Several DNA-damage detection and repair mechanisms have evolved to repair double-strand breaks induced by mutagens. Later in evolutionary history, DNA single- and double-strand cuts made possible immune diversity by V(D)J recombination and recombination at meiosis. Such cuts are induced endogenously and are highly regulated and controlled. In meiosis, DNA cuts are essential for the initiation of homologous recombination, and for the formation of joint molecule and crossovers. Many proteins that function during somatic DNA-damage detection and repair are also active during (...) homologous recombination. However, their meiotic functions may be altered from their somatic roles through localization, posttranslational modifications and/or interactions with meiosis-specific proteins. Presumably, somatic repair functions and meiotic recombination diverged during evolution, resulting in adaptations specific to sexual reproduction. BioEssays 27:795–808, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

We show that the maximal linear extension theorem for well partial orders is equivalent over RCA0 to ATR0. Analogously, the maximal chain theorem for well partial orders is equivalent to ATR0 over RCA0.

In this study the author has focused on the impact of activeness and independence on the quality of life of seniors. Activeness is taken to mean the participation in regular everyday tasks. Functional independence is independence in everyday life. Quality of life in old age describes the level of satisfaction with life and indicators of successful ageing. The survey was conducted in October 2013 among four groups of seniors. Two variables determined the distribution of respondents: the level of activeness and (...) the functional independence of the seniors. The study involved 99 seniors from Sopot and Gdansk. Functional independence has a much greater impact on the quality of life of seniors than activeness in as much as independence is influenced by our state of health over which we may always have full control, whereas activeness to a large extent depends on ourselves. (shrink)

Neste artigo intentamos empreender uma leitura do judaísmo antigo, ou veterotestamentário, em alguns de seus aspectos principais, à contraluz da visão maquiaveliana do papel da religião na organização e expansão do Estado. O primeiro passo desta empresa será dado ao expormos os traços fundantes e delineadores da tradição judaica antiga, principalmente nos livros que compõe o chamado velho testamento, demonstrando o uso da religião na ordenação e expansão do Estado, bem como na formação do indivíduo. Em um segundo momento demonstraremos (...) como se cria uma nova tradição judaica, influenciada e influenciadora do mundo grego antigo, logo no início da era cristã a qual será assimilada e explorada em seu viés místico no humanismo renascentista. Esta tradição judaico helenístico será a mais conhecida e assimilada nos círculos eruditos europeus da renascença. Por fim, buscaremos demonstrar como os traços constitutivos do judaísmo antigo, em detrimento ao judaísmo helenístico, podem ser lidos à luz da descrição maquiaveliana do papel da religião na organização e expansão do Estado e na formação do indivíduo. (shrink)

In this brief article we will seek to support the thesis that there is in the thought of Coluccio Salutati, 14th century Florentine chancellor and prominent humanist, a clear republicanism that turns to the issue of the freedom of the republic and the active life of the individuals participating in it. However, in connection with this demonstration, we will also maintain that such republicanism has strong traces of Augustinian influence, mainly in view of the disposition of laws in the political (...) arrangement, as well as the relationship between active life and the search for a human being’s own good. In view of this, we intend to demonstrate that, in general, Salutati’s Renaissance republicanism turns to the defence of the republic, its freedom and its characteristic of the proper scenario for the active life of individuals, however, it still maintains an ethical-political perspective typical of the medieval period, centrally influenced by Augustinian thought. (shrink)

The paper aims at describing the findings and conclusions formulated in the analysis of the authorship factor in legal discourse. It is hypothesised that verbal structures show systemically varied distribution across legal discourse and the relevant distinctions run through the authorship categories. When it comes to the aim of the research it draws on the tradition of sociolinguistic methodology targeting issues related to language variation which follows the basic assumptions of functional grammar. From the point of view of the material (...) covered by the analysis it contributes to the research on legal discourse and specifically on its specialised domain referred to as corporate, company or business discourse. It provides additional empirical data pointing to the non-homogeneity of the legal style and formal distinctions originating from rich contextual background. The study is conducted on the material of a custom-designed corpus of English legal texts, classified as secondary genres. Methodologically, the study makes use of the tenets of supervised search of digitalised corpora and automatic data extraction based on discrete units, subsequent identification of recurring longer contiguous and/or non-contiguous sequences, if any, built around the axis of specific verbal structures and finally qualitative comparative analysis of the material. The discussion presents sample data and focuses on the most salient categories, both quantitatively and qualitatively. The inductive approach confirms the formal divergencies in the communicative situation covered by the analysis. The findings encapsulate patterns and tendencies in the quantitative distribution of verbal structures depending on the authorship category. It may be concluded that authorship is a factor delineating distinctions as regards the repertoire of grammatical instruments exploited, which contributes to the specific stylistic profile of given authors. This shows that the thesis posed is verified positively and the study shows further, more detailed distinctions running through groups of subcategories distinguished within the authorship categories specified upon the start of the research. (shrink)

Context is a notion that is commonly invoked in many linguistic studies, either with very general reference or, more specifically, in the light of one of a number of research approaches which assign distinct definitions to context, ranging from factors that can be recovered from a text, through social parameters serving as an index for the appropriation of discursive performance, to factors that bring texts into being and give them meaning. This exploratory and descriptive research problematises the notion of context (...) specifically on the grounds of English/Polish translation of corporate documentation processed in company registration proceedings, touching upon factors that are presumed to be discursively relevant in this communicative situation. The study is conducted from the perspective of the sociocultural approach and it adopts the parallel corpus methodology. The author discusses the concept of context on the ground of legal communication and secondarily presents a corpus-based description of the context categories that are idiosyncratic and potentially discursively relevant for the said communicative situation in the cross-linguistic perspective. The contextual variation is tested for its capacity to affect translation performance. The results reveal specific tendencies as regards the distribution patterns in the values corresponding to the investigated context categories. They point to some divergencies in translation output caused by the source text variantivity and they pave the way and directions for further research. Already at this stage the findings may have significant pedagogical value and they constitute a solid starting point for sociolinguistic research on discourse variantivity. (shrink)

We study the provability in subsystems of second-order arithmetic of two theorems of Harrington and Shelah [6] about Borel quasi-orderings of the reals. These theorems turn out to be provable in ATR0, thus giving further evidence to the observation that ATR0 is the minimal subsystem of second-order arithmetic in which significant portion of descriptive set theory can be developed. As in [6] considering the lightface versions of the theorems will be instrumental in their proof and the main techniques employed will (...) be the reflection principles and Gandy forcing. (shrink)

Name der Zeitschrift: Millennium Jahrgang: 13 Heft: 1 Seiten: 41-46.

In this paper we give a proof of the II12-completeness of the set of countable better quasi orderings . This result was conjectured by Clote in [2] and proved by the author in his Ph.d. thesis [6] . Here we prove it using Simpson's definition of better quasi ordering and as little bqo theory as possible.

The paper presents findings gathered in an exploratory, descriptive, corpus-based analysis of a parallel corpus composed of English corporate documents and their translations into Polish with regard to the frequency-related, binary strategy distribution pattern. In general, the author posits a distinctiveness of interlingual communication in the domain of law, as delineated by the institutional and disciplinary framework. The material extracted from the corpus and studied for its generic features points to the hermetic character of corporate written communication in English. The (...) thesis to be verified is whether there are any tendencies in the distribution of the translation strategies in the corpus texts. The research question was operationalised via coding the corpus extracts according to the binary strategy division scheme. Further, the data have been discussed in reference to the sociocultural background of the communicative situation covered under the analysis in order to account for the translators’ motivation. (shrink)

We show that the quasi-order of continuous embeddability between finitely branching dendrites (a natural class of fairly simple compacta) is $\Sigma_1^1$ -complete. We also show that embeddability between countable linear orders with infinitely many colors is $\Sigma_1^1$ -complete.

The paper explores the hypothesis that multinomials can act as authorship-based style distinguishing markers in legal communication. Specifically, the analysis focuses on identifying the quantitative distribution patterns of structural categories of multinomials as typical for two authorship categories and on their communicative function. The two authorship categories that are contrasted here are legal professionals/experts and lay people. The analysis is conducted in the corpus-based methodology with a custom-designed corpus of English, authentic texts found in the legal trade, in the domain (...) of company registration proceedings. The findings confirm that multinomials that are conventionally considered to be a feature of professional legal communication are also cognitively salient in lay communication. Further, the texts drafted by the two categories of authors are profiled by structurally distinct multinomials. Functionally, it has been demonstrated that the structurally distinct types of multinomials that are found quantitatively salient in the two authorship categories are used predominantly for specific stylistic and/or pragmatic functions. Stylistically, multinomials contribute to conventional and ritual patterns which are used to meet the formality standards that have evolved in specific legal professions where authority is of particular importance. Pragmatic factors which account for quantitative salience of specific, structurally profiled categories of multinomials involve mainly reduplication of multinomials that embody norm-related concepts, which is required on the ground of intertextuality and ensures the materialisation of legal effect. (shrink)

We study the reverse mathematics of interval orders. We establish the logical strength of the implications among various definitions of the notion of interval order. We also consider the strength of different versions of the characterization theorem for interval orders: a partial order is an interval order if and only if it does not contain 2 \oplus 2. We also study proper interval orders and their characterization theorem: a partial order is a proper interval order if and only if it (...) contains neither 2 \oplus 2 nor 3 \oplus 1. (shrink)

O presente artigo, de natureza bibliográfica, objetiva discutir alguns desafios políticos e epistemológicos postos aos movimentos sociais e à educação popular no contexto das sociedades complexas. Parte-se do reconhecimento que estamos vivendo, nas últimas décadas, transformações profundas que impactam em todas as dimensões da vida tanto individual quanto social. Esses processos ocorrem em espaços locais, mas impactam globalmente, assim como existem tendências globalizantes que impactam nos espaços locais, na subjetividade e nas relações intersubjetivas. O incremento de tecnologias acelera esses processos, (...) trazendo implicações políticas, pedagógicas, sociais e culturais. Um conjunto de mudanças em curso ainda são de difícil avaliação dado que são movimentos em curso, mas, nem por isso, deixam de colocar novas exigências epistêmicas e políticas, ou seja, as realidades emergentes sempre desafiam a construção de novos referenciais e novas práticas. Os movimentos sociais e a educação popular não estão imunes a essas influências. Daí o desafio para pensar o emergente atentando para o residual e o dominante, conforme propõe Raymond Williams, visto que estão profundamente imbricados. Nesse contexto, questiona-se a respeito das contribuições de referenciais clássicos, tanto das ciências sociais quanto pedagógicas, na análise da realidade e na fundamentação de projetos emancipatórios. Buscando dar conta dessas questões, o texto inicia contextualizando algumas tendências no âmbito do eixo temático “educação popular e movimentos sociais” tendo como base as dez edições da Anpedsul e segue com um diagnóstico das transformações em curso que tornam as sociedades complexas. Na sequência, são analisados alguns desafios políticos e epistemológicos visando a dar conta de uma compreensão mais ampla dos complexos fenômenos emergentes e, para concluir, uma reflexão sobre o papel dos clássicos nas investigações e pesquisas relativas aos movimentos sociais e a educação popular. Palavras-chave: Movimentos sociais. Educação popular. Política. Epistemologia. Sociedades complexas. (shrink)

Este trabalho é uma continuação da pesquisa anterior apresentada no MES 11 (Marcone & Bortolucci, 2021), onde buscávamos entender o papel do ledor (leitor), pessoa que lê o teste para o deficiente visual durante uma avaliação. O trabalho realizado desde então e até o segundo semestre de 2022, seguindo as conclusões tiradas em nosso trabalho anterior, foi focado no estudo, compreensão e sistematização do processo de adaptação de itens, aqueles relacionados à matemática como desenhos, tabelas, gráficos, enunciados e tudo relacionado (...) à elaboração de questões de matemática, e à atividade do ledor de teste de matemática. Para tanto, foram realizadas entrevistas com três profissionais diretamente vinculados a esse tipo de atividade, com ampla experiência na atividade de adaptação de testes matemáticos, além da análise de referenciais teóricos sobre o tema. Apresentaremos os principais pontos abordados em cada entrevista, como a necessidade de o processo de adaptação do teste ocorrer simultaneamente à construção do teste, para que as intervenções necessárias possam ocorrer antes da montagem do teste ser concluída, seguido de uma discussão, com conclusões mostrando o quão importante é descrever uma imagem adequadamente, com o mínimo de informações, para que o candidato possa realizar o teste no tempo que tiver. Esta pesquisa foi avaliada por um comitê de ética independente e autorizada a ser realizada. (shrink)

D. Jacquart / A. Paravicini Bagliani (textes reunis par), Le Moyen.ge et les sciences, SISMEL-Edizioni del Galluzzo, Firenze 2021 (Micrologus Library, 100).

Tencionamos, neste artigo, demonstrar os meandros constitutivos do que seja um formalismo moral em Immanuel Kant, tendo como pressuposto teórico sua compreensão de uma teoria da vontade. Este movimento de análise e demonstração teórica terá como fio condutor a ideia de autonomia que permeia a construção da vontade no formalismo kantiano, ou seja, a pressuposição de uma possível autonomia formal da razão é a base na qual se assenta a teoria moral deste pensador. Para execução de nossa pretensão será necessário (...) reconstituir os pontos nevrálgicos do que venha a ser uma teoria da vontade para em seguida analisar os pressupostos kantianos que realçam a centralidade da autonomia da razão na compreensão de uma vontade livre. Desta maneira, o que se pretende por em desnudo é a originalidade kantiana, em relação à tradição que promulga a vontade como marca da liberdade humana, a partir de seu pressuposto de autonomia formal na constituição moral do indivíduo humano. (shrink)

We study the computability-theoretic complexity and proof-theoretic strength of the following statements: (1) "If X is a well-ordering, then so is ε X ", and (2) "If X is a well-ordering, then so is φ(α, X)", where α is a fixed computable ordinal and φ represents the two-placed Veblen function. For the former statement, we show that ω iterations of the Turing jump are necessary in the proof and that the statement is equivalent to ${\mathrm{A}\mathrm{C}\mathrm{A}}_{0}^{+}$ over RCA₀. To prove the (...) latter statement we need to use ω α iterations of the Turing jump, and we show that the statement is equivalent to ${\mathrm{\Pi }}_{{\mathrm{\omega }}^{\mathrm{\alpha }}}^{0}{-\mathrm{C}\mathrm{A}}_{0}$ . Our proofs are purely computability-theoretic. We also give a new proof of a result of Friedman: the statement "if x is a well-ordering, then so is φ(x, 0)" is equivalent to ATR₀ over RCA₀. (shrink)

The purpose of this succinct work is to present N. Machiavelli's classic republican view from his proposition of an inevitable paradox, the founding of an expansionist republic, difficult to govern, or the founding of a stable, but small and weak republic. Such a paradox, according to Machiavelli, should direct and condition all the constitutive devices of the republic when choosing what will be its destiny as a political body. The model of republic preferred by the Florentine will be the expansionist (...) model of Rome, leading him to assume all the devices that gave this republic its power. From this presentation of the Machiavellian proposition, we will analyse the assimilation of republican thought in England from the Elizabethan period, as well as the political-social scenario that exists there. This itinerary will allow us to understand, in general, why classical republicanism was received on English soil from the perspective of establishing a mixed, stable government, thus favouring the spread of the Venice myth as a serene republic and delaying the use, even that mitigated, of the republican presuppositions expressed in the Machiavellian work that directed towards a Roman model. (shrink)

Neste breve artigo, argumentaremos que a pandemia da Covid-19, como outras na história humana, colocou em desnudo as bases da estrutura político-econômica moderna. Defenderemos que tais bases apoiam-se em dois esteios, uma noção política de ‘Estado’, ápice da organização humana, e uma concepção racionalista, técnica e produtiva, que promulga a possibilidade de resposta a qualquer crise surgida na sociedade. Como contrapondo a esta estrutura, apresentaremos a teoria maquiaveliana, que aponta para uma relação indelével entre política e fator natural, natureza e (...) sociedade. Nesta teoria, com uma concepção antropológica própria, as necessidades impostas pela natureza frente a ação humana são determinantes para se pensar a própria construção política. Como resultado, consideraremos ser necessário repensar a estrutura político-econômica moderna em seus pretensos mitos de incontestável avanço político, por meio do ‘Estado’, e inabalável base racional, principalmente técnico-produtiva, retomando o lugar de importância do fator natural para constituição de uma sociedade mais ‘humana’. (shrink)

Our objective in this brief article is guided by the demonstration of the existence of a theory of political action in Machiavelli's republican thought, with such a theory having its own character that directs it to highlight the action of individuals in the social context. In addition to this objective, we hope to support the thesis that such a theory of political action has a republican scope, not just “republicanist”, in keeping with the Machiavellian preference for institutions that impress on (...) individuals a civic sense based above all on the materiality of political action in the body social. From this assertion, we indicate that our itinerary will be guided by the demonstration of the search for the valorization of political action in Machiavelli's theory, the materiality of such action, to the detriment of its pure intention, the central focus of Florentine's work. This disposition of the centrality of political action in Machiavelli republicanism will underscore its appreciation for outlining the political functions of the search for recognition, glory and especially the benefit of the political body as a whole. (shrink)

Tencionamos, neste artigo, tratar da questão da imitação no pensamento maquiaveliano. Tomaremos como balizas suas postulações acerca da natureza do homem, as possibilidades de formatação de uma república profícua em vista desta natureza e o papel dos exemplos dos indivíduos que agem em prol do bem da república. Sendo a questão da imitação o fio condutor, elegeremos ainda um tripé para demonstrar nossa hipótese, a saber, o fator antropológico; o fator educacional; o fator político. Por este movimento, pretende-se demonstrar que (...) a aparente negatividade das postulações maquiavelianas sobre a natureza humana não inviabilizam a promulgação de uma república estável, tendo os bons exemplos políticos um papel preponderante neste propósito. (shrink)

The intention of this brief article is to demonstrate, through the Machiavellian and Shakespearean analyzes, mediated by the latter's work, “The Merchant of Venice”, the contrast between the classical republican conception and the modern political ideal of freedom. We will take as a gauge the ideas of social belonging (religion, social recognition); legal constitution of rights (individual freedom), trying to understand how these aspects are constructed in the representations of the city of Venice by the two authors. For this undertaking, (...) it will be necessary to understand the Machiavellian understanding of the political and social structures that founded and sustained the Venice of his time. Then understand the scenario in which Shakespeare sees the Venice of his era, analyzing his work mentioned. Finally, we will try to demonstrate how one can extract from this intricate approximation subsidies to think the contrast between the traces of a classic republican thought and the incipient points of a modern conception of individual freedom. (shrink)

When a linear order has an order preserving surjection onto each of its suborders, we say that it is strongly surjective. We prove that the set of countable strongly surjective linear orders is a [Formula: see text]-complete set. Using hypotheses beyond ZFC, we prove the existence of uncountable strongly surjective orders.

We investigate the uniform computational content of the open and clopen Ramsey theorems in the Weihrauch lattice. While they are known to be equivalent to $\mathrm {ATR_0}$ from the point of view of reverse mathematics, there is not a canonical way to phrase them as multivalued functions. We identify eight different multivalued functions and study their degree from the point of view of Weihrauch, strong Weihrauch, and arithmetic Weihrauch reducibility. In particular one of our functions turns out to be strictly (...) stronger than any previously studied multivalued functions arising from statements around $\mathrm {ATR}_0$. (shrink)

From Hippocrates and Galen, meteorological medicine studied the impact of environmental factors and weather phenomena on mental and bodily health. This theory has been largely diffused by medical works and encyclopaedias, such as those of Vincentius de Beauvais and Bartholomeus Anglicus. However, its reception within mediaeval meteorology still remains to be fully inquired, partly because it was not a traditional topic to be discussed in the question commentaries on the Meteorologica of Aristotle. This article aims to focus on three Parisian (...) quaestiones on the Meteorologica in which Radulphus Brito and Themo Iudaei de Monasterio utilised concepts of meteorological medicine as a tool to explain meteorological principles. The medical theory is used to clarify how antiperistasis works within animals’ bellies and its impacts on their general health; and in the second one, to describe the harmful impacts water has on human and animal bodies; and then thirdly, to explain the process of generating rain. (shrink)

We prove that the maximal order type of the wqo of linear orders of finite Hausdorff rank under embeddability is φ2, the first fixed point of the ε-function. We then show that Fraïssé’s conjecture restricted to linear orders of finite Hausdorff rank is provable in +“φ2 is well-ordered” and, over , implies +“φ2 is well-ordered”.

This article explores a key question in the history of science: Could untrained officials learn and apply practical knowledge by reading how-to books and collaborating with expert practitioners? Notably, historians of science have studied workplaces such as the mines as arenas of knowledge exchange between workers, expert practitioners, and learned humanists. This article uses a labor history approach to explore what this exchange meant in practice. It analyzes the attempts of an untrained official in the mines of the Medici family (...) to learn and reproduce practical knowledge about prospecting and surveying. By the mid-sixteenth century, this official read Georg Agricola’s (1494–1555) mining treatises and had access to the expertise of German miners from the renowned mining districts of Central Europe. The analysis of his reports based on the reading of the book, along with the hierarchical organization of labor established by the German experts in the Medici mines, reveals that the presence of craftsmen and scholarly works reinforced, rather than blurred, the boundaries of knowledge in early modern mines. (shrink)

The situation of childhood and the adolescence in the Republic of Argentina as object of social politics is discussed from a clinical point of view. This matter seems to be connected to the problems of (personal) security, sometimes mingling the barrier that separates this from the way Justice fu..

The purpose of this paper is to present some of the findings (which were reported on more extensively in earlier work) regarding the visibility of gender issues in the literature on selected information and communication technologies (ICTs) with a view to make predictions about potential ethical issues that the application of these ICTs may bring about in the future. On the basis of the analysis of around 100 published sources, which dealt with various aspects of selected ICTs, conclusions have been (...) drawn regarding gender issues and concerns that the applications of these ICTs may cause. The authors' analysis is theoretically informed by critical discourse analysis (CDA) which assumes that texts, both written and spoken, as well as other forms of symbolic representations, are indicative of social practices. Of particular methodological relevance was the survey of methods of text and discourse analysis presented in Titscher et al and especially the application of keyword search as a way to measure the prominence of each investigated method. This approach to literature surveying proved very useful in selecting analytic material: only those published sources on the selected four ICTs have been included in the survey, for which the analysis of keywords, abstracts and indexes of terms indicated authors' interest in gender issues. Findings - First, ICTs such as affective computing, ambient intelligence, and artificial intelligence, have been found to have the potential of positively affecting gender power relations and thus positively affecting gender balance in the areas of labour market related to ICT across EU countries and worldwide. Second, more research on the relationship between gender and ICT design, application and representation is needed, so as to enhance a better understanding of ethical issues resulting from unequal participation of women and men in all aspects of ICT production and implementation, which in itself is an ethical dilemma with which both the ICT business and legislators have to grapple. The paper offers insight into the relationship between the level of attention devoted to particular ICTs by ICT researchers, as evidenced in the reviewed literature, and the likelihood of the application of a particular ICT in the future, which is looked at and assessed from a gender perspective. (shrink)

There are close similarities between the Weihrauch lattice and the zoo of axiom systems in reverse mathematics. Following these similarities has often allowed researchers to translate results from one setting to the other. However, amongst the big five axiom systems from reverse mathematics, so far $\mathrm {ATR}_0$ has no identified counterpart in the Weihrauch degrees. We explore and evaluate several candidates, and conclude that the situation is complicated.

Numerous social, economic and academic pressures can have a negative impact on representations of biomedical research. We review several of the forces playing an increasingly pernicious role in how health and science information is interpreted, shared and used, drawing discussions towards the role of narrative. In turn, we explore how aspects of narrative are used in different social contexts and communication environments, and present creative responses that may help counter the negative trends. As traditional methods of communication have in many (...) ways failed the public, changes in approach are required, including the creative use of narratives. (shrink)