Ancient pathways promoting unicellularity and multicellularity are associated with cancer, the former being pro‐oncogenic and the latter acting to suppress oncogenesis. However, there are only a limited number of non‐vertebrate models for studying these pathways. Here, we review Dictyostelium discoideum and describe how it can be used to understand these gene networks. D. discoideum has a unicellular and multicellular life cycle, making it possible to study orthologs of cancer‐associated genes in both phases. During development, differentiated amoebae form a fruiting body (...) composed of a mass of spores that are supported atop a stalk. A portion of the cells sacrifice themselves to become non‐reproductive stalk cells. Cheating disrupts the principles of multicellularity, as cheater cells alter their cell fate to preferentially become spores. Importantly, D. discoideum has gene networks and several strategies for maintaining multicellularity. Therefore, D. discoideum can help us better understand how conserved genes and pathways involved in multicellularity also influence cancer development, potentially identifying new therapeutic avenues. (shrink)

Is knowledge relative? Many academics across the humanities say that it is. However those who work in mainstream epistemology generally consider that it is not. Metaepistemology and Relativism questions whether the kind of anti-relativistic background that underlies typical projects in mainstream epistemology can on closer inspection be vindicated.

This article discusses the role of diagrams in mathematical reasoning in the light of a case study in analysis. In the example presented certain combinatorial expressions were first found by using diagrams. In the published proofs the pictures were replaced by reasoning about permutation groups. This article argues that, even though the diagrams are not present in the published papers, they still play a role in the formulation of the proofs. It is shown that they play a role in concept (...) formation as well as representations of proofs. In addition we note that 'visualization' is used in two different ways. In the first sense 'visualization' denotes our inner mental pictures, which enable us to see that a certain fact holds, whereas in the other sense 'visualization' denotes a diagram or representation of something. (shrink)

IntroductionEnabling education programs, otherwise known as Foundation Studies or Preparatory programs, provide pathways for students typically under-represented in higher education. Students in Enabling programs often face distinct challenges in their induction to academic culture which can implicate them in cases of misconduct. This case study addresses a gap in the enabling literature reporting on how a culture of academic integrity can be developed for students and staff in these programs through an educative approach.Case descriptionThis paper outlines how an educative approach (...) to academic integrity is implemented within the Enabling programs of two Australian universities.Discussion and reflectionThis case study reflects upon an approach which makes specific reference to the key elements of ‘support’, ‘approach’ and ‘responsibility’ as highlighted in Bretag and Mahmud’s seminal paper. The paper reports a reduction in misconduct cases at the two institutions suggesting a positive correlation between the interventions and students’ understanding of ethical academic practice. This study reflects upon practitioner experiences with academic integrity investigations to evaluate the effectiveness of this approach.ConclusionsThe authors show that it is possible to ensure academic integrity practices and values are upheld within a supportive learning environment appropriate to a students’ level of study. (shrink)

Could a computer have a mind? What kind of machine would this be? Exactly what do we mean by 'mind' anyway?The notion of the 'intelligent' machine, whilst continuing to feature in numerous entertaining and frightening fictions, has also been the focus of a serious and dedicated research tradition. Reflecting on these fictions, and on the research tradition that pursues 'Artificial Intelligence', raises a number of vexing philosophical issues. Minds and Computers introduces readers to these issues by offering an engaging, coherent, (...) and highly approachable interdisciplinary introduction to the Philosophy of Artificial Intelligence.Readers are presented with introductory material from each of the disciplines which constitute Cognitive Science: Philosophy, Neuroscience, Psychology, Computer Science, and Linguistics. Throughout, readers are encouraged to consider the implications of this disparate and wide-ranging material for the possibility of developing machines with minds. And they can expect to de. (shrink)

Introduction: Christian moral action -- Stanley Hauerwas -- Reinhard Hütter -- Common threads -- Thomas Aquinas -- Toward an ecumenical ethic of grace -- Conclusion: A community-centered ecumenical ethic of grace.

This paper takes as a starting point certain notions from Peirce's writings and uses them to propose a picture of the part of mathematical practice that consists of hypothesis formation. In particular, three processes of hypothesis formation are considered: abstraction, generalisation, and an abductive-like inference. In addition Peirce's pragmatic conception of truth and existence in terms of higher-order concepts are used in order to obtain a kind of pragmatic realist picture of mathematics.

The healthcare ethics consultant holds a widely described role in the modern American hospital. S/he may practice within a clinical discipline and be trained in bioethics, or be a trained phi...

Two recent papers by Michael Burke bearing upon the persistence of people and commonplace things illustrate the fact that the quest for synchronic ontological economy is likely to encourage a disturbing diachronic proliferation of entities. This discussion argues that Burke's promise of ontological economy is seriously compromised by the fact that his proposed metaphysic does violence to standard intuitions concerning the persistence of people and commonplace things. In effect, Burke would have us achieve synchronic economy (rejection of coincident entities) by (...) postulating strongly counterintuitive transtemporal claims of numerical diversity. The argument is made that the price of Burkean economy is too high. (shrink)

Amid increasing demands from students and the public, universities have recently reinvigorated their efforts to increase the number of faculty from underrepresented populations. Although a myriad of piecemeal programs targeting individual recruitment and development have been piloted at several institutions, overall growth in faculty diversity remains almost negligible and highly localized. To bring about genuine change, we hypothesize a consortia approach that links individuals to hiring opportunities within a state university system might be more effective. Here we present a case (...) study describing the progress of the NSF-funded Alliances for Graduate Education and the Professoriate PROMISE Academy Alliance, a consortium within the University System of Maryland collaborating to develop, implement, self-study, evaluate, and disseminate a unique postdoc-to-faculty conversion model in the biomedical sciences. The initiative centers on diversifying faculty across five institutions in the USM, including teaching-focused institutions, comprehensive universities, research institutions, and professional schools. Components of this approach include enhanced recruiting and hiring practices to attract outstanding postdoctoral scholars from underrepresented backgrounds, multi-institutional networking and professional development, and facilitated processes to transition postdocs into tenure-track positions at their postdoctoral institution or another institution in the state system. This model is distinct from more deficit-based approaches because it goes beyond focusing on building the individual’s skills to enter the professoriate. This program restructures the traditionally short-term nature of postdoctoral employment and incorporates a pathway to a tenure-track professorship at the same institution or within the same statewide system where the postdoc is trained. This multi-institutional model leverages collaboration and distinct institutional strengths to create cross-institutional support, advocacy, and policy. Importantly, it uses a decentralized financial structure that makes this approach distinctly replicable. Recognizing the immediate need for more collaborative approaches to diversify faculty and a lack of literature about such approaches, this case study describes the development of, and potential benefits of, a state university system, as well as the qualitative lessons learned from self-study, internal evaluation, external evaluation, and NSF site visits. The AGEP PROMISE Academy can serve as a model for replication at other university systems hoping to diversify their faculty. (shrink)

This chapter is intended to provide a new definition of insurrectionist ethics that cuts in many ways against the grain of positions already engraved in the literature. That is done by considering the various elements of a novel definition of insurrectionist ethics. One that treats fundamental, structural, and systemic oppression as the conditions that give warrant to an insurrectionist response. A notion of necro-depictions is articulated as an essential conceptual tool to understanding the duty to insurrect or resist oppression. It (...) is here argued that insurrectionists ethics is an anti-ethical position that operates from an understanding of the severe ethical constraints under which oppressed people are forced to deliberate about the appropriate ends to seek through voluntary action. Insurrectionist ethics requires the transvaluation of existing values, and radical reformulation of conceptions of personhood, humanity, and liberation, among others, to render comprehensible its radical aims of social transformation, and abolition of present conditions of oppression. (shrink)

Die Geheimnisse der oberen und der unteren Welt: Magie im Islam zwischen Glaube und Wissenschaft. Edited by Sebastian Günther and Dorothee Pielow. Leiden: Brill, 2019. Pp. xlii + 644. $179, €149.

We shall proceed as follows: In section ii, we shall give a brief over-view of the literature on Gilbert, more to indicate general directions of interest than to present any in-depth analysis. Then, in the main body of this presentation, section iii, we will present three ways in which we think it is accurate to claim that Gilbert influenced Descartes. These are: (1) Gilbert gave Descartes a new definition of an organ; (2) Gilbert gave Descartes a new definition of what (...) constitutes life and animation; (3) Gilbert gave Descartes a new view of natural motion. (shrink)

Whereas many environmentalists have traditionally argued in favour of small‐scale, decentralised communities as a solution to the environmental crises which we appear to face, some environmental political theorists have recently argued against decentralisation. In this article I first show that game theory seems, at first glance, to support the insistence by statists that decentralisation is highly impracticable. But, second, I then attempt to demonstrate that, on closer inspection, game theory actually provides considerable support for the decentralist case.

A distinction should be made between the theoretical possibility of measuring freedom and the practical possibility of doing so. Most of this book has been concerned with the theoretical possibility of measuring freedom. Given the various practical difficulties involved in quantifying available action, some empirical indicators need to be found. Nevertheless, the search for such indicators without a theoretical understanding of that which they are intended to indicate is difficult. One possibility is to be found in a combination of an (...) exchange-value metric and a metric of broadly defined political freedom-types. (shrink)

Jonathan Kvanvig has recently attempted to reconcile the problem of (apparently) pointless truths with the claim that the value of truth is unrestricted—that truth is always and everywhere valuable. In this paper, I critically evaluate Kvanvig’s argument and show it to be defective at a crucial juncture. I propose my own alternative strategy for generating Kvanvig’s result—an alternative that parts ways with Kvanvig’s own conception of the cognitively ideal.

Mapping figures in cinema as an experiential process inscribed within historically specific aesthetic regimes. The three long essays in this book explore mapping as a process of violent inscription on colonial landscapes (Malcomess); a practice of c.

ArgumentsPhysicians who counsel expectant parents about the needs for resuscitation and intensive care for an extremely preterm infant must be able to address many clinical facts and be prepared to face several ethical considerations. Such counseling is generally more than an acquisition of informed consent. It must be guided by ethical principles, values held dear by parents, relational priorities and directed toward an informed and shared decision-making process. Parents may come with a need for clinical facts, a desire that they (...) be heard as they express their values, and to help physicians realize that many are determined to follow a certain path well before such counseling occurs. They may well not be moved by counseling of the physician but still desire to be heard, respected, and allowed to contribute to their newborn’s care plans.ConclusionsRealizing this, the physician can be accepting and develop a trusting relationship with the parents that will be of value throughout the hospitalization regardless of outcome. (shrink)

Across the world, pain is under-treated in emergency departments. We canvass the literature testifying to this problem, the reasons why this problem is so important, and then some of the main hypotheses that have been advanced in explanation of the problem. We then argue for the plausibility of two new hypotheses: pain's under-treatment in the ED is due partly to an epistemic preference for signs over symptoms on the part of some practitioners, and some ED practices that themselves worsen pain (...) by increasing patients' anxiety and fear. Our argument includes the following logic. Some ED practitioners depart from formal guidance in basing their acute pain assessments on observable features rather than on patient reports of pain. This is potentially due to an epistemic preference for signs over symptoms which aims to circumvent intentional and/or unintentional misrepresentation on the part of patients. However, conducting pain assessments in line with this epistemic preference contributes to the under-treatment of pain in at least three respects, which we detail. Moreover, it may do little to help the practitioner circumvent any intentional misrepresentation on the part of the patient, as we explain. Second, we examine at least four ED practices that may be contributing to the under-treatment of pain by increasing patient anxiety and fear, which can worsen pain. These practices include failing to provide orienting information and partially objectifying patients so as to problem-solve along lines pre-established by modern medical science. We conclude by touching on some potential solutions for ED practice. (shrink)