns provides deeper insight into an author’s mindset towards the subject area discussed in his work and generally speaking the investigation of the rhetoric of science and philosophy leads to a better understanding of different epistemic cultures both in philosophy and science. (shrink)

Metaphor theory has shifted from asking whether metaphor is 'conceptual' or 'linguistic' to debating whether it is 'embodied' or 'discursive'. Although recent work in the social and cognitive sciences has yielded clear opportunities to resolve that dispute, the divide between discourse- and cognition-oriented approaches has remained. To unite the field, this book brings together leading metaphor researchers from a number of disciplines. It collects major arguments and presents a wide variety of empirical evidence, placing special emphasis on the embodiment and (...) socio-cultural embeddedness of cognition, as well as the multi-modal and social-interactive nature of communication. It shows that metaphor theory can only profit from an approach that takes multiple perspectives into consideration and tries to account for findings yielded by multiple methodologies. By doing so, it works towards a dynamic, multi-dimensional, socio-cognitive model of metaphor that goes beyond what research traditions have separately achieved. (shrink)

The article investigates the relevance of the concepts of truth and truthfulness in culturalistic, psychoanalytical and neuro-biological theories of trauma from a philosophical point of view. The background for this is the recent claim of some brain scientists to produce an overall view of the human situation. This claim is shown to be false. The article comes to the conclusion that the subjective perception of a traumatic event is indispensable in order to understand the phenomena of post-traumatic stress disorder (PTSD). (...) History and other moral sciences are always concerned with the reconstruction of past internal perspectives. The example of trauma shows that this work is indispensable wherever brain research might lead us to. (shrink)

Journal Name: Cognitive Linguistics Issue: Ahead of print.

Bd. 1. Prozess, Gefühl und Raum-Zeit -- Bd. 2. Die Gifford Lectures und ihre Deutung.

A given statement may be plausible, well founded or true. An individual action may be judged courageous, useful or good. Human beings are judged as well, for statements or actions that invite such evaluations, though the terms used may be different: a person may be described as truthful and virtuous, clever and happy. Epistemology and ethics – the theories that justify theoretical and practical judgements – may address not only the criteria used to assess states of belief, assertions, knowledge and (...) the like, actions, omissions and feelings, but also thepeoplethat give rise to them. Nowadays, the issue of when and how ahuman beingbecomes clever, truthful, good or happy is less a matter of philosophy and more a question for religion, psychology and pedagogy. This has not always been the case. There has been a perceptible shift in moral philosophy: in antiquity, inquiries as to when alifeis to be classified as good or happy were prevalent; in the modern era, the focus is primarily on when anindividual actionis to be regarded as right or good, wrong or bad. (shrink)

Yvonne Hütter-Almerigi und Dirk Jörke haben wichtige Einwände zu meinem Essay über eine mögliche Dritte Aufklärung vorgetragen. Ich danke ihnen sehr für die Aufmerksamkeit, die sie meinem Text haben zukommen lassen und für die Mühe, die sie sich mit der Entwicklung ihrer wertvollen Kritik gemacht haben. Ich weiss nicht, ob ich auf ihre Kritiken angemessen regieren kann, weil mir Kompetenzen in den Bereichen der empirischen Sozialforschung und der Ökonomie fehlen, die für die Beantwortung manc...

Name der Zeitschrift: Deutsche Zeitschrift für Philosophie Jahrgang: 64 Heft: 5 Seiten: 852-863.

On June 30, 1908, a mysterious explosion erupted in the skies over a vast woodland area of Siberia. Known as the Tunguska Event, it has been a source of wild conjecture over the past century, attributed to causes ranging from meteors to a small black hole to antimatter. In this imaginative book, Michael Hampe sets four fictional men based on real-life scholars—a physicist, a philosopher, a biologist, and a mathematician —adrift on the open ocean, in a dense fog, to discuss (...) what they think happened. The result is a playful and highly illuminating exploration of the definition of nature, mankind’s role within it, and what its end might be. Tunguska, Or the End of Nature uses its four-man setup to tackle some of today’s burning issues—such as climate change, environmental destruction, and resource management—from a diverse range of perspectives. With a kind of foreboding, it asks what the world was like, and will be like, without us, whether we are negligible and the universe random, whether nature can truly be explained, whether it is good or evil, or whether nature is simply a thought we think. This is a profoundly unique work, a thrillingly interdisciplinary piece of scholarly literature that probes the mysteries of nature and humans alike. (shrink)