Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other (...) diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors. (shrink)

Light of the Nations is a philosophical work written by the Jewish intellectual and eminent biblical commentator Obadiah Sforno (ca. 1475-1550). His treatise, an apology for both Jewish and universal monotheistic beliefs, was published in Hebrew in 1537 under the title Or 'Ammim and was translated by the author into Latin as Lumen Gentium in 1548. Written in the style of a classical medieval Scholastic summa, the treatise's multilingual and multicultural dimensions reveal key humanist ideas that prevailed in the cities (...) of northern Italy during the early modern period, while also speaking to its author's abiding exegetical rationality. (shrink)

The philosophical and exegetical oeuvre, biography and legacy of the Jewish-Italian Renaissance Rabbi Obadiah Sforno (c. 1475–1550) are revisited for the first time by international scholars presenting in-depth studies on the thoughts of a man “between two worlds”.