The transhumanist project of reshaping human beings by promoting their improvement through technological innovations has a broad agenda. This study focuses on the enhancement of the human organism through genetic modification techniques. Transhumanism values and a discussion of their philosophical background provide a framework to understand its ideals. Genetics and ethics are employed to assess the claims of the transhumanist program of human enhancement. A succinct description of central concepts in genetics and an explanation of current techniques to edit the (...) human genome serve to assess the capabilities and limitations of editing techniques. Potential benefits and liabilities of human enhancement through genome editing are discussed to appraise its feasibility. Ethical considerations of genome editing inform a reflection on the implications of introducing heritable changes in the genome of individuals. It is concluded that the transhumanist program is underpinned by a large number of hypotheses rather than by sufficient evidence. (shrink)

How physicians approach patients and the problems they present is much influenced by the conceptual models around which their knowledge is organized. In this paper the implications of the biopsychosocial model for the study and care of a patient with an acute myocardial infarction are presented and contrasted with approaches used by adherents of the more traditional biomedical model. CiteULike Connotea Del.icio.us What's this?

Agency is the human capacity to freely choose one’s thoughts, motivations and actions without undue internal or external influences; it is distinguished from decisional capacity. Four well-known conditions that can deeply affect agency are depression, demoralization, existential distress, and family dysfunction. The study reviews how they may diminish agency in persons whose circumstances may lead them to consider or request euthanasia or assisted suicide. Since agency has been a relatively neglected dimension of autonomous choice at the end of life, it (...) is argued that to respect the autonomy of individuals, it is essential to establish their agency. (shrink)

I know about you only from your valuable books and from the little that was communicated to me by telephone in Moscow in September. Nevertheless, we share a warm interest in Greek culture generally and philosophy in particular.

The posthumanist project proposes directing the evolution of human beings by promoting their improvement through technological means to create a variety of entities that will have few or no common...

Ethical theory in business ethics texts lacks sufficient specificity to be used as a tool of analysis. The result is that business faculty do not see the course in business ethics as helpful to their students, and the students do not see the course as helpful in their careers.A further difficulty is the inclusion of material which is not seen by business faculty, as appropriate or germane to the practice of decision-making. Issues such as the legitimacy of the corporation, or (...) capitalism versus Marxism, are of Iittle interest or help to the person in business.Finally, the text cases are too often of a policy nature, and do not deal with issues faced by a majority of those in business. The result is the lack of engaging the moral imagination of the students.Unless the course is redesigned so that it is seen by business faculty as more relevant, it will continue to be required by only a small number of business programs. (shrink)

"Translating Key Terms Terms in Lu Cheng's Records in the Chuan xi lu: Some Preliminary Considerations" Draft paper for the 2024 Conference on [Wang] Yangming's Learning of Mind, Shaoxing, Zhejiang. Updated October 4, 2024. The final version will appear in the conference volume. -/- Criticism and suggestions welcome. Please do email.

Current psychological research on causal inference is dominated by two basic approaches: the covariation approach and the mechanism approach. This article reviews these two approaches, evaluates the contributions and limitations of each approach, and suggests how these approaches might be integrated into a more comprehensive framework. Covariation theorists assume that cognizers infer causal relations from conditional probabilities computed over samples of multiple events, but they do not provide an adequate account of how cognizers constrain their search for candidate causes and (...) relevant evidence. Mechanism theorists assume that cognizers use their knowledge of potential mechanisms to infer the causes of individual events, but they do not account for the origins of this kind of knowledge. Theorists might integrate these approaches into a framework that overcomes these limitations by (1) examining important relations between cognizers' beliefs about the nature of causality, the logic of causal inference, and the processes cognizers use to make causal inferences, and (2) providing a more complete account of cognizers' conceptions of causality and the origins of those conceptions. (shrink)

The course in business ethics is required by an increasing number of business programs. Accordingly, it seems appropriate to evaluate the text materials used from the perspective of the business student.Relative to early criticisms, recent texts represent considerable improvements in their use of case materials and in the manner by which they involve the student in decision-making situations. However, there are two distortions present in all of the texts examined. First, they concentrate too heavily on cases of a policy, or (...) general management, nature. The result is an inadequate coverage of the functional areas of the firm in which graduates begin their employment. Second, they concentrate too heavily on manufacturing firms, and thus do not introduce students to the ethical problems found where they are most likely to work, in service firms. (shrink)

Energy concepts in theology and natural science are studied to see how they may aid the science‐theology dialogue. Relationships between divine and human energies in classical Christology and energy ideas in process theology are significant. In physics, energy has related roles as something conserved and as the generator of temporal development. We explore ways in which God and the world may interact to produce evolution of the universe. Possible connections between the double role of physical energy and the bipolar character (...) of God in process theology are noted. Energy helps to describe God's relationship with the world in both theological viewpoints and, thus, may bridge them. (shrink)

Neisseria gonorrhoeae, the bacterium that causes the sexually transmitted disease gonorrhea, demonstrates extensive antigenic heterogeneity in its surface components. The organism has the capacity to switch on and off the synthesis of different versions of components such as pili, outer membrane proteins, and lipopolysaccharide. Recent studies have shown that the gonococcus uses novel and complex mechanisms, of types not described previously, to store different versions of genetic information for surface proteins, and to regulate expression of those genes.

Keywords: A theological approach to understanding time and change in a modern way must consider the relationships between thermal physics and time as elucidated during the past century and a half. The fact of temporal change, including death and decay, has been a religious problem since antiquity, so that some traditions have simply attempted to transcend the world of change. However, a major current of the Christian tradition has seen change as a fundamental aspect of God's creation, and one with (...) which God becomes identified in the Incarnation. This implies approval of history, as having an ultimate value, rather than transcendence of it.We examine thermodynamics, and especially its Second Law, in order to understand more precisely the issues of temporal change. The Second Law states a universal tendency toward increasing disorder, and several implications of this law are discussed. Of particular significance, however, is the work of Prigogine and others on nonequilibrium thermodynamics, drawing attention to such phenomena as the enhancement of chemical reaction rates and the formation of “dissipative structures” in nonequilibrium situations. Such possibilities may be of considerable importance for understanding chemical and biological evolution.These ideas can be included in an evolutionary picture in which, following Teilhard de Chardin, the Body of Christ is seen as the future of evolution‐an “ultimate dissipative structure” in which the world of time and change is united with God. Suffering, death, and decay receive their meaning from the future. Within this framework it is therefore possible to believe that the material world of history may be part of the eschatological future and that science provides hints, though not predictions, of how that may happen. (shrink)

Ian Barbour has distinguished eight theologies of God's role in nature, together with corresponding models of divine activity. This essay examines these ideas in the light of a theology of the cross. Three of Barbour's approaches—the neo‐Thomist, the kenotic, and the existentialist—are able to provide different aspects of a theology of divine action that is consistent with belief that God's definitive revelation takes place in the Crucifixion and Resurrection of Jesus of Nazareth. These approaches encourage attention to a part of (...) traditional doctrines of Providence, the idea that God acts by “cooperation” with natural processes. The kenotic character of divine involvement in the world means that the regularities of the basic interactions of physics are maintained. The idea of cooperation can be extrapolated into the past, to give some insight into ways of understanding God's activity in originating the universe. (shrink)

Wang Yangming (1472-1529) and his School of Mind dominated the intellectual world of sixteenth-century Ming China (1368-1644), and his Confucian philosophy has since remained an essential component of East Asian philosophical discourse. Yet, the volume of publications on him in the Western-language literature has consistently paled in comparison to the volume of scholarship on classical Chinese philosophy, modern Chinese philosophy, Buddhism, and Daoism. Studying Wang Yangming: History of a Sinological Field explains the history of writing in the West about the (...) famed Ming dynasty scholar-official. From eighteenth-century French Jesuit books to English-language publications in 2020, this book provides a historical overview and summary of a literature published by scholars attempting to grapple with one of the most influential Confucians in the history of China, East Asia, and the world. (shrink)

We can understand viewed scenes and extract task-relevant information within a few hundred milliseconds. This process is generally supported by three cortical regions that show selectivity for scene images: parahippocampal place area (PPA), medial place area (MPA) and occipital place area (OPA). Prior studies have focused on the visual information each region is responsive to, usually within the context of recognition or navigation. Here, we move beyond these tasks to investigate gaze allocation during scene viewing. Eye movements rely on a (...) scene’s visual representation to direct saccades, and thus foveal vision. In particular, we focus on the contribution of OPA, which is i) located in occipito-parietal cortex, likely feeding information into parts of the dorsal pathway critical for eye movements, and ii) contains strong retinotopic representations of the contralateral visual field. Participants viewed scene images for 1034 ms while their eye movements were recorded. On half of the trials, a 500 ms train of five transcranial magnetic stimulation (TMS) pulses was applied to the participant’s cortex, starting at scene onset. TMS was applied to the right hemisphere over either OPA or the occipital face area (OFA), which also exhibits a contralateral visual field bias but shows selectivity for face stimuli. Participants generally made an overall left-to-right, top-to-bottom pattern of eye movements across all conditions. When TMS was applied to OPA, there was an increased saccade latency for eye movements toward the contralateral relative to the ipsilateral visual field after the final TMS pulse (400ms). Additionally, TMS to the OPA biased fixation positions away from the contralateral side of the scene compared to the control condition, while the OFA group showed no such effect. There was no effect on horizontal saccade amplitudes. These combined results suggest that OPA might serve to represent local scene information that can then be utilized by visuomotor control networks to guide gaze allocation in natural scenes. (shrink)

The chromocenter of Drosophila polytene chromosomes, which consists of two major chromatin types, has long been a troublesome region in molecular terms. The recent microcloning of part of this region, the isolation of a monoclonal antibody to a beta‐heterochromatin binding protein, and new in situ studies now shed a little more light on this chromosomal region.

IN THIS PAPER I shall try to exhibit certain interconnections within and between the "dialectical stages" of self-consciousness and active reason which appear not to have been noticed by Hegel scholars. I take as my text Hegel's remark, in a letter to Schelling dated May 1, 1807, that "the whole" of the Phenomenology is "by its nature" an "interlocking hither and thither." The more closely one studies the Phenomenology, the more clearly one can see that its parts--even those which are (...) widely separated--do indeed "interlock.". (shrink)

Criticism and recommendations are very much welcome. Please don't hesitate to contact me with them. -/- .

Nie Bao 聶豹 (1487–1563) was a Neo-Confucian philosopher and scholar-official of sixteenthcentury Ming China. In his Ming ru xue an 明儒學案 (Case studies of Ming Confucians), Huang Zongxi 黃宗羲 placed him in the Jiangxi (Jiangyou 江右) group of Wang Yangming followers. Nie Bao met the influential founder of the Ming School of Mind in 1526 and was inspired by his teaching of the innate knowing (liangzhi 良知). However, he differed from other followers in his quietist approach to realizing and extending (...) this knowledge. While developing his ideas over the course of two decades, as a holder of the highest civil service examination degree, Nie Bao also held a series of impactful official positions, and earned a reputation for effectiveness and integrity. However, he was also the unwitting victim of factionalism at the Ming court, which led to his imprisonment in 1548. The goal of this article is to provide a sketch of Nie Bao’s political trajectory and intellectual development from his early years until his imprisonment, as well as translation of significant passages pertaining to that trajectory and development. By the time of his imprisonment, Nie Bao had articulated the essential elements of his philosophy of returning to the root (by which he meant silence), and attaining centeredness and, with that, his unique interpretation of his teacher’s central tenet. (shrink)

For researchers and students interested in the connections between theoretically informed work and the possibilities for bettering people's everyday lives, this ...

Semën [Simon] Liudvigovich Frank was born in Moscow, the son of a doctor. He studied law at Moscow University, joined a student Marxist group headed by P.B. Struve, and as a result was barred by the Russian authorities from living in any of the Russian “university cities.” He continued his university education at the Universities of Berlin and Munich. His first published work was a critique of Marx’s theory of value. Between 1902 and 1905 he divided his time among Berlin, (...) Munich, and Moscow. In 1902 he published his first philosophical essay, on Nietzsche’s doctrine of Fernstenliebe. He was a contributor—along with Nicolas Berdyaev, S.N. Bulgakov, and Struve—to three influential symposium volumes: Problemy idealizma [Problems of idealism], Vekhi [Signposts], and Iz glubiny [De profundis]. This last work was printed but its release was blocked by Soviet censorship. All of these works were originally published in Moscow; all of them have, in the past three or four years, been republished in Moscow, but for more than seventy years they were banned in the Soviet Union and could be reprinted only abroad. (shrink)