Ancient pathways promoting unicellularity and multicellularity are associated with cancer, the former being pro‐oncogenic and the latter acting to suppress oncogenesis. However, there are only a limited number of non‐vertebrate models for studying these pathways. Here, we review Dictyostelium discoideum and describe how it can be used to understand these gene networks. D. discoideum has a unicellular and multicellular life cycle, making it possible to study orthologs of cancer‐associated genes in both phases. During development, differentiated amoebae form a fruiting body (...) composed of a mass of spores that are supported atop a stalk. A portion of the cells sacrifice themselves to become non‐reproductive stalk cells. Cheating disrupts the principles of multicellularity, as cheater cells alter their cell fate to preferentially become spores. Importantly, D. discoideum has gene networks and several strategies for maintaining multicellularity. Therefore, D. discoideum can help us better understand how conserved genes and pathways involved in multicellularity also influence cancer development, potentially identifying new therapeutic avenues. (shrink)

Ernest Sosa (1940-) is a central figure in contemporary epistemology. He is best known for pioneering the subfield of virtue epistemology, as well as developing across four decades his own distinctive framework in this tradition. Besides providing an overview of this work, this article offers a guide to Sosa’s other contributions to epistemology, stretching back to his first publication in 1964. The organization is as follows. §1 reviews Sosa’s distinctive brand of virtue epistemology and its development since 1980. §2 provides (...) a fuller synopsis of Sosa’s contributions to epistemology in five parts, covering his work on (i) the structure of justification and knowledge, (ii) the dawning of knowledge and understanding, (iii) skepticism and the possibility of empirical knowledge, (iv) methodology and the possibility of philosophy, and (v) the relationship between mind and world. Our aim is to encourage renewed appreciation of the full scope and depth of Sosa’s epistemology. We hope the reader will benefit from (re)exploring Sosa’s work guided by the map detailed below. (shrink)

Is knowledge relative? Many academics across the humanities say that it is. However those who work in mainstream epistemology generally consider that it is not. Metaepistemology and Relativism questions whether the kind of anti-relativistic background that underlies typical projects in mainstream epistemology can on closer inspection be vindicated.

Could a computer have a mind? What kind of machine would this be? Exactly what do we mean by 'mind' anyway?The notion of the 'intelligent' machine, whilst continuing to feature in numerous entertaining and frightening fictions, has also been the focus of a serious and dedicated research tradition. Reflecting on these fictions, and on the research tradition that pursues 'Artificial Intelligence', raises a number of vexing philosophical issues. Minds and Computers introduces readers to these issues by offering an engaging, coherent, (...) and highly approachable interdisciplinary introduction to the Philosophy of Artificial Intelligence.Readers are presented with introductory material from each of the disciplines which constitute Cognitive Science: Philosophy, Neuroscience, Psychology, Computer Science, and Linguistics. Throughout, readers are encouraged to consider the implications of this disparate and wide-ranging material for the possibility of developing machines with minds. And they can expect to de. (shrink)

This paper takes as a starting point certain notions from Peirce's writings and uses them to propose a picture of the part of mathematical practice that consists of hypothesis formation. In particular, three processes of hypothesis formation are considered: abstraction, generalisation, and an abductive-like inference. In addition Peirce's pragmatic conception of truth and existence in terms of higher-order concepts are used in order to obtain a kind of pragmatic realist picture of mathematics.

The healthcare ethics consultant holds a widely described role in the modern American hospital. S/he may practice within a clinical discipline and be trained in bioethics, or be a trained phi...

Carers often interfere with the choices of people living with dementia. On neorepublican and (most) relational egalitarian views, interference can be justified if it tracks a person's interests: if it does not lead to a relationship of domination. However, the kind of environment-shaping interventions carers often pursue would be considered infantilising or objectionably paternalistic in other cases. In this paper, I defend this indirect approach and argue that it offers the best prospects of dementia care without domination.

Clowes, Gärtner, and Hipólito (2021) describe the Mind-Technology Problem as a new constellation of philosophical problems about the nature of mind generated by advances in technology we increasingly rely on to meet both theoretical and practical aims. We agree with Clowes, Gärtner, and Hipólito that the problems they identify frame a timely and worthwhile new research programme. We aim to contribute to this research programme by motivating and canvassing the key contours of four different Mind-Technology problems that arise for, and (...) which are distinctive to, approaches to knowledge-how that give abilities a central theoretical role in explaining intelligent states and behaviour. The result is an agenda in the theory of know-how aimed at reconciling prevailing anti-intellectualist thinking about know-how apt abilities and their exercise with the datum that much of our know-how is increasingly supported by our use of smart technological scaffolding. We don’t fully answer the questions we raise; our objective is to put them on the map and show why we think they matter. (shrink)

Amid increasing demands from students and the public, universities have recently reinvigorated their efforts to increase the number of faculty from underrepresented populations. Although a myriad of piecemeal programs targeting individual recruitment and development have been piloted at several institutions, overall growth in faculty diversity remains almost negligible and highly localized. To bring about genuine change, we hypothesize a consortia approach that links individuals to hiring opportunities within a state university system might be more effective. Here we present a case (...) study describing the progress of the NSF-funded Alliances for Graduate Education and the Professoriate PROMISE Academy Alliance, a consortium within the University System of Maryland collaborating to develop, implement, self-study, evaluate, and disseminate a unique postdoc-to-faculty conversion model in the biomedical sciences. The initiative centers on diversifying faculty across five institutions in the USM, including teaching-focused institutions, comprehensive universities, research institutions, and professional schools. Components of this approach include enhanced recruiting and hiring practices to attract outstanding postdoctoral scholars from underrepresented backgrounds, multi-institutional networking and professional development, and facilitated processes to transition postdocs into tenure-track positions at their postdoctoral institution or another institution in the state system. This model is distinct from more deficit-based approaches because it goes beyond focusing on building the individual’s skills to enter the professoriate. This program restructures the traditionally short-term nature of postdoctoral employment and incorporates a pathway to a tenure-track professorship at the same institution or within the same statewide system where the postdoc is trained. This multi-institutional model leverages collaboration and distinct institutional strengths to create cross-institutional support, advocacy, and policy. Importantly, it uses a decentralized financial structure that makes this approach distinctly replicable. Recognizing the immediate need for more collaborative approaches to diversify faculty and a lack of literature about such approaches, this case study describes the development of, and potential benefits of, a state university system, as well as the qualitative lessons learned from self-study, internal evaluation, external evaluation, and NSF site visits. The AGEP PROMISE Academy can serve as a model for replication at other university systems hoping to diversify their faculty. (shrink)

Die Geheimnisse der oberen und der unteren Welt: Magie im Islam zwischen Glaube und Wissenschaft. Edited by Sebastian Günther and Dorothee Pielow. Leiden: Brill, 2019. Pp. xlii + 644. $179, €149.

We shall proceed as follows: In section ii, we shall give a brief over-view of the literature on Gilbert, more to indicate general directions of interest than to present any in-depth analysis. Then, in the main body of this presentation, section iii, we will present three ways in which we think it is accurate to claim that Gilbert influenced Descartes. These are: (1) Gilbert gave Descartes a new definition of an organ; (2) Gilbert gave Descartes a new definition of what (...) constitutes life and animation; (3) Gilbert gave Descartes a new view of natural motion. (shrink)

Whereas many environmentalists have traditionally argued in favour of small‐scale, decentralised communities as a solution to the environmental crises which we appear to face, some environmental political theorists have recently argued against decentralisation. In this article I first show that game theory seems, at first glance, to support the insistence by statists that decentralisation is highly impracticable. But, second, I then attempt to demonstrate that, on closer inspection, game theory actually provides considerable support for the decentralist case.

A distinction should be made between the theoretical possibility of measuring freedom and the practical possibility of doing so. Most of this book has been concerned with the theoretical possibility of measuring freedom. Given the various practical difficulties involved in quantifying available action, some empirical indicators need to be found. Nevertheless, the search for such indicators without a theoretical understanding of that which they are intended to indicate is difficult. One possibility is to be found in a combination of an (...) exchange-value metric and a metric of broadly defined political freedom-types. (shrink)

Mapping figures in cinema as an experiential process inscribed within historically specific aesthetic regimes. The three long essays in this book explore mapping as a process of violent inscription on colonial landscapes (Malcomess); a practice of c.

In this commentary, I explore the ethically relevant dimensions of menu labelling. The evidence that menu labelling changes purchasing or consumption behaviour is contentious and inconclusive; there is some suggestion that menu labelling may preferentially influence the behaviour of healthier and wealthier citizens. Some suggest that menu labelling is unjust, as it fails to direct resources towards those who most need them. An alternative is to see menu labels as just one of a set of strategies that can increase people’s (...) real opportunities to be healthy. Complementing strategies will be necessary to ensure that all citizens can consider and value food choices, which may include becoming a more critical consumer in the food marketplace. Menu labels may also have the potential to shift our attention from people to food, reallocate responsibility in the food environment and facilitate structural change. It would be a mistake to expect too much of menu labels alone: rather, they should be integrated into a broader programme that supports health opportunities, especially for the least well off. (shrink)