In order to study early human development while avoiding the burdens associated with human embryo research, scientists are redirecting their efforts towards so-called human embryo-like structures (hELS). hELS are created from clusters of human pluripotent stem cells and seem capable of mimicking early human development with increasing accuracy. Notwithstanding, hELS research finds itself at the intersection of historically controversial fields, and the expectation that it might be received as similarly sensitive is prompting proactive law reform in many jurisdictions, including the (...) Netherlands. However, studies on the public perception of hELS research remain scarce. To help guide policymakers and fill this gap in the literature, we conducted an explorative qualitative study aimed at mapping the range of perspectives in the Netherlands on the creation and research use of hELS. This article reports on a subset of our findings, namely those pertaining to (the degrees of and requirements for) confidence in research with hELS and its regulation. Despite commonly found disparities in confidence on emerging biotechnologies, we also found wide consensus regarding the requirements for having (more) confidence in hELS research. We conclude by reflecting on how these findings could be relevant to researchers and (Dutch) policymakers when interpreted within the context of their limitations. (shrink)

Recent advancements in developmental biology enable the creation of embryo-like structures from human stem cells, which we refer to as human embryo-like structures (hELS). These structures provide promising tools to complement—and perhaps ultimately replace—the use of human embryos in clinical and fundamental research. But what if these hELS—when further improved—also have a claim to moral status? What would that imply for their research use? In this paper, we explore these questions in relation to the traditional answer as to why human (...) embryos should be given greater protection than other (non-)human cells: the so-called Argument from Potential (AfP). According to the AfP, human embryos deserve special moral status because they have the unique potential to develop into persons. While some take the development of hELS to challenge the very foundations of the AfP, the ongoing debate suggests that its dismissal would be premature. Since the AfP is a spectrum of views with different moral implications, it does not need to imply that research with human embryos or hELS that (may) have ‘active’ potential should be completely off-limits. However, the problem with determining active potential in hELS is that this depends on development passing through ‘potentiality switches’ about the precise coordinates of which we are still in the dark. As long as this epistemic uncertainty persists, extending embryo research regulations to research with specific types of hELS would amount to a form of regulative precaution that as such would require further justification. (shrink)

This article uses narrative accounts of women who are intended parents to show the health and financial implications of infertility treatments (particularly in vitro fertilization), underregulation, and lack of funding in the United States and abroad. It argues that providing access to infertility treatment and regulating for safety are necessary means of protecting the health of women diagnosed with infertility and women who, through the sale of their reproductive goods and services, are the catalysts to conception. Many moral ambiguities arise (...) from the utilization of assistive reproductive technologies to treat infertility, requiring careful scrutiny of market and nonmarket values. (shrink)

We give strengthened versions of the Herwig–Lascar and Hodkinson–Otto extension theorems for partial automorphisms of finite structures. Such strengthenings yield several combinatorial and group-theoretic consequences for homogeneous structures. For instance, we establish a coherent form of the extension property for partial automorphisms for certain Fraïssé classes. We deduce from these results that the isometry group of the rational Urysohn space, the automorphism group of the Fraïssé limit of any Fraïssé class that is the class of all ${\cal F}$-free structures, and (...) the automorphism group of any free homogeneous structure over a finite relational language all contain a dense locally finite subgroup. We also show that any free homogeneous structure admits ample generics. (shrink)

The purpose of this essay is to formulate a sociological critique of the concept of scarcity in mainstream economics by synthesising necessary conceptions in the construction of a theoretical structure with greater explanatory power than the current mainstream articulation. Mainstream economics asserts the universality of scarcity. A critical scrutiny of this assertion is conducted by discussing the empirical phenomenon of global hunger in relation to a theoretical elaboration of the concepts of scarcity and abundance. The historical origins of the scarcity (...) postulate is traced to the work of Carl Menger. The concern of global hunger shows that there is abundance of food goods, but still frustration of human needs occurs. An alternative approach is developed through a theoretical synthesis of Menger, Amartya Sen and critical realism, which asserts an ontologically stratified, differentiated and geo-historically conditioned understanding of scarcity and abundance. It is proposed that this approach is more fruitful than the scarcity postulate in explaining the process and conditions of frustration and satisfaction of human needs. Merely postulating scarcity tends to veil the underlying causes of poverty in general and hunger in particular. Central implications of the new model for socioeconomic analysis are considered. (shrink)

We show that the countable universal ω‐categorical bowtie‐free graph admits generic automorphisms. Moreover, we show that this graph is not finitely homogenisable.

We use the Tolman–Oppenheimer–Volkoff equations for a Chaplygin type fluid to study, analytically and numerically, the global behavior of static solutions of spherically symmetric objects. Two possible regimes are especially investigated. The first one is the phantom regime in which the pressure module exceeds the energy density. In this case the equator is absent and all the solutions have the geometry of a truncated spheroid with the same kind of singularity. The second case is the normal regime for which we (...) determine all the solutions, excluding the de Sitter one, corresponding to a tri-dimensional spheroidal geometry. Beyond the equator, three possible cases are considered; the first case has a closed spheroid characterized by a Schwarzschild-kind singularity with an infinite blue-shift at the south pole, the second case configuration has a regular spheroid and the third case has configuration of a truncated spheroid having a scalar curvature singularity to a finite value of the radial distance. We also compare all the geometric configurations with ones obtained in the special case of Chaplygin gas. (shrink)

Background Investigative genetic genealogy (IGG) is a technique that involves uploading genotypes developed from perpetrator DNA left at a crime scene, or DNA from unidentified remains, to public genetic genealogy databases to identify genetic relatives and, through the creation of a family tree, the individual who was the source of the DNA. As policymakers demonstrate interest in regulating IGG, it is important to understand public perspectives on IGG to determine whether proposed policies are aligned with public attitudes.Methods We conducted eight (...) focus groups with members of the public (N = 72), sampled from four geographically diverse US regions, to explore general attitudes and perspectives regarding aspects of IGG practices, applications, and policies. Five major topics were explored in each focus group: when IGG should be used; who should perform IGG; how to approach consent for genetic database users; what systems of oversight should govern IGG practitioners; and whether to notify database users if their data are involved in law enforcement (LE) matching.Results Participants were supportive of IGG in most scenarios, especially for cold and violent cases. The favorable attitudes toward IGG were, however, tempered by distrust of law enforcement among some participants. All participants agreed that databases must inform users if IGG is allowed, but they did not agree on how individual database users should be allowed to opt out or whether to notify them if their data are involved in specific investigations. All participants agreed that IGG should be subject to some prescriptive guidelines, regulations, or accountability mechanisms.Conclusions These findings suggest broad public support for IGG, and interest in developing systems of accountability for its practice. Our study provides useful insight for policy makers, genomic database stewards, law enforcement, and other stakeholders in IGG’s practice, and suggests multiple directions for future research. (shrink)

We show that the countable universal homogeneous meet-tree has a generic automorphism, but does not have a generic pair of automorphisms.

This article examines Kamel Daoud’s treatment of solidarity and the absurd in Meursault, contre-enquête and posits that the question of how to live in solidarity with others is central to the novel, although the word ‘solidarity’ never appears in it. After recalling Camus’s discussion of the absurd in Le Mythe de Sisyphe and of solidarity in L’Homme révolté, the article examines the manner in which Haroun, Daoud’s narrator and the brother of the Arab Meursault killed in L’Étranger, reveals (...) his own failures of solidarity. He justly criticizes Meursault for privileging his confrontation with the absurd over the death of the Arab he did not even name, but Haroun too has killed. Haroun has, however, a greater understanding of solidarity than his fellows: he at least recognizes that murder is significant. He thus joins Meursault as an unworthy prophet who proclaims the absurd while surrounded by people who flee from it—and proclaiming the absurd can be a gesture of solidarity when one speaks for others, as Haroun speaks for his brother Moussa. Daoud’s novel reminds us that there are no final answers telling us how to live in solidarity with others and that we must do so all the same. (shrink)

A Dictionary of Medieval Judeo-Arabic in the India Book Letters from the Geniza and in Other Texts. By Mordechai Akiva Friedman. Jerusalem: Ben-Zvi Institute, 2016. Pp. xxii + 1017. $37.A Unique Hebrew Glossary from India: An Analysis of Judeo-Urdu. By Aaron D. Rubin. Gorgias Handbooks. Piscataway, NJ: Gorgias Press, 2016. Pp. xii + 134. $48.

The use of slang, abusive, and offensive language has become common practice on social media. Even though social media companies have censorship polices for slang, abusive, vulgar, and offensive language, due to limited resources and research in the automatic detection of abusive language mechanisms other than English, this condemnable act is still practiced. This study proposes USAD, a lexicon-based intelligent framework to detect abusive and slang words in Perso-Arabic-scripted Urdu Tweets. Furthermore, due to the nonavailability of the standard dataset, (...) we also design and annotate a dataset of abusive, offensive, and slang word Perso-Arabic-scripted Urdu as our second significant contribution for future research. The results show that our proposed USAD model can identify 72.6% correctly as abusive or nonabusive Tweet. Additionally, we have also identified some key factors that can help the researchers improve their abusive language detection models. (shrink)

This article extends Georg Lukács’s theorization pertaining to historical fiction by considering a novel written in response to colonial conditions. It treats Abdulhalim Sharar’s Urdu Malik al-‘Aziz and Virginia (1888) as a case where a fictional version of the encounter between Muslims and Christians during the crusades in the twelfth century is used to counter the colonial Indian present in the nineteenth century. I suggest that novels such as Sharar’s exemplify a vein of global thought since the nineteenth century (...) that resisted historicism but without abandoning the notion that the past was real. Deploying a genre that came to the fore in colonial conditions, Sharar imagines an alternative future by narrating the past otherwise via fiction. (shrink)

In the perceptual learning of lexical tones, an automatic and robust attention-to-phonology system enables native tonal listeners to adapt to acoustically non-optimal speech, such as phonetic conflicts in daily communications. Previous tone research reveals that non-native listeners who do not linguistically employ lexical tones in their mother tongue may find it challenging to attend to the tonal dimension or integrate it with the segmental features. However, it is unknown whether the attentional interference initially caused by a maternal attentional system would (...) continue influencing the non-optimal tone perception for simultaneous bilingual teenagers. From an endpoint in the age of language acquisition, we investigate whether the tone-specific attention mechanism developed by the Urdu-Cantonese simultaneous bilinguals is automatic enough to assist them in adapting to a phonetically-conflicting environment. Three groups of teenagers engaged in a four-condition ABX task: Urdu-Cantonese simultaneous bilinguals, Cantonese native listeners, and Urdu-speaking, late learners of Cantonese. The results showed that although the simultaneous bilinguals could phonologically process Cantonese tones in a Cantonese-like way under a conflict-free listening condition, they still failed in adapting to the phonetic conflicts, especially the segment-induced ones. It thus demonstrated that the simultaneous exposure and years of regular education in Hong Kong local schools still could not automatically guarantee simultaneous bilingual processing of Cantonese tones. In interpreting the findings, it hypothesized that, except for simultaneous exposure, the development of a tone-specific attention mechanism is also likely to be L1-inhibitory, tone experience-driven, and language-specific for simultaneous bilinguals. (shrink)

This is a study of Master Ramchandra, a nineteenth-century Indian mathematician, social commentator and Urdu journalist. The contradictions manifest in his projects, it is contended, were actually the products of the contradictions manifest in the political and ideological thinking of the period. One encounters in his writings a dominant critique of the prevalent religious, social and educational systems and also a call for social transformation, wherein scientific rationality and realism came to play an important role. Ramchandra's understanding is quite (...) close to that of the Comtean positivists. An attempt is made here to locate this emerging scientism within the context of nineteenth-century colonial politics. (shrink)

This article takes the linguistic space of North India during the nineteenth and twentieth centuries and tries to see how a nationalistic linguistic ideology that was shaping up at that time, creating Hindi and Urdu linguistic communities, used gender as a tool to portray and assert a masculinist vision of language and nation. It involved not just censoring certain representations of women and their cultural spaces, but also using the issue of ‘vulgar’ representations as a premise to marginalize certain (...) languages and their literature. The article looks at the colonial ideology that worked as an enforcer for the nationalists to work towards achieving what they felt as a sanitized and moral form of literature and culture. The linguistic ideology that accompanied these revisions was of projecting Hindi (Khari Boli) as a national language while limiting spaces of other languages, such as Braj, Urdu and Bhojpuri, in the region, by criticizing either their use of sexual imagery or by stereotyping them in a gendered way. This article investigates the arguments of nationalist writers and highlights their masculinist and patriarchal ideas in their bid for the new national language. (shrink)

This article introduces the LITMUS-MAIN and motivates the adaptation of this instrument into Chinese languages and language pairs involving a Chinese language, namely Cantonese, Mandarin, Kam, Urdu. We propose that these new adapted protocols not only contribute to the theoretical discussion on story grammar and widen the evidential base of MAIN to include more languages in studying bilinguals, they also offer new methods of assessing language development in young children that have the potential to tease apart the effects of (...) language impairment and bilingualism and improve the identification of Developmental Language Disorder. These new protocols are the first tools to be designed for the dual assessment of language skills in these particular languages, in particular narrative skills in bilingual children speaking these languages. By catering to under-researched languages and over-looked groups of bilingual children, these new tools could improve the clinical management for certain bilingual ethnic minority children such as Urdu-Cantonese and Kam-Mandarin bilinguals, as well as promote the study of these groups and their acquisition issues. Advances in understanding the theoretical and acquisition issues in childhood bilingualism can also be made possible using these new tools. (shrink)

Code switching is defined as the use of two or more languages or varieties of language in conversation. It is a general phenomenon in Pakistani society. This research was conducted through a qualitative descriptive method; it produces descriptive data in the form of code switched sentences from editorial of Urdu newspaper. In this research paper I discussed code switching in editorial of an Urdu newspaper. Daily Khabrain Newspaper was selected for this purpose. One week newspapers were collected for (...) research from 1st January, 2020 to 7th January, 2020 to analyze code switching in editorial. In this research paper I discussed code switching in editorial of an Urdu newspaper. Aims and Objectives are; in this research paper I discussed code switching in editorial of an Urdu newspaper. Research Question was what type of code switching is in editorial in Daily Khabrain Newspaper? Daily Khabrain Newspaper from first January 2020 to 7th January 2020 was collected for the analysis of language or code switching and its type in editorial. Through the analysis of data of newspaper it can be concluded that the type of code switching was intra sentential, word code switching and total integrated Urdu. (shrink)