Multiple studies show that periodic reanalysis of genomic test results held by clinical laboratories delivers significant increases in overall diagnostic yield. However, while there is a widespread consensus that implementing routine reanalysis procedures is highly desirable, there is an equally widespread understanding that routine reanalysis of individual patient results is not presently feasible to perform for all patients. Instead, researchers, geneticists and ethicists are beginning to turn their attention to one part of reanalysis—reinterpretation of previously classified variants—as a means of (...) achieving similar ends to large-scale individual reanalysis but in a more sustainable manner. This has led some to ask whether the responsible implementation of genomics in healthcare requires that diagnostic laboratories routinely reinterpret their genomic variant classifications and reissue patient reports in the case of materially relevant changes. In this paper, we set out the nature and scope of any such obligation, and analyse some of the main ethical considerations pertaining to a putative duty to reinterpret. We discern and assess three potential outcomes of reinterpretation—upgrades, downgrades and regrades—in light of ongoing duties of care, systemic error risks and diagnostic equity. We argue against the existence of any general duty to reinterpret genomic variant classifications, yet we contend that a suitably restricted duty to reinterpret ought to be recognised, and that the responsible implementation of genomics into healthcare must take this into account. (shrink)

Volume 20, Issue 3, March 2020, Page 88-90.

Part I of Frege’s Grundgesetze is devoted to the “exposition [Darlegung]” of his formal system.

We look at recent accounts of the indefinite extensibility of the concept set and compare them with a certain linguistic model of indefinite extensibility. We suggest that the linguistic model has much to recommend over alternative accounts of indefinite extensibility, and we defend it against three prima facie objections.

The Igbo knowledge system articulated by Amaechi Udefi is insufficient to ensure knowledge progress as opposed to the system found in fallibilism theory. The reason is that there is a level of intellectual openness fallibilism theory guarantees that is not found in Udefi’s thought. This paper aims to do a comparative study of fallibilism theory and Udefi’s account of the Igbo knowledge system. The study also investigates to what extent each knowledge system can ensure knowledge growth and development. The significance (...) of this study is to highlight the importance of knowledge progress in the overall development of society. This paper argues that even though Udefi and Popper were reasoning from different cultural environments, Popper’s falsifiability theory is more open to knowledge progress than Udefi’s Igbo knowledge system. The expository, historical, comparative and evaluative methods were used. (shrink)

We give three counterexamples to the folklore claim that in an arbitrary theory, if a complete type p over a set B does not divide over $C\subseteq B$, then no extension of p to a complete type over $\operatorname {acl}(B)$ divides over C. Two of our examples are also the first known theories where all sets are extension bases for nonforking, but forking and dividing differ for complete types (answering a question of Adler). One example is an $\mathrm {NSOP}_1$ theory (...) with a complete type that forks, but does not divide, over a model (answering a question of d’Elbée). Moreover, dividing independence fails to imply M-independence in this example (which refutes another folklore claim). In addition to these counterexamples, we summarize various related properties of dividing that are still true. We also address consequences for previous literature, including an earlier unpublished result about forking and dividing in free amalgamation theories, and some claims about dividing in the theory of generic $K_{m,n}$ -free incidence structures. (shrink)

Groups are ubiquitous in our lives. But while some of them are highly structured and appear to support a shared intentionality and even a shared agency, others are much less cohesive and do not seem to demand much of their individual members. Queues, for example, seem to be, at a given time, nothing over and above some individuals as they exemplify a certain spatial arrangement. Indeed, the main aim of this paper is to develop the more general thought that at (...) a given time, a group is nothing over and above some individual members as they exemplify a certain complex condition. The general conception of groups that emerges is able to accommodate a variety of constraints on a reasonable answer to the question of what are groups. (shrink)

Between 1765 and 1767 Quesnay published Droit naturel and Despotisme de la Chine. I show that these texts are strongly related. I study their various versions and editions, some of which were previously poorly known, and attempt to evaluate their readership. I uncover a lost manuscript and neglected sources of Despotisme de la Chine which help to clarify various points about the text. It is shown that it was finished most probably well before the end of 1766. Its economic contents (...) are briefly described, whether they are similar to other writings of Quesnay or seem to alter his doctrine. It is suggested that Despotisme de la Chine was read by Adam Smith and that he took from it many lines on China found in Wealth of Nations. The paper ends with a proposal of a new edition of Droit naturel and Despotisme de la Chine. (shrink)

As it has historically been the case with many pandemics, the Covid-19 experience will induce many philosophers to reconsider the value of medical practice. This should be a good opportunity to critically scrutinize the way medical research and medical interventions are carried out. For much of its history, medicine has been very inefficient. But, even in its contemporary forms, a review of common protocols in medical research and medical interventions reveal many shortcomings, especially related to methodological flaws, and more importantly, (...) conflicts of interests due to profit incentives. In the face of these problems, we propose a program of “gentle medicine”. This term, originally formulated by philosopher Jacob Stegenga, describes a form of medicine in which physicians intervene less than they currently do. As part of this general program, we advance a series of reform recommendations that could be enacted both by medical staff in their everyday practice, but also by public health officials and policymakers. (shrink)

Plato and Xenophon: Comparative Studies contains a wide variety of comparative studies of the writings of Plato and Xenophon, from philosophical, literary, and historical perspectives.

Busca-se neste artigo apresentar, ainda que de forma panorâmica, algumas inferências sobre o estatuto da Ética no primeiro Wittgenstein, a partir da noção de análise completa da proposição e com base na teoria pictórica exposta no Tractatus. Tais inferências terão como plano de fundo a exposição que Wittgenstein faz em sua Conferência sobre a Ética, de 1929, onde o filósofo parece sustentar uma relação intrínseca entre juízos de valor ético e a perspectiva da primeira pessoa.

I present a puzzle for absolutely unrestricted quantification. One important advantage of absolutely unrestricted quantification is that it allows us to entertain perfectly general theories. Whereas most of our theories restrict attention to one or another parcel of reality, other theories are genuinely comprehensive taking absolutely all objects into their domain. The puzzle arises when we notice that absolutely unrestricted theories sometimes impose incompatible constraints on the size of the universe.

This article seeks to contribute to a vision for leadership in business based on a recovery of virtue. The vision for leadership articulated here draws principally on the writings of the classical philosopher Aristotle and of the contemporary philosopher Josef Pieper. Without discounting the ever-increasing complexity of modern business, this essay will attempt to reconstruct Aristotle’s emphasis on virtue and moral character, and argues for the philosopher’s relevance to modern management and corporate leadership. The paper concludes that the message of (...) virtue is a message of hope and attempts to find plain language to articulate its value to those engaged in business or concerned with the formulation of government policy. (shrink)

Business Ethics, the Environment &Responsibility, Volume 32, Issue S1, Page 1-3, April 2023.

The ArgumentThis paper argues that the development of the history of science as a discipline should be seen in the context of the bitter nineteenth-century conflict between religion and secular culture in Catholic countries. In this context, neo-Thomist theologians were interested in formulating a Catholic strategy of accommodation to modern science and to modern social systems that would also permit rejection of both modern social theory and the positivist theory of science. While theologians such as Cornoldi and Mercier worked with (...) the positivist image of science common in their day, Duhem opted to reformulate the conception of scientific theory. His religiously motivated assignment of a central place to the history of science – as the only way of hinting at the prospective rapprochement between the conventionalist sphere of scientific theory and the metaphysics of the real world – played a formative role in its development. Duhem's conception of the function of the history of science directed the attention of scholars in the field to medieval science as a point of origin for modern science. (shrink)

We study a case that applies hermeneutics to social sciences, in particular to the Austrian School of economics. We argue that an inaccurate treatment of hermeneutics contributed to an epistemological downgrade of the Austrian School in the economic scientific community. We discuss hoe this shortcoming can be fixed and how a proper hermeneutic application to the Austrian school explains why this school of thought is neither positivist nor postmodern.

In [12], Ernst Zermelo described a succession of models for the axioms of set theory as initial segments of a cumulative hierarchy of levelsUαVα. The recursive definition of theVα's is:Thus, a little reflection on the axioms of Zermelo-Fraenkel set theory shows thatVω, the first transfinite level of the hierarchy, is a model of all the axioms ofZFwith the exception of the axiom of infinity. And, in general, one finds that ifκis a strongly inaccessible ordinal, thenVκis a model of all of (...) the axioms ofZF. Doubtless, when cast as a first-order theory,ZFdoes not characterize the structures 〈Vκ,∈∩〉 forκa strongly inaccessible ordinal, by the Löwenheim-Skolem theorem. Still, one of the main achievements of [12] consisted in establishing that a characterization of these models can be attained when one ventures into second-order logic. For let second-orderZFbe, as usual, the theory that results fromZFwhen the axiom schema of replacement is replaced by its second-order universal closure. Then, it is a remarkable result due to Zermelo that second-orderZFcan only be satisfied in models of the form 〈Vκ,∈∩〉 forκa strongly inaccessible ordinal. (shrink)

Dao Cao Dai (Caodaism in English) is the third largest religion in Viet Nam (after Buddhism and Roman Catholicism).

We fix a family of actions A which represents the set of possible choices of the players in a game. A sequence (a1, ..., an) of actions represents the consecutive choices of the players, ai ∈ A.