We present here the hypothesis that the unique microenvironmental pH landscape of acid‐base transporting epithelia is an important factor in development of epithelial cancers, by rendering the epithelial and stromal cells pre‐adapted to the heterogeneous extracellular pH (pHe) in the tumor microenvironment. Cells residing in organs with net acid‐base transporting epithelia such as the pancreatic ductal and gastric epithelia are exposed to very different, temporally highly variable pHe values apically and basolaterally. This translates into spatially and temporally non‐uniform intracellular pH (...) (pHi) patterns. Disturbed pHe‐ and pHi‐homeostasis contributes to essentially all hallmarks of cancer. Our hypothesis, that the physiological pHe microenvironment in acid‐base secreting epithelia shapes cancers arising in these tissues, can be tested using novel imaging tools. The acidic tumor pHe in turn might be exploited therapeutically. Pancreatic cancers are used as our prime example, but we propose that this concept is also relevant for other cancers of acid‐base transporting epithelia. (shrink)

While research on object individuation assumes that even very young children are able to perceive objects as particulars, we argue that the results of relevant studies can be explained in terms of feature discrimination. We propose that children start out navigating the world with a feature‐based ontology and only later become able to individuate objects spatiotemporally. Furthermore, object individuation is a cognitively demanding achievement resting on a uniquely human form of enculturation, namely the acquisition of deictic demonstratives. We conclude by (...) outlining empirical expectations for operationalizations of our proposal. (shrink)

What does the way we clarify and revise concepts reveal about the nature of concepts? This paper investigates the ontological commitments of conceptual analysis and explication regarding their supposed subject matter – concepts. It demonstrates the benefits of a cognitivist account of concepts, according to which they are not items on which the subject operates cognitively, but rather ways in which the subject operates. The proposed view helps to handle alternating references to ‘concepts’ and ‘terms’ in instructions on analysis and (...) explication. Furthermore, its virtue lies not in the capacity to render concepts ‘shareable’ but in its ontological parsimony. (shrink)

Fábio Alves dos Santos (1954-2013) cursou Pedagogia, Ciências Sociais e Teologia, era Especialista em Filosofia da Religião (PUC Minas), Advogado (PUC Minas) e Mestre em Direito Constitucional (UFMG). Lecionou na PUC Minas como professor de Cultura Religiosa e depois como professor no Curso de Direito, atuando principalmente no Serviço de Assistência Judiciária – SAJ, especialmente cuidado de causas populares como as da ASMARE (Associação dos Catadores de Papel, Papelão e Material Reaproveitável de Belo Horizonte), da Pastoral de Rua, da (...) Pastoral Carcerária, de movimentos de “Sem Casa”, de ocupações e tantos outros grupos. Fábio sofria de grave problema de visão há mais de 15 anos. Quase ficou cego depois de diversas cirurgias de miopia. Isso, porém, não o impedia de seguir seu constante compromisso com as lutas populares. Na última entrevista que concedeu, menos de um mês antes de sua morte (19 de outubro de 2013), depois de duro sofrimento de quase dois anos, no tratamento de um câncer no pâncreas, conta um pouco de sua vida, sua luta e sua percepção de várias realidades, especialmente da Igreja e da pastoral. Militante formado na Teologia da Libertação, de profunda espiritualidade, marcada por traços da religiosidade popular nordestina e comprometida com a libertação, Fábio Alves também buscou em sua vida abrir-se à teologia do pluralismo religioso, especialmente com o Santo Daime, em cuja tradição religiosa chegou a ser “fardado”, mantendo uma profunda atitude espiritual aberta ao diálogo inter-religioso. Sua primeira publicação foi “Começo de mundo novo: sofrimento, luta e vitória dos posseiros de Santana dos Frades”, Sergipe, numa versão popular em 1981 e outra pela Editora Vozes (1990). Fruto de sua dissertação de mestrado, publicou o livro “Direito Agrário: política fundiária no Brasil (1995). Em 2001 saiu seu último livro, uma coletânea de artigos publicados em diversos jornais: “Em defesa da vida”. Num artigo em Horizonte (2004), juntamente com o advogado, amigo e colega Prof. Cristiano de Melo Bastos, discutiu “A prática jurídica na missão da PUC Minas”. Palavras-chave : Teologia da Libertação. Militância. Igreja Católica. Pastoral. Lutas populares. (shrink)

This paper presents a proof of concept for a graphical models approach to assessing the moral coherence and moral robustness of systems of social interactions. “Moral coherence” refers to the degree to which the rights and duties of agents within a system are effectively respected when agents in the system comply with the rights and duties that are recognized as in force for the relevant context of interaction. “Moral robustness” refers to the degree to which a system of social interaction (...) is configured to ensure that the interests of agents are effectively respected even in the face of noncompliance. Using the case of conscientious objection of pharmacists to filling prescriptions for emergency contraception as an example, we illustrate how a graphical models approach can help stakeholders identify structural weaknesses in systems of social interaction and evaluate the relative merits of alternate organizational structures. By illustrating the merits of a graphical models approach we hope to spur further developments in this area. (shrink)

In this paper, I start with the opposition between the Husserlian project of a phenomenology of the experience of time, started in 1905, and the mathematical and physical theory of time as it comes out of Einstein’s special theory of relativity in the same year. Although the contrast between the two approaches is apparent, my aim is to show that the original program of Husserl’s time theory is the constitution of an objective time and a time of the world, starting (...) from the intuitive giveness of time, i.e., from time as it appears. To show this, I stress the structural similarity between Husserl’s original question of time and the problem of a phenomenology of space constitution as it was first developed in the his manuscripts from the nineteenth century, in which we find the threefold question of the origin of our representation of space, of the geometrization of intuitive space, and of the constitution of transcendent world space. Finally, I reconsider some of Husserl’s main theses about the phenomenological constitution of objective time in light of the main results of special relativity time-theory, introducing several corrections to central assumptions that underlie Husserl’s theory of time. (shrink)

The term ‘speciesism’ was once coined to name discrimination against nonhuman animals as well as the bias that such discrimination expresses. It has sparked a debate on criteria for being morally considerable and the relative significance of human and nonhuman animals’ interests. Many defenses of the preferential consideration of humans have come with a denial of the normative meaning of the term ‘speciesism’ itself. In fact, defenders of the moral relevance of species membership and their critics alike have often used (...) ‘speciesism’ as a merely descriptive technical term for classifying positions in normative ethics. This paper argues that this terminological choice severely impoverishes our ethical vocabulary and moral conceptual scheme. It obscures the considerable common ground among theorists with differing views on the relevance of various properties for moral consideration. It is often overlooked that even most defenders of the preferential treatment of one’s fellow species members have good reason to hold on to the normative notion that ‘speciesism’ was originally meant to be. Two distinct types of concepts are involved when differential treatment along species lines is addressed in a normative and a descriptive way, respectively. The term ‘speciesism’ should be reserved for the normative concept and kept apart from the descriptive term ‘speciescentrism.’ Attempts to redefine speciesism as something that is not wrong by definition are shown to be epistemically and morally harmful for the same reasons attempts to redefine racism and sexism in this way are. (shrink)

Frauke Albersmeier | : In Zoopolis, Donaldson and Kymlicka dismiss the abolitionist, or extinctionist approach in animal rights theory as insufficient in its theoretical foundation and disproportional regarding the means it promotes to prevent domesticated animals from suffering abuse by humans. Among the consequences of their counterproposal—granting domesticated animals citizenship—is an increased pressure to justify any interference with domesticated animals’ reproductive activities. This paper attempts to give such justification with reference to domesticated animals’ specific state of vulnerability, but also (...) takes into account the interest of the mixed society to prevent overly demanding obligations. Even while recognizing existing domesticated animals as citizens, humans might be unable to fully meet their obligation to protect the most dependent of them, and therefore might be justified in conditionally subscribing to “extinctionism” and limiting these animals’ reproduction to the point of their ultimate extinction. Therefore, rather than upholding a strict opposition between extinctionism in any form and a political framework for animal rights, out of reasonable concern for the well-being of domesticated animals in the societies they have been placed in, a qualified extinctionist approach should be incorporated into the political framework developed in Zoopolis. | : Dans Zoopolis, Donaldson et Kymlicka rejettent l’approche abolitionniste, ou extinctionniste, de la théorie du droit des animaux. Ils estiment que ses fondements théoriques sont insuffisants et que les mesures qu’elle promeut pour protéger les animaux domestiques des abus des humains sont disproportionnées. Leur contre-proposition – qui accorde la citoyenneté aux animaux domestiques – a plusieurs conséquences, parmi lesquelles un renforcement de la justification de toutes les formes d’ingérence dans la reproduction des animaux domestiques. Cet article tente de justifier pareille ingérence en raison de l’état particulier de vulnérabilité des animaux domestiques, mais tient également compte du fait que la société mixte a intérêt à éviter l’établissement d’obligations trop exigeantes. Cependant, les humains peuvent accorder aux animaux domestiques existant un statut de citoyen tout en s’avérant incapables de remplir pleinement leur obligation de protéger les plus dépendants d’entre eux. Ils pourraient par conséquent être justifiés de souscrire de manière conditionnelle à « l’extinctionnisme » et limiter la reproduction de ces animaux jusqu’à leur extinction. C’est pourquoi, au lieu de maintenir une opposition stricte entre l’extinctionnisme sous toutes ses formes et l’élaboration d’un cadre politique pour le droit des animaux, l’on devrait, par souci du bien-être des animaux domestiques dans les sociétés dans lesquelles ils vivent, insérer une approche extinctionniste conditionnelle dans le cadre politique élaboré dans Zoopolis. (shrink)

John Stuart Mill (1806-1873) gehört im angelsächsischen Raum seit jeher zu den Klassikern der Ideengeschichte. Aber auch im deutschsprachigen Raum wird er immer stärker rezipiert: Viele seiner Hauptschriften wurden neu editiert, sein Denken erfreut sich über die disziplinären Grenzen hinweg bis hinein in die Feuilletons wachsender Aufmerksamkeit. Das liegt nicht zuletzt an Mills ungewöhnlich undogmatischer Denkhaltung, die sich in der Berücksichtigung und Synthese verschiedenster Denkrichtungen niederschlägt. Seine Schriften zeugen von einem differenzierten Blick auf gesellschaftspolitische Zusammenhänge, was sie auch für moderne (...) Debatten vielfältig anschlussfähig macht. Das Handbuch stellt John Stuart Mills Leben, die wichtigsten Einflüsse auf sein Denken, sein Werk und die zentralen Konzepte sowie die Rezeption seines Denkens im Rahmen unterschiedlicher Diskurse vor. (shrink)

Disney's Zootopia (2016) is a crime story about the involuntary partnership between Judy Hopps, the first rabbit police officer in the city of Zootopia, and Nick Wilde, a red fox making his living as a con artist. What makes Zootopia a utopia and the city of Judy's dreams is that it appears to be “where anyone can be anything.” Zootopia confronts people with three utopian ideals: of security and social order, of individual self‐determination and fulfillment, and of a just multispecies (...) society. Zootopia begins with the founding myth that tells the story of how the animals overcame an anything‐but‐ideal natural state, in which prey animals lived in constant fear of predators. Zootopia is too much of a metaphor for human ways of life to be a utopian human‐animal society, and too “messy” to count as a metaphoric utopia for humans. (shrink)

Journal of Philosophy of Education, EarlyView.

This paper is concerned with the ethics of popularizing moral philosophy. In particular, it addresses the question of whether ethicists engaged in public debates should restrict themselves to acting as impartial informants or moderators rather than advocates of their own moral opinions. I dismiss the idea that being an impartial servant to moral debates is the default or even the only defensible way to publicly exercise ethical expertise and thus, to popularize moral philosophy. Using a case example from the public (...) debate about the human use of nonhuman animals, I highlight the benefits and risks of endorsing an advocate’s and a teacher’s or moderator’s role, respectively. I argue for a general requirement of judgment transparency which entails that the publicly engaged philosopher ought to be clear and consistent about the type of role she takes on, her publicly advanced opinions generally ought to be her professional ones and that she ought to flag her private opinions. I finally show that, despite general concerns about conflicts of interest, exercising ethical expertise and engaging in advocacy, i.e., acting as if one were a moral expert, are not incompatible modes of public engagement for the moral philosopher. (shrink)

English summary: John Stuart Mill is not a classical proponent of liberalism, who wanted to reduce the scope of state competency to a minimum. The present work depicts Mill as a very versatile and unorthodox thinker, whose social revisions of the idea of the laissez-faire state gave his concept of the state connectivity to contemporary society. The individual studies discussed in this meaning of those particular aspects of Millian thought, which reject classical liberal doctrine. The background of the criticism of (...) the neoliberal social order also appears in this volume with valuable contributions for the current discourse. German description: John Stuart Mill ist kein klassischer Vertreter des Liberalismus, der die Staatstatigkeit auf ein Minimum reduzieren will. Der vorliegende Band zeigt Mill als ausserst vielseitigen und undogmatischen Denker, dessen soziale Korrekturen am Konzept des liberalen Nachtwachterstaates seinen Staatsbegriff auch heute noch anschlussfahig machen. Die einzelnen Beitrage diskutieren in diesem Sinne insbesondere diejenigen Aspekte des Mill'schen Denkens, die ueber die klassisch liberale Lehre hinaus weisen. Hier finden sich gerade auch vor dem Hintergrund der Kritik an neoliberalen Ordnungsvorstellungen wertvolle Anregungen fuer aktuelle Diskurse. (shrink)

Die vorliegende Arbeit beschaftigt sich mit einem theoretischen Ansatz innerhalb der Semantik, der bisher in Europa wenig Zuspruch fand: die Prototypensemantik. Die Autorin weist nach, dass metaphorische Redewendungen sehr wohl strukturiert und vollstandig mit Mitteln moderner empirischer Forschung analysiert werden konnen. Vor allem soll diese Arbeit als Anstoss verstanden werden, neue Wege in der Semantik zu gehen. Diese ist eine Disziplin, in der eben nicht nur rein sprachwissenschaftliche Erkenntnisse und Methoden Verwendung finden sollten, da sie die Verbindung zwischen Sprache, Mensch (...) und Welt darstellt. Es ist daher notwendig, die Sprache in ihrem 'naturlichen' Zusammenhang zu betrachten.". (shrink)

Academic and public debates are increasingly concerned with the question whether and how algorithmic decision-making may reinforce social inequality. Most previous research on this topic originates from computer science. The social sciences, however, have huge potentials to contribute to research on social consequences of ADM. Based on a process model of ADM systems, we demonstrate how social sciences may advance the literature on the impacts of ADM on social inequality by uncovering and mitigating biases in training data, by understanding data (...) processing and analysis, as well as by studying social contexts of algorithms in practice. Furthermore, we show that fairness notions need to be evaluated with respect to specific outcomes of ADM systems and with respect to concrete social contexts. Social sciences may evaluate how individuals handle algorithmic decisions in practice and how single decisions aggregate to macro social outcomes. In this overview, we highlight how social sciences can apply their knowledge on social stratification and on substantive domains of ADM applications to advance the understanding of social impacts of ADM. (shrink)

Many Europeans are concerned about the living conditions of farm animals because they view animals as beings that possess interests of their own. Against this background the introduction of an animal welfare label is being intensively discussed in Europe. In choosing a market-based instrument to take these concerns into account, normative judgments are made about the formation of preferences, the value system that is implicitly assumed, and the distribution of property rights. From the perspective of classical institutional economics it can (...) be shown that the introduction of a label as an institutional change does not redefine institutions in a way that allows them to consider the interests of animals for their own sake. Rather, the label only redefines the property rights that humans have over animals. The market segregation into privileged and normal animals conflicts with the idea of equality between sentient animals. Within the group of humans only the interests of those who act on markets count. The commodification of their moral concerns assumes that people always decide based on their own interests, which can be traded off. The lexicographical ordering of preferences, which occurs when humans view animals as entities with rights, is not compatible with the normative assumptions of markets. Furthermore, interpreting animal suffering as market failure that can be corrected by labeling impedes a reasoned dialog within the society about the values and beliefs that serve as a basis for preference formation. Thus, an animal welfare label cannot replace a fundamental societal debate about legal standards on animal well-being. (shrink)

Rodrigo Borges (2020, 2017) argumenta que os supostos casos de conhecimento via falsidade não são casos nos quais o status epistêmico da crença-alvo p dependa de uma crença falsa e, ainda assim, concede que a crença em p é uma instância de conhecimento. O objetivo deste artigo é analisar essa alegação. Para isso, iniciarei explicando o que é o problema do conhecimento via falsidade e, na sequência apresentarei a proposta concessiva de Rodrigo Borges. Por fim, argumentarei que essa proposta não (...) é adequada por não acomodar todos os supostos casos de conhecimento via falsidade. (shrink)

We argue that objectivity is acquired by learning to refer to particular situations, that is, by developing episodicity. This contrasts with the widespread idea that genericity is crucial in developing humans’ ability to conceive of an objective world. According to the collective intentionality account, objectivity is acquired by contrasting one’s particular perspective in the “here and now” with a generic group perspective on how things are generally. However, this line of argument rests on confusing two independent notions of genericity: social (...) and worldly genericity. Holding these two notions apart shows that there is no coherent developmental route from episodicity to objectivity via genericity. In effect, the collective intentionality account presupposes objectivity. Alternatively, episodicity may develop by enculturation into the common practice of spatial-indexical use. This ability establishes an initial, socially shared spatiotemporal reference system comprising the basis for objectivity. (shrink)

The current understanding of cognitive development rests on the premise that infants can individuate objects early on. However, the so-called object-first account faces severe difficulties explaining extant empirical findings in object individuation tasks while alternative, more parsimonious explanations are available. In this paper, we assume that children start as feature-thinkers without being able to individuate objects and show how this ability can be learned by thinkers who do not already implicitly possess the notion of an object. Based on Tugendhat's ideas (...) on the relation between singular terms and object reference, we argue that spatial indexicals comprise the fundamental means of object individuation and describe how feature thinkers might acquire the complex substitutional system of spatial indexicals. In closing, two accounts of object cognition that do not rely on symbolic capacities, namely Pylyshyn's FINST indexes and Burge's perceptual objectivity, are critically discussed. (shrink)

Face à la nouvelle sensibilité de l'homme contemporain envers les questions écologiques, à l’importance qu’il accorde au soin de la planète, et dans le sillage de la publication de Laudato Si’, la vision de Teilhard de Chardin apparaît à nouveau actuelle. Bien que les questions et l’état des sciences aient changé considérablement depuis sa mort en 1955, la portée cosmologique de la christologie teilhardienne fait de la perspective du jésuite paléontologue une source inespérée pour une pratique chrétienne adaptée aux exigences (...) du monde moderne. À partir de sa notion d’Église en tant que Corps cosmique du Christ, où toutes les créatures de notre vaste univers sont englobées au sein de la sphère ecclésiale elle-même, la communion entre les êtres s’étend au-delà des êtres humains, fondant un profond respect pour toutes les créatures. Le présent ouvrage cherche à préciser et à justifier, d’un côté, l’insertion de Teilhard au sein de la tradition chrétienne et à envisager, d’un autre, les conséquences pratiques de cette ecclésiologie écologique, notamment dans la spiritualité, l’éthique et la liturgie. Andreas Gonçalves Lind est un prêtre jésuite luso-allemand qui, pour le moment, fait une thèse doctorale sur la phénoménologie henryenne de la Vie à l’Université de Namur comme boursier de la FCT – Fundação para a Ciência e Tecnologia (Portugal). (shrink)

The ability to refer to objects – singular reference – is arguably the decisive innovation on the way to human propositional cognition. This article argues that object individuation requires singular reference because basic singular terms, namely spatial indexicals, provide a symbolic frame of reference for object individuation. The authors suggest that singular reference is intrinsically connected to essential characteristics of propositionality: among other things, it guarantees the situation-independence of meaning, allows for the distinction between truth and falsehood, and enables us (...) to think about possibilities. The authors sketch how singular reference gives rise to the development of predication, the powerful logical tool of quantification, and forms the basis for differentiating between belief and desire. (shrink)

The object of this paper is to show how one is able to construct a paraconsistent theory of models that reflects much of the classical one. In other words the aim is to demonstrate that there is a very smooth and natural transition from the model theory of classical logic to that of certain categories of paraconsistent logic. To this end we take an extension of da Costa''sC 1 = (obtained by adding the axiom A A) and prove for it (...) results which correspond to many major classical model theories, taken from Shoenfield [5]. In particular we prove counterparts of the theorems of o-Tarski and Chang-o-Suszko, Craig-Robinson and the Beth definability theorem. (shrink)

Pope Jorge Mario Bergoglio released the "Encyclical Laudato Si': on the care of common home" on June 18, 2015, the same day that the National Oceanic and Atmospheric Administration has shown that the temperature of Earth continues increasing and that May of 2015 was Earth's warmest month, since 1880. By endorsing the scientific knowledge in relation to anthropogenic factors on global warming and by defending actions to confront the causes of climate change and ecosystem degradation, the Holy See has taken (...) a key step to put Catholics at the forefront of global ecological struggle and to encourage the signing of the global treaty to replace the Kyoto Protocol at the 21st Conference of the Parties, that will take place in December in Paris. But the encyclical of Pope Francis proposes a larger task that is to protect the poorest of the poor countries, addressing jointly the human environment and the natural environment from the perspective of an integral ecology. The purpose of this paper is to analyze the advances and limitations of the propositions of the encyclical Laudato Si ' and to expand the dialogue on gender relations and deep ecology. (shrink)