Reproductive diseases are a long‐standing problem and have become more common in the world. Currently, 15% of the world's population suffers from infertility, and half of them are women. Maturation of oocytes, successful fertilization, and high‐quality embryos are prerequisites for pregnancy. With the development of assisted reproductive technology and advanced genetic assays, we have found that infertility in many young female patients is caused by mutations in various developmental regulators. These pathogenic factors may result in impediment of oocyte maturation, failure (...) of fertilization or early embryonic development arrest. In this review, we categorize these clinically‐identified, mutated genetic factors by their molecular characteristics: nuclear factors (PALT2, TRIP13, WEE2, TBPL2, REC114, MEI1 and CDC20), cytoplasmic factors (TLE6, PADI6, NLRP2/5, FBXO43, MOS and BTG4), a factor unique to primates (TUBB8), cell membrane factor (PANX1), and zona pellucida factors (ZP1‐3). We compared discrepancies observed in phenotypes between human and mouse models to provide clues for clinical diagnosis and treatment of related reproductive diseases. (shrink)

This singular work presents the most comprehensive and nuanced studies available in any Western language of Chinese aesthetic thought and practice during the ...

In this article, we examine the empirical association between firm value and CSR engagement for firms in sinful industries, such as tobacco, gambling, and alcohol, as well as industries involved with emerging environmental, social, or ethical issues, i.e., weapon, oil, cement, and biotech. We develop and test three hypotheses, the window-dressing hypothesis, the value-enhancement hypothesis, and the value-irrelevance hypothesis. Using an extesive US sample from 1995 to 2009, we find that CSR engagement of firms in controversial industries positively affects firm (...) value after controlling for various firm characteristics. To address the potential endogeneity problem, we further estimate a system of equations and change regression and continue to find a positive relation between CSR engagement and firm value. Our findings support the value-enhancement hypothesis and are consistent with the premise that the top management of US firms in controversial industries, in general, considers social responsibility important even though their products are harmful to human being, society, or environment. (shrink)

This study investigated the role of entrepreneurial passion in recognition of opportunity, developing entrepreneurial self-efficacy, and entrepreneurial intention, in the shaping of entrepreneurial actions in the presence of proactive personality. This study applied partial least squares structural equation modeling to test the hypotheses on a sample of 346 university students from Jiangsu province, China. The output of the study showed that entrepreneurial passion positively and significantly influenced entrepreneurial alertness, entrepreneurial self-efficacy to entrepreneurial intention, and entrepreneurial behavior. The findings also showed (...) that a proactive personality positively and significantly moderated the relationship between entrepreneurial intention and entrepreneurial behavior. (shrink)

There are numerous traces of Nietzsche's influence in Wang Guowei's "On the Dream of the Red Chamber" even though there is not a single mention of Nietzsche's name in that seminal essay. Nietzschean thought looms large where Wang openly disagrees with or quietly departs from the views of Schopenhauer and, to a lesser extent, those of Kant and Aristotle. His questioning of Schopenhauer's "no-life-ism" harks back to Nietzsche's challenge to Schopenhauer's life-negating ethics. His portrayal of Bao Yu reveals three distinctive (...) character traits of the Nietzschean overman. In particular, the praise of Bao Yu's rebellious character reveals Wang's preference for the iconoclastic Nietzschean overman over the passive Schopenhauerian saint. A strong influence of Nietzsche's views of tragedy may also be observed in Wang's discussion of the tragic form. His modification of Aristotle's catharsis seems to have been made in the spirit of Nietzsche's criticism of its "pathological discharge." His stress on the ultimate salvational function of the Dream strongly reminds us of what Nietzsche has said about the life-saving role of the Dionysian tragedy in the Birth. Finally, in his conditional endorsement of "live-life-ism" we can see a thinly disguised repudiation of the extreme Darwinian tendency he mistakenly reads into Nietzsche's works. It should not be surprising that there are so many echoes of Nietzschean thought in "On the Dream." While writing this essay Wang was deeply occupied with the study of Nietzsche's aesthetic and ethical theories through comparisons with Schopenhauer's. If this influence of Nietzsche can be established on the basis of the evidence given above, there is then a need to reassess Nietzschean thought as a catalyst more important than hitherto thought for the rethinking of traditional Chinese literary and cultural traditions--a broad twentieth-century critical and intellectual trend initiated by none other than Wang's "On the Dream.". (shrink)

This article examines the impact of traditional Chinese culture on organ donation from the perspective of Confucianism, Buddhism, and Taoism. In each of these cultural systems, it appears that there are some particular sayings or remarks that are often taken in modern Chinese society to be contrary to organ donation, especially cadaveric organ donation. However, this article argues that the central concerns of Buddhism, Confucianism, and Taoism are “great love,” “ren,” and “dao,” which can be reasonably interpreted to support organ (...) donation. The author understands that each cultural system, in order to play its cultural function, must have its central concerns as well as relevant ritual practices (li) that incarnate its religious and ethical commitments. That is, each plays a general cultural role, which influences organ donation in particular not merely through abstract or general ethical principles and teachings, but through a combination of ethical teachings and the forming of particular ritual practices. This article contends that the primary reason Chinese individuals fail to donate sufficient cadaveric organs for transplantation is not because particular remarks or sayings from each of these systems appear to conflict with donation. Neither is it that the central concerns of these systems cannot support cadaveric donation. Rather, it is that modern Chinese individuals have failed to develop and secure relevant ritual practices that support the central concerns of organ transplantation. The article concludes that in order to promote more donations, there is a need to form relevant ritual practices supporting organ donation in conformity with the central concerns of these cultural systems. (shrink)

Seminal work by Knobe, Prasada, and Newman (2013) distinguished a set of concepts, which they named “dual‐character concepts.” Unlike traditional concepts, they require two distinct criteria for determining category membership. For example, the prototypical dual‐character concept “artist” has both a concrete dimension of artistic skills, and an abstract dimension of aesthetic sensibility and values. Therefore, someone can be a good artist on the concrete dimension but not truly an artist on the abstract dimension. Does this analysis capture people's understanding of (...) cornerstone social categories, such as gender, around which society and everyday life have traditionally been organized? Gender, too, may be conceived as having not only a concrete dimension but also a distinct dimension of abstract norms and values. As with dual‐character concepts, violations of abstract norms and values may result in someone being judged as not truly a man/woman. Here, we provide the first empirical assessment of applying the dual‐character framework to people's conception of gender. We found that, on some measures that primarily relied on metalinguistic cues, gender concepts did indeed resemble dual‐character concepts. However, on other measures that depicted transgressions of traditional gender norms, neither “man” nor “woman” appeared dual‐character‐like, in that participants did not disqualify people from being truly a man or truly a woman. In a series of follow‐up studies, we examined whether moral norms have come to replace gender role norms for the abstract dimension. Implications for the evolution of concepts and categories are explored. (shrink)

The article explores a gradual refinement of the notion of reflection in Husserlian phenomenology. In his early period, Husserl takes phenomenological reflection to attain adequate evidence, since its object is self-given in an absolute and complete manner. However, this conception of reflection does not remain unchanged. Husserl later realizes that immanent perception or phenomenological reflection also involves a certain horizonality and naivety that has to do with its temporal nature and must be queried in a further critical, apodictic reflection. Focusing (...) more on the notion of apodicticity than adequacy, Husserl subsequently ascribes a new methodological role to reflection: instead of a mere epistemic warrant that guarantees for us the ultimate truth of our experiential life once and for all, phenomenological reflection ensures the strictness of phenomenology insofar as it entails an ethical-existential dimension as the norm of a life-form where the subject pursues full self-understanding and self-justification. (shrink)

Between the sense of self and the reality of self Content Type Journal Article Category Book Review Pages 113-118 DOI 10.1007/s11097-011-9234-y Authors Wenjing Cai, Center for Subjectivity Research, University of Copenhagen, Njalsgade 140-142, 5th floor, 2300 Copenhagen, Denmark Journal Phenomenology and the Cognitive Sciences Online ISSN 1572-8676 Print ISSN 1568-7759 Journal Volume Volume 11 Journal Issue Volume 11, Number 1.

We show that there is a generalized high degree which is a minimal cover of a minimal degree. This is the highest jump class one can reach by finite iterations of minimality. This result also answers an old question by Lerman.

Interpersonal Needs Questionnaire is a self-report measure of perceived burdensomeness and thwarted belongingness with five versions in recent studies. There are five versions of INQ. But results from studies using different versions are quite different. Current suicide behavior among teenagers has attracted much attention. But which version is more suitable for teenage samples is still uncertain. It is important to compare the potential differences in different versions of INQ to identify the most psychometrically available version to predict teenagers' acquired capability (...) for suicide and provide them with timely help to reduce teenagers' suicide rates. This study compared the construct validity, internal consistency, validity, and average test information of each version in the sample of teenagers. Results showed the 10-item version provided the most average test information in both thwarted belongingness subscale and perceived burdensomeness subscale, and the INQ-10 is more suitable for teenage samples. (shrink)

This study aims to identify the influence of knowledge management practices on the entrepreneurial and organizational performance with the mediating effect of dynamic capabilities and moderating role of opportunity recognition. Data were gathered from 486 entrepreneurs and applied a structural equation model to test the hypotheses. We found that knowledge management practices have a positive and significant influence on dynamic capabilities, as well as have a significant impact on entrepreneurial and organizational performance. Moreover, results indicated that dynamic capabilities partially mediate (...) in the relationship between knowledge management practices on entrepreneurial and organizational performance. Furthermore, the relationship between knowledge management practices with entrepreneurial and organizational performance strengthening by opportunity recognition. Further, implications and limitations were discussed in the paper. (shrink)

Recently, decomposition-based multiobjective evolutionary algorithms have good performances in the field of multiobjective optimization problems and have been paid attention by many scholars. Generally, a MOP is decomposed into a number of subproblems through a set of weight vectors with good uniformly and aggregate functions. The main role of weight vectors is to ensure the diversity and convergence of obtained solutions. However, these algorithms with uniformity of weight vectors cannot obtain a set of solutions with good diversity on some MOPs (...) with complex Pareto optimal fronts. To deal with this problem, an improved decomposition-based multiobjective evolutionary algorithm with adaptive weight adjustment is proposed. Firstly, a new method based on uniform design and crowding distance is used to generate a set of weight vectors with good uniformly. Secondly, according to the distances of obtained nondominated solutions, an adaptive weight vector adjustment strategy is proposed to redistribute the weight vectors of subobjective spaces. Thirdly, a selection strategy is used to help each subobjective space to obtain a nondominated solution. Comparing with six efficient state-of-the-art algorithms, for example, NSGAII, MOEA/D, MOEA/D-AWA, EMOSA, RVEA, and KnEA on some benchmark functions, the proposed algorithm is able to find a set of solutions with better diversity and convergence. (shrink)

We study the global properties of [Formula: see text], the Turing degrees of the n-r.e. sets. In Theorem 1.5, we show that the first order of [Formula: see text] is not decidable. In Theorem 1.6, we show that for any two n and m with n < m, [Formula: see text] is not a Σ1-substructure of [Formula: see text].

Background: The relationship between healthcare professionals and patients in the Spanish health sector has undergone dramatic change. One aspect of this is that the use of informed consent has become a key factor in the delivery of adequate healthcare. But although a certain period of time has already passed since informed consent started to be used, in Spain there is still doubt about how adequately informed consent is being used. Objectives: (a) To look at how patients understand the notion and (...) purpose of informed consent, and (b) how the informed consent is applied – the way patients receive such information affects their level of participation and decision making during the time they receive medical care. Methodology: We use interpretative description of interviews with patients. We developed guiding questions for the interviews with patients in two preliminary and exploratory focus groups. Then, we carried out 20 personal open-ended interviews with 20 purposive selected patients with illnesses that had a serious impact on their lives. Ethical considerations: Permission from ethical committees and institutions involved in the study, and consent and confidentiality were ensured before conducting the research. Results: The findings show that while patients agreed that their consent should be necessary for health professionals to be able to intervene, they had serious difficulty obtaining and then understanding information offered to them at the moment when they were being asked to sign informed consent documents. The participants were critical of the consent documents, which they considered were treated as merely a formality and even some of them had felt coerced to sign. Discussion: Participants confirmed that the informed consent documents that they signed did not meet their ethical objectives. Their perception of the purpose of consent indicates that informed consent document may still be largely understood as a formality rather an ethical obligation. (shrink)

The aim is to deeply understand the current situation of College English Teaching. By consulting the theories of Deep Learning and Edge Computing, this work designs a Questionnaire Survey to understand the current situation of college English learning and teaching. Then, Adaptive Deep Learning and EC are introduced into CET. Finally, the corresponding conclusions and suggestions are drawn. Specifically, the purpose and time of college students’ vocabulary learning are investigated. The results suggest that students’ English vocabulary learning is shallow. They (...) have not really mastered the meaning and usage of vocabulary. Simultaneously, teachers’ vocabulary teaching methods are analyzed from three aspects: root affixes, vocabulary collocation, or repeated reading and memory. The teaching method is excellent from the teacher’s perspective but far from perfect from the students’ perspective. Introducing ADL and EC into CET enhances students’ class concentration time, homework submission efficiency, and academic performance. More than half of the students believe that the new teaching method introducing ADL and EC can make them more confident and motivated in English learning. Therefore, it has great reference significance for applying ADL and EC in CET. (shrink)

本书论述了艺术与想象力、艺术门类的相互关系、艺术与社会的参照分析、生活对艺术的启示、艺术欣赏三总体等。.

从公元前624年(周襄王二十八年)起,至公元1945年止,中外著名哲学家和思想家的生卒年,著作和学术活动年代,确有记载的都尽量收入本年表,与哲学有关的历史事件与哲学邻近的其他学科的重大发现和重要思想家 及其著作也予收入。.

The Trends in International Mathematics and Science Study found that even though children from all East Asian countries outperformed American children, American students reported higher self-evaluation of their math and science abilities than did students from East Asian countries such as China, Korea, and Japan (Mullis, Martin, Gonzalez, & Chrostowski, 2004). Such cross-cultural differences in self-appraisal fit the stereotype of the modest East Asian and contribute to the received view that East Asians have less positive self-concepts than Americans. This view (...) was summarized recently by Heine, Lehman, Markus, and Kitayama (1999) as follows: ‘‘The need for positive self-regard, as it is currently conceptualized, is not a universal, but rather is rooted in significant aspects of North American culture’’ (p. 766; but cf. Sedikides, Gaertner, & Vevea. (shrink)

本書收有八篇論文，除了論及朱子學的詮釋外，亦關涉了東亞朱子學的區域特色與交流互動。由本書所收論文，可具體而微地看到東亞儒者對朱子學的討論，有基本架構上的同，也有不同契入角度之異，這種同異互現的結果，使 得不同時代及區域的朱子學，因其差異的詮釋而發展了豐富的內涵。.