The TRIM/RBCC proteins are defined by the presence of the tripartite motif composed of a RING domain, one or two B‐box motifs and a coiled‐coil region. These proteins are involved in a plethora of cellular processes such as apoptosis, cell cycle regulation and viral response. Consistently, their alteration results in many diverse pathological conditions. The highly conserved modular structure of these proteins suggests that a common biochemical function may underlie their assorted cellular roles. Here, we review recent data indicating that (...) some TRIM/RBCC proteins are implicated in ubiquitination and propose that this large protein family represents a novel class of ‘single protein RING finger’ ubiquitin E3 ligases. BioEssays 27:1147–1157, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

If well-designed, the results of a Randomised Clinical Trial can justify a causal claim between treatment and effect in the study population; however, additional information might be needed to carry over this result to another population. RCTs have been criticized exactly on grounds of failing to provide this sort of information Evidence, inference and enquiry. Oxford University Press, New York, 2011), as well as to black-box important details regarding the mechanisms underpinning the causal law instantiated by the RCT result. On (...) the other side, so-called In Silico Clinical Trials face the same criticisms addressed against standard modelling and simulation techniques, and cannot be equated to experiments Philosophy of molecular medicine: foundational issues in research and practice, Routledge, New York, 2017; Parker in Synthese 169:483–496, 2009; Parke in Philos Sci 81:516–536, 2014; Diez Roux in Am J Epidemiol 181:100–102, 2015 and related discussions in Frigg and Reiss in Synthese 169:593–613, 2009; Winsberg in Synthese 169:575–592, 2009; Beisbart and Norton in Int Stud Philos Sci 26:403–422, 2012). We undertake a formal analysis of both methods in order to identify their distinct contribution to causal inference in the clinical setting. Britton et al.’s study :E2098–E2105, 2013) on the impact of ion current variability on cardiac electrophysiology is used for illustrative purposes. We deduce that, by predicting variability through interpolation, ISCTs aid with problems regarding extrapolation of RCTs results, and therefore in assessing their external validity. Furthermore, ISCTs can be said to encode “thick” causal knowledge —as opposed to “thin” difference-making information inferred from RCTs. Hence, ISCTs and RCTs cannot replace one another but rather, they are complementary in that the former provide information about the determinants of variability of causal effects, while the latter can, under certain conditions, establish causality in the first place. (shrink)

This article provides a spatial analysis of the conceptual framework of fluid dynamics during the nineteenth century, focusing on the transition from the Euler equation to the Navier–Stokes equation. A dynamic version of Peter Gärdenfors's theory of conceptual spaces is applied which distinguishes changes of five types: addition and deletion of special laws; change of metric; change in importance; change in separability; addition and deletion of dimensions. The case instantiates all types but the deletion of dimensions. We also provide a (...) new view upon limiting case reduction at the conceptual level that clarifies the relation between the predecessor and successor conceptual framework. The nineteenth-century development of fluid dynamics is argued to be an instance of normal science development. (shrink)

Festa, E., Roux, S. (2008). The Enigma of the Inclined Plane from Heron to Galileo. In: Laird, W.R., Roux, S. (eds) Mechanics and Natural Philosophy Before the Scientific Revolution. Boston Studies in the Philosophy of Science, vol 254. Springer, Dordrecht.

I begin by briefly recalling two facts of seventeenth century intellectual history: not only is a fourth part devoted to method added to the three parts traditionally contained in logic treatises, but in a number of texts the terms "logic" and "method" are blurred. I then give an explanation of these two facts with the following ideas: 1/ Since the criticism of Aristotelian sciences at the beginning of the seventeenth century was in particular focused on logic, the question was asked (...) as to what could replace or supplement it. 2/ Although method was very generally supposed to fulfil this function, its objectives were not clear. I propose a distinction between four ideas of method, which I call method-disposition, method-demonstration, method-invention and method-purification. 3/ The blurring between logic and method comes partly from the fact that some of these ideas take up elements of the then existant logic, but, in a context marked by the reception of Descartes's work, we must also take into account the fact that, since Descartes had not composed a logic and since he had not really explain what his method was, his successors were looking for what both might have been. (shrink)

Lorsqu'il commence la rédaction du Prince au début de l'année 1513, Nicolas Machiavel met le principe nuovo Médicis sur la voie de la création d'un Etat libre et de la refondation du vivere libero florentin. Texte d'intervention, resserré dans l'espace et dans le temps d'une conjoncture et d'une occasion politique, Le Prince, et plus largement l'oeuvre de Machiavel, formule les questions politiques fondatrices : qu'est-ce qui peut rendre légitime l'autorité? À quelles conditions les hommes peuvent-ils instituer la vie libre? Ce (...) livre reconstitue le cheminement du discours machiavélien à partir de ses concepts clés (la virtù, la fortune, la forme, la matière et l'occasion), situés dans leur matérialité historique. L'oeuvre de Machiavel travaille en profondeur les pensées de la "modernité" politique. Une autre modernité apparaît, marquée par une tradition civique dont on n'a pas épuisé la fécondité, et qui permet de repenser radicalement la notion de démocratie. (shrink)

Stimulation of airway myocytes by contractile agents such as acetylcholine (ACh) activates a Ca2+-activated Cl– current (IClCa) which may play a key role in calcium homeostasis of airway myocytes and hence in airway reactivity. The aim of the present study was to model IClCa in airway smooth muscle cells using a computerised model previously designed for simulation of cardiac myocyte functioning. Modelling was based on a simple resistor-battery permeation model combined with multiple binding site activation by calcium. In order to (...) validate the model, a combination of equations, used to mimic [Ca2+]i response to ACh stimulation, were incorporated into the model. The results indicate that the model developed in this article accounts for experimental recordings and electrophysiological characteristics of this current in airway smooth muscle cells, with parameter values consistent with those calculated from experimental data. Such a model may thus be used to predict IClCa functioning, though additional experimental data from airway myocytes would be useful to more accurately determine some parameter values of the model. (shrink)

Levinas’ relationship to Platonism is ambiguous. In Totality and Infinity, indeed, references to Plato’s writings are multiple and Levinas depicts Plato as following two diverging paths. On the one hand, Levinas considers Plato’s writings to be works that consecrate the primacy of identity over difference, of the Same over the Other. On the other hand, Platonism is presented as a philosophy of absolute transcendence due to its refusal to make the Good a simple ontological principle and to its attempt to (...) free the Good from all forms of totality. The present study aims to show that, although Levinas criticizes the first path taken by Plato, he conceives of himself as partially in line with Plato’s philosophy of absolute transcendence, albeit in a paradoxical form. In this way, Levinas understands the meaning of the Platonic approach in an original way. (shrink)

En la actividad científica se pueden distinguir tres tipos principales de representación científica: proyectiva, subsuntiva y reductiva. Tras unas breves considcraciones introductorias, se presentan las características más destacadas de cada uno de estos tres tipos principales de representación científica y se abstrae a partir de ellas el esquema al que toda Teoría General de la Representación Científica (TGRC) se debe adecuar. A continuación se exponen las lineas generales de la principal propuesta presente en la literatura para desarrollar TGRC y se (...) hacen algunas consideraciones criticas. La conclusión provisional es que esta propuesta tiene, al menos por el momento, el problema de ser, o bien demasiado liberal, o bien demasiado conservadora. Por último, se propone un enfoque alternativo a explorar que pretende estar libre de los problemas deI anterior.We can distinguish three main types of representation in scientific practice: projective, subsuntive and reductive. After some brief introductory remarks, we present the more salient characteristics of these three main types of scientific representation and we abstract from them a scheme that any General Theory for Scientific Representation (GTSR) must fit. Then we offer the general traits of the main existing proposal for a GTSR and we make some criticisms. The provisional conclusion is that this proposal is, as it stands, either too liberal or too conservative. Finally, we propose to explore an alternative approach which intends to solve these difficulties. (shrink)

Dans sa thèse de médecine de 1943 sur le normal et le pathologique, Georges Canguilhem se sert largement des idées de Kurt Goldstein lorsqu’il définit la normalité comme la capacité de l’organisme à créer de nouvelles normes de vie dans un débat polarisé avec son milieu. Pourtant, il déclara ensuite que les conceptions de Goldstein avaient constitué pour lui un « encouragement et non une inspiration ». Les archives personnelles de Canguilhem nous permettent effectivement de considérer le rapport de Canguilhem (...) à Goldstein comme une convergence plutôt que comme une influence mais surtout, l’usage que Canguilhem fait de Goldstein nous permet de mieux saisir la portée de ses propres idées. Nous interrogeons dans une première partie la conception holiste de l’organisme de Goldstein, dans ses rapports à la gestalt-théorie et à Kant, conception qui se réfère au processus d’actualisation de l’essence de l’organisme dans son rapport avec le milieu. Ceci nous permet d’appréhender l’usage que fait Canguilhem de certains concepts et idées de Goldstein pour élaborer son propre concept de normativité vitale. Dans une deuxième partie, nous nous proposons de comprendre la manière dont Canguilhem pose le problème du rapport de la connaissance à la normativité vitale à partir de sa lecture des textes du neurologue allemand. (shrink)

La Philosophie de la Révélation propose une véritable philosophie de la fonction diabolique. Le diable est le principe des religions païennes en même temps que celui du mal . Cette double fonction donne la mesure de l’Erhabenheit du diable, sa « majesté », qui traduit l’idée du mot grec kyriotès, de souveraineté. Cette analyse s’oppose aux représentations qui manquent le principe de la majesté diabolique. Négativement, le diable n’est ni une créature ni un principe éternellement mauvais. Positivement, Schelling repense en (...) termes philosophiques, par sa théorie des Potenzen divines, les interprétations traditionnelles non spéculatives : le diable ne diffère pas de la première puissance réactivée par l’homme alors même qu’elle devait se reposer en lui ; c’est conformément à l’essence de cette puissance, qui est ce qui ne doit pas mais peut être manifeste, qu’il ravage l’homme. Pour jouir d’une existence usurpée, le diable ne peut qu’user du soupçon, du mensonge et de la jalousie, vouloir tenter et perdre l’homme. Cette nécessité en fait l’outil paradoxal de la révélation.In Philosophy of Revelation, Schelling suggests a true philosophy of the diabolical function. The devil is the principle of pagan religions as well as of evil . Such a twofold function gives measure of the devil’s Erhabenheit, i.e. the devil’s majesty which indeed well translates the idea intrinsic of the term kyriotès, i.e. the idea of sovereignty. Shelling’s analysis is critical against representations which seem quite apart from the diabolical principle and its majesty. Negatively, the devil is no more a creature than an eternally evil principle. Positively, Schelling recaptures through philosophical terms according to his theory of divine Potenzen non speculative tradition : the devil is in no way different from the first power reactivated by man when in fact it were to rest in him ; thus does he play havoc with man in a manner identical to the essence of this latter power which is what should not but may be manifest. In order to enjoy a so-called usurped existence, the devil can but use suspicion, lies and jealousy, the only stake is to tempt and mislay man. It is such a necessity which turns him into the paradoxical tool of revelation. (shrink)

The mechanical philosophy that emerged during the Scientific Revolution can be characterised as a reductionism according to which all physical phenomena are to be explained in terms of corpuscles of different sizes, shapes, and motions. It provided early modern natural philosophers with a unified view of nature that contrasted primarily with the Aristotelian view of nature, but also with other naturalist, hermetic, mystic, occultist, Paracelsian, and chymical accounts. Indeed, early modern natural philosophers devised mechanical explanations of almost every kind of (...) phenomena; even supranatural phenomena, such as transubstantiation, or phenomena today described as paranormal, like the action of sympathetic powder on a wound, the influence of the stars on terrestrial events, or the identification of thieves with a divining rod, were given mechanical explanations. Confronting this explanatory deluge, historians adopted two opposing narratives. The first narrative amounted to view the mechanical philosophy as a well-identified category that captured something about early modern natural philosophy. The critical narratives of the last thirty years, however, have deconstructed both the belief that it is an adequate historical category and the conviction that it made a positive contribution to the sciences. First, in an era that privileged microscopic case studies over sweeping panoramas, and emic over etic categories, ‘mechanical philosophy’ came to be thought of as lacking any real descriptive significance. Second, from an evaluative point of view, it has been claimed that the mechanical philosophy had no impact on the development of the new sciences. Considering these descriptive and evaluative challenges, taking the mechanical philosophy at face value is historically inadequate and philosophically naïve. Hence the questions addressed in this chapter: What to do with the mechanical philosophy? Does it have to be dropped completely as a category? And, if not, how is it to be used? My view is that it captures something of the transformations that we put under the umbrella of the Scientific Revolution, but that it is not possible to treat it as a naturally given category. Rather, to be employed usefully, it needs conceptual clarification and historical specification. (shrink)

Fundamentos de filosofía de la ciencia es una obra de carácter general destinada principalmente a servir de guía a alumnos y profesores en la ensañanza universitaria de esta disciplina, en especial para los estudios de Filosofía, pero también para los de Humanidades y Ciencias Humanas y Naturales. La obra está estructurada en diferentes niveles para facilitar su utilización como libro de texto, tanto en cursos introductorios generales como en seminarios específicos. Aunque el público universitario es su principal destinatario, se ha (...) concebido para que cualquier lector interesado en la disciplina y con determinados conocimientos previos pueda acceder, con provecho, a las diversas partes de la misma. Ha diferencia de la mayoría de introducciones a la Filosofía de la Ciencia, la orientación de esta obra no es histórica sino temática, cubriendo los diferentes ámbitos conceptuales de la disciplina. Su contenido, dado que su finalidad es presentar los fundamentos de la materia, se centra en los grandes temas clásicos de la disciplina. El núcleo temático lo conforma la triada "conceptos-leyes-teorías" en torno a cuyos componentes se presentan los restantes temas: contrastación de hipótesis, medición, explicación, relaciones interteóricas, el problema de la inducción y el cambio teórico. En tanto que introducción general de la disciplina, en esta obra no se pretende ninguna tesis metacientífica o metafilosófica sustantiva, sino exponer de forma clara los principales problemas filosóficos que plantea la actividad científica y discutir las diferentes aproximaciones a los mismos.. (shrink)

On sait peu de choses d’Edme Mariotte, membre de l’Académie royale des sciences de 1668 à 1684. Une analyse de son Essai de logique montre cependant que, pour défendre ses pratiques expérimentales, il s’appropria des bribes venues de différentes traditions intellectuelles. Ainsi, ce livre examine ce qu’on entendait par « méthode » à la fin du XVIIe siècle, les épistémologies de la physique qui s’affrontaient alors, quelques débats ouverts par la gestion de l’héritage cartésien. Mais l’essentiel sera peut-être la question (...) suivante : comment reconstituer les idées d’un savant ordinaire, qui n’a ni bouleversé l’ordre des sciences, ni montré une perspicacité épistémologique exceptionnelle ? (shrink)

Sophie Roux confronte la critique du « sokalisme » qu’on trouve dans La Querelle des imposteurs d’Yves Jeanneret et la manière dont Impostures intellectuelles dessine le partage entre « littéraires » et « scientifiques ».

L'évangélisation des Indiens du Mexique fut entreprise dans une perspective messianique et eschatologique, notamment par les missionnaires franciscains formés aux idéaux des 'spirituels' et influencés par les prophéties millénaristes de Joachim de Flore. Dans leur esprit, l'Église, en voie de dépérissement dans le 'Vieux Monde' corrompu, allait 'renaître' dans ce monde 'nouveau', dont les populations semblaient vivre en état d'innocence et qui se laissaient convertir avec tant de docilité. Il fallut bientôt déchanter : l'idolâtrie persistait, les Indiens se revoltaient, ils (...) étaient massacrés, et bientôt décimés par des épidémies de caractère 'apocalyptique'. Alors on s'interrogeait : la violence peut-elle être acceptée comme une nécessité pour extirper le culte des démons, hâter l'évangélisation, consolider la conversion de ces peuples? (shrink)

Partie de l’homme et de sa poièsis pour en nier les limites et se représenter un produire supérieur, la création digne du Dieu créateur du ciel et de la terre, la philosophie occidentale a fini par l’appliquer à l’homme-artiste : partie d’une conception trop anthropomorphique de la production divine, elle a fini par promouvoir une conception théomorphique de la création humaine. On érige en méthode un tel théomorphisme afin de voir d’abord comment les diverses conceptions de la création divine éclairent (...) effectivement la création humaine. On explore ensuite la relation de l’œuvre au principe créateur : qu’est et que devient l’œuvre une fois qu’elle est créée? Et que peut nous apprendre sur la création même le destin du créé? (shrink)

Este artículo examina cómo la tragedia griega, especialmente Antígona de Sófocles recupera y amplia el mito. En efecto, el mito encuentra en la tragedia un despliegue tal que en muchas ocasiones llega a competir con el canon mítico. Es también nuestra intención analizar de qué modo opera el mito en la dinámica dramática; esto es, en qué medida le es funcional a la representación trágica. This article examines how the Greek tragedy, especially Sophocles' Antigone recuperates and expands the myth. Indeed, (...) the tragedy displays the myth in a way that it can compete with the mythic canon in many occasions. It is also our intention to examine how the myth operates in the dramatic dynamics, that is, to what extent it is functional to the tragic representation. (shrink)

Roux begins by exploring the texts in which the origins of the scientific notion of thought experiments are usually said to be found. Her general claim is simple: the emergence of the notion of thought experiments relies on a succession of misunderstandings and omissions. She then examines, in a more systematic perspective, the three characteristics of the broad category of thought experiments nowadays in circulation: thought experiments are counterfactual, they involve a concrete scenario and they have a well-delimited cognitive (...) intention. Her aim in exploring these characteristics is twofold. Firstly, it is to show that each of these characteristics, considered individually, may be taken in a more or less strict sense, and consequently to explain the proliferation of thought experiments. Secondly, it is to suggest that the recent debates on thought experiments might have arisen because these three characteristics are not easily conciliated when they are considered together. Finally, in a third and last section, the nine essays of the introduced book are presented. (shrink)

Drawing on the Agency-Stewardship approach, which suggests that manager profile may range from the agent model to the steward model, this article aims to examine how important CEOs are to corporate social responsibility (CSR). Specifically, this exploratory study proposes the existence of a relationship between manager profile and CSR practices and that this relation is mediated by the perceived role of ethics and social responsibility. After applying a mediated regression analysis using survey information collected from 149 CEOs in Spain, results (...) show that those closer to the steward model are more inclined to attach great importance to ethics and social responsibility, and to implement CSR practices in their companies. Results also provide support for the suggested mediating effect. Thus, this article extends research in understanding top managers as drivers for CSR and suggests new ways to deal with this issue empirically. (shrink)

A biological function is supposed to be performed adequately, and hence may fail to do so: this is dysfunction. This raises two questions. One is how to make explicit the way in which function can be discriminated from dysfunction without confusing dysfunction with non-function. The second question is how what is “right” and “wrong” can be legitimated by natural regulatory norms. A function can be viewed as a quality to which at least one variable with a definite set of values (...) is associated. Accordingly, function and dysfunction are the same quality of the same trait, but differ in the values associated to this variable. Dysfunction occurs when the associated set of values does not match this normal state. Biological systems have the epistemic singularity that their existence is the consequence of two distinct causal regimes, the so-called “proximate” and “ultimate” causes, whose convergence defines a system’s prescriptive normality. Each cause imposes restrictive rules that limit the possible ways these systems can putatively exist. When a system is insensitive to ultimate cause, it is determined by proximate causation alone, and hence escapes its own prescriptive norms. In conclusion: The normality of a biological system is defined by the convergence of proximate and ultimate causes. A function is a variable-associated quality whose values are defined relative to the norms of the system. Dysfunction occurs when the set of values of the same variable does not match the normality of the system, which can occur when the system is insensitive to ultimate causation. (shrink)

The History of scepticism from Erasmus to Spinoza is often called upon to support three theses: first, that Descartes had a dogmatic notion of systematic knowledge, and therefore of physics; second, that the hypothetical epistemology of physics which spread during the xviith century was the result of a general sceptical crisis; third, that this epistemology was more successful in England than in France. I reject these three theses: I point first to the tension in Descartes’ works between the ideal of (...) a completely certain science and a physics replete with hypotheses; further, I argue that the use of hypotheses by mechanical philosophers cannot be separated from their conception of physics; finally I show that, at the end of the xviith century, physicists in France as well as in England spoke through hypotheses and I examine different ways of explaining this shared practice. Richard H. Popkin’s book serves therefore as a starting point for insights into the general problem: to what extent and for what reasons some propositions in physics have been presented as hypotheses in the xviith century? (shrink)

El problema de los conflictos normativos ha constituido uno de los principales obstáculos para un tratamiento lógico-formal de los razonamientos jurídicos. Una de las recientes estrategias para abordar esta cuestión se apoya en las lógicas no-monotónicas desarrolladas en el ámbito de la Inteligencia Artificial con el fin de representar el razonamiento común. Sin embargo, un análisis en detalle nos llevará a cuestionar este enfoque.

This is the first volume of a two-volume project whose aim is to publish all the known Middle English manuscript translations of the French Somme le mi, a thirteenth-century manual of religious instruction offering teaching on the Decalogue, the seven deadly sins and their remedies, compiled by the Dominican friar Laurent of Orleans. The project extends and deepens our knowledge of the influence of this popular French text, known today only from the versions entitled The Ayen bite of Inwit and (...) The Book of Vices and Virtues, published in 1866 and 1942, respectively. This volume presents the versions extant in BL MSS Royal 18. A. x and Add. 37677; the second will cover the versions in Cambridge, Corpus Christi College, MS 494, Oxford, Bodleian Library, MS Ashmole 1286, and Oxford, Bodleian Library, MS e Musaeo 23. The texts of both volumes have been prepared with the help of the recently-published edition of the French text, a circumstance from which the earlier English editions were unable to benefit. It is likely that the versions edited here for the first time will make a considerable contribution to our understanding of the processes of textual transmission and to that of translation itself in English literary circles of the fifteenth century. (shrink)

"Estos dos modos de ver la explicación no son incompatibles entre sí; cada uno ofrece un modo razonable de analizar la explicación. De hecho, pueden ser tomados como representando dos aspectos diferentes pero compatibles de la explicación científica" (1989, p. 183). "[estos dos enfoques] se han desarrollado hasta el punto en que pueden coexistir pacíficamente como dos aspectos distintos de la explicación científica" (1992, p. 39). "No rechazo la posibilidad de una teoría [unificacionista] de este tipo; creo que ella no (...) entraría en conflicto con la explicación causal sino que la complementaría " (2001a, p. 10). (shrink)

Una parte de la explicación del gran florecimiento en los EE. UU. de la filosofía analítica, particularmente la filosofía analítica del lenguaje, después de la segunda guerra mundial está sin duda en la amplitud de la comunidad de filósofos que un país grande en dimensiones permite. Pues conseguir un buen nivel de excelencia en la práctica de este modo de entender la filosofía requiere una amplia comunidad de colegas en que difundir y contrastar nuevas ideas. Conscientes de esto, los filósofos (...) analíticos continentales estamos embarcados en la tarea de ampliar recíprocamente nuestras comunidades, aprovechando el impulso del proyecto de mayor unión política europea. Aunque, a diferencia de lo que ocurría en EE. UU. en el tiempo a que nos hemos referido antes, existen importantes obstáculos culturales, hay buenas razones para ser optimistas. Existe claramente la voluntad, lo que ha permitido en la última década llevar a cabo con éxito proyectos tales como los de la European Society for Philosophy and Psychology y la European Society for Analytic Philosophy, así como establecer importantes lazos de conocimiento mutuo a través de pequeños seminarios bilaterales. Y existe también algo muy importante: el que los temas que más interesan a los filósofos del lenguaje continentales son muy próximos; algo que, aventuramos, lo explica parcialmente una formación que presta más atención a la tradición filosófica que la de nuestros colegas americanos. Estos temas incluyen típicamente la referencia, particularmente la referencia de expresiones indéxicas, así como cuestiones relativas a la objetividad, las condiciones de verdad, el realismo y el antirrealismo. (shrink)

According to a grand narrative that long ago ceased to be told, there was a seventeenth century Scientific Revolution, during which a few heroes conquered nature thanks to mathematics. When this grand narrative was brought into question, our perspectives on the question of mathematization should have changed. It seems, however, that they were instead set aside, both because of a general distrust towards sweeping narratives that are always subject to the suspicion that they overlook the unyielding complexity of real history, (...) and because of a shift in our interests. The more obscure and idiosyncratic they are, an alchemist, a patron of the sciences or a lunatic collector is nowadays honored in journals of the history of sciences. As for the general issues involved in the question of mathematization, they are rejected as obsolete, or reserved for specialized journals in the history of mathematics. The article « Forms of mathematization » examines in general the notion of mathematization, distinguishes different forms of mathematization and defends a renewed study of the forms of mathematization in the history of the early sciences. (shrink)

In the history of the scientific revolution, Descartes is often considered as the mechanical philosopher par excellence, and opposed as such to the founder of mechanical science, that is to say, Galileo: this cliché is not without foundation, but it must not make us forget that Descartes was himself a practitioner of mechanical science. In the article "Cartesian Mechanics" I detail the meaning and reach of "mechanics" in the Cartesian corpus, and do so in three steps. 1. I begin by (...) explaining the genesis of the thesis which states that there is no difference between the physical and the mechanical; this thesis is so famous that it is often imagined that it is constituted in Descartes's first writings. But we can in fact show that the first works of Descartes and Beeckman arise from a "physico-mathematical" practice which does not necessarily imply a complete reworking of traditional physics, even if it might have favored the Cartesian ambition for a physics as certain as geometry; it was only in the late 1630s that Descartes began to systematically affirm the identity of physics and mechanics, or of "rules of motion", of "laws of Nature" and of "laws of mechanics". I then analyze the consequences of this affirmation. 2. In the second part of this article I provide a step-by-step commentary of the response proposed by Descartes in a letter to Mersenne in July 1638 to the question raised by Beaugrand's Geostatice (...) dissertatio mathematica (1636), that is to say the question of whether a body weighs more when it is farther from the center of Earth than when it is close. Compared with other texts of the Cartesian corpus, this sample of mechanics has been little analyzed (to my knowledge, the only analyses are those of P. Duhem, P. Costabel, A. Gabbey and D. Garber). This text is nonetheless extremely interesting: Descartes responds to the geostatic question in turn in terms of physics, then mathematics; even more interesting, the examination of the details of his procedures allows us to confront Cartesian statics to other writings, whether those of Guidobaldo del Monte, Galileo, Stevin, Mersenne or Roberval. 3. In the third and final section, I analyze the reasons that lead Descartes to exclude velocity from his statics, I examine the difficulties that his explanation of gravity created for statics, and conclude with the confrontation between mechanical philosophy and mechanical science in the case of Descartes. (shrink)

The ontological status of forces and their causal role in Descartes’ physical world is debated among Descartes scholars. The question of forces is embedded in another more general question, namely to determine which causal activity should be attributed to God, and which causal activity should be attributed to physical bodies. Three distinct positions were attributed to Descartes: 1. he was an occasionalist and he attributed no causal power to forces, 2. he was a pure conservationist and he conceived forces as (...) entities distinct from matter and motion, 3. he was a concurrentist who attributed causal activity both to God and to second causes, especially to forces and laws. These three interpretations seem to exhaust the possibilities. In this chapter however, I defend another interpretation of Descartes’ position, according to which God intervenes in this world only to conserve it by his ordinary concurrence (in this I agree with the conservationist interpretation), without, for all that, forces or laws being specific entities (in this I agree with the occasionalist interpretation). My interpretation leads to downplaying the strong relationship which is assumed to exist between Descartes’ physics and his metaphysics. (shrink)