This essay examines the arguments for and against working towards the objective of human germ line engineering for medical purposes. Germ line changes which result as a secondary consequence of other well designed and ethically acceptable manipulations of somatic cells to cure an otherwise fatal disease can be seen as acceptable. More serious objections apply to intentional germ line interventions because of the unacceptability of using a person solely as a vehicle for creating uncertain genetic change in his descendants. It (...) is also morally unacceptable to use the promise of future benefit to experiment on fetuses or embryos when other more effective technologies exist to help parents have healthy children. Using new genetic technologies to select desirable genotypes among gametes is less problematic and affords a promising new technique for avoiding intergenerational harms. Keywords: embryo research, germ line manipulation, intergenerational ethics, secondary germ line effects CiteULike Connotea Del.icio.us What's this? (shrink)

Hunger continues to be one of humanity's greatest challenges despite the existence of a more-than-adequate global food supply equal to 2,800 kilocalories for every person every day. In measuring progress, policy-makers and concerned citizens across the globe rely on information supplied by the Food and Agriculture Organization (FAO), an agency of the United Nations. In 2010 the FAO reported that in the wake of the 2007–2008 food-price spikes and global economic crisis, the number of people experiencing hunger worldwide since 2005–2007 (...) had increased by 150 million, rising above 1 billion in 2009. However, in itsState of Food Insecurity in the World 2012(SOFI 12) the FAO presented new estimates, having revamped its methods and reinterpreted its hunger data back to 1990. The revised numbers for the period 1990–1992 to 2010–2012 reverse the trend to a steadily falling one. Based on the FAO's new calculations, extreme undernourishment peaked in 1990 at a record-breaking one billion, followed by a significant decline through 2006, when progress stalled but did not reverse (see chart below). (shrink)

In this note some epistemological problems in general theories about living systems are considered; in particular, the question of hidden connections between different areas of experience, such as folk biology and scientific biology, and hidden connections between central concepts of theoretical biology, such as function, semiosis, closure and life.

This paper uses six policy problems in public health to illustrate the complexity of value considerations in decision-making, and derives an ethic for health protection policies based on the primacy of non-harming. In the first part, health policy is shown to require value considerations beyond simple utilitarianism. In the second, the author posits that much of health impairment can be traced to erosions of health outside the immediate control and consent of the individual. Accordingly, he argues that health impairing actions (...) on the part of others warrant strict regulations in spite of the paternalistic nature of such interventions. The priority for these interventions should be set along a gradient of vulnerability and autonomy, with the greatest hazards to non-consent giving persons warranting the greatest controls. Special attention to fetuses and developing infants is thereby justified, and actions which prevent harms are shown to have priority over those which mitigate harms, ameliorate their effects or promote good. (shrink)

Cryptocurrencies such as Bitcoin, SETLcoin, Ether, Solar Coin, or Liberty Reserve exist since 2009. Because of their decentralized control, they are often considered a threat or alternative to the conventional centralized banking system. While the technological implication of some such currencies, especially of Bitcoin, has attracted much attention, so far there is little discussion about the entire field of cryptocurrencies and very little academic literature addressing its ethical significance. In this article, we thus address the impact of “blockchain technology” on (...) the nature of financial transactions from a business ethics perspective. We begin with a survey on relevant literature from neighboring disciplines. Next, we work towards a 3 × 3 framework for current debates on the ethics of cryptocurrencies : we combine the micro, meso, and macro levels of business and society with assessments of the potential ethical impact of cryptocurrencies as morally beneficial, detrimental, and ambiguous. In addition, we highlight possible avenues for future research, such as the changing roles of the miners and regulators, the prosocial use of cryptocurrencies, the antisocial use for shadow banking and transactions in the ‘dark net’ and cryptocurrencies’ effect on inflation and deflation. (shrink)

If cosmology is to obtain knowledge about the whole universe, it faces an underdetermination problem: Alternative space-time models are compatible with our evidence. The problem can be avoided though, if there are good reasons to adopt the Cosmological Principle (CP), because, assuming the principle, one can confine oneself to the small class of homogeneous and isotropic space-time models. The aim of this paper is to ask whether there are good reasons to adopt the Cosmological Principle in order to avoid underdetermination (...) in cosmology. Various strategies to justify the CP are examined. For instance, arguments to the effect that the truth of the CP follows generically from a large set of initial conditions; an inference to the best explanation; and an inductive strategy are assessed. I conclude that a convincing justification of the CP has not yet been established, but this claim is contingent on a number of results that may have to be revised in the future. (shrink)

This article pursues the question whether and inasmuch theories of corporate responsibility are dependent on conceptions of managerial freedom. I argue that neglect of the idea of freedom in economic theory has led to an inadequate conceptualization of the ethical responsibilities of corporations within management theory. In a critical review of the history of economic ideas, I investigate why and how the idea of freedom was gradually removed from the canon of economics. This reconstruction aims at a deconstruction of certain (...) axioms of neoclassical economics that hamper contemporary efforts in integrating ethics firmly into management education. I intend to show by these deconstructive endeavors that a constructive use of the idea of responsible freedom could correct and complement the current quantitative focus in business theory through qualitative orientations. I argue that with the help of qualitative success criteria, the strategic integration of the tenets of both business ethics and Corporate Social Responsibility into business practice can be advanced by further research. (shrink)

The Human Genome Project is an expensive, ambitious, and controversial attempt to locate and map every one of the approximately 100,000 genes in the human body. If it works, and we are able, for instance, to identify markers for genetic diseases long before they develop, who will have the right to obtain such information? What will be the consequences for health care, health insurance, employability, and research priorities? And, more broadly, how will attitudes toward human differences be affected, morally and (...) socially, by the setting of a genetic “standard”? The compatibility of individual rights and genetic fairness is challenged by the technological possibilities of the future, making it difficult to create an agenda for a “just genetics.” Beginning with an account of the utopian dreams and authoritarian tendencies of historical eugenics movements, this book’s nine essays probe the potential social uses and abuses of detailed genetic information. Lucid and wide-ranging, these contributions will interest bioethicists, legal scholars, and policy makers. Essays: “The Genome Project and the Meaning of Difference,” Timothy F. Murphy “Eugenics and the Human Genome Project: Is the Past Prologue?,” Daniel J. Kevles “Handle with Care: Race, Class, and Genetics,” Arthur L. Caplan “Public Choices and Private Choices: Legal Regulation of Genetic Testing,” Lori B. Andrews “Rules for Gene Banks: Protecting Privacy in the Genetics Age,” George J. Annas “Use of Genetic Information by Private Insurers,” Robert J. Pokorski “The Genome Project, Individual Differences, and Just Health Care,” Norman Daniels “Just Genetics: A Problem Agenda,” Leonard M. Fleck “Justice and the Limitations of Genetic Knowledge,” Marc A. Lappé. (shrink)

1Center for the Philosophy of Nature and Science Studies, Blegdamsvej 17, DK-2100 Copenhagen, Denmark. Published pp. 117-124 in: Mark Bedeau, Phil Husbands, Tim Hutton, Sanjev Kumar and Hideaki Suzuki : Workshop and Tutorial Proceedings. Ninth International Conference on the Simulation and Synthesis of Living Systems.

Monte Carlo simulations arrive at their results by introducing randomness, sometimes derived from a physical randomizing device. Nonetheless, we argue, they open no new epistemic channels beyond that already employed by traditional simulations: the inference by ordinary argumentation of conclusions from assumptions built into the simulations. We show that Monte Carlo simulations cannot produce knowledge other than by inference, and that they resemble other computer simulations in the manner in which they derive their conclusions. Simple examples of Monte Carlo simulations (...) are analysed to identify the underlying inferences. (shrink)

It is argued that the notion of Umwelt is relevant for contemporary discussions within theoretical biology, biosemiotics, the study of Artificial Life, Autonomous Systems Research and philosophy of biology. Focus is put on the question of whether an artificial creature can have a phenomenal world in the sense of the Umwelt notion of Jakob von Uexküll, one of the founding figures of biosemiotics. Rather than vitalism, Uexküll's position can be interpreted as a version of qualitative organicism. A historical sketch of (...) Autonomous Systems Research (ASR) is presented to show its theoretical roots and fruitful opposition to traditional AI style robotics. It is argued that these artificial systems are only partly 'situated' because they do not in the full sense of the word experience an Umwelt. A deeper understanding of truly situated autonomous systems as being a kind of complex selforganizing semiotic agents with emergent qualitative properties must be gained, not only from the broad field of theoretical biology, but also from the perspective of biosemiotics in the Uexküll tradition. The paper is thus an investigation of a new notion of autonomy that includes a qualitative aspect of the organism. This indicates that the Umwelt concept is not reducible to purely functional notions. (shrink)

Within the next few years scientists will almost certainly have pieced together a broad map of the major gene locations on the twenty‐three human chromosomes. The rapid unfolding of this new knowledge raises new questions: What limits, if any, should be imposed on its acquisition? Who should control the wealth of resulting data? How should it be used? If, because of a deep‐seated need for certitude, many persons are likely to perceive a positive gene probe test as an indicator of (...) biologic destiny, probes may acquire a misleading status in our medical armamentarium. (shrink)

Contradictions of the Welfare State is the first collection of Offe's essays to appear in a single volume in English, and it contains a selection of his most important recent work on the breakdown of the post-war settlement.

Lamenting the deplorable state of business ethics is, itself, a staple of the deplorable state of business ethics. But if, as its many critics claim, business ethics continuously fails to deliver on its promise, what could take its place in management education? After business ethics—How else can we integrate ethics into the curriculum? This article argues that an ethical grounding of business theory and corporate practice requires a critique of conventional economics, replacing the mechanistic paradigm that predominated economics over the (...) last 200 years with a humanistic alternative. (shrink)

Today’s globalized economy cannot be governed by legal strictures alone. A combination of self-interest and regulation is not enough to avoid the recurrence of its systemic crises. We also need virtues and a sense of corporate responsibility in order to assure the sustained success of the global economy. Yet whose virtues shall prevail in a pluralistic world? The moral theory of Thomas Aquinas meets the present need for a business ethics that transcends the legal realm by linking the ideas of (...) justice and virtue in an ingenious way. While allowing for, and incorporating, the specificities of region and religion, industry and culture, Thomas’s virtue theory coordinates private and public activities through a set of context-invariant, justice-oriented norms with conceptual appeal to contemporary questions of global business ethics.In our article, we first sketch how Aquinas’s theory can be also of relevance to a non-confessional audience through its appeal to the ‘natural light of reason.’ Then we explain how his theory of ‘natural law’ aligns his ideas of virtue and justice. From this vantage point, we address the tension between cultural diversity and moral uniformity in the economic sphere in general and in today’s globalized business world in particular. Throughout the article, we aim to show that by interpreting the virtue-dimension of business in light of the idea of social justice, Aquinas’s conception of virtuous business conduct gains inter-personal and inter-cultural validity that establishes social justice as the global virtue of business. (shrink)

Several US states are enacting 'right-to-die' laws, in the wake of the Karen Quinlan case. But the way such a law is drafted may cast doubt on a patient's existing common law right to control all aspects of his own treatment; it may give legal sanction to a lower standard of medical care that society at present expects from doctors; and it may lead to conflict between the patient's directive and his doctor's clinical judgement which cannot readily be resolved. The (...) laws themselves are categorised as a) legalising active killing or b) defining rights of patients to control treatment or c) assigning to others the rights to control treatment where the patient is not competent. The California law is discussed critically. The conclusion is that such legislation is not a satisfactory answer to the ethical problem of euthanasia. (shrink)

Asserts the need for Americans to reclaim their traditional values of freedom, democracy and fairness and offers alternatives to accepting political and economic absolutes.

The idea of a higher level phenomenon having a downward causal influence on a lower level process or entity has taken a variety of forms. In order to discuss the relation between emergence and downward causation, the specific variety of the thesis of downward causation (DC) must be identified. Based on some ontological theses about inter-level relations, types of causation and the possibility of reduction, three versions of DC are distinguished. Of these, the `Strong' form of DC is held to (...) be in conflict with contemporary science; the `Medium' version of DC may for instance describe thoughts constraining neurophysiological states, while the `Weak' form of DC is physically acceptable but may not in practice be a feasible description of the mind/brain or the cell/molecule relation. All forms have their specific problems, but the Medium and the Weak version seems to be most promising. (shrink)

If we are to constrain our place in the world, two principles are often appealed to in science. According to the Copernican Principle, we do not occupy a privileged position within the Universe. The Cosmological Principle, on the other hand, says that our observations would roughly be the same, if we were located at any other place in the Universe. In our paper we analyze these principles from a logical and philosophical point of view. We show how they are related, (...) how they can be supported and what use is made of them. Our main results are: 1. There is a logical gap between both principles insofar as the Cosmological Principle is significantly stronger than the Copernican Principle. 2. A step that is often taken for establishing the Cosmological Principle on the base of the Copernican Principle and observations is not incontestable as it stands, but can be supplemented with a different argument. 3. The Cosmological Principle might be crucial for cosmology to the extent it is not supported by empirical evidence. (shrink)

The present paper discusses a topic often neglected by contemporary philosophy of biology: The relation between metaphorical notions of living organisms as information processing systems, the attempts to model such systems by computational means (e.g., Artificial Life research), and the idea that life itself is a computational phenomenon. This question has ramifications in theoretical biology and thedefinition of Iife, in theoretical computer science and the concept of computation, and in semiotics (the study of signs in the most general sense, including (...) information, signification, and meaning), and the concept of the interpreter. It is argued, that the theory of autopoietic systems known from theoretical biology should be integrated with a biosemiotic reflection on the natural history of signs. (shrink)

This article builds on feminist scholarship on new biologies and the body to describe the temporal politics of epigenetic research related to the human placenta. Drawing on interviews with scientists and observations at conferences and in laboratories, we argue that epigenetic research simultaneously positions placenta tissue as a way back into maternal and fetal bodies following birth, as a lens onto children’s future well-being, and as a bankable resource for ongoing research. Our findings reflect how developmental models of health have (...) helped recast the placenta as an agential organ that is uniquely responsive to environments during pregnancy and capable of embodying biological evidence about the effects of in utero experiences after birth. We develop the concept of ‘recursive embodiment’ to describe how placenta epigenetics is reimagining relationships between bodies and environments across developmental, epigenetic, and generational time, and the impacts this has for experiences of pregnancy and responsibilities related to children’s health. (shrink)

Business Ethics: A European Review, EarlyView.

The search for a quantum theory of the gravitational field is one of the great open problems in theoretical physics. This book presents a self-contained discussion of the concepts, methods and applications that can be expected in such a theory. The two main approaches to its construction - the direct quantisation of Einstein's general theory of relativity and string theory - are covered. Whereas the first attempts to construct a viable theory for the gravitational field alone, string theory assumes that (...) a quantum theory of gravity will be achieved only through a unification of all the interactions. However, both employ the general method of quantisation of constrained systems, which is described together with illustrative examples relevant for quantum gravity. There is a detailed presentation of the main approaches employed in quantum general relativity: path-integral quantisation, the background-field method and canonical quantum gravity in the metric, connection and loop formulations. The discussion of string theory centres around its quantum-gravitational aspects and the comparison with quantum general relativity. Physical applications discussed at length include the quantisation of black holes, quantum cosmology, the indications of a discrete structure of spacetime, and the origin of irreversibility. This book will be of interest to researchers and students working in relativity and gravitation, cosmology, quantum field theory and related topics. It will also be of interest to mathematicians and philosophers of science. (shrink)

Der Beitrag von Claus Pias geht von zwei Beobachtungen aus: einem Zurücktreten des Medienbegriffs innerhalb medienwissenschaftlicher Forschung und eines Desinteresses sogenannter ›Digitalisierung‹ ihr gegenüber. Er untersucht, inwiefern Medientheorie (von McLuhan und Kittler bis zu den sogenannten Digital Humanities) durch einen starken Medienbegriff an der Herausbildung von Zeitsemantiken und Narrativen von ›Digitalisierung‹ beteiligt war und von ihnen profitiert hat. Als Konsequenz fordert Pias zu medienwissenschaftlicher Grundlagenforschung auf, die mit einer strategischen Revision und Aktualisierung von ›Medien‹ als Begriff und Gegenstand einhergeht. (...) Der Beitrag von Kathrin Peters stimmt mit dieser Lagebeschreibung nur teilweise überein. Die Skepsis gegenüber den Zukunfts- und Dringlichkeitsrhetoriken gegenwärtiger Digitalisierungsoffensiven wird von ihr geteilt, dass allerdings vor allem eine Medienwissenschaft des ›medientechnischen a priori‹ eine Antwort auf den gegenwarts- und an- wendungsfixierten Digitalisierungsdiskurs liefern könnte, erscheint Peters als zu kurz gegriffen. Andere medienwissenschaftliche Ausrichtungen sind dazu ebenso in der Lage: medienwissenschaftliche Analysen zu Kolonialität und Postkolonialität, feministische, gen- der- und queertheoretische Fragestellungen, eine medienwissenschaftlich informiert Wissenschaftsforschung und Affekttheorie – um nur einige zu nennen. Es geht um Konzepte von Medienwissenschaft als Fragestellung, die ihre Gegenstände in den verschiedensten Bereichen hervorbringen, dabei aber zugleich als Mittel und Mittler immer wieder unsichtbar werden. Debate: Media Studies without Media Claus Pias’ article starts out from two points of observation: a recession of the term media within the field of media studies and a dis- interest of the so-called digitalization in this particular term. Pias examines the impact media theory (ranging from McLuhan and Kittler to the so-called Digital Humanities) had on the development of time semantics and the narratives of ›digitalization‹ due to the use of a strong media term, and how media theory profited from it. mAs a result, Pias calls for establishing basis research in media studies, going hand in hand with a strategic revision and update of media, as a term as well as a subject. In her article, Kathrin Peters only partially agrees with this evaluation. She shares the scepticism concerning future-rhetoric as well as priority-rhetoric, both featuring heavily in current digital offensives; however, in her opinion it is not enough to hope for answers on today’s digitalization-discourse from media studies hailing the media-technical a priori. There are other approaches in media studies which are able to offer these answers: analysis of colonialism and post-colonialism, feministic, gender- and queer-theoretical questions, a media-informed science of knowledge and affect theory, just to name a few of them. It is all about concepts of media science being perceived as problems which bring forth their own subjects in various areas of research, yet as a tool as well as an intermediary, they are frequently overlooked. (shrink)

The development of form in living organisms continues to challenge biological research. The concept of biological information encoded in the genetic program that controls development forms a major part of the semiotic metaphor in biology. Development is here seen in analogy to an execution of a program, written in a formal language in the computer. Other versions of the semiotic or "nature-as-language" metaphor use other formal or informal aspects of language to comprehend the specific structural relations in nature as explored (...) by molecular and evolutionary biology. This intuitively appealing complex of related ideas, which has a long history in the philosophy of nature and biology, is critically reviewed. The general nature of metaphor in science is considered, and different levels of metaphorical transfer of signification is distinguished. It is argued, that the metaphors may be of considerable value, not only heuristically, but in order to comprehend the irreducible nature of living organisms. In arguing for a semiotic perspective on living nature, it makes a marked difference whether the departure is made from the tradition of F. de Saussure´s structural linguistics or from the tradition of general semiotics of C. S. Peirce. An agenda is made for a Peircean perspective on the semiotics of nature. (shrink)

Philosophy Compass, Volume 17, Issue 6, June 2022.

In summary, the creation and maintenance of the Wistar Rats as standardized animals can be attributed to the breeding work of Helen Dean King, coupled with the management and husbandry methods of Milton Greenman and Louise Duhring, and with supporting documentation provided by Henry Donaldson. The widespread use of the Wistar Rats, however, is a function of the ingenuity of Milton Greenman who saw in them a way for a small institution to provide service to science. Greenman's rhetoric, as captured (...) in his Director's Reports, prepared annually from 1905 until his death in 1937, shows that he was unusually sensitive to his times and to the economics of science and of society. In the era when biology was being defined, he recognized in the rat the potential to be a living analog to the pure chemicals that legitimated experimental science. From management literature he extracted the ideals of uniformity of product, standards of quality, and efficiency of production, applying them to scientific practice to generate an animal model that thrives as standard equipment in laboratories throughout the world today.I will close with a quote from Frederick W. Taylor that is a cogent statement of the contribution to science and scientific progress made by standardized tools and their creators. Equating the surgeon and the workman, Taylor wrote: [He is given] the finest implements, each one of which has been the subject of special study and development ... [and] the very best knowledge of his predecessors; and, provided with standard implements and methods which represent the best knowledge of the world up to date, he is able to use his own originality and ingenuity to make real additions to the world's knowledge, instead of reinventing things which are old.Standardized tools, whether surgeons' implements or laboratory-bred rats, are one of the vehicles for carrying scientific knowledge forward from generation to generation. In this sense, Greenman's Wistar Rats have done their job, in his words, of “providing service to science.”. (shrink)

N. Bostrom’s simulation argument and two additional assumptions imply that we likely live in a computer simulation. The argument is based upon the following assumption about the workings of realistic brain simulations: The hardware of a computer on which a brain simulation is run bears a close analogy to the brain itself. To inquire whether this is so, I analyze how computer simulations trace processes in their targets. I describe simulations as fictional, mathematical, pictorial, and material models. Even though the (...) computer hardware does provide a material model of the target, this does not suffice to underwrite the simulation argument because the ways in which parts of the computer hardware interact during simulations do not resemble the ways in which neurons interact in the brain. Further, there are computer simulations of all kinds of systems, and it would be unreasonable to infer that some computers display consciousness just because they simulate brains rather than, say, galaxies. (shrink)

In his Critique of Pure Reason, in the chapter on the antinomy of pure reason, Kant not only argues that aprioristic cosmology is doomed to failure; he also implies that empirical knowledge about the universe is impossible. Today, such a negative verdict about the possibility of cosmological knowledge seems implausible because physical cosmology has made substantial progress. In particular, the spatiotemporal extension of the universe now seems a matter of empirical investigation in which models figure centrally. But I think it (...) is worth considering the possibility that Kant got something right and that he offers insights that can help us to better understand problems in present-day cosmology. In this article, I explore a striking coincidence: according to both Kant and current wisdom, cosmology faces a serious underdetermination problem regarding the spatiotemporal extension of the world. As a closer analysis reveals, however, Kant and modern cosmology differ on the reasons why underdetermination arises. In current cosmology, underdetermination follows from laws that are knowable a posteriori, and not only from the very idea of cosmological knowledge, as Kant would have it. This suggests that the current underdetermination problem is not fully a Kantian one. (shrink)