This paper defends a constructive interpretation of the Critique of Pure Reason, which is built in analogy with an experimental construction that Kant believes to characteristic of chemistry. I also argue for a way to reconcile the methodological perspective of the constructivist method with that of transcendental reflection. I therefore provide a constructive explanation for what Kant describes as being pure reason and the argument of the transcendental deduction. I propose to frame the different perspectives in such a way that (...) the experimental construction is the ratio cognoscendi of pure reason, while pure reason is the ratio essendi of the experimental construction. O’Neill (1989, 2015) is one of the most important scholars that have argued for a constructivist reading of the Critique of pure reason (CPR). In this paper I develop and explore new aspects of this line of interpretation. One of the main criticisms raised against constructivist readings of Kant’s philosophy is an alleged commitment to subjectivism or voluntarism (cf. Kleingeld & Willaschek 2019). This concern led some scholars to rename their position as constitutivist instead (Korsgaard 2009; Sensen 2013, 2017; Formosa 2011). Constitutivism, is intended to be a sort of constructivism capable of avoiding voluntarism. However, it becomes difficult, sometimes, to differentiate between the constitutivist and foundationalist positions, which are based on transcendental reflection and imply a sort of realist perspective on reason. The same preoccupation applies to the constructivist interpretation of the CPR. In order to deal with this issue, the following questions must be addressed: how can constructivism justify the necessity and universality of transcendental principles of pure reason without compromising the normative and procedural aspects of the construction? How to reconcile arguments based on the analysis of representations and faculties with a constructivist procedure? Or even, how may transcendental reflection, as a view of the possibility of a priori cognition, be rendered compatible with a constructive procedure? This paper is divided into three sections, followed by brief final remarks. The first section outlines the main characteristics of constructivism and relates them to Kant’s positions about the nature of philosophy and its method. The second part argues for a type of experimental constructivism that might serve as a guiding analogy to understand the method underlying the CPR. Thirdly, I will show how the transcendental subject and pure reason are derived from this experimental construction. The conclusion briefly points out some advantages of this position. (shrink)

Summary The purpose of this work is to translate some of Robert Boyle's chemical experiments into the terms of modern chemistry. Most of the reactions involve sensible qualities, since there are on it considerable helpful tracking descriptions like heating, hissing, colour changing, etc. For a long time in the history of science, this procedure was seen as an exercise in anachronism which should be avoided at all costs. Recently many scholars have demonstrated that chemical translation can assist (...) with historical work instead of causing confusion, and it may be very useful as a tool for the history of chemistry and for reproducing past chemical experiments. (shrink)

There are some who would question the need to republish papers that have already appeared elsewhere. Walter Pauel once said that scholars should think in terms of books rather than research papers since the latter become lost in the literature. When he told me this year ago I was not entirely convinced. Surely the young scholar must publish papers to secure his academic position. In addition, throughout his career he attends conferences many of which will require the publication of his (...) papers in the resultant conference volumes. By their very nature such papers often discuss topics in greater detail than that scholar's subsequent books. In this case also the papers tend to become "lost" even when there exit extensive guides to the literature such as the Critical Bibliography published annually in Isis for historians of science. Many of my own papers over the past forty-five years have indeed appeared in such conference volumes as in journals. (shrink)

This paper explores how a set of observations on the weight of lead were interpreted and assessed between the 1540s and the 1630s across three different interconnecting disciplines: medicine, mineralogy and chemistry. The epistemic import of these discussions will be demonstrated by showing: 1) the changing role and articulation of experience and quantification in the investigation of metals; and 2) the notions associated with weight in different disciplinary frameworks. In medicine and mineralogy, weight was not considered as a specific subject (...) of inquiry in itself, but as a “sign” indicating other relevant properties of metals. In contrast, the chemistry tradition was increasingly concerned with the specific investigation of weight as a property of matter, as seen in the debates that took place in the “chemical revolution.” In addition, this study will reveal the versatility, polysemy, and parallel purposes of the recourse to experiential knowledge in different contexts, where the same “facts” operate within different disciplines. (shrink)

In The Conditions for Ethical Chemical Restraint, Crutchfield and Redinger (2024) propose ethical standards for the use of chemical restraints, which they consider normatively distinct from physica...

I discuss two puzzling and neglected passages in the Critique of Practical Reason, namely, V:92 and V:163. In these passages Kant claims that practical philosophers should follow the paradigm of the chemist and conduct experiments on common human reason. I explain Kant’s conception of the chemical experiment, provide a detailed interpretation of the two passages in question, and conclude by applying the structure of the chemical experiment to the Analytic of the Critique of Practical Reason. Chemical (...) experiments as a model of ethics should be understood as a method of confirming that a philosophical theory systematizes and defends ideas that ordinary rational agents are already committed to. (shrink)

This argument map presents Paul Loewi’s crucial experiment in which he showed that neural transmissions of signals are chemical in nature, not electrical, in form of an argumentation. The map can be used in science education to show how the formulation of hypotheses should be related to a corresponding determination of experimental designs.

Long-standing neglect of the chemical senses in the philosophy of perception is due, mostly, to their being regarded as ‘lower’ senses. Smell, taste, and chemically irritated touch are thought to produce mere bodily sensations. However, empirically informed theories of perception can show how these senses lead to perception of objective properties, and why they cannot be treated as special cases of perception modelled on vision. The senses of taste, touch, and smell also combine to create unified perceptions of flavour. (...) The nature of these multimodal experiences and the character of our awareness of them puts pressure on the traditional idea that each episode of perception goes one or other of the five senses. Thus, the chemical senses, far from being peripheral to the concerns of the philosophy of perception, may hold important clues to the multisensory nature of perception in general. (shrink)

The ArgumentThe overall portrayal of early modern experimentation as a new method of securing assent within a philosophical discourse sketched in many of the recent studies on the historical origin of experimentation is questioned by the analysis of the experimental practice of chemistry at the Paris Academy. Chemical experimentation at the Paris Academy in the late seventeenth and early eighteenth century originated in a different tradition than the philosophical. It continued and developed the material culture of the chemical (...) work shops of the sixteenth and seventeenth centuries, and explored epistemic objects which had rather loose connections to philosophy. On the other hand, I argue against the classical dichotomy between the work of the mind that of the hand, and for an epistemology of experimentation that acknowledges that experimental manipulation goes hand in hand with reflexion. In particuler, I argue against the view that chemists at the Paris Academy were “pragmatists” who merely gathered experimental facts and classified substances and operations without perplexing themselves over general conceptions. I claim that the chemists at the Paris Academy constructed a general conception framework which shaped the significance of their experiments. This conception that I call conception of the chemical combination, compound and reaction was rather quickly reified into an experimental fact. Despite its generality it was a genuine chemical conception rather independent of philosophy. (shrink)

The ArgumentThe relation between alchemy and early chemistry is still open to debate. How did what is now often dismissed as a pseudo-science contribute to the emerging science of chemistry, a subject that by the late eighteenth century, was often held up as a model for other sciences? Alchemy may have bequeathed to chemistry some processes and apparatus; more fundamental, however, was a transformation in mentality. It was in the seventeenth century that much of this transformation took place.A study that (...) was deeply anthropomorphic, making constant use of allegories and symbolism, and with a language rejoicing in mystery and concealment, gradually became depersonalized, much more objective, and more open. Poetic descriptions, a moral dimension, and a hierarchical view of matter all disappeared. Practical considerations required a concern for greater purity of materials, necessary for the successful replication of experiments. A study of the series of seventeenth-century French textbooks of chemistry from Beguin to Lemery reveals a growing desire for practical results and plain speaking. Robert Boyle was particularly influential in urging the necessity of plain language. The creation of a suitable language to denote and differentiate among different chemical species was a crucial step in the development of early chemistry, thus preparing the way for the systematic names introduced in the following century and the full organization of the science on rational lines. (shrink)

Smell can be understood as a cultural phenomenon, historically signified, enforcing social structures or transgressing them, creating social bonds – empowering or disempowering people. The perception of smell consists not only of the sensation of the odours themselves, but of the experiences and emotions associated with them. Odours, unlike colours, for instance, cannot be named, only described; in the realm of olfaction, we must make do with descriptions, analogies and recollections. It is an elusive phenomenon. From natural environments to urban (...) spaces, the large variety of odours can stimulate our olfactory senses and evoke experiences, in which pleasant and unpleasant, and even non-smelling scents, can be combined as parameters of spatial limits and social bounds. Thus, smell can be used to structure and classify different aspects of the world, from time and space to gender and selfhood. The aim of this text is to comprehend some chemical and cultural aspects of smells and odours, and their potential to elaborate social connections and configure spatial orientations. Based on some examples from the Bororo of Brazil and the aboriginal inhabitants of the Andaman Islands, odours are understood as cultural classification systems and means of ordering the world. At the end, some artists – such as Usman Haque, Rion Willard and Jenny Marketou – will be presented since their art works proposals of mapping and describing physical spaces through smells and odours can be apprehended as a medium to create evocative experiences. (shrink)

Two different models for chemical bond were developed almost simultaneously after the Schrödinger formulation of quantum theory. These are known as the valence bond (VB) and molecular orbital (MO) theories. Initially chemists preferred the VB theory and ignored the MO theory. Now the VB theory is almost dropped out of currency. The context of discovery and Linus Pauling’s overpowering influence gave the VB theory its initial advantage. The current universal acceptance of the MO theory is due to its ability (...) to provide direct interpretation of many different types of experiments now being pursued. In current research both localized bonds and delocalized charge distributions play important roles and the MO theory has been successful in giving a good account of both. (shrink)

By the end of the Second World War the advancing allied forces discovered a new nerve gas in Germany. It was called Tabun. Codenamed GA, it was found to be extremely toxic. British experts were immediately dispatched to examine the agent. On arrival, they discovered that German scientists had also developed even more toxic nerve agents, including Sarin, known as GB. The first organized testing of Sarin on humans began in October 1951 at Porton Down in Wiltshire, Britain's biochemical warfare (...) establishment since the First World War. In February 1953, volunteer number 562 experienced the first recorded serious adverse reaction. Testing continued. Two months later, on April 27, six subjects were given 300 milligrams of Sarin. One of the volunteers, a man named Kelly, suffered serious ill effects, fell into a coma, but then recovered. Although asked by their superiors to reduce the amount tested to the “lowest range of dosage”—which would have been somewhere in the region of 10–15 milligrams—Porton's scientists continued their tests with a “lower” dosage, reducing it from 300 to 200 milligrams. (shrink)

The landscape of seventeenth-century chemistry is complex, and it is impossible to find in it either a clear-cut distinction between alchemy and chemistry or a sort of simple identification of the two. The seventeenth-century cultural context contained a rich variety of "chemical" discourses with arguments ranging from specific experiments to the justification of the validity of chemistry and its novelty in terms of its extraordinary antiquity. On the basis of an analysis of the works by O. Borch, J.J. (...) Glauber, and J. J. Becher, this paper tries to demonstrate that a historical reconstruction of "chemistry" must consider these different levels of the chemical debate. Only then will it be possible to appreciate the outstanding role played by G.E. Stahl in founding modern chemistry. The paper argues in favor of a contextualization of the historical research on seventeenth-century chemistry. (shrink)

By comparing chemistry to art, chemists have recently made claims to the aesthetic value, even beauty, of some of their products. This paper takes these claims seriously and turns them into a systematic investigation of the aesthetics of chemical products. I distinguish three types of chemical products - materials, molecules, and molecular models - and use a wide variety of aesthetic theories suitable for an investigation of the corresponding sorts of objects. These include aesthetics of materials, idealistic aesthetics (...) from Plato to Kant and Schopenhauer, psychological approaches of Ernst Gombrich and Rudolf Arnheim, and semiotic aesthetics of Nelson Goodman and Umberto Eco. Although the investigation does not support recent claims, I point out where aesthetics does and can play an import role in chemistry. Particularly, Eco's approach helps us understand that and how aesthetic experience can be a driving force in chemical research. (shrink)

This paper explores the use of chemical symbolism in works by the new media artist Sonya Rapoport, with a focus on the pivotal Cobalt series from the late 1970s. These works, drawings on computer printouts generated by research at the Lawrence Berkeley Laboratory, respond to experiments in nuclear chemistry. They mark the beginning of three productive decades in which Rapoport produced a variety of images related to chemistry in her work. She states, “I looked for authentic research projects (...) that were interesting to me, preferably with captivating pictorial subject matter. Then came the creative chaotic process of resolving a cohesive product that combined scientific research with art concept.” Rapoport had an unusual degree of access to scientific materials through her husband, organic chemist Henry Rapoport, a faculty member at the University of California, Berkeley. At the time of production, these works were outside mainstream art world interests and they have received little critical attention. This paper examines the development of Rapoport’s images and places her use of chemical references in context in her lifetime of work. (shrink)

The creation of pharmacotherapies, such as Selective Serotonin Reuptake Inhibitors (SSRIs), for the treatment of depression was hailed as a great breakthrough in mental health care. However, since that time, serious questions have arisen as to their safety and the way they are prescribed without full information being provided to patients about a range of important issues, including the possible aetiologies of depression, and the efficacy and potential side-effects of medication. These issues have been especially important in the care and (...) treatment of young people, as there is evidence that SSRIs may be implicated in increased suicidal behaviour. In this article, we examine the experiences of five individuals who were prescribed an SSRI in their late teens or early twenties, and discuss some of the ethical issues that arise from their accounts. (shrink)

The recent rapid development of information technology, such as sensing technology, communications technology, and database, allows us to use simulation experiments for analyzing serious accidents caused by hazardous chemicals. Due to the toxicity and diffusion of hazardous chemicals, these accidents often lead to not only severe consequences and economic losses, but also traffic jams at the same time. Emergency evacuation after hazardous chemical accidents is an effective means to reduce the loss of life and property and to smoothly (...) resume the transport network as soon as possible. This paper considers the dynamic changes of the hazardous chemicals’ concentration after their leakage and simulates the diffusion process. Based on the characteristics of emergency evacuation of hazardous chemical accidents, we build a mixed-integer programming model and design a heuristic algorithm using network optimization and diffusion simulation. We then verify the validity and feasibility of the algorithm using Jinan, China, as a computational example. In the end, we compare the results from different scenarios to explore the key factors affecting the effectiveness of the evacuation process. (shrink)

In his Kritik der reinen Vernunft, Kant asserts that laws of nature “carry with them an expression of necessity”. There is, however, widespread interpretive disagreement regarding the nature and source of the necessity of empirical laws of natural sciences in Kant's system. It is especially unclear how chemistry—a science without a clear, straightforward connection to the a priori principles of the understanding—could contain such genuine, empirical laws. Existing accounts of the necessity of causal laws unfortunately fail to illuminate the possibility (...) of non-physical laws. In this paper, I develop an alternative, ‘ideational’ account of natural laws, according to which ideas of reason necessitate the laws of some non-physical sciences. Chemical laws, for instance, are grounded on ideas of the elements, and the chemist aims to reduce her phenomena to these elements via experimentation. Although such ideas are beyond the possibility of experience, their postulation is necessary for the achievement of reason's theoretical ends: the unification and explanation of the cognitions of science. (shrink)

This chapter argues that smell and flavour perception present distinctive challenges for phenomenological reflection, but that these difficulties can be addressed through a ‘gestaltist’ approach to perceptual organisation. I argue that the ‘chemical’ senses do not generally allow immediate access to ordinary objects like roses and apples, but rather to odours and flavours, the diffuse nature of which make it hard to get a grip on the associated perceptual phenomenology. Drawing on the work of gestalt psychologists and phenomenologists, I (...) outline a modality-neutral approach that emphasises the irreducibly structured nature of perceptual experience and is especially useful for thinking about experiences that are not targeted at ordinary physical objects. Such an approach can clarify and explain nebulous aspects of perceptual experience, illuminating elements of our smell and flavour experiences that may be indeterminate. (shrink)

This paper investigates the emergence, in the second part of the 17th century, of a new body of experimental knowledge dealing with the chemical transformations of water taking place in plants. We call this body of experimental knowledge a “chemical history of vegetation.” We show that this chemical natural history originated, in terms of recipes and methods of investigation, in the works of Francis Bacon and that it was constructed in accordance with Bacon's precepts for putting together (...) natural and experimental histories. Our paper covers a wide array of experimental investigations, carried out by people with different backgrounds, theoretical assumptions, and metaphysical allegiances (Thomas Browne, Robert Sharrock, Robert Boyle, Nehemiah Grew, John Beale, and John Evelyn). We claim that, despite their differences, these naturalists had a lot in common. First, they treated plants as laboratories of chemical investigation. Second, they used the experiments with plants to develop tools, hypotheses, and operational concepts, which travelled from one naturalist to the other, even when their respective explanatory vocabularies were widely different. Third, we show that some of them also manifested an interest in defining and clarifying the limits and structure of this new body of experimental knowledge, displaying, thus, a certain disciplinary unity. (shrink)

Chemical engineering - as a recognised skill in the workplace, as an academic discipline, and as an acknowledged profession - is scarcely a century old. Yet from a contested existence before the First World War, chemical engineering had become one of the 'big four' engineering professions in Britain, and a major contributor to Western economies, by the end of the twentieth century. The subject had distinct national trajectories. In Britain - too long seen as shaped by American experiences (...) - the emergence of recognised chemical engineers was the result of professional aspirations and contingency, and shaped by a shifting ecology of institutions, firms and government. Drawing upon extensive archival research, this book examines the evolution of technical practice, working environment and social interactions of chemical engineering. It will be of considerable interest to historians, sociologists of the professions, and to practitioners themselves. (shrink)

This paper investigates the determinants of the diffusion of the international environmental management system standard ISO 14001 within the chemical industry using a panel of 126 different countries during the period 2000 to 2003. We investigate how institutional pressure originating from different stakeholders such as governments, businesses, and the civil society and forces related to trade will drive the diffusion. Our results show that the level of community involvement within a particular country and the previous experience of businesses with (...) voluntary standards such as Responsible Care and ISO 9000 impacts ISO 14001 adoption in chemical firms. (shrink)

A review of the chemical education research literature suggests that the term constructivism is used in two ways: experience-based constructivism and discipline-based constructivism. These two perspectives are examined as an epistemology in relation to the teaching and learning of the concept of idealization in chemistry. It is claimed that experience-based constructivism is powerless to inform the origin of such concepts in chemistry and while discipline-based constructivism can admit such theoretical concepts as idealization it does not offer any unique perspectives (...) that cannot be obtained from other models. Chemical education researchers do not consistently appeal to constructivism as an epistemology or as a teaching/learning perspective and it is shown that, while it draws attention to worthwhile teaching/learning strategies, it cannot be considered as foundational to chemical education research and tends to be used more as an educational label than as an undergirding theory. (shrink)

The historical background of the discovery of adverse health effects of medicines, food additives, pesticides, and other chemicals is reviewed, and the development of national and international regulations and testing procedures to protect the public against the toxic effects of these drugs and chemicals is outlined. Ethical considerations of the safety evaluation of drugs and chemicals by human experimentation and animal toxicity studies, ethical problems associated with clinical trials, with the falsification of clinical and toxicological data, and with inadequate experimental (...) methodology, are reviewed, and the ethics of the marketing of drugs and their post-marketing surveillance, are similarly considered. These ethical problems are illustrated with many specific examples, including the drugs neoarsphenamine, chloramphenicol, thalidomide, diethyl stilboestrol and benoxaprofen. (shrink)

First responders to chemical, biological, radiological, or nuclear (CBRN) events face decisions having significant human consequences. Some operational decisions are supported by standard operating procedures, yet these may not suffice for ethical decisions. Responders will be forced to weigh their options, factoring-in contextual peculiarities; they will require guidance on how they can approach novel (indeed unique) ethical problems: they need strategies for “on the spot” ethical decision making. The primary aim of this paper is to examine how first responders (...) should approach on the spot ethical decision-making amid the stress and uncertainty of a CBRN event. Drawing on the long-term professional CBRN experience of one of the authors, this paper sets out a series of practical ethical dilemmas potentially arising in the context of a large-scale chemical incident. We propose a broadly consequentialist approach to on the spot ethical decision-making, but one which incorporates ethical values and rights as “side-constraints”. (shrink)

The philosophy of perception has been dominated by vision, with very little discussion of the chemical senses – olfaction and gustation. In this second entry of a pair on olfactory experience, I consider what olfaction has to tell us about two issues: the nature of perceptual objects and the nature of perceptual properties and, in particular, the secondary qualities. Given the scant work on olfaction in the philosophical literature, my discussion not only surveys what philosophers have said about olfaction (...) so far, but considers the most plausible views and/or most pressing questions in each area of inquiry. (shrink)

In 2002 the American Chemical Society (ACS) asked its members to submit proposals for the "ten most beautiful experiments in chemistry" (C&EN, Nov. 18, 2002, p. 5) and then proudly published the result of the vote in its Chemical and Engineering News magazine (C&EN, Aug. 25, 2003, pp. 27-30). Democratic as the procedure is, it avoids asking critical questions: What is an experiment? What is beauty? What is chemistry? In fact, you need not be able to give (...) an answer to these questions in order to vote. We could even imagine none of the voters being able to answer any of the questions in explicit terms. And yet, the members of the society might correctly consider the result valid, not only with regard to the top ten list but also regarding its implicit definitions of what ‘experiment’, ‘beauty’, and ‘chemistry’ means. The result thus reflects the tacit knowledge and the unquestioned feelings of the majority, as they have previously been trained to respond to such unusual questions, and helps newcomers to acculturate easily. However, such implicit consensus definitions and assessments are neither binding for non-members, nor suitable for explicit debates. Prompted by the questions of what a beautiful experiment in chemistry is, you might repeat the top ten list you have learnt by heart, but otherwise remain silent. (shrink)

This article examines the chemistry of race at the turn of the nineteenth century. Physicians, philosophers, and intellectuals from Benjamin Rush to Everard Home defined the skin color of Africans as resulting from the changes of the body's humors. Radical physicians like Benjamin Rush believed that he could “cure” African slaves of what he identified as indicative of sickness, their skin color, as they were essentially sick white people in his mind. Overall, the study seeks to explain the medical and (...) chemical understanding of race and the potential for “curing” blackness. Often these cures were linked to balancing and unblocking the fluids. A justification for these ideas comes from cases where people seemed to have spontaneously turned black and experiments where black people were turned white. (shrink)

Taste as Experience puts the pleasure of food at the center of human experience. It shows how the sense of taste informs our preferences for and relationship to nature, pushes us toward ethical practices of consumption, and impresses upon us the importance of aesthetics. Eating is often dismissed as a necessary aspect of survival, and our personal enjoyment of food is considered a quirk. Nicola Perullo sees food as the only portion of the world we take in on a daily (...) basis, constituting our first and most significant encounter with the earth. Perullo has long observed people's food practices and has listened to their food experiences. He draws on years of research to explain the complex meanings behind our food choices and the thinking that accompanies our gustatory actions. He also considers our indifference toward food as a force influencing us as much as engagement. For Perullo, taste is value and wisdom. It cannot be reduced to mere chemical or cultural factors but embodies the quality and quantity of our earthly experience. (shrink)

This article attempts a contextual study of the origin and early development of August Kekulé's theory of aromatic compounds. The terminus a quo is essentially August Hofmann's coining of the modern chemical denotation of ‘aromatic’ in 1855; the terminus ad quem is the first full codification of Kekulé's theory in the sixth fascicle of his Lehrbuch der organischen Chemie, published in the summer of 1866. Kekulé's theory is viewed in context with the earlier and concurrent experimental work of such (...) chemists as Hermann Kolbe, Friedrich Beilstein, Rudolph Fittig, and Hugo Müller. The reception of the theory is briefly examined. Attention is paid to the role of Kekulé's molecular models and of his celebrated dream anecdote of the snake that seizes its own tail. The episode is used as a case study for the continuity of scientific progress, and to illustrate the close reciprocal interactions of hypothesis and experiment in the evolution of a scientific theory. (shrink)

In his celebrated historic-epistemological work Identité et réalité, Émile Meyerson claimed that the scientific conservation principles were first suggested and accepted for philosophical reasons, and only afterwards were submitted to experimental tests. One of the instances he discussed in his book is the principle of mass conservation in chemical reactions. Meyerson pointed out that several authors, from Antiquity to Kant, accepted the idea of quantitative conservation of matter; and Lavoisier himself was strongly influenced by a priori ideas, using this (...) principle instead of attempting to test it. This paper will review Meyerson’s claim and historic evidence, focusing especially the late nineteenth and early twentieth century, when the principle of mass conservation was tested in highly accurate experiments. Instead of confirming the principle, some of those experiments led to the detection of anomalies. Hans Landolt, for instance, noticed that there were some small violations of the principle. He observed mass variations of about 10−6 in chemical reactions produced in hermetically sealed glass tubes. Since Landolt was a famous chemist, his results produced a strong response. Several researchers repeated his experiments, with different results. Landolt himself improved his experiments, with a balance that could detect mass changes of 10−7. After changes of the experimental procedure, the chemical reactions did not show significant mass changes. There was not, however, any “crucial experiment” “proving” that mass was conserved. The observed anomalies were set aside mainly by theoretical reasons, after the discovery of radioactivity and the development of the theory of relativity. (shrink)

I analyse scientific articles on human pheromones from a critical feminist perspective, using new materialist feminist theories, in particular, the work of Judith Butler, Karen Barad and Annemarie Mol. Pheromones were defined by Karlson and Lüscher in 1959 as ‘substances which are secreted to the outside by an individual and received by a second individual of the same species, in which they release a specific reaction – for example, a definite behavior or a developmental process’. In humans, it remains unclear (...) whether substances act as pheromones. With reference to Butler, I show how heteronormativity as a discourse influences research on two potential human pheromones, androstadienone and estratetraenol. I argue that experiments on these two substances have been set up to combine sex-specificity, heterosexuality and reproduction. In these experiments, only the inconsistent effects of androstadienone and estratetraenol were demonstrated. With reference to Barad, I interpret this inconsistency as an indicator of ‘resistant matter’. I argue that in order to experimentally show ‘heteronormative pheromones’ materialities (pheromones) have to merge with discourse (heteronormativity). Androstadienone and estratetraenol partly refuse this collaboration. Finally, I refer to Mol's concept of multiple realities and discuss whether alternative, non-heteronormative effects of pheromones occur instead. (shrink)

This paper uses scientific perspectivism as a lens for understanding acid experiments from the Chemical Revolution. I argue that this account has several advantages over several recent interpretations of this period, interpretations that do not neatly capture some of the historical experiments on acids. The perspectival view is distinctive in that it avoids discontinuity, allows for the rational resolution of disagreement, and is sensitive to the historical epistemic context.

What did nineteenth-century chemists know? This essay uses Emil Fischer’s classic study of the sugars in 1880s and 90s Germany to argue that chemists’ knowledge was not primarily vested in the theories of valence, structure, and stereochemistry that have been the subject of so much historical and philosophical analysis of chemistry in this period. Nor can chemistry be reduced to a merely manipulative exercise requiring little or no intellectual input. Examining what chemists themselves termed the “art of chemical experimentation” (...) reveals chemical practice as inseparable from its cognitive component, and it explains how chemists integrated theory with experiment through reason. (shrink)

Replacing animal procedures with methods such as cells and tissues in vitro, volunteer studies, physicochemical techniques and computer modelling, is driven by legislative, scientific and moral imperatives. Non‐animal approaches are now considered as advanced methods that can overcome many of the limitations of animal experiments. In testing medicines and chemicals, in vitro assays have spared hundreds of thousands of animals. In contrast, academic animal use continues to rise and the concept of replacement seems less well accepted in university research. (...) Even so, some animal procedures have been replaced in neurological, reproductive and dentistry research and progress is being made in fields such as respiratory illnesses, pain and sepsis. Systematic reviews of the transferability of animal data to the clinical setting may encourage a fresh look for novel non‐animal methods and, as mainstream funding becomes available, more advances in replacement are expected. BioEssays 29:918–926, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Between 1869 and 1871, D. I. Mendeleev, a teacher at the University at St Petersburg published a textbook of general chemistry intended for his students. The title, Principles of Chemistry was typical for the time: it meant that chemistry was no longer an inquiry on the ultimate principles of matter but had become a science firmly established on a few principles derived from experiment.

For centuries the question of the origin of life had focused on the question of the spontaneous generation of life, at least primitive forms of life, from inanimate matter, an idea that had been promoted most prominently by Aristotle. The widespread belief in spontaneous generation, which had been adopted by the Church, too, was finally abandoned at the beginning of the twentieth century, when the question of the origin of life became related to that of the artificial generation of life (...) in the laboratory. This paper examines the role of social authorities, researchers’ basic beliefs, crucial experiments, and scientific advance in the controversies about spontaneous generation from the seventeenth to the nineteenth centuries and analyzes the subsequent debates about the synthesis of artificial life in the changing scientific contexts of the nineteenth and early-twentieth centuries. It shows that despite the importance of social authorities, basic beliefs, and crucial experiments scientific advances, especially those in microbiology, were the single most important factor in the stepwise abandoning of the doctrine of spontaneous generation. Research on the origin of life and the artificial synthesis of life became scientifically addressed only when it got rid of the idea of constant smooth transitions between inanimate matter and life and explored possible chemical and physical mechanisms of the specificity of basic molecules and processes of life. (shrink)

This book introduces an events-based approach to understanding digital experience. Focusing on the event-ontologies of Bergson and Whitehead's process metaphysics, it explores subjective experience and objective reality as unified 'events' in the form of concrete slabs of existence. Such slabs are temporally defined by a term or period, in which all physical-chemical processes and personal subjective experience are included. Bringing together insights from a range of different specialisms, it urges us to consider a science of nature that includes both (...) physical and non-physical realities and, from this ontological position, draws on philosophy, media, and user experience practice to provide a new account of the technological or virtual world of today. An examination of the manner in which process philosophy may be applied to contemporary digital experience, this volume will appeal to scholars of philosophy, science and technology studies and information systems. (shrink)

Visual experience is often characterised as being essentially spatial, and auditory experience essentially temporal. But this contrast, which is based upon the temporal structure of the objects of sensory experience rather than the experiences to which they give rise, is somewhat superficial. By carefully examining the various sources of temporal variation in the chemical senses we can more clearly identify the temporal profile of the resulting smell and taste (aka flavour) experiences. This in turn suggests that at least some (...) of the objects of olfactory experience have significant temporal structure, including interactions between odorants and the body’s own sensory systems. This can help to inform our understanding not only of the metaphysics of olfaction, but the temporal structure of sensory processing and experience in other sense-modalities, including vision and audition. (shrink)

This article examines to what extent a particular case of cross-disciplinary research in the 1930s was structured by mechanistic reasoning. For this purpose, it identifies the interfield theories that allowed biologists and chemists to use each other’s techniques and findings, and that provided the basis for the experiments performed to identify plant growth hormones and to learn more about their role in the mechanism of plant growth. In 1930, chemists and biologists in Utrecht and Pasadena began to cooperatively study (...) plant growth. I will argue that these researchers decided to join forces because they believed to rely on each other’s findings and methods to solve their research problems adequately. In the course of the cooperation, organic chemists arrived at isolating plant growth hormones by using a test method developed in plant physiology. This achievement, in turn, facilitated biologists’ investigation of the mechanism of plant growth. Researchers eventually believed to have the means to study the relation between a substance’s molecular structure and its physiological activity. The way they conceptualized the problem of identifying hormones and unraveling the mechanism of plant growth, as well as their actual research actions are compatible with the new mechanists’ account of mechanism research. The study illustrates that focusing on researchers’ mechanistic reasoning can contribute considerably to explaining the structure of cross-disciplinary research projects. (shrink)

There is unquestionably a plethora of details and mysteries regarding the mind and the body. However, with the advent of psychopharmacology (the study of how psychedelics inform or alter brain states) there are more issues at hand. Do psychedelics allow us to access deeper areas of our consciousness? Are we having a spiritual experience under the influence of psychedelics? Dr. Rick Strassman does not want to continue asking these rather conspiratorial-like questions. Instead, Dr. Strassman believes that there is one special, (...) endogenous psychedelic, synthesized within the human physiological framework: N, N-Dymthethyltryptamine. Dr. Strassman concludes that this chemical is produced within and around the pineal gland, and is often the catalyst for spiritual and religious experiences. I will explore this topic further under the framework of discovering whether a naturalistic type explanation of spiritual experiences accounts for all types of spiritual experiences and whether one may be rational or justified in believing in God if a naturalist could explain spiritual experiences. (shrink)

Thought experiments in the history of science display a striking asymmetry between chemistry and physics, namely that chemistry seems to lack well-known examples, whereas physics presents many famous examples. This asymmetry, I argue, is not independent data concerning the chemistry/physics distinction. The laws of chemistry such as the periodic table are incurably special, in that they make testable predictions only for a very restricted range of physical conditions in the universe which are necessarily conditioned by the contingences of (...) class='Hi'>chemical investigation. The argument depends on how ‚thought experiment’ is construed. Here, several recent accounts of thought experiments are surveyed to help formulate what I call ‚crucial’ thought experiments. These have a historical role in helping to judge between hypotheses in physics, but are not helpful in chemistry past or present. (shrink)