Sickle cell haemoglobin polymerization reduces erythrocyte deformability, causing deleterous vaso-occlusions. The double-nucleation model states that polymers grow from HbS aggregates, the nuclei, in solution , onto existing polymers . When linearized at initial HbS concentration, this model predicts early polymerization and its characteristic delay-time :591–610, 611–631, 1985). Addressing its relevance for describing complete polymerization, we constructed the full, non-linearized model . Here, we compare the simulated outputs to experimental progress curves . Within 10% from start, average root mean square deviation (...) between simulated and experimental curves is 0.04 ± 0.01 . Conversely, for complete progress curves, averaged rms is 0.48 ± 0.04. This figure is improved to 0.13 ± 0.01 by adjusting heterogeneous pathway parameters : the nucleus stability , and the fraction of polymer surface available for nucleation , from 5e−7, to 13 . Similar results are obtained at 37°C. We conclude that the physico-chemical description of heterogeneous nucleation warrants refinements in order to capture the whole HbS polymerization process. (shrink)

"Der Beitrag verhandelt den Begriff des Muts und beginnt diese Verhandlung ausgehend von der Frage, wie eine Kategorie, die die Geschichte der Philosophie zu durchziehen scheint, gegenwärtig an Relevanz und Einfluss verlieren kann. Er identifiziert den Grund dafür in der aristotelischen Bestimmung des Muts als männlich-militärischer Tugend und setzt dieser Bestimmung in der Folge eine Neubestimmung entgegen, die zu denken versucht, was weiblicher Mut sein kann. The paper discusses the concept of courage, starting from the question of how it is (...) possible that a category, which seems to permeate the history of philosophy, currently loses its relevance and influence. It identifies the rea- son for this in the Aristotelian definition of courage as a male and military virtue, and subsequently confronts it with a new definition, trying to imagine what female courage could be like. ". (shrink)

Name der Zeitschrift: Der Islam Jahrgang: 93 Heft: 2 Seiten: 585-588.

Certain artworks are––whatever else they are––statements about the value of art. A particularly striking form of such a statement is made by a class of artworks we can call “high-cost art.” High-cost artworks are those with greater costs relative to benefits for their artists or displayers. I will argue here that those art forms that are most likely to include high-cost works are particularly effective at communicating artistic value-claims, and suggest that by so championing the value of art, these artworks (...) themselves increase in artistic value. (shrink)

What is responsibility? -- Being responsible -- Being responsible in your community.

One of the most important lesson to be learned from the corona pandemic might be, that it makes a difference which normativity sets the norms for our way of living. It makes no small difference to the life of humans and society, whether this normativity is prophylactic or pedagogical. Disease, insecurity and death are faithful companions of the pandemic; and prophylactic reason rules in times of such critical occurences. In such times it might occur that pedagogy so to speak falls (...) into the hands of prophylaxis, thus turning pedagogy into a handmaid of prophylaxis. The essay problematizes this through non-simultaneous specula principum rooted in the ancient art of medicine and living. (shrink)

Introduction -- The Complexity of Resource Curse -- Resource Curse as a Complex Case of Global Justice -- General Theory of Global Justice -- The Robustness of the General Theory -- Conclusion.

The notion of world government is anathema to most political theorists. This is the case due to the arguments that a world government is infeasible, undesirable and unnecessary. This threef...

What steps are needed to make life better and more convivial? The Second Convivialist Manifesto has presented a short diagnosis of the current crises and sketches of a possible and desirable future. It has been a necessary work of theoretical synthesis, but preserving a viable world also requires passion. It is thus urgent to show what people would gain from a shift to a post-neoliberal and post-growth convivialist future. This volume includes a theoretical debate on convivialism which reflects dystopias and (...) shows the multiple and major obstacles that convivialism will have to face. Mainly, however, the contributors to this volume create sketches of a convivial future and collect accounts of another future world which is attractive for as many as possible. (shrink)