This paper is devoted to introduce a novel fourth-order hyperchaotic system. The hyperchaotic system is constructed by adding a linear feedback control level based on a modified Lorenz-like chaotic circuit with reduced number of amplifiers. The local dynamical entities, such as the basic dynamical behavior, the divergence, the eigenvalue, and the Lyapunov exponents of the new hyperchaotic system, are all investigated analytically and numerically. Then, an active control method is derived to achieve global chaotic synchronization of the novel hyperchaotic system (...) through making the synchronization error system asymptotically stable at the origin based on Lyapunov stability theory. Next, the proposed novel hyperchaotic system is applied to construct another new hyperchaotic system with circuit deformation and design a new hyperchaotic secure communication circuit. Furthermore, the implementation of two novel electronic circuits of the proposed hyperchaotic systems is presented, examined, and realized using physical components. A good qualitative agreement is shown between the simulations and the experimental results around 500 kHz and below 1 MHz. (shrink)

In this paper, a novel no-equilibrium 5D memristive hyperchaotic system is proposed, which is achieved by introducing an ideal flux-controlled memristor model and two constant terms into an improved 4D self-excited hyperchaotic system. The system parameters-dependent and memristor initial conditions-dependent dynamical characteristics of the proposed memristive hyperchaotic system are investigated in terms of phase portrait, Lyapunov exponent spectrum, bifurcation diagram, Poincaré map, and time series. Then, the hidden dynamic attractors such as periodic, quasiperiodic, chaotic, and hyperchaotic attractors are found under (...) the variation of its system parameters. Meanwhile, the most striking phenomena of hidden extreme multistability, transient hyperchaotic behavior, and offset boosting control are revealed for appropriate sets of the memristor and other initial conditions. Finally, a hardware electronic circuit is designed, and the experimental results are well consistent with the numerical simulations, which demonstrate the feasibility of this novel 5D memristive hyperchaotic system. (shrink)

Narrow Band-pass filtering techniques have been a challenging task since the inception of audio and telecommunication applications. The challenge involves keeping quality factor, gain and mid-frequency of the filter independent of each other. The critical applications require a design that ensures mid-frequency immune to the circuit component tolerances. It becomes increasingly difficult for low-frequency applications where the shift in few Hz in mid-frequency would cause desired frequencies to fall outside the filter’s bandwidth and go undetected. The selection of right topology (...) of the filter for the best performance is the key to successful design. This book objectively compares the relative performance of none popular narrow band-pass filter topologies. The filter topologies are evaluated using a real-world practical example of designing an extremely narrow band-pass filter. The book provides guidelines for selecting the right topology for the low-frequency narrow band-pass filter. (shrink)

This commentary is intended to illuminate Gold's & Stoljar 's main contentions by exploiting a favorite comparison, namely, that between biology and electronics. Roughly, and leaving out Darwinian theory and the like, biology is physics and chemistry plus natural history just as electronics is physics plus wiring diagrams. Natural history contains generalizations, not laws. Psychology and cognitive science typically give more abstract explanations, as do “block diagrams” in electronics, and are less dispensable.

In this paper, we examine the pioneering research on electronic noise—the current fluctuations in electronic circuit devices due to their intrinsic physical characteristics rather than their defects—in Germany and the U.S. during the 1910s–1920s. Such research was not just another demonstration of the general randomness of the physical world Einstein’s work on Brownian motion had revealed. In contrast, we stress the importance of a particular engineering context to electronic noise studies: the motivation to design and improve high-gain (...) thermionic-tube amplifiers for radio and wired communications. Engineering scientists’ endeavors to understand electronic noise started in 1918, when Walter Schottky at Siemens formulated a theory of “shot noise,” current fluctuations owing to the random emissions of discrete electrons in a tube. Schottky’s theory was revised and experimentally tested at Siemens, General Electric, and AT&T during the 1920s, leading to the discoveries of several other types of noise and an increasing interest in the thermal fluctuations in electronic circuits. In 1925–1928, J.B. Johnson and Harry Nyquist at Bell Labs developed a theory of thermal noise for any electrical resistor at a non-zero temperature. Although these studies were initiated to chart the fundamental performance limit of electronic technology, they ended up assisting the empirical determination of individual electronic components’ characteristics. (shrink)

This paper is expected to introduce a novel memductor-based chaotic system. The local dynamical entities, such as the basic dynamical behavior, the divergence, the stability of equilibrium set, and the Lyapunov exponent, are all investigated analytically and numerically to reveal the dynamic characteristics of the new memductor-based chaotic system as the system parameters and the initial state of memristor change. Subsequently, an active control method is derived to study the synchronous stability of the novel memductor-based chaotic system through making the (...) synchronization error system asymptotically stable at the origin. Further to these, a memductor-based chaotic circuit is designed, realized, and applied to construct a new memductor-based secure communication circuit by employing the basic electronic components and memristor. Furthermore, the design principle of the memductor-based chaotic circuit is thoroughly analyzed and the concept of “the memductor-based chaotic circuit defect quantification index” is proposed for the first time to verify whether the chaotic output is consistent with the mathematical model. A good qualitative agreement is shown between the simulations and the experimental validation results. (shrink)

Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.

Dynamical analysis, chaos suppression and electronic implementation of the synchronous reluctance motor without external inputs are investigated in this paper. The different dynamical behaviors found in the SynRM without external inputs are illustrated in the two parameters largest Lyapunov exponent diagrams, one parameter bifurcation diagram, and phase portraits. The three single controllers are designed to suppress the chaotic behaviors found in SynRM without external inputs. The three proposed single controllers are simple and easy to implement. Numerical simulation results show (...) that the three proposed single controllers are effective. Finally, the dynamical behaviors found in the SynRM without external inputs and the physical feasibility of the three proposed single controllers are validated through circuit implementation on OrCAD-PSpice software. (shrink)

This book explains, in lay terms, the surprisingly simple system of mathematical logic used in digital computer circuitry. Anecdotal in its style and often funny, it follows the development of this logic system from its origins in Victorian England to its rediscovery in this century as the foundation of all modern computing machinery. ONES AND ZEROS will be enjoyed by anyone who has a general interest in science and technology.

Registration of a series of the two-dimensional electron microscope images of the brain tissue into volumetric form is an important technique that can be used for neuronal circuit reconstruction. However, complex appearance changes of neuronal morphology in adjacent sections bring difficulty in finding correct correspondences, making serial section neural image registration challenging. To solve this problem, we consider whether there are such stable "markers" in the neural images to alleviate registration difficulty. In this paper, we employ the spherical deformation model (...) to simulate the local neuron structure and analyze the relationship between registration accuracy and neuronal structure shapes in two adjacent sections. The relevant analysis proves that regular circular structures in the section images are instrumental in seeking robust corresponding relationships. Then, we design a new serial section image registration framework driven by this neuronal morphological model, fully utilizing the characteristics of the anatomical structure of nerve tissue and obtaining more reasonable corresponding relationships. Specifically, we leverage a deep membrane segmentation network and neural morphological physical selection model to select the stable rounded regions in neural images. Then, we combine feature extraction and global optimization of correspondence position to obtain the deformation field of multiple images. Experiments on real and synthetic serial EM section neural image datasets have demonstrated that our proposed method could achieve more reasonable and reliable registration results, outperforming the state-of-the-art approaches in qualitative and quantitative analysis. (shrink)

Giulio Tononi's integrated information theory (IIT) proposes explaining consciousness by directly identifying it with integrated information. We examine the construct validity of IIT's measure of consciousness,phi(Φ), by analyzing its formal properties, its relation to key aspects of consciousness, and its co-variation with relevant empirical circumstances. Our analysis shows that IIT's identification of consciousness with the causal efficacy with which differentiated networks accomplish global information transfer (which is what Φ in fact measures) is mistaken. This misidentification has the consequence of requiring (...) the attribution of consciousness to a range of natural systems and artifacts that include, but are not limited to, large-scale electrical power grids, gene-regulation networks, some electronic circuit boards, and social networks. Instead of treating this consequence of the theory as a disconfirmation, IIT embraces it. By regarding these systems as bearers of consciousnessex hypothesi, IIT is led toward the orbit of panpsychist ideation. This departure from science as we know it can be avoided by recognizing the functional misattribution at the heart of IIT's identity claim. We show, for example, what function is actually performed, at least in the human case, by the cortical combination of differentiation with integration that IIT identifies with consciousness. Finally, we examine what lessons may be drawn from IIT's failure to provide a credible account of consciousness for progress in the very active field of research concerned with exploring the phenomenon from formal and neural points of view. (shrink)

We present a new viable nonlinear chaotic paradigm. This paradigm has four nonlinear terms. The essential features of the new paradigm have been investigated. Our new system is confirmed to have chaotic behaviors by calculating its Lyapunov exponents. The relations of the system states are displayed by a suggested new signal flow graph. The proposed SFG is discussed via some graph theory tools, and some of its hidden features are calculated. In addition, the system is realized via constructing its (...) class='Hi'>electronic circuit which helps in the real applications. Also, a robust controller for the system is designed with the aid of a genetic algorithm. (shrink)

In an instant classic paper ; 2002: 179–182) biologist Yuri Lazebnik deplores the poor effectiveness of the approach adopted by biologists to understand and “fix” biological systems. Lazebnik suggests that to remedy this state of things biologist should take inspiration from the approach used by engineers to design, understand, and troubleshoot technological systems. In the present paper I substantiate Lazebnik’s analysis by concretely showing how to apply the engineering approach to biological problems. I use an actual example of electronic (...) circuit troubleshooting to ground the thesis that, in engineering, the crucial phases of any non-trivial troubleshooting process are aimed at generating a mechanistic explanation of the functioning of the system, which makes extensive recourse to problem-driven qualitative reasoning possibly based on cognitive artifacts applied to systems that are known to have been designed for function. To show how to translate these findings into biological practice I consider a concrete example of biological model building and “troubleshooting”, aimed at the identification of a “fix” for the human immune system in presence of progressing cancer, autoimmune disease, and transplant rejection. The result is a novel immune system model—the danger model with regulatory cells— and new, original hypotheses concerning the development, prophylaxis, and therapy of these unwanted biological processes. Based on the manifest efficacy of the proposed approach, I suggest a refocusing of the activity of theoretical biologists along the engineering-inspired lines illustrated in the paper. (shrink)

This paper focuses on philosophical toy objects and neo-pataphysicist disciplines, everyday resistance by futility and play. Contemporary electromagnetic toys, smart objects and the Internet of Things will be compared to the seventeenth-century Wunderkammer objects. Historic naturalia, objects and actual toy gadgetry will all be unveiled as alternate W.A.S.T.E. (Pynchon 1964) communications devices, among Habsburg peers. A proof of evidence for the functions of futile toys as resistance objects is given through the presentation of electronic circuit board designs as new (...) bachelor machines, chindogus (useless objects), subcutaneous Radio Frequency Bijoux (RFID-implants) and game fashion, as introduced by the author. But what are the consequences of the use of futile toys on the streets of everyday life? Do they entail a sustainable nascent practice in arts? Who is allowed to play with the electromagnetic parallel worlds? Do electronic toys offer a parallel communications system in their futility? What is the actual role of electronic toys in an inverse trajectory backwards to their harbingers, which are philosophical toys, jeux bijoux (blingblings to play with), Wunderkammer-toys (for peers to establish links with Potlatch-like gifts to tighten social relations) and the Ludic Spielzeug (a toy which empowers the player to recognize the futile toy as tool of resistance and backtalk to given economic and discourse order)? (shrink)

Chaotic dynamics can be related to analog computation. A possibility of electronically implementing the chaos -driven contracting system in the target article is explored with an analog electronic circuit with inevitable noise from the viewpoint of analog computation with chaotic neurons.

This paper examines two parallel discussions of scientific modeling which have invoked experimentation in addressing the role of models in scientific inquiry. One side discusses the experimental character of models, whereas the other focuses on their exploratory uses. Although both relate modeling to experimentation, they do so differently. The former has considered the similarities and differences between models and experiments, addressing, in particular, the epistemic value of materiality. By contrast, the focus on exploratory modeling has highlighted the various kinds of (...) exploratory functions of models in the early stages of inquiry. These two perspectives on modeling are discussed through a case study in the field of synthetic biology. The research practice in question explores biological control by making use of an ensemble of different epistemic means: mathematical models and simulations, synthetic genetic circuits and intracellular measuring devices, and finally electronic circuits. We argue that the study of exploratory modeling should trace the ways different epistemic means, in different materialities, are being combined over time. Finally, the epistemic status of such novel investigative objects as synthetic genetic circuits is evaluated, with the conclusion that they can function as both experiments and models. (shrink)

Rice Combinational and Sequential Logic This text provides a guide to combinational and sequential logic, introducing students to the basic concepts then progressing to HND/first year undergraduate level. It has a highly practical emphasis, enabling the reader to simulate, build and test the circuits discussed in the text. Electronics Workbench files are provided for simulation, while easy-to-use XPLA software and specially designed hardware encourage the reader to build and test the circuits using programmable logic. The text itself contains (...) many self-assessment questions, complete with detailed answers, allowing students to test themselves as they learn. No previous experience of the topic is required and an abundance of practical examples helps students to apply the basic principles. The accompanying CD-ROM provides the XPLA development system software and Electronics Workbench files, as well as the Xilinx Webpack development system and 'walkthrough'. Hardware for Programmable Logic experiments can either be purchased or built following instructions from the text. Altogether, the text, software and hardware provide an interactive and stimulating teaching and learning resource. F. (shrink)

A study is reported which focused on the problem-solving strategies employed by expert electronics engineers pursuing a real-world task: integrated-circuit design. Verbal protocol data were analysed so as to reveal aspects of the organisation and sequencing of ongoing design activity. These analyses indicated that the designers were implementing a highly systematic solution-development strategy which deviated only a small degree from a normatively optimal top-down and breadth-first method. Although some of the observed deviation could be described as opportunistic in nature, much (...) of it reflected the rapid depth-first exploration of tentative solution ideas. We argue that switches from a predominantly breadth-first mode of problem solving to depth-first or opportunistic modes may be an important aspect of the expert's strategic knowledge about how to conduct the design process effectively when faced with difficulties, uncertainties, and design impasses. (shrink)

Memristor is the fourth basic electronic element discovered in addition to resistor, capacitor, and inductor. It is a nonlinear gadget with memory features which can be used for realizing chaotic, memory, neural network, and other similar circuits and systems. In this paper, a novel memristor-based fractional-order chaotic system is presented, and this chaotic system is taken as an example to analyze its dynamic characteristics. First, we used Adomian algorithm to solve the proposed fractional-order chaotic system and yield a (...) chaotic phase diagram. Then, we examined the Lyapunov exponent spectrum, bifurcation, SE complexity, and basin of attraction of this system. We used the resulting Lyapunov exponent to describe the state of the basin of attraction of this fractional-order chaotic system. As the local minimum point of Lyapunov exponential function is the stable point in phase space, when this stable point in phase space comes into the lowest region of the basin of attraction, the solution of the chaotic system is yielded. In the analysis, we yielded the solution of the system equation with the same method used to solve the local minimum of Lyapunov exponential function. Our system analysis also revealed the multistability of this system. (shrink)

'Brainjacking’ refers to the exercise of unauthorized control of another’s electronic brain implant. Whilst the possibility of hacking a Brain–Computer Interface (BCI) has already been proven in both experimental and real-life settings, there is reason to believe that it will soon be possible to interfere with the software settings of the Implanted Pulse Generators (IPGs) that play a central role in Deep Brain Stimulation (DBS) systems. Whilst brainjacking raises ethical concerns pertaining to privacy and physical or psychological harm, we (...) claim that the possibility of brainjacking DBS raises particularly profound concerns about individual autonomy, since the possibility of hacking such devices raises the prospect of third parties exerting influence over the neural circuits underpinning the subject’s cognitive, emotional and motivational states. However, although it seems natural to assume that brainjacking represents a profound threat to individual autonomy, we suggest that the implications of brainjacking for individual autonomy are complicated by the fact that technologies targeted by brainjacking often serve to enhance certain aspects of the user’s autonomy. The difficulty of ascertaining the implications of brainjacking DBS for individual autonomy is exacerbated by the varied understandings of autonomy in the neuroethical and philosophical literature. In this paper, we seek to bring some conceptual clarity to this area by mapping out some of the prominent views concerning the different dimension of autonomous agency, and the implications of brainjacking DBS for each dimension. Drawing on three hypothetical case studies, we show that there could plausibly be some circumstances in which brainjacking could potentially be carried out in ways that could serve to enhance certain dimensions of the target’s autonomy. Our analysis raises further questions about the power, scope, and necessity of obtaining prior consent in seeking to protect patient autonomy when directly interfering with their neural states, in particular in the context of self-regulating closed-loop stimulation devices. (shrink)

The extent to which machine metaphors are used in synthetic biology is striking. These metaphors contain a specific perspective on organisms as well as on scientific and technological progress. Expressions such as “genetically engineered machine”, “genetic circuit”, and “platform organism”, taken from the realms of electronic engineering, car manufacturing, and information technology, highlight specific aspects of the functioning of living beings while at the same time hiding others, such as evolutionary change and interdependencies in ecosystems. Since these latter aspects (...) are relevant for, for example, risk evaluation of uncontained uses of synthetic organisms, it is ethically imperative to resist the thrust of machine metaphors in this respect. In addition, from the perspective of the machine metaphor viewing an entity as a moral agent or patient becomes dubious. If one were to regard living beings, including humans, as machines, it becomes difficult to justify ascriptions of moral status. Finally, the machine metaphor reinforces beliefs in the potential of synthetic biology to play a decisive role in solving societal problems, and downplays the role of alternative technological, and social and political measures. (shrink)

Focused on the field of knowledge lying between digital and analog circuit theory, this new text will help engineers working with digital systems shorten their product development cycles and help fix their latest design problems. The scope of the material covered includes signal reflection, crosstalk, and noise problems which occur in high speed digital machines (above 10 megahertz). This volume will be of practical use to digital logic designers, staff and senior communications scientists, and all those interested in digital design.

Oggi il libro elettronico imita il libro a stampa come i primi incunaboli imitavano i manoscritti, l’esplosione delle modalità di comunicazione elettroniche è altrettanto rivoluzionaria di quello che fu l’invenzione della stampa a caratteri mobili centinaia di anni fa, e il lettore contemporaneo ha altrettante difficoltà ad assimilare gli e-book di quante ne ebbero i lettori del Quattrocento a familiarizzare con gli incunaboli. Siamo in un periodo nel quale testo a stampa e testo digitale coesistono e sicuramente continueranno a farlo (...) per qualche altro tempo ancora. Non pretendiamo dunque a tutti i costi di analizzare in termini dualistici ( o carta o digitale ) un fenomeno che è ancora in corso e basandoci invece su quello che ci insegna la storia del libro proviamo piuttosto a riconoscere che oggi stiamo assistendo a un cambiamento che almeno per un verso è effettivamente inedito perché, per la prima volta nella storia, avviene simultaneamente su più piani, con la trasformazione contemporanea del supporto della scrittura, della tecnica della sua riproduzione, delle modalità della sua diffusione e infine dei modi di leggere. Tutto il circuito della comunicazione editoriale classicamente intesa è messo in discussione e con il digitale il mercato librario è destinato a crescere, ma attraverso una grande mutazione delle sue logiche di funzionamento. Today, the e-book imitate the printed book exactly as the first incunabula once imitated the manuscripts; the explosion of the electronic communication is just as revolutionary as it was the invention of the movable type printing hundreds of years ago; and the contemporary reader is facing, with the e-book, the same difficulty than the readers of the fifteenth century have had with the incunabula. We are in a period in which paper and digital definitely coexist and they surely will continue to do it for a few more years to come. So, rather than insisting on analyze in dualistic terms (or paper or digital) a phenomenon that is still in progress, and relying instead on what we learn from the history of the book, we should try to recognize that today we are witnessing a change that at least in one way is actually different because, for the first time in history, it takes place at the same time on several levels, with the simultaneously transformation of the writing's media , the technique of its reproduction, the way of its spread , and finally the practice of reading . The classic communication circuit is being revisited, and the editorial market is meant to grow in the digital era, but throughout a big change in its behavior. (shrink)

continent. 1.2 (2011): 92-93. A collection of Images produced by intentionally corrupting the circuitry of a Kodak DC280 2 MP digitalcamera. By rewiring the electronics of a digital camera, glitched images are produced in a manner that parallels chemically processing unexposed film or photographic paper to produce photographic images without exposure to light. The DCP Series of Digital Images are direct visualizations of data generated by a digital camera as it takes a picture. Electronic processes associated with the normal (...) operations of the camera, which are usually taken for granted, are revealed through an act of intervention. The camera is turned inside­out through complexes of short­circuits, selected by the artist, transforming the camera from a picture taking device to a data capturing device that renders raw data (electronic signals) as images. In essence, these images are snap­shots of electronic signals dancing through the camera's circuits, manually rerouted, written directly to the on­board memory device. Rather than seeing images of the world through a lens, we catch a glimpse of what the camera sees when it is forced to peer inside its own mind. With the digital photo, this light, from out of the night, no longer comes entirely from the day, it doesn't come from a past day that would simply have become night (like the photons emenating from Baudelaire's face.) It comes from Hades, from the realm of the dead, from underground: it is an electric light, set free by materials from deep within the belly of the earth. And electronic, that is to say, a decomposed light. Digitization breaks the chain, it introduces manipulation even into the spectrum, and by the same token, it makes phantoms and phantasms indistinct. Photons become pixels that are in turn reduced zeroes and ones on which discrete calculations can be performed. Essentially indubitable when it was analog (whatever its accidental manipulability), the this was has become essentially doubtful when it is digital (it is nonmanipulation that becomes accidental). —Bernard Steigler, The Discrete Image There are so many ways to take something apart. Deconstruction, differentiation, dissection, dissolution. A whole slew of concepts and processes towards atomization which aim, eventually, to evoke or locate an essence of some kind, in material science as in philosophy. In picking things apart, what is it we attempt to do? To simplify? To comprehend? To confront? To disprove? With Stearns’ DCP Series we see that destructive scrutiny can sometimes bring about new forms. To create this series of images, Stearns applies circuit bending techniques to modern photography—his fingers and stray wires cutting across the camera’s circuitry at the moment of registration. As with Moholy­Nagy’s vinyl records and Nam June Paik’s cathode ray TVs, Stearns deconstructs the technological inscription of his era. In so doing, the function of the digital camera is revealed, but its transduction inverted: A recorder becomes a synthesizer, the scientist an artist. In a single, simple gesture, these works example a media archeology of the present. We resist the urge to call these photographs. —Jamie Allen. (shrink)

At the most mundane level, CCTV observes bodies, and as such attaches great importance to the specific features of the human body. At the same time, however, bodies tend to disappear, as they are represented electronically by the camera monitors and, in the case of image recording, by the computer systems processing data. The roles of bodies(either as targets of surveillance or as translations into flows of disembodied information), however, are not unimportant or inconsequential, but may in fact give rise (...) to a number of tangible ethical dilemmas. Firstly, the virtual representation of the embodied actor is not a neutral, unproblematic process. Body representation techniques such as CCTV produce constructions of the subject that involve judgmental, discriminatory processes of categorisation and are based on asymmetrical relations between observers and observed. Secondly, the `data doubles' are not inconsequential: the representations of the body produced by CCTV can have palpable consequences for the embodied self and its life chances. The widespread use of CCTV could therefore give rise to individual as well as social issues, and possibly in a different manner than previous surveillance technologies. This fact signals the need for(re-)conceptualisations of moral values (such as privacy) applicable to the case of CCTV which take into account the importance of bodily protections. (shrink)

continent. 1.2 (2011): 76-77. Please click to listen to the mp3 files of deep brain recordings of individual brain cells, the smallest unit of the brain, in a whole, intact living brain. Each brain region’s cells possess an electrical signature. During recordings electrical signals are transformed into sound to facilitate auditory identification of cells during a process called “mapping.” Subthalamic nucleus by continent Cortex by continent Mapping is an important step in successfully identifying and localizing the appropriate target site in (...) the brain for an experimental therapeutic procedure called deep brain stimulation which has been used for patients with movement disorders and, more recently, for patients with psychiatric disorders. Thalamus by continent I have pursued a career as a neuroscientist for the past decade because I wanted to learn about the mind. In my most recent research, I record electrical activity from individual cells in the brain, and look at individual brain cells with a high resolution, electron microscope. Globus Pallidus (internal segment) by continent Globus Pallidus (external segment) by continent The closer I examine the brain, the less I learn about the mind. Rather, what has been most informative about the mind is how people—neuroscientists and non-neuroscientists alike—interpret neuroscience data. Some cognitive neuroscientists have proposed the qualities we hold most precious as humans, like morality and free will, exist only in the context of human interaction. Likewise, I propose that the mind does not exist in a vacuum and one’s mind only necessitates distinction in a social context, and the mind’s existence may only be relevant due to its relative relationships. In sum, bodies have brains. People have minds. Striatum by continent I invite readers to reflect on and/or refute these statements after listening to these recordings of the brain in action. These regions are part of the cortico-basal ganglia-thalamo-cortical circuit, which is thought to possess parallel, functionally segregated loops including a motor-movement circuit and limbic-emotional circuit which work together to generate behavior (e.g. motivated movements) and have been researched for their role in Parkinson’s disease as well as Obsessive Compulsive Disorder. EDITOR'S SUGGESTED RESOURCES Michael Gazzaniga's lecture, “Free Yet Determined and Constrained” at Edinburgh University Gifford Lectures in 19 October, 2009 is an excellent discussion of the field. It can be viewed on Edinburgh University's Youtube channel . The Cognitive Neuroscience of the Mind . Eds. Patricia A. Reuter-Lorenz, Kathleen Baynes, George R. Mangun, and Elizabeth A. Phelps. Cambridge: MIT Press. 2010. Print. (shrink)

Freely falling point-like objects converge toward the center of the Earth. Hence the gravitational field of the Earth is inhomogeneous, and possesses a tidal component. The free fall of an extended quantum mechanical object such as a hydrogen atom prepared in a high principal-quantum-number state, i.e. a circular Rydberg atom, is predicted to fall more slowly than a classical point-like object, when both objects are dropped from the same height above the Earth’s surface. This indicates that, apart from transitions between (...) quantum states, the atom exhibits a kind of quantum mechanical incompressibility during free fall in inhomogeneous, tidal gravitational fields like those of the Earth.A superconducting ring-like system with a persistent current circulating around it behaves like the circular Rydberg atom during free fall. Like the electronic wavefunction of the freely falling atom, the Cooper-pair wavefunction is quantum mechanically incompressible. The ions in the lattice of the superconductor, however, are not incompressible, since they do not possess a globally coherent quantum phase. The resulting difference during free fall in the response of the nonlocalizable Cooper pairs of electrons and the localizable ions to inhomogeneous gravitational fields is predicted to lead to a charge separation effect, which in turn leads to a large Coulomb force that opposes the convergence caused by the tidal gravitational force on the superconducting system.A “Cavendish-like” experiment is proposed for observing the charge separation effect induced by inhomogeneous gravitational fields in a superconducting circuit. The charge separation effect is determined to be limited by a pair-breaking process that occurs when low frequency gravitational perturbations are present. (shrink)

"Offering integrated coverage of both digital and computer design, this text offers well-organized, concise, yet comprehensive content, presented from a contemporary engineering viewpoint. Understanding of the material is supported by clear explanations and a progressive development of examples ranging from sample combinatorial applications to a CISC architecture built upon a RISC core. A thorough coverage of traditional topics is combined with increased attention to computer-aided design, problem formulation, solution verification, and the building of problem-solving skills."--BOOK JACKET.

This seminar report discusses the low-voltage current-mode analog circuits and their various aspects. The need of high speed, high performance, low power circuits because of the advent of the portable electronic and mobile communication systems and difficulties faced in achieving that in today’s scenario are presented. Current mode circuits are the best suited candidates for the above. Their advantages are discussed here and a comparison with the conventional voltage mode circuits has been presented. The principle (...) and the implementation of the most common current mode circuits i.e. the current conveyors, has been described. The basic device level techniques also play important role in the design of smarter and efficient circuits. Some of those techniques have also been discussed here. For illustration of these techniques, low power V-I converter using current mirrors and a low- voltage power efficient operational amplifier cell topology is presented. (shrink)

The very rapid developments in the field of computers in the last few years have made it possible to solve, with their aid, problems utterly new in character. The first "generation" of electronic computers, in the 1950's, was one of capricious and cumbersome vacuum-tube devices, but even it brought a fundamental change in our notions of the kind of tasks machines were capable of solving. The second "generation" - transistorized computers - is a substantial improvement. More compact and dependable, (...) these machines have come into wide use in the control of various processes. Today the third "generation" is in birth, consisting of microminiaturized computers employing solid-state circuits. Such computers are no larger than a small suitcase and it is supposed, not without reason, that in the future they will become pocket-size. It is clear that these possibilities create an utterly new situation. Whereas formerly there was still some validity in posing the question of a clear-cut division of functions between man and a large stationary computer that carried out certain calculations on his instructions, today the question of man-computer interaction takes the center of the stage. (shrink)

In this presentation we shall discuss the nature of mind vis-a-vis the brain and computers. Such a comparison presumes a general equivalence of brains and computers and models the brain as a huge biological computer, with consciousness added. The uniqueness of Mind in the lines of ancient Indian thought has been accpted as the basic concept in the analysis. Regarding the chief difference between mind and brain, material of the mind is taken to be subtle matter.The brain is made of (...) gross matter and is a part of the physical body. Considering the brain and the computer, the brain is a biological structure made of organic molecules, whereas computer chips are inorganic objects manufactured by etching circuits on the surface of silica chips. Thus the human brain, occupying volume, is a volumetric entity whereas a computer, as electronic circuitry on a silica chip, is an areal entity. This explains the vast processing power andexceptional capabilities of the human brain. (shrink)

This guide accompanies the following article(s): ‘Full Disclosure of the “Raw Data” of Research on Humans: Citizens’ Rights, Product Manufacturer’s Obligations and the Quality of the Scientific Database.’Philosophy Compass 6/2 (2011): 90–99. doi: 10.1111/j.1747‐9991.2010.00376.x Author’s Introduction Securing consent (and informed consent) from patients and research study participants is a key concern in patient care and research on humans. Yet, the legal doctrines of consent and informed consent differ in their applications. In patient care, the judicial doctrines of consent and informed (...) consent are disclosure doctrines based on the obligation of physicians to inform their patients of the following types of information: the nature of the procedure the physician is recommending in the patent’s care (P), the alternatives to the physician‐recommendation (A), and the risks of procedure and its alternatives (R). In addition, the physician must provide truthful answers to the patient’s questions (Q) to the best of the physician’s abilities. In research on humans, the onus of disclosure by study sponsors and principal investigators is much greater than in patient care precisely because the purpose of research is not patient care. The purpose of research is the identification and development of new generalizable knowledge. Thus, participation in a research study or trial may not benefit the study volunteer at all. In addition, the participant may carry a heavy risk burden in relationship to any testing of a newly designed drug or device as part of their experiences in the research study. Presently, despite the risks borne by the research study participant, the raw data collected from volunteers in research trials are treated by courts as if they were the private property of the study sponsor rather than generally owed to the public as would be expected by an effort like research participation aimed at contributing to the development of generalizable knowledge. This paper reviews the obligations that study sponsors owe to their study participants based on the very definition of research as a systematic activity whose purpose is to develop generalizable knowledge to help all humans. Author Recommends Court cases Canterbury v. Spence, United States Court of Appeals, District of Columbia Circuit 464 F.2d 772 (1972). (Federal appellate decision heard in the District of Columbia, USA) Reibl v. Hughes, 2 S.C.R. 880 (1980). (Supreme Court of Canada) Rogers v. Whitaker, 175 C.L. R. 479 (1992). (High Court of Australia) Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985) (House of Lords) Canterbury v. Spence is the landmark Federal informed consent case in the United States heard in the District of Columbia. In this case, Judge Spottswood Robinson articulated the reasonable person standard of informed consent. This standard was subsequently adopted by the Supreme Court of Canada (Reibl v. Hughes, 2 S.C.R. 880 (1980)) and the High Court of Australia (Rogers v. Whitaker, 175 C.L. R. 479 (1992)). The House of Lords rejected the reasonable person standard in England in Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985). Book Mazur, Dennis J. The Science and Ethics of Research on Humans. Baltimore, MD: Johns Hopkins University Press, 2007. This book is a detailed guide for the review of scientific and ethical aspects of research on humans contained in the research study protocols and research informed consent forms which need to be submitted by study sponsors and principal investigators to institutional review boards (IRBs) for IRB review before a research study can receive approval to be conducted within a human study population in those institutions over which the IRB has authority. It also presents basic definitions in the area of research on humans and basic approaches to help conduct a deep review of the underlying scientific and ethical issues that are present within a research study protocol and its accompanying research informed consent form. Report National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Guidelines for the Protection of Human Subjects of Research. Washington, DC: DHEW Publications, 1978 (78‐0012). This U.S. National Commission in the Belmont Report argued for the necessity of a reasonable volunteer standard in research on humans in the United States. Arguing that the professional standard and the reasonable person standard of consent and informed consent were insufficient to base a disclosure standard in research on humans, this National Commission developed the reasonable volunteer standard where a study participant is to be approached in research informed consent with that information that a reasonable volunteer would want to know. Online Materials Belmont Report: Syllabus Topics for Lecture and Discussion Week I: Introduction and Overview Readings: Rogers v. Whitaker, 175 C.L.R. 479 (1992). (High Court of Australia) Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985) (House of Lords) Week II: The Different Standards of Consent and Informed Consent Readings: Canterbury v. Spence, 464 F.2d 772 (1972). (Federal appellate opinion heard in the District of Columbia) Sidaway v. Board of Governors of the Bethlem Royal Hospital and the Maudsley Hospital and Others. 1 A.C. 871 (1985) (House of Lords) Week III: Definition of Research Reading: Mazur, Dennis J. The Science and Ethics of Research on Humans. Baltimore, MD: Johns Hopkins University Press, 2007. (Especially Chapters 2 and 3) Week IV: How to Review a Research Study Protocol and Research Informed Consent Form Reading: Mazur, Dennis J. The Science and Ethics of Research on Humans. Baltimore, MD: Johns Hopkins University Press, 2007. (Especially Chapters 4–6, 10, and 12–14) Week V: Obligations in Research of Humans Versus Patient Care Reading: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Guidelines for the Protection of Human Subjects of Research. Washington, DC: DHEW Publications, 1978 (78‐0012). Focus Questions • How do the judicial doctrines of consent in England and Australia compare to the judicial doctrines of informed consent in the United States and Canada? • How does a professional standard of disclosure differ from a reasonable person standard of disclosure? • What is the definition of research? • How is a research study (study proposal and research informed consent form) reviewed from scientific and ethical bases for considerations of approval by an IRB? • How do the obligations of a study sponsor, a principal investigator, and a research team conducting a research trial on human study participants differ from the obligations of a physician caring for a patient? • Should all raw data of research derived from humans be made available to the public for use in developing generalizable knowledge to help others, or should raw data be considered the private property of the study sponsors (for example, prescription drug manufacturers), who fund the research trials? Seminar/project Idea Draw a timeline of the development of the basic concepts of consent and informed consent in patient care and in patient research. On this timeline, first place the dates of the key court cases in England, the United States, Canada, and Australia on consent and informed consent. Then place the date of the development of the Belmont Report. Why do differences exist between these four countries in terms of the legal requirements of informedness of a patient (in medical care) and a study participant (in medical research)? What roles if any do the concepts of self‐determination and self‐decision have in consent and informed consent in patient care and in informed consent in research on humans among the four countries of interest? What are the realities of research on human participants that require a new standard of informed consent, the reasonable volunteer standard, to be developed beyond the two standards in patient care, the professional standard, and the reasonable person standard? Counterpoint Arguments The following are counterpoint arguments that need to be appreciated to more fully understand the concepts that impact the thesis that ‘raw data’ should be open to the public to allow the opportunity of checking of the results of its associated scientific paper and for further analysis. De‐Identified (Anonymized) Raw Data A current approach to identifying (anonymizinig) raw data is based on the Health Insurance Portability and Accountability Act (HIPAA) of 1996 (P.L.104‐191). HIPAA was enacted by the U.S. Congress in 1996 to keep a person’s medical information private. In a research study, a person’s private medical information can become research data. HIPAA’s Privacy Rule allows a covered entity to de‐identify data by removing all 18 elements that could be used to identify the individual or the individual’s relatives, employers, or household members; these elements are enumerated in the Privacy Rule. The covered entity must also have no actual knowledge that the remaining information could be used alone or in combination with other information to identify the individual who is the subject of the information. Under this method, the identifiers that must be removed are the following: 1 Names. 2 All geographic subdivisions smaller than a state, including street address, city, county, precinct, ZIP Code, and their equivalent geographical codes, except for the initial three digits of a ZIP Code if, according to the current publicly available data from the Bureau of the Census: 2a. The geographic unit formed by combining all ZIP Codes with the same three initial digits contains more than 20,000 people. 2b. The initial three digits of a ZIP Code for all such geographic units containing 20,000 or fewer people are changed to 000. 3 All elements of dates (except year) for dates directly related to an individual, including birth date, admission date, discharge date, and date of death, and all ages over 89 and all elements of dates (including year) indicative of such age, except that such ages and elements may be aggregated into a single category of age 90 or older. 4 Telephone numbers. 5 Facsimile numbers. 6 Electronic mail addresses. 7 Social security numbers. 8 Medical record numbers. 9 Health plan beneficiary numbers. 10 Account numbers. 11 Certificate/license numbers. 12 Vehicle identifiers and serial numbers, including license plate numbers. 13 Device identifiers and serial numbers. 14 Web universal resource locators (URLs). 15 Internet protocol (IP) address numbers. 16 Biometric identifiers, including fingerprints and voiceprints. 17 Full‐face photographic images and any comparable images. 18 Any other unique identifying number, characteristic, or code, unless otherwise permitted by the Privacy Rule for re‐identification. Even though ‘raw data’ can be de‐identified (anonymized) so that there is no way to trace back the data to the study participant from which it was drawn, there are still questions whether the ‘de‐identified raw data’ can be given to other researchers or made public without the original study participant’s approval. It may be the case that this approval could be done at the start of any research study where the individual considering study participation would be counseled on what the process of de‐identification consists of and would be asked whether the participant would allow use of the data by other researchers or made available to the public in a de‐identified state. However, there may be questions of the study participants as to whether the data are truly de‐identified and untraceable back to the study participant since the participant would not be able to see the process actually being carried out in detail in all relevant circumstances. Using Raw Data in Context Simply being in possession of raw data is never enough to build on that data from a research perspective. Researchers need to understand the context of the scientific research study in which the data were collected. This research context includes (but is not limited to): (i) the scientific hypothesis of the research study, (ii) the inclusion and exclusion criteria selected by the research designers of the study to determine which study participants were included and which were excluded from the study, (iii) the methods used to collect the data and possibilities of errors in the data collection processes, and (iv) answers to questions regarding whether any data were excluded from the study data and why these data were excluded. Ownership Rights Over Data There are ownership rights over data. Ownership rights include court decision making related to the question which parties are to be considered as the owners of the data. Possible owners here include (but are not limited to) (i) the study sponsor whose only role was to fund that study, (ii) the principal investigator(s) who developed the scientific hypothesis, and (iii) individual study participants through special contracts made by individual participants who negotiate such contracts with study sponsors and principal investigators to share in the ownership of data. Examples of such data are participant sources of unique gene lines or unique cell lines to be used in future research. Objections to Data Sharing Finally, individual researchers may simply object to sharing data. A researcher’s arguments here may be simply stating that he or she has a right to fully analyze the data since the collection of the data was the researchers’ idea in the first place. These researchers may argue that they have the right to mine the data as fully as they can before deciding to make the data open to the public for others to analyze. Works Cited 1 Kaiser, J. ‘Making Clinical Data Widely Available.’Science 322.5899 (10 Oct. 2008): 217–8. 2 de Lusignan, S., J.F. Metsemakers, P. Houwink, V. Gunnarsdottir, and J. van der Lei. ‘Routinely Collected General Practice Data: Goldmines for Research? A Report of the European Federation for Medical Informatics Primary Care Informatics Working Group (EFMI PCIWG) from MIE2006, Maastricht, The Netherlands.’Informatics in Primary Care 14.3 (2006): 203–9. 3 Sim, I. ‘Human Studies Database Project’, CTSA Data Repositories Symposium (17 Oct. 2008). 23 Nov. 2010. 4 Sim, I., C.G. Chute, H. Lehmann, R. Nagarajan, M. Nahm, and R.H. Scheuermann. ‘Keeping Raw Data in Context.’Science 323.5915 (6 Feb. 2009): 713. 5 U.S. Department of Health and Human Services, National Institutes of Health, HIPAA Privacy Rule, Information for Researchers. 13 Nov. 2010. 6 Wilczynski, N.L., R.B. Haynes, and Hedges Team. ‘EMBASE Search Strategies for Identifying Methodologically Sound Diagnostic Studies for Use by Clinicians and Researchers.’BMC Medicine 29.3 (March 2005): 7. (shrink)

In this paper it is analyzed from the informational perspective the relation between mind and body, an ancient philosophic issue defined as a problem, which still did not receive up to date an adequate solution. By introducing/using the concept of information, it is shown that this concept includes two facets, one of them referring to the common communications and another one referring to a hidden/structuring matter-related information, effectively acting in the human body and in the living systems, which determines the (...) dynamic inter-change of information between specific structures of the organism by electric/electronic/chemical agents and genetic/epigenetic processes. It is shown that the maintenance of body, permanently and obligatory depending on the external matter (foods, air, water) resources, needed to provide both the structuring/restructuring basic material and energy, determines the necessary existence of an info-managing system, administrating the internal mechano-chemical/physical processes. As a natural consequence, such a system should organize and assure own survival by an effective informational operability to detect the external food resources, to select the appropriate interest information and to decide as a function of circumstances. One important component in such an informational system is memory, allowing to dispose of the reference informational data for analysis/comparison and the selection between good and bad binary possible decisions. The memory receives and stores therefore signals from external reality and from the body itself, referring to the emotional reaction, digestion status, creation, and inherited predilections, within specific info-neural communication circuits between the brain and body execution/sensitive organs, the human body appearing as an integrated info-matter self-managed dynamic system. The specific body components memorize information with different degrees of info-integration: short/long-term integration, emotive/action reaction, info-abilities, culminating with the integration in the chromosomal structures by epigenetic processes. The new acquired information is transgenerationally transmissible, and is manifested as new traits, showing the adaptation capability of the human and close relation between mind and body. Analyzing the results of such a mind-body informational model in comparison with the earlier assumed/proposed/asserted archaic, Greek and Occidental philosophies, which represent only partial aspects of this relation, it is shown that this informational model, elaborated in terms of information on the basis of scientific reasons and arguments, constitutes a general, realist, and coherent model of the mind-body relation, able to integrate and/or explain most of the others. (shrink)