On the the foundations of Swahili linguistic history and comparative linguistics.

This intriguing and ground-breaking book is the first in-depth study of the development of philosophy of science in the United States during the Cold War. It documents the political vitality of logical empiricism and Otto Neurath's Unity of Science Movement when these projects emigrated to the US in the 1930s and follows their de-politicization by a convergence of intellectual, cultural and political forces in the 1950s. Students of logical empiricism and the Vienna Circle treat these as strictly intellectual non-political projects. (...) In fact, the refugee philosophers of science were highly active politically and debated questions about values inside and outside science, as a result of which their philosophy of science was scrutinized politically both from within and without the profession, by such institutions as J. Edgar Hoover's FBI. It will prove absorbing reading to philosophers and historians of science, intellectual historians, and scholars of Cold War studies. (shrink)

Bishop John A.T. Robinson's Honest to God was exceptionally successful. In the decade following its publication more than a million copies were sold in seventeen different languages. Robinson was aware that numerous awkward questions were being asked about traditional Christian beliefs, which it was no longer possible to ignore. His purpose was not so much to question traditional ideas of God as to suggest alternatives for those who found them unsatisfactory . He wanted to convince such persons that (...) an inability to believe what is stated in the Bible or the prayer book does not disqualify them from calling themselves Christians and presenting themselves at church. He speaks of traditional Christian beliefs, as stated in the New Testament, as a ‘language’ and thinks that Christianity should be conveyed to people in a variety of languages. By employing, as he does, the language of such Christian scholars as Bonhoeffer, Tillich and Bultmann, an atheist may find himself able to call himself a Christian. But the old familiar language of the Bible remains more pleasing to most of God's children, particularly to his ‘older children’ , so we must not give it up, although he allows that it is becoming increasingly unpopular, so that without ‘the kind of revolution’ he is advocating, ‘Christian faith and practice … will come to be abandoned’. (shrink)

Cognitive science is a child of the 1950s, the product of a time when psychology, anthropology and linguistics were redefining themselves and computer science and neuroscience as disciplines were coming into existence. Psychology could not participate in the cognitive revolution until it had freed itself from behaviorism, thus restoring cognition to scientific respectability. By then, it was becoming clear in several disciplines that the solution to some of their problems depended crucially on solving problems traditionally allocated to other (...) disciplines. Collaboration was called for: this is a personal account of how it came about. (shrink)

It is the thesis of this paper that the term scientific law can and should mean in the social sciences exactly what it means in any of the other sciences. There seems to be considerable agreement among scientists as well as others that a scientific law is a generalized and verifiable statement, within measurable degrees of accuracy, of how certain events occur under stated conditions. If I were to attempt a more specific statement I would say that a law (...) is a group of verbal or mathematical symbols designating an unlimited number of defined events in terms of a limited number of reactions so that the performance of specified operations always yields predictable results within measurable limits. (shrink)

Philosophical (p-) zombies are constructs that possess all of the behavioral features and responses of a sentient human being, yet are not conscious. P-zombies are intimately linked to the hard problem of consciousness and have been invoked as arguments against physicalist approaches. But what if we were to invert the characteristics of p-zombies? Such an inverse (i-) zombie would possess all of the behavioral features and responses of an insensate being yet would nonetheless be conscious. While p-zombies are logically (...) possible but naturally improbable, an approximation of i-zombies actually exists: individuals experiencing what is referred to as “anesthesia awareness.” Patients under general anesthesia may be intubated (preventing speech), paralyzed (preventing movement), and narcotized (minimizing response to nociceptive stimuli). Thus, they appear—and typically are—unconscious. In 1-2 cases/1000, however, patients may be aware of intraoperative events, sometimes without any objective indices. Furthermore, a much higher percentage of patients (22% in a recent study) may have the subjective experience of dreaming during general anesthesia. P-zombies confront us with the hard problem of consciousness—how do we explain the presence of qualia? I-zombies present a more practical problem—how do we detect the presence of qualia? The current investigation compares p-zombies to i-zombies and explores the “hard problem” of unconsciousness with a focus on anesthesia awareness. (shrink)

Everyone has felt those tingling, tickly sensations occurring spontaneously all over the body in the absence of stimuli. But does anyone know where they come from? Here, right-handed subjects were asked to focus on one hand while looking at it and while looking away and subsequently to map and describe the spatial and qualitative attributes of sensations arising spontaneously. The spatial distribution of spontaneous sensations followed a proximo-distal gradient, similar to the one previously described for the density of receptive (...) units. The intensity and spatial extent of the reported sensations were modulated by the focusing condition, especially in respect of the left hand. Convergent focusing acted upon the conscious perception of sensations by enhancing or suppressing them. To our knowledge, this is the first ever study of spontaneous sensations, and it offers considerable insight into their sources. The presence of the proximo-distal distributional gradient is a clear sign that receptive units are involved. The enhancement/suppression effects also confirm the involvement of attention. Finally, left-hand dominance suggests several right-hemisphere processes may be involved, such as spatial and tactile perception, and probably interoception. (shrink)

In the spring of 1937, the University of Chicago Press mailed hundreds of subscription forms for its latest enterprise – a projected series of twenty short monographs by various philosophers and scientists. Together the monographs were to form the first section of the International Encyclopedia of Unified Science. Included in each mailing was an introductory prospectus which began:Recent years have witnessed a striking growth of interest in the scientific enterprise as a whole and especially in the unity of science. (...) The concern throughout the world for the logic of science, the history of science, and the sociology of science reveals a comprehensive international movement interested in considering science as a whole in terms of the scientific temper itself. A science of science is appearing. The extreme specialization within science demands as its corrective an interest in the scientific edifice in its entirety. This is especially necessary if science is to satisfy its inherent urge for the systematization of its results and methods and if science is to perform adequately its educational role in the modern world. Science is gradually rousing itself for the performance of its total task. (shrink)

This chapter contains sections titled: “God is a woman” From Mother Goddesses to Classical Theism It's Like This “Defective and misbegotten” “The true mother of life and all things” Mothers Made in the Image of God Notes.

Among pathogenic micro‐organisms that evade the mammalian immune responses, Trypanosoma brucei has developed the most elaborate capacity for antigenic variation. Trypanosomes branched early during eukaryotic evolution. They are characterized by many aberrations, ranging from the unusual compartmentation of metabolic pathways to the heresy of RNA editing. The ubiquitous phenomenon of glycosylphosphatidylinositol‐anchoring of eukaryotic plasma membrane proteins and RNA trans‐splicing (trypanosome genes contain no introns), which adds an identical leader sequence to all trypanosome mRNAs, were first defined during studies of (...) antigenic variation. Genetic transformation of trypanosomes and the high efficiency of gene targeting provide new opportunities to investigate the regulation of antigenic variation. There is every reason to expect trypanosomes to provide further surprises and insights into the evolution of genetic regulatory mechanisms. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Literate Education in the Hellenistic and Roman WorldsGeorge A. KennedyTeresa Morgan. Literate Education in the Hellenistic and Roman Worlds. Cambridge: Cambridge University Press, 1998. xviii + 364 pp. Cloth, $64.95. (Cambridge Classical Studies)This book is a study of the evidence for elementary education found in papyri in comparison with what is found in literary sources, especially in descriptions of teaching reading and writing by Quintilian, Plutarch, and his (...) alter ego, Pseudo-Plutarch. Although H.I. Marrou (A History of Education in Antiquity [New York 1956]) and others have cited exercises on papyri, much of the information is scattered and difficult for the nonspecialist, and Morgan performs a valuable service in reviewing it systematically. About four hundred exercises have been found on papyri, dating from the third century before Christ to the Byzantine period. They provide a record of practice in writing and evidence for what was read at an elementary stage in Greco-Roman Egypt. Morgan classifies them into copies of single letters, alphabets, syllabaries, word lists, gnomic sayings (the largest single group), short nongnomic quotations, scholia, grammatical exercises, rhetorical exercises, and other. The nongnomic quotations come chiefly from the Homeric poems (total 58), Euripides (20), and Menander (7). Rhetorical exercises are limited to rather simple narratives of myths, fables, chrias, and incidents from epic, with a very few historical subjects; there is no example of declamation or exercise in argumentation in the papyri.Morgan argues (pp. 71-72) for a "core" curriculum, consisting of methods of learning to read and write, with reading of gnomic sayings and of parts of the Homeric epics, and a "peripheral" curriculum, in which individual teachers experimented with other texts and other types of exercise. Students in Egyptian towns and villages were on the margins of Greek culture, and in many instances Greek was not their native language. Greco-Roman literate education gave them access, at varying social levels, to a world of culture and a route to power. "We can now begin to see how that culture is imparted," she says (103). "It [the education] begins by reducing the pupil to a reciter of nonsense, before feeding him, bit by bit, fragments of cultural information out of context." This is highly [End Page 331] authoritative: the pupil must accept what the teacher says before thinking or articulating anything originally, and this is repeated at every stage of education short of the schools of rhetoric and philosophy. The reference to "him" is necessary, for the papyri provide no evidence for the education of girls, and references to women in the exercises are almost entirely negative in tone.In a chapter entitled "Grammar and the Power of Language" (152-89) Morgan argues persuasively that formal grammar was not used in antiquity as a way to teach Greek to nonnative speakers; it was, instead, an initiation into a slightly higher level of education and taught the student how to recognize, and to a limited extent how to use, "correct" language. She speculates that it also provided a model of the relationship between the grammar of a sentence and what it represents in the world, "such that the grammatical accuracy of a sentence helps to guarantee the truth of the utterance" (188). However that may be, classicists need to understand how pervasive, all over the world, is the use of separate registers of formal language; to be taken seriously, speakers and writers everywhere have needed to employ the appropriate linguistic register as well as a number of other formal conventions (see my recent discussion in Comparative Rhetoric: An Historical and Cross-Cultural Introduction [Oxford 1997] esp. 64-68, 101-5, 125-27, 228).The following chapter, "Rhetoric: Art and Articulation" (190-239), attempts, as Morgan puts it, "to widen a little what we understand as the aims and effects of learning rhetoric" (197). Elementary rhetorical exercises as found in the papyri would not have produced a civic orator: "They teach pupils, most of whom are likely to use their literacy as bureaucratic middleman in a variety of posts, to read and analyse complicated texts, to articulate and pass on information in clear and concise form. The pupils who had learnt this much... (shrink)

The first of 3 objectives in this study was to address the major problem with Null Hypothesis Significance Testing (NHST) and 2 common misconceptions related to NHST that cause confusion for students and researchers. The misconcep- tions are (a) a smaller p indicates a stronger relationship and (b) statistical signifi- cance indicates practical importance. The second objective was to determine how this problem and the misconceptions were treated in 12 recent textbooks used in edu- cation research methods and statistics (...) classes. The third objective was to examine how the textbooks’ presentations relate to current best practices and how much help they provide for students. The results show that almost all of the textbooks fail to acknowledge that there is controversy surrounding NHST. Most of the textbooks dealt, at least minimally, with the alleged misconceptions of interest, but they pro- vided relatively little help for students. (shrink)

C.S. Lewis, the scholar of English mediaeval and Renaissance literature who died in 1963 and is still widely respected as a Christian apologist, complained that academic biblical scholars simply assume that miracles cannot have occurred in the fashion reported in the New Testament. In a lecture quoted by A.I.C. Heron 1 , he said: ‘The canon “If miraculous, unhistorical” is one they bring to their study of the texts, not one they have learned from it.’ In fact, as John Kent (...) retorted, they did not rule out in advance the idea of supernatural events, but were able, without it, to give adequate and plausible accounts of how the biblical documents reached their present form, by means of a method ‘based on questions of probability in terms of evidence’, not ‘on an a priori rejection of miracle’. 2 Conclusions concerning historical events of any kind are similarly based. ‘No historians’, says the historian R.J. Evans, ‘really believe in the absolute truth of what they are writing, simply in its probable truth, which they have done their utmost to establish by following the usual rules of evidence’. 3 To this question of ‘absolute’ truth I shall return. (shrink)

The cognitive unbinding paradigm suggests that the synthesis of neural information is attenuated by general anesthesia. Here, we analyzed the functional organization of brain activities in the conscious and anesthetized states, based on functional segregation and integration. Electroencephalography recordings were obtained from 14 subjects undergoing induction of general anesthesia with propofol. We quantified changes in mean information integration capacity in each band of the EEG. After induction with propofol, mean information integration capacity was reduced most prominently in the γ (...) band of the EEG . Furthermore, we demonstrate that loss of consciousness is reflected by the breakdown of the spatiotemporal organization of γ waves. We conclude that induction of general anesthesia with propofol reduces the capacity for information integration in the brain. These data directly support the information integration theory of consciousness and the cognitive unbinding paradigm of general anesthesia. (shrink)

In one study funded by the United States Department of Agriculture, people from North Dakota were interviewed to discover which moral principles they use in evaluating the morality of transgenic organisms and their introduction into markets. It was found that although the moral codes the human subjects employed were very similar, their views on transgenics were vastly different. In this paper, the codes that were used by the respondents are developed, compared to that of the academically (...) composed Belmont Report, and then modified to create the more practical Common Moral Code. At the end, it is shown that the Common Moral Code has inherent inconsistency flaws that might be resolvable, but would require extensive work on the definition of terms and principles. However, the effort is worthwhile, especially if it results in a common moral code that all those involved in the debate are willing to use in negotiating a resolution to their differences. (shrink)

This volume is a direct result of a conference held at Princeton University to honor George A. Miller, an extraordinary psychologist. A distinguished panel of speakers from various disciplines -- psychology, philosophy, neuroscience and artificial intelligence -- were challenged to respond to Dr. Miller's query: "What has happened to cognition? In other words, what has the past 30 years contributed to our understanding of the mind? Do we really know anything that wasn't already clear to William James?" Each (...) participant tried to stand back a little from his or her most recent work, but to address the general question from his or her particular standpoint. The chapters in the present volume derive from that occasion. (shrink)

Frontoparietal connectivity has been suggested to be important in conscious processing and its interruption is thought to be one mechanism of general anesthesia. Data in animals demonstrate that feedforward processing of information may persist during the anesthetized state, while feedback processing is inhibited. We investigated the directionality and functional organization of frontoparietal connectivity in 10 human subjects anesthetized with propofol on two separate occasions. Multichannel electroencephalography and a computational method of assessing directed functional connectivity were employed. We demonstrate that (...) directed feedback connectivity is diminished with loss of consciousness and returns with responsiveness to verbal command. We also applied the Dendrogram classification method to assess the global organization of directed functional connectivity during consciousness and anesthesia. We demonstrate a state-specific hierarchy and subject-specific subhierarchy in functional organization. These data support the hypothesis that specific states of human consciousness are defined by specific states of frontoparietal connectivity. (shrink)

The association of resilience-related factors with frailty is a recent research topic. Dispositional optimism and context sensitivity are two psychological factors that differently contribute to individual resilience. This study aimed at investigating whether dispositional optimism and context sensitivity might contribute to a multifactorial model of frailty, together with established relevant factors such as cognitive and physical factors. This cross-sectional study involved 141 elderly outpatients aged ≥65 years, who were referred to the Geriatrics and Multidimensional Evaluation Clinic of the University (...) Hospital of Messina. We used the following measures: the Mini-Mental State Examination to screen for global cognitive functioning; 4-m gait speed and handgrip strength to measure physical performance; a 35-item Frailty Index to evaluate patients’ frailty status; the revised Life Orientation Test to gauge dispositional optimism; and the Context Sensitivity Index to measure context sensitivity. We found that LOT-R, CSI, and MMSE were all significantly associated with FI. Gait speed was only marginally associated with FI. The present study showed a novel association of dispositional optimism and context sensitivity with frailty among elderly outpatients. These preliminary findings support a multidimensional approach to frailty in which even peculiar psychological features might provide a significant contribution. (shrink)

People of the Big Voice tells the visual history of Ho-Chunk families at the turn of the twentieth century and beyond as depicted through the lens of Black River Falls, Wisconsin studio photographer, Charles Van Schaick. The family relationships between those who “sat for the photographer” are clearly visible in these images—sisters, friends, families, young couples—who appear and reappear to fill in a chronicle spanning from 1879 to 1942. Also included are candid shots of Ho-Chunk on the streets of Black (...) River Falls, outside family dwellings, and at powwows. As author and Ho-Chunk tribal member Amy Lonetree writes, “A significant number of the images were taken just a few short years after the darkest, most devastating period for the Ho-Chunk. Invasion, diseases, warfare, forced assimilation, loss of land, and repeated forced removals from our beloved homelands left the Ho-Chunk people in a fight for their culture and their lives.” The book includes three introductory essays and 300-plus duotone photographs and captions in gallery style. Unique to the project are the identifications in the captions, which were researched over many years with the help of tribal members and genealogists, and include both English and Ho-Chunk names. (shrink)

This study aimed at investigating depression, anxiety, and stress symptoms among healthcare workers and examine the role of expressive flexibility and context sensitivity as key components of resilience in understanding reported symptoms. We hypothesized a significant and different contribution of resilience components in explaining depression, anxiety, and stress. A total sample of 218 Italian healthcare workers participated in this study through an online survey during the lockdown, consequently to the COVID-19. The Depression Anxiety Stress Scales-21 was used to measure depression, (...) anxiety, and stress; the Flexible Regulation of Emotional Expression scale was used to measure the ability to enhance and suppress emotional expression; the Context Sensitivity Index was used to measure the ability to accurately perceive contextual cues and determine cue absence. Demographic and work-related data were also collected. DASS-21 cut-off scores were used to verify the mental status among the respondents. Correlational analyses examined relationships between DASS-21, FREE, and CSI, followed by three regression analyses with depression, anxiety, and stress as dependent variables, controlling for age, gender, and work experience. Enhancement and suppression abilities, cue presence, and cue absence served as independent variables. The results showed a prevalence of moderate to extremely severe symptoms of 8% for depression, 9.8% for anxiety, and 8.9% for stress. Results of correlational analysis highlighted that enhance ability was inversely associated with depression and stress. Suppression ability was inversely associated with depression, anxiety, and stress. The ability to perceive contextual cues was inversely associated with depression and anxiety. The regression analysis showed that the ability to enhance emotional expression was statistically significant to explain depression among healthcare workers. In predicting anxiety, age, and the ability to accurately perceive contextual cues and determine cue absence made substantial contributions as predictors. In the last regression model, age, work experience, and the ability to suppress emotional expression were significant predictors of stress. This study’s findings can help understand the specific contributions of enhancement and suppression abilities and sensitivity to stressor context cues in predicting depression, anxiety, and stress among healthcare workers. Psychological interventions to prevent burnout should consider these relationships. (shrink)

Psychedelics have been recognized as model interventions for studying altered states of consciousness. However, few empirical studies of the shamanic state of consciousness, which is anecdotally similar to the psychedelic state, exist. We investigated the neural correlates of shamanic trance using high-density electroencephalography (EEG) in 24 shamanic practitioners and 24 healthy controls during rest, shamanic drumming, and classical music listening, followed by an assessment of altered states of consciousness. EEG data were used to assess changes in absolute power, connectivity, (...) signal diversity, and criticality, which were correlated with assessment measures. We also compared assessment scores to those of individuals in a previous study under the influence of psychedelics. Shamanic practitioners were significantly different from controls in several domains of altered states of consciousness, with scores comparable to or exceeding that of healthy volunteers under the influence of psychedelics. Practitioners also displayed increased gamma power during drumming that positively correlated with elementary visual alterations. Furthermore, shamanic practitioners had decreased low alpha and increased low beta connectivity during drumming and classical music and decreased neural signal diversity in the gamma band during drumming that inversely correlated with insightfulness. Finally, criticality in practitioners was increased during drumming in the low and high beta and gamma bands, with increases in the low beta band correlating with complex imagery and elementary visual alterations. These findings suggest that psychedelic drug-induced and non-pharmacologic alterations in consciousness have overlapping phenomenal traits but are distinct states of consciousness, as reflected by the unique brain-related changes during shamanic trance compared to previous literature investigating the psychedelic state. (shrink)

The integration of ethical analysis in Health Technology Assessment (HTA) has proven difficult to implement even though it is explicitly recognized as an important component of such assessments in HTA literature. When compared to the standardized scientific method for systematic reviews in HTA, the diversity of ethical analysis has been characterized as a fundamental barrier to the integration of ethics. The present paper aims to identify the theoretical and practical differences between the approaches underpinning ethical analysis in HTA and clarify (...) the reasons for such diversity. Our systematic review of HTA literature pertaining to the barriers to the integration of ethics in HTA identified nine ethical approaches: Principlism, Casuistry, Coherence Analysis, Wide Reflective Equilibrium, Axiology, the Socratic approach, the Triangular model, Constructive Technology Assessment and Social Shaping of Technology. Citations pertaining to each approach were extracted and categorized according to three constitutive components of ethical argumentation established in a previous research evaluating nanotechnologies: i) the disciplinary foundation that grounds the validity of the ethical evaluation, ii) the characteristics of such evaluation, iii) the operational process involved in applying it to a particular case (i.e., its practical reasoning). This comparison shows that, 1) the difference between these approaches rests primarily on their disciplinary foundation (rooted in philosophy, philosophy/theology, or sociology), 2) their complexity can be observed in the distinct characteristics of ethical evaluation deriving from their differing disciplinary foundation, and 3) although four different types of operationalization procedure were identified, little information was available in regards to the practical reasoning associated with these approaches. (shrink)

Previous work employing graph theory and nonlinear analysis has found increased spatial and temporal disorder, respectively, of functional brain connectivity in schizophrenia. We present a new method combining graph theory and nonlinear techniques that measures the temporal disorder of functional brain connections. Multichannel electroencephalographic data were windowed and functional networks were reconstructed using the minimum spanning trees of correlation matrices. Using a method based on Shannon entropy, we found elevated connection entropy in gamma activity of patients with schizophrenia; (...) however, gamma connection entropy remained elevated in patients with schizophrenia even after a reduction in symptoms due to treatment with antipsychotics. Our results are consistent with several possibilities: aberrant functional connectivity is epiphenomenal to schizophrenia, aberrant functional connectivity is a central feature but antipsychotics reduce symptoms by an independent mechanism, or connection entropy is not an appropriately sensitive measure of brain abnormalities in schizophrenia. (shrink)

Background The rise of a new generation of intelligent neuroprostheses, brain-computer interfaces (BCI) and adaptive closed-loop brain stimulation devices hastens the clinical deployment of neurotechnologies to treat neurological and neuropsychiatric disorders. However, it remains unclear how these nascent technologies may impact the subjective experience of their users. To inform this debate, it is crucial to have a solid understanding how more established current technologies already affect their users. In recent years, researchers have used qualitative research methods to explore the subjective (...) experience of individuals who become users of clinical neurotechnology. Yet, a synthesis of these more recent findings focusing on qualitative methods is still lacking. Methods To address this gap in the literature, we systematically searched five databases for original research articles that investigated subjective experiences of persons using or receiving neuroprosthetics, BCIs or neuromodulation with qualitative interviews and raised normative questions. Results 36 research articles were included and analysed using qualitative content analysis. Our findings synthesise the current scientific literature and reveal a pronounced focus on usability and other technical aspects of user experience. In parallel, they highlight a relative neglect of considerations regarding agency, self-perception, personal identity and subjective experience. Conclusions Our synthesis of the existing qualitative literature on clinical neurotechnology highlights the need to expand the current methodological focus as to investigate also non-technical aspects of user experience. Given the critical role considerations of agency, self-perception and personal identity play in assessing the ethical and legal significance of these technologies, our findings reveal a critical gap in the existing literature. This review provides a comprehensive synthesis of the current qualitative research landscape on neurotechnology and the limitations thereof. These findings can inform researchers on how to study the subjective experience of neurotechnology users more holistically and build patient-centred neurotechnology. (shrink)

In this follow-up to the highly successful _Ethnography Unbound,_ Michael Burawoy and nine colleagues break the bounds of conventional sociology, to explore the mutual shaping of local struggles and global forces. In contrast to the lofty debates between radical theorists, these nine studies excavate the dynamics and histories of globalization by extending out from the concrete, everyday world. The authors were participant observers in diverse struggles over extending citizenship, medicalizing breast cancer, dumping toxic waste, privatizing nursing homes, the degradation (...) of work, the withdrawal of welfare rights, and the elaboration of body politics. From their insider vantage points, they show how groups negotiate, circumvent, challenge, and even re-create the complex global web that entangles them. Traversing continents and extending over three years, this collaborative research developed its own distinctive method of "grounded globalization" to grasp the evaporation of traditional workplaces, the dissolution of enclaved communities, and the fluidity of identities. Forged between the local and global, these compelling essays make a powerful case for ethnography's insight into global dynamics. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because (...) the accepted baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

What is it to be a woman? What is it to be a man? We start by laying out desiderata for an analysis of 'woman' and 'man': descriptively, it should link these gender categories to sex biology without reducing them to sex biology, and politically, it should help us explain and combat traditional sexism while also allowing us to make sense of the activist view that gendering should be consensual. Using a Putnam-style 'Twin Earth' example, we argue that none of (...) the existing analyses in the feminist literature succeeds in meeting all of our desiderata. Finally, we propose a positive account that we believe can satisfy all the desiderata outlined. According to our theory, the genders 'woman' and 'man' are individuated not by their contemporary connections to sex biology, but by their historical continuity with classes that were originally closely connected to sex biology. (shrink)

PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

Both practitioners and scholars are increasingly interested in the idea of the human-centered organization. This term first appeared in the late 1950s and has gained attention in the last ten years. Awareness of the need for human-centeredness grew during the COVID-19 pandemic, in which many organizational leaders were compelled to focus on employee health, safety, and well-being. In this paper, we review and synthesize the rather fragmented scholarly and practitioner literature on human-centered organization (HCO) to develop an integrated definition (...) and framework. The 26 sources reviewed in depth indicate that the HCO construct is primarily utilized in two ways. First, human-centered design scholars and practitioners conceive of HCOs as employing human-centered design practices. The second discourse involves the humanistic management and culture literature, which conceives of HCOs as embodying humanistic values and cultures. After reviewing these separate discourses, we synthesize them in an integrated definition as well as framework of HCO. The framework starts from humanistic values such as dignity, well-being, and justice, which are pivotal in creating organizational practices characterized by a common good purpose, positive human experiences on the job, team structures to coordinate work, and participatory tools and approaches. (shrink)

George Berkeley (1685-1753) is the superstar of Irish Philosophy. He entered Trinity College, Dublin, in 1700 and became a fellow in 1707. In 1724 he resigned his Fellowship to become Dean of Derry, and in 1734 he was made Bishop of Cloyne. He settled in Oxford in 1752 and died the following year. The work of George Berkeley is marked by its diversity and range. His writings take in such topics as mathematics, psychology, politics, health, economics, deism and (...) education, as well as that with which he is most associated - philosophy. Whatever topic he dealt with, his grasp of the subject matter was always impressive and his criticisms of his contemporaries often acute. Among the most noteable of the British Empiricists, he took his starting point from Locke's new 'way of ideas', but he rejected abstract ideas and the possibility of real existence outside perception. It is for this doctrine that he is most known - that there is no such thing as matter, and that things are collections of ideas which can exist only in our minds and only for so long as they are perceived. This philosophy, summed up in his phrase 'to be is to be perceived', he termed 'immaterialism'. A.C. Fraser's collection includes a series of what were previously unpublished notes by Berkeley on all the main topics of his philosophy. This, the 1901 edition, was the first complete edition of his works. (shrink)

The worldwide COVID-19 pandemic has shed more light on the difficulty of making health care decisions integrating scientific knowledge and values associated to life and death issues, human suffering, quality of life, economic losses, liberty of movement, etc. But the difficulties related to health care decisions and the use of innovative drugs or technologies are not new, and many countries have created agencies that have the mandate to evaluate new technologies in health care. Health Technological Assessment (HTA) reports’ aim is (...) to guide the decision makers in these difficult matters. There are two ethical components in HTA. The first is the report’s presentation of an ethical evaluation of the technology. The second is the value-ladenness of the HTA decision-making process itself. When implicit value judgments are not elicited, the justification of the final decision cannot be transparent. The present paper aims to identify and elicit the implicit value-judgments related to each step of the HTA process. This research is grounded on an applied ethics decision-making paradigm based on the role of value judgments in the decision-making process. The first part discusses two different approaches to values and value judgments in HTA. In the second part, citations mentioning value judgments extracted from a systematic review on the integration of ethics into HTA were categorized to elicit the value judgments and their criteria for each different HTA decision-making steps. The results show that there are 18 decision-making steps in the HTA process where 23 implicit value-judgments can be recognized. The range of these value judgments encompasses the whole HTA process: from the initial request, the presenting of the principal issues, to the final report’s dissemination. Since stakeholders need to understand which value judgments the conclusion of a report relies on, eliciting the implicit value judgments in the HTA decision-making process should yield more transparency. (shrink)

Child assent is recommended in addition to parental consent when enrolling children in clinical research; however, appreciation and relevance ascribed to these concepts vary in different contexts, and information on attitudes towards storage of biological samples for future research is limited, especially in developing countries. We assessed caregivers’ understanding and appreciation of consent and assent procedures, and their attitudes towards use of stored blood samples for future research prior to enrolling a child in clinical research. A total of 17 in-depth (...) interviews were conducted with primary caregivers of children at enrolment or on the immediate follow-up date. All caregivers recalled significant amount information from the study information sheet and were able to appropriately link such information to the consent process. While all participants confirmed information received prior to blood sampling as adequate, a few noted that the purpose was not sufficiently well communicated. Caregivers felt children were cognitively vulnerable, and prone to decisions that were not necessarily in their best interest. Nearly all caregivers felt it was their right and responsibility to overrule objections from their ward’s regarding enrolment into specific study or receipt of a therapeutic procedure. There were no objections or concerns regarding use of stored biological samples for future research purposes. There is thus, a need to improve understanding of caregivers on the information provided during the informed consent process. Context-specific studies on the age of assent in specific populations are needed. (shrink)

For Descartes, minds were essentially non-extended things. Contemporary cognitive science prides itself on having exorcised the Cartesian ghost from the biological machine. However, it remains committed to the Cartesian vision of the mental as something purely inner. Against the idea that the mind resides solely in the brain, advocates of the situated and embodied nature of cognition have long stressed the importance of dynamic brain-body-environment couplings, the opportunistic exploitation of bodily morphology, the strategic performance of epistemically potent actions, the (...) generation and use of external representations, and the cognitive scaffolding provided by artifacts and social-cultural practices. According to the “extended mind” thesis, a significant portion of human cognition literally extends beyond the brain into the body and its environment. My goal in this book is to clarify the nature and scope of this thesis, and to defend its central insight that cognition is not confined to the boundaries of the biological individual. (shrink)

This paper examines selected writings of the American science writer Waldemar Kaempffert, Science Editor for the New York Times, in public support of Otto Neurath, his Isotype projects, and his Unity of Science Movement. Attention is focused first on Kaempffert’s writings in the 1930s, when some intellectuals, the American public, and their elected leaders were relatively sympathetic with Neurath’s quest to unify the sciences in ways that would advance and direct scientific research toward practical goals. Attention then turns to (...) the 1940s to examine the debate over the nature, scope, and limits of wartime research and Vannevar Bush’s call for a national institution to support research. Against Bush, James Bryant Conant, and others, Kaempffert argued vigorously for a foundation that would adopt values and methods of the Unity of Science Movement, but he lost that argument as the National Science Foundation finally took shape. To suggest that this public debate influenced not only the decline of Neurath’s Unity of Science Movement but the scholarly development of history and philosophy of science after the war, the paper considers early writings and events in the life of Conant’s protégé Thomas Kuhn, whose Structure of Scientific Revolutions helped shape that development. (shrink)

<Hylas> It is indeed something unusual; but my thoughts were so taken up with a subject I was discoursing of last night, that finding I could not sleep, ...

Early life stress precedes alterations to neuro-immune activation, which may mediate an increased risk for stress-related psychiatric disorders, potentially through alterations of central kynurenine pathway metabolites, the latter being relatively unexplored. We hypothesized that ELS in a non-human primate model would lead to a reduction of neuroprotective and increases of neurotoxic KP metabolites. Twelve adult female bonnet macaques reared under conditions of maternal variable foraging demand were compared to 27 age- and weight-matched non-VFD-exposed female controls. Baseline behavioral observations of (...) social affiliation were taken over a 12-week period followed by the first cerebrospinal fluid sample. Subjects were then either exposed to a 12-week repeated separation paradigm or assigned to a “no-RSP” condition followed by a second CSF. We used high-performance liquid chromatography for kynurenine, tryptophan, 5-hydroxyindoleacetic acid, kynurenic acid, and anthranilic acid as a proxy for quinolinic acid determination. At baseline, social affiliation scores were reduced in VFD-reared versus control subjects. CSF log KYNA and log KYNA/KYN ratio were lower in VFD-reared versus control subjects. CSF log KYNA/KYN was positively correlated with CSF log ANTH in VFD only. Controlling for log KYNA/KYN, log ANTH was elevated in VFD-reared subjects versus controls. CSF log KYNA/KYN obtained post-RSP was positively correlated with mean social affiliation scores during RSP, specifically in VFD. ELS is associated with a reduced neuroprotective and increased neurotoxic pathway products. That the two contrasting processes are paradoxically correlated following ELS suggests a cross-talk between two opposing KP enzymatic systems. (shrink)

The will has generated a wider range of opinions than most phenomena, lacking as it does both an animal model and consistent behavioral correlates. It has even been held not to exist. The commentators approached my intertemporal bargaining (picoeconomic) model from many angles. Doubts about the existence of the underlying phenomenon, hyperbolic discounting, were still raised by some, but other commentators added to the evidence for it, which I regard now as overwhelming. Where mechanisms of self-control were specified, (...) I found it possible to place them within a picoeconomic framework. (shrink)

In 1984 we reported the results of surveying a nationwide sample of college students about selected business ethics issues. We concluded that (a) college students were in general concerned about the issues investigated and (b) female students were relatively more concerned than were male students. The present study replicated our earlier study and not only corroborated both of its conclusions, but also found a higher level of concern than had been observed previously.

Do our lives have meaning? Should we create more people? Is death bad? Should we commit suicide? Would it be better if we were immortal? Should we be optimistic or pessimistic? Life, Death, and Meaning brings together key readings, primarily by English-speaking philosophers, on such 'big questions.'.

Nigeria has over 57% of its population as youths. The nation is rich in human and mineral resources, yet the level of youth unemployment continues to rise and to pose serious socio-economic and political threats. The aim of this study was to highlight the strong link between the high level of youth unemployment and the rising tide of violence and criminalization of the public space in Nigeria. In other words, we argued that the youth routinely took out their frustrations in (...) violent and criminal forms. The study was set in Aba, city of Abia state, which is arguably the largest commercial town in the south-east region of Nigeria. It is also synonymous with violent and criminal social breakdowns. This empirical study adopted a multi-phase sampling technique for the data collection procedure, including the distribution of questionnaires, extensive library research and personal observation. By implication, both primary and secondary sources were used. The results show that youth unemployment was on the increase and government efforts alone were inadequate to solve the problem. In conclusion, the all-hands-on-deck approach was advocated. This entailed that the visibility of the church at almost every level of community life, especially at the grass-root level must be used as a vital platform to reach the people. Thus, it was recommended that the church should actively tap into the multifarious professional capacities of her members and use them as resource persons to creatively tackle the problem of youth unemployment.Contribution: This article contributes to the concept ‘faith seeking understanding’. It includes a systematic and practical reflection, within a paradigm in which the intersection of social sciences and theology generates a transdisciplinary contested discourse. (shrink)

Forty-five children between the ages of nine and twelve years, who were forced to flee their native Sudan and seek refuge in Egypt, were interviewed about their everyday life in Cairo. Phenomenological analyses of the transcripts revealed the physical, social and technological dimensions to their encounter with a new cultural world. The interviews also revealed the extent to which the children had to face racism, discrimination and social exclusion. Specific analyses of children’s difficulties in learning a new form (...) of Arabic and their involvement in play and games indicated that a refugee child develops his or her self-identity as a stranger by reflecting on particular confrontations with the new environment. Finally, comparative analyses across age groups led to the construction of a phenomenological-developmental model of the child refugee. Both the model and the findings are discussed in the context of Alfred Schutz’s (1964a) essay The Stranger, George Herbert Mead’s (1967) communicative model of the self and Binnie Kristal-Andersson’s (2000) psychological framework for understanding migration. (shrink)

In the April 2008 issue (volume 69, issue number 2) of the Journal of the History of Ideas, George Cotkin published his article, "History's Moral Turn." Four essays responding to Cotkin's article, written by Neil Jumonville, Michael O'Brien, James Livingston, and Lewis Perry, were also published in the April 2008 issue. In this essay, "A Conversation about Morals and History," Cotkin addresses the critiques of each of these four historians.

How did I come to non-reductive neurophilosophy? Let me sketch my biography a little. When I was young, I always wanted to study philosophy, the basic questions of the world, humans and the mind fascinated me – going down to the bottom of things. However, I did not want to study philosophy in isolation from the science. My fascination was and still is on the mind and specifically subjectivity as core feature of the mind. Subjectivity and mind are obviously key (...) topics in philosophy. However, having grown up from the mid/end of the 20 th century allowed me to also study the mind empirically and thus to complement philosophy by science. At my time there were no neuroscience programs yet. Hence, the only way to study the brain and its connection to the mind was to go into medicine which I did parallel to my philosophy studies. ER -. (shrink)

The move from the modern to the present requires a new paradigm for philosophical thought. The Eurocentric modern times were marked by individualism, objectivism, and a secularism. The encounter with the East now opens religious and interior horizons which for Huntington promised a clash of civilizations. The alternative for these global times is to broaden the philosophical paradigm by thinking now in terms of the whole, opening human subjectivity, and thereby enabling a hermeneutics of mutual understanding and cooperation for (...) a global community. (shrink)

BackgroundThe emergence of artificial intelligence (AI) in medicine has prompted the development of numerous ethical guidelines, while the involvement of patients in the creation of these documents lags behind. As part of the European PROFID project we explore patient perspectives on the ethical implications of AI in care for patients at increased risk of sudden cardiac death (SCD).AimExplore perspectives of patients on the ethical use of AI, particularly in clinical decision-making regarding the implantation of an implantable cardioverter-defibrillator (ICD).MethodsSemi-structured, future scenario-based (...) interviews were conducted among patients who had either an ICD and/or a heart condition with increased risk of SCD in Germany (n = 9) and the Netherlands (n = 15). We used the principles of the European Commission’s Ethics Guidelines for Trustworthy AI to structure the interviews.ResultsSix themes arose from the interviews: the ability of AI to rectify human doctors’ limitations; the objectivity of data; whether AI can serve as second opinion; AI explainability and patient trust; the importance of the ‘human touch’; and the personalization of care. Overall, our results reveal a strong desire among patients for more personalized and patient-centered care in the context of ICD implantation. Participants in our study express significant concerns about the further loss of the ‘human touch’ in healthcare when AI is introduced in clinical settings. They believe that this aspect of care is currently inadequately recognized in clinical practice. Participants attribute to doctors the responsibility of evaluating AI recommendations for clinical relevance and aligning them with patients’ individual contexts and values, in consultation with the patient.ConclusionThe ‘human touch’ patients exclusively ascribe to human medical practitioners extends beyond sympathy and kindness, and has clinical relevance in medical decision-making. Because this cannot be replaced by AI, we suggest that normative research into the ‘right to a human doctor’ is needed. Furthermore, policies on patient-centered AI integration in clinical practice should encompass the ethics of everyday practice rather than only principle-based ethics. We suggest that an empirical ethics approach grounded in ethnographic research is exceptionally well-suited to pave the way forward. (shrink)

In this article, we investigate how the concept of Care Biography and related concepts are understood and operationalised and describe how it can be applied to advancing our understanding and practice of holistic and person‐centred care. Walker and Avant's eight‐step concept analysis method was conducted involving multiple database searches, with potential or actual applications of Care Biography identified based on multiple discussions among all authors. Our findings demonstrate Care Biography to be a novel overarching concept derived from the conjunction of (...) multiple other concepts and applicable across multiple care settings. Concepts related to Care Biography exist but were more narrowly defined and mainly applied in intensive care, aged care, and palliative care settings. They are associated with the themes of Meaningfulness and Existential Coping, Empathy and Understanding, Promoting Positive Relationships, Social and Cultural Contexts, and Self‐Care, which we used to inform and refine our concept analysis of Care Biography. In Conclusion, the concept of Care Biography, can provide a deeper understanding of a person and their care needs, facilitate integrated and personalised care, empower people to be in control of their care throughout their life, and help promote ethical standards of care. (shrink)

First published in 1897 in the avant-garde journal Jugend, Simmel’s fairy tale tells the story of the emergence of a sense of grievance about differences in the ability to grow roses which became constructed as a ‘terrible inequality’. Although moves were made to address this inequality so that everyone became able to grow roses, differences remained in how well different rose gardens grew, which in turn came to be perceived as an equally oppressive form of inequality. A translator’s note (...) outlines the significance of the text for the sociological analysis of inequality and the pursuit of equality, placing it in the context of related theories of inequality, recognition, distinction, the narcissism of minor differences, and ressentiment. (shrink)

The history of the early phenomenological movement involves a tale of two schisms. The Great Phenomenological Schism originated between 1905 and 1913, as many of his contemporaries, for example, Pfänder, Scheler, Reinach, Stein, and Ingarden, rejected Husserl’s transformation of phenomenology from the descriptive psychology of his Logical Investigations into the transcendental idealism of his Ideas I. The Phenomenological-Existential Schism started between 1927 and 1933, as with Being and Time Heidegger moved away from Husserl’s transcendental phenomenology of consciousness toward an ontological (...) analytic of existence. Yet these schisms were not unrelated developments. Closely following the documentary evidence to determine the exemplary nature of Heidegger’s critique of Husserl’s move into transcendental idealism, this essay establishes the inextricable linkage between the Great Phenomenological Schism and the Phenomenological-Existential Schism. (shrink)

Previous studies with adult participants have investigated reasoning from one or two uncertain premises with simple deductive arguments. Three exploratory experiments were designed to extend these results by investigating the evaluation of the plausibility of the conclusion of "combined" arguments, i.e. arguments constituted by two or more "atomic" standard arguments which each involved the same conclusion and one uncertain premise out of two. One example is "If she meets Nicolas it is very improbable she will go to the swimming (...) pool; if she meets Sophie it is very probable she will go to the swimming pool; she meets Nicolas; she meets Sophie". With two conflicting arguments, one supporting and one unfavourable, participants chose a compromise stance (Exp. 1), unless the thematic content of the premises allows one to consider one argument as more important than the other (Exp. 3). With two favourable arguments and rather unfamiliar materials, two typical behaviours appeared. One consisted in choosing a degree of plausibility of the conclusion that is intermediate between the modals asserted in the premises, and the other in choosing a more favourable degree than the most favourable modal (Exp. 1). The plausibility of the conclusion increased when the number of supporting atomic arguments increased from one to three, and decreased when the number of unfavourable arguments increased (Exp. 2). Theoretical implications are discussed and a model is sketched. (shrink)

People are often inaccurate in their predictions of performance on a variety of cognitive tasks. We tested whether receptivity to bullshit – the tendency to perceive meaningless statements as profound – would relate to the accuracy of metacognitive judgments on several problem-solving tasks. Individuals who were highly receptive to bullshit were less accurate in their predictions of performance on creative problem-solving tasks, but not on verbal analogy or recall tasks. Further, individuals with high BS receptivity were less (...) able to discriminate between solvable and unsolvable problems when making metacognitive judgments. These findings support the possibility that the tendency to perceive semantic connections where none exist, as indicated by high bullshit receptivity, may lead to inaccurate predictions of performance on tasks that require noticing and utilizing distant semantic connections. (shrink)