Background: Evidence suggesting adverse drug reactions often emerges unsystematically and unpredictably in form of anecdotal reports, case series and survey data. Safety trials and observational studies also provide crucial information regarding the (un-)safety of drugs. Hence, integrating multiple types of pharmacovigilance evidence is key to minimising the risks of harm. Methods: In previous work, we began the development of a Bayesian framework for aggregating multiple types of evidence to assess the probability of a putative causal link between drugs and side (...) effects. This framework arose out of a philosophical analysis of the Bradford Hill Guidelines. In this article, we expand the Bayesian framework and add “evidential modulators,” which bear on the assessment of the reliability of incoming study results. The overall framework for evidence synthesis, “E-Synthesis”, is then applied to a case study. Results: Theoretically and computationally, E-Synthesis exploits coherence of partly or fully independent evidence converging towards the hypothesis of interest (or of conflicting evidence with respect to it), in order to update its posterior probability. With respect to other frameworks for evidence synthesis, our Bayesian model has the unique feature of grounding its inferential machinery on a consolidated theory of hypothesis confirmation (Bayesian epistemology), and in allowing any data from heterogeneous sources (cell-data, clinical trials, epidemiological studies), and methods (e.g., frequentist hypothesis testing, Bayesian adaptive trials, etc.) to be quantitatively integrated into the same inferential framework. Conclusions: E-Synthesis is highly flexible concerning the allowed input, while at the same time relying on a consistent computational system, that is philosophically and statistically grounded. Furthermore, by introducing evidential modulators, and thereby breaking up the different dimensions of evidence (strength, relevance, reliability), E-Synthesis allows them to be explicitly tracked in updating causal hypotheses. (shrink)

La fundamental idea orteguiana de que «mi vida» es «razón», difiere radicalmente de la concepción fenomenológica de la razón que alumbra Husserl en Ideen, esencialmente fundada en el ser. La razón vital es teoría del hombre, que es su proyecto circunstancial; su estímulo argumental procede de una reflexión estética sobre todo orientada a la comprensión del realismo y del idealismo artísticos, y cuyas consecuencias filosóficas serán decisivas.

La experiencia de la pobreza llama a la economía a humanizarse y a la filosofía a pensar etimológicamente desde las “normas de la casa”. Se descubre, entonces, el sentido de las épocas y de las generaciones filosóficas, la razón de su fecundidad y de su pobreza, así como la relación entre estas y la justicia.

Multidimensional theories of well-being are locked into a debate about value judgment. They seek to settle which dimensions should matter for measurement and policy, and, more importantly, on what grounds to decide what should matter. Moreover, there is a gulf between theory and practice, given that measurement and policy are rarely rooted in a coherent ethical framework. Our paper engages in the debate concerning the legitimate grounds for selecting dimensions. Combining Amartya Sen's capability approach and John Rawls’ method of political (...) constructivism, we explore whether the constitution and its public culture can be used as an ethically sound informational base for selecting dimensions, and if so, why. We apply this ‘constitutional approach’ to the Italian case with the aim of deriving a set of publicly justifiable dimensions of well-being. It is a long-standing Constitution with broad public consultation at its base, which still enjoys a wide consensus. We seek to show why there is a need for more ethically sound methodological approaches to measuring well-being, pointing out the advantages of the constitutional approach, and how it may enrich the work of practitioners engaged in the policies of well-being. (shrink)

. This article analyses some of the anatomical waxes in the Museo della Specola in Florence. Executed in at least two different periods in the history of Florentine wax modelling, they project culturally determined images of the body which are analysed from a historico-semiotic perspective. “Rotten corpses,” a “disembowelled woman” and a “flayed man” emerge as salient figures in the collection and reveal the close tie between anatomical representations and aesthetics, social relations and religious scruples, in other words, the culture (...) tout court which produced them. (shrink)

The right to ‘domestic remedies’, which ideally connects ‘subsidiarity’ and ‘embeddedness’ of the ECHR in the legal systems of member States, is deemed to play a crucial role for the Strasbourg machinery survival as well as for an effective protection of human rights, especially in the field of the ‘reasonable-time’ requirement. In this respect the Italian case seems an excellent test. Once a compensatory remedy was introduced in the Italian legal system by Law No. 80 of 2001 (the ‘Pinto Act’), (...) it soon appeared that such a remedy could be considered ‘effective’ in so far as it was implemented in accordance with the ECtHR’s jurisprudence. Therefore a legal tool for the interaction between ECtHR and Italian courts had to be found. Nevertheless, the results of this interaction might suggest that the domestic remedy has neither increased the protection of the reasonable-time requirement in Italy nor is it the final solution to the ECtHR’s overload. (shrink)

BackgroundPositive psychosocial factors can play an important role in the development of cardiovascular disease. Among them, psychological resilience is defined as the capacity of responding positively to stressful events. Our aim was to assess whether PR is associated with CVD or metabolic disturbances through a systematic review.MethodsWe gathered articles from PubMed, Web of Science, PsycInfo, and Google Scholar up to October 28, 2021. We included articles that were in English, were observational, and had PR examined as exposure. The CVD outcomes (...) were either clinical or metabolic outcomes.ResultsOur literature search identified 3,800 studies, of which 17 met the inclusion criteria. Of them, seven were longitudinal and 10 cross-sectional, and 13 were on adults and four on children. The exposure assessment was heterogeneous, i.e., 12 studies used different kinds of self-administered questionnaires and five used interviews with a psychologist. Regarding outcomes, five studies investigated CVD, seven obesity, one metabolic syndrome, two hypertension, four dyslipidemia, and four diabetes. In longitudinal studies, PR was found to have an inverse association with included outcomes in five studies from the Swedish military conscription cohort but had no association with CVD in a study on African-American women and was associated with slower progression of diabetes in a general population. The cross-sectional studies showed that the prevalence of disease was not associated with PR in many cases but the progression of disease was associated with PR.ConclusionPR seems to have a possibly favorable association with CVD and metabolic disturbances that differs according to the type of outcome and population. Our study limitations are given by the small number of studies available and the heterogeneity in PR measurement.Systematic Review Registration[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=237109], identifier [CRD42021237109]. (shrink)

La filosofía de Brentano, más conocida por introducir el antiguo concepto de intencionalidad para distinguir los fenómenos psíquicos de los físicos, acaba siendo una peculiar metafísica en que el objeto es función de la actividad autoperceptiva del sujeto. Los conceptos de juicio como reconocimiento y de conciencia secundaria como percepción interna tienen un papel fundamental en este proceso, porque establecen, desde el comienzo de su doctrina, un ámbito de realidad indudable en que se cumple el concepto clásico de verdad como (...) adaequatio rei et intellectus; si bien con un sentido esencialmente original porque el perceptor resulta ser, a la vez, el percibido. Finalmente, pasando por una comparación con la fenomenología, podremos comprender que esta nueva relación que introduce Brentano entre sujeto y objeto se acerca a las concepciones pragmatistas, anticipando, en su sentido más profundo, importantes cambios filosóficos del existencialismo del siglo XX y de la razón vital. (shrink)

What is life, and where does it come from? The question is very old, but it reemerged in the seventeenth century with the crisis of the Aristotelian-Galenic paradigm. Matter was now stripped of any impulse and capacity for self-organization; therefore, it was necessary to find something that would take into account the strength and information that it seemed to hold, especially in what were considered vital phenomena. Georg Ernst Stahl and Friedrich Hoffmann, both professors in Halle and responsible for two (...) of the most famous medical systems of the first half of the eighteenth century, offered solutions to the problem that only appear to be very different. The first invoked the soul as an ideal place of production of the energy that allowed the human body to fight the putrefactive forces in the natural world; the second referred to the concept of ether, to which he attributed modes of action basically similar to those that tradition attributed to vegetative and sensitive souls. This paper highlights the positions of the two physicians, setting them in the climate of the revisitation of ancient certainties that characterized natural philosophy in the seventeenth and eighteenth centuries. (shrink)

«Hermeneutic» means interpretation, that is, looking from a point of view. In this study we try to interpret from the vital reason, the method of Ortega y Gasset, his and his disciple Julián Marías, the Aristotelian concept of «substance». If life is the radical reality, as Ortega stresses, and the person its programmatic realization, in Marías’ opinion, a vital reason of the concept of οὐσία, means to discover its capacity to understand human life. We will find, as a matter of (...) fact, that there are four limits, essentially, that distance the philosopher from that comprehension. By them, we will find the core of the greatest contradictions of the Aristotelian thought, that has been subject to intense critics throughout its history. We will concern, especially, on the function of language in the Greek conception of reason, on the interpretations that brought to «being» and «entity» as Aristotle’s thought starting point «Hermenéutica» significa interpretar, mirar desde un punto de vista. En este estudio buscamos interpretar desde la «razón vital», el método de Ortega y Gasset y su discípulo Julián Marías, el concepto aristotélico de «sustancia». Si la vida es la realidad radical, como afirma Ortega, y la persona es su realización programática, según entiende Marías, una razón vital de la οὐσία significa descubrir su capacidad de comprensión para con la vida humana. Encontraremos, entonces, que hay esencialmente cuatro límites que desvían de esa comprensión; mediante ellos, habremos encontrado el núcleo de importantes contradicciones del pensamiento aristotélico que han sido objeto de encendidos debates a lo largo de la historia. Nos centraremos, sobre todo, en la función del lenguaje en la concepción de la razón griega, en los supuestos interpretativos del «ser» y del «ente» como puntos de partida del pensamiento de Aristóteles . (shrink)

The Excellency of a Free State by Marchamont Nedham was remarkably successful in revolutionary Europe. The French edition produced in Paris in 1790 by Theophile Mandar was later used for an Italian translation, published in early 1798 in Milan, at the time of the Cisalpine Republic, by Pietro Custodi. The biographies of the two translators – both engaged in the radical politics of their time – suggest some considerations on how first one and then the other thought they could make (...) use of Needham’s text. Mandar translated Nedham to suggest the fragility of English political culture in the face of the long road travelled instead by French political philosophy. Custodi’s translation was the opposite of Mandar’s, as it showed instead all the uncertainties that in Milan could lead to the loss of liberty. In both cases, in one translation as in the other, very little remained of Nedham, because his words were used to develop a different discourse, where the translations in another language – and in a quite different context – played the role of an instrument to validate theses constructed elsewhere and established in another political framework. (shrink)

A pesar de los matices y variaciones de significado, el concepto husserliano de intencionalidad no deja de estar al servicio de la idea clásica de la verdad como adaequatio, finalmente adaptada al orden monádico de la conciencia trascendental. Veremos, sin embargo, que en los análisis de Husserl sobre la conciencia interna del tiempo se manifiesta toda la dificultad para interpretar intencionalmente la esfera pasiva de la conciencia, peligrando la peculiar vocación a la verdad de la misma intencionalidad. Intentaremos, mediante las (...) últimas ideas husserlianas sobre la constitución eidética, encontrar una génesis pasiva del sentido ideal intencional sin perder su referencia egológica. Abstract: Despite the nuances and differences of meaning, the husserlian’s concept of intentionality supplies coherently that of classic true as adaequatio, even if adapted to the monadic order of transcendental conscience. We will show how Husserl’s analysis of inner time consciousness shows all the difficulties for an intentional interpretation of the passive sphere of consciousness, altering the peculiar vocation of intentionality to truth. Through the latest husserlian ideas on constitution, we will try to find a passive genesis to the ideal meaning of intentionality without losing its egologic reference. -/- . (shrink)

. The subject of this paper is Georg Ernst Stahl's reflections on epilepsy. In the German physician's work, the concept of disease is stratified: it is the morbid idea which causes dysfunctions in the animal economy, as well as irregular motion, overabundance and ultimately an alteration of the corporeal humours. In particular, epilepsy is an affection deriving from an altered functioning of the bodily motions, caused by abnormal blood flow, intestinal worms, anatomical defects, foreign bodies, and the passions of the (...) soul. While a certain medical tradition attributed a nervous origin to epilepsy, Stahl, giving it a humoural genesis, openly shows the theoretical premises on which his physiology rests. So, Stahlian physiology appears to be a non-mechanistic, teleological-inspired, hydraulicism. (shrink)

For a better understanding of Julián Marías’ Metaphysic Antropology, it is recommendable going back to the Ortega’s mereology, epistemology and metaphysic, especially in order to clarify the meaning of “structure”, “system”, “organ” and “function”. The vital reason is personal project as the systematic openness to its circumstance, whose unitary, empirical and structural structure is “man”.

En approfondissant la pensée d'Ortega, nous découvrons que la métaphysique est une science de la réalité radicale, du sens et un mode de vie. Nous verrons que la réalité radicale est la vie individuelle et que le sens de la raison vitale est personnel, ce qui implique un changement dans la conception traditionnelle du sujet, de l'objet et de la vérité.

Le problème du temps chez Michel Henry n’a pas encore fait l’objet d’une étude séparée. Le rejet abrupt de cette question chez l’auteur n’a certainement pas favorisé l’intérêt des critiques pour ce sujet. Dans un premier temps, en 1963 dans L’Essence de la manifestation , Michel Henry considère le problème du temps (à travers le filtre du Kantbuch de Heidegger) comme étant le « même » que celui de la récepti­vité, soit en le renvoyant à l’auto-affection. Celle-ci étant comprise comme (...) opposée ou, mieux encore, comme « étrangère » au kantisme, en tant qu’elle est affection pathétique de soi à soi. Puis, en 2000, dans Incarnation , Michel Henry conteste au « flux temporel » des Leçons pour une conscience intime du temps de Husserl la volonté néantisante du moment présent, tout en l’utilisant subrepticement dans des moments clés de son argumentation ; il lui oppose le sens de l’ « apparaître » s’auto-fondant. Enfin, nous proposons de reprendre les concepts henryens d’ « effort » et de « pouvoir-toucher », présents dans la deuxième partie d’ Incarnation , pour penser une « origine de l’espacement » préalable à la pensée de la tempora­lité ek-statique comme à celle de l’espace. (shrink)

This paper deals with the dialectic “nature/culture” in the thought of José Ortega y Gasset and related to the ideas of salvation and tragedy. Justify the elaboration of his article in the fact that this topic has not been studied in-depth through the complete works of the philosopher of the vital reason. The results/conclusions are the following ones: In a first period, it stands out the primate of culture in Ortega´s thought, who considers the last one as saviour and also (...) as something antagonistic in relation to the more instinctive and irrational nature of the individual human being as a member of humanity. We can say that submission to natural inclinations, that symbolize our barbarous, irrational and savage side, appears in Ortega’s early writings as a form of tragedy or “radical evil” ; on the other hand, in his latter thought those ones will be interpreted by Ortega not in negative terms, but as something in continuity with culture, which can became a form of tragedy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:“It’s not true, but I believe it”: Discussions on jettatura in Naples between the End of the Eighteenth and Beginning of the Nineteenth CenturiesFrancesco Paolo de CegliaIntroduction: What is Jettatura?Non èvero...ma ci credo (“It’s not true... but I believe it”) is the title of a comedy by the Italian actor and playwright, Peppino De Filippo, younger brother of the more famous Eduardo, which was staged for the first time (...) in 1942. The narrated events take place in the twentieth century and concern Gervasio Savastano, a Neapolitan businessman who is tormented by the fear of jettatura. The character, victim of grotesque events, first sacks a worker, believing him to be a jettatore, and then hires another, who is a hunchback and so should bring him good luck. In the end, however, it is discovered that the presumed jettatore has never harmed anyone and that the hunchback is not what he seems: he has stuffed his jacket in order to enter into the good graces of the gullible businessman and marry his daughter, with whom he has planned a con trick. The “lucky” events ascribed to his presence can therefore be considered casual. The epilogue? In keeping with the logic of compromise, typical of the brothers De Filippo’s theater, even though the character is rationally convinced of the unfounded nature of his beliefs, he remains adamant: “It’s not true, but I believe it” in other words.1 [End Page 75]“Where I come from, jettatura rules,” wrote the journalist and scriptwriter Giuseppe Marotta in 1947. Indeed, it is still a part of popular Neapolitan culture today.2 Often confused with similar beliefs, such as fascination (fascino) and the evil eye (malocchio), jettatura assumed its present form between the end of the eighteenth and beginning of the nineteenth century, at a time when a polite debate on its nature was taking shape in the city. In this period, the epistemological pluralism animating the discussions was translated into a variety of interpretative hypotheses and literary genres, in which grotesque atmospheres and spirited quips also found room, all perfectly in line with what could be considered the Weltanschauung of Savastano. It is the purpose of this article to examine these discussions, which even spread the term abroad and, with it, the “local color” of the concept.Nineteenth-century European writers on jettatura knew the Neapolitan authors well, and either quoted them explicitly or associated them with characters whose names were a deformation of real people’s: for example, Volitta for Valletta (Stendhal), don Jo (Stendhal) or Ojori (Dumas) for De Jorio. They explained that jettatura corresponded to the more familiar evil eye, but they left the term in Italian, as if to underline the fact that it was untranslatable.Is jettatura a mere anthropological issue, linked to a “primitive” culture, in the face of which official science would remain refractory? A belief that could not be exported or shared by those educated in more “highly developed” contexts? Well, in part, yes. Nevertheless, in the 1840s there was a visitor to Naples who expressed himself in the following terms: “When a foreigner arrives in Naples, at first he laughs at jettatura, then, little by little, he becomes troubled by it, and finally, after a stay of three months, you will see him covered in horns and with his right hand forever clenched [to ward off evil].”3 [End Page 76]So wrote the novelist Alexandre Dumas, père, one of the many travellers who, after having completed the Grand Tour of southern Italy, decided to describe its picturesque scenes and backward customs.4 Creating a veritable topos of travel literature, in the same period the philologist Karl August Mayer commented, “often foreigners let themselves be influenced” by local “superstitions.”5 Indeed many of them were captivated by these Neapolitan beliefs, despite their desire to remain objective and detached; and so they were “converted,” and driven to seek scientific explanations, often after meeting “a Real Jettatore,” whose image had nothing in common with the exotic fantasies of “a French Novelist’s Idea of Jettatore.”6Actually, Dumas and Mayer probably exaggerated somewhat in order to make their descriptions more... (shrink)

The meaning of justice can be defined according to a juridical, human, theological, ethical, biomedical, or social perspective. It should guarantee the protection of life and health, personal, civil, political, economic, and religious rights, as well as non-discrimination, inclusion, protection, and access to care. In this review, we deal with three theoretical concepts that define justice in all its aspects. (1) The utilitarian theory, which justifies moral statements on the basis of the evaluation of the consequences that an action produces, (...) elaborating a pragmatic model of medical science. (2) The libertarian theory, which considers freedom as the highest political aim, thus absolutizing the rights of the individual; here, the principle of self-determination, with respect to which the principle of permission/consent is the fundamental presupposition, plays a central role in the definition of the person. (3) The iusnaturalist theory, in which man’s moral freedom is identified with the ability to act by choosing what the intellect indicates to him as good; the natural moral law that drives every conscience to do good is therefore realized in respect for the person in the fullness of his rights. In conclusion, different forms and conceptions of justice correspond to different organizations of society and different ways of addressing ethical issues in the biomedical domain. (shrink)

I. Sens du monisme Généalogie du terme et disparition ultérieure du « monisme ontologique » La critique formulée contre le monisme ontologique apparaît comme l’un des points majeurs constituant la grande originalité de L’essence de la manifestation, originalité qui se retrouve déjà dans la formation de l’expression en question (le syntagme « monisme ontologique »). Celle-ci semble ne pas avoir d’équivalent dans la tradition philosophique. Christian Wolff avait en premier élaboré ce terme (« m...

En los reproches que José Ortega y Gasset le hace a Martin Heidegger sobre el problema del ser, al afirmar que este no puede ser un ciego punto de partida, una creencia, se evidencia la distancia entre dos perspectivas unidas por el horizonte real que pretenden explorar: la vida humana. Sin embargo,..