Ectopeptidases are transmembrane proteins present in a wide variety of tissues and cell types. Dysregulated expression of certain ectopeptidases in human malignancies suggests their value as clinical markers. Ectopeptidase interaction with agonistic antibodies or their inhibitors has revealed that these ectoenzymes are able to modulate bioactive peptide responses and to influence growth, apoptosis and differentiation, as well as adhesion and motility, all functions involved in normal and tumoral processes. There is evidence that ectopeptidase-mediated signal transduction frequently involves tyrosine phosphorylation. Combined (...) analyses of gene organization and regulation of ectopeptidases by various physiological factors have provided insights into their structure–function relationships. Understanding the roles of ectopeptidases in pathophysiology may have implications in considering them as therapeutic targets. BioEssays 23:251–260, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

One of the first Swiss performance artists, Manon has fashioned a career for herself out of the identities of others. Whether exploring the limits of gender or the beauty of decay, Manon—through her personas, installations, and performance pieces—continually foregrounds the instability of place and self. Her most recent project, She Was Once MISS RIMINI, is one of her most brutal and touching. Here, she literally depicts imagined futures for an aging beauty queen. Each exquisite image in this pictorial essay teases (...) out the possible paths Miss Rimini—an alter-ego for Manon who “happened” upon a beauty pageant in the early 1970s and walked away with the crown—could have taken. A small-town diva? A hypersensitive viola player? Perhaps even a psychiatric patient? She Was Once MISS RIMINI is a trenchant meditation on the art, or artifice, of growing older. Costume, lipstick, lighting, attitude—all aspects of self-presentation are in concert here with quiet critiques of social and economic systems that limit the options of older women. Accompanied by an enlightening introduction by art theorist Brigitte Ulmer, She Was Once MISS RIMINI is the first and only documentation of Miss Rimini and one of the first books in English on Manon. (shrink)

This paper aims to determine whether we can locate temporal passage in a non-dynamical (block universe) world. In particular, we seek to determine both whether temporal passage can be located somewhere in our world if it is non-dynamical, and also to home in on where in such a world temporal passage can be located, if it can be located anywhere. We investigate this question by seeking to determine, across three experiments, whether the folk concept of temporal passage can be satisfied (...) in our world if it is non-dynamical, and, if it can, what sort of thing in our world satisfies that concept. In particular, we focus on the question of whether that concept (if satisfied) is satisfied by something mind-dependent or something mind-independent. In other words, we ask, is temporal passage something that is at least partially in the mind, or is it entirely external to the mind? We find, contrary to what is often assumed by dynamists and non-dynamists alike, that the folk concept of temporal passage is satisfied in our world conditional on it being non-dynamical, and that the concept is satisfied by something mind-independent. This provides further ammunition for recent deflationary accounts of temporal passage that attempt to locate passage somewhere in our non-dynamical world. (shrink)

Grace de Laguna was a philosopher working in the first part of the twentieth century on analytic and speculative philosophy, as well as on the psychology and philosophy of language, especially the social function of language. Joel Katzav’s lead essay focuses mainly on the former part of her work, while my commentary focuses mostly on the latter. Katzav shows how her work played a role in the development of analytic philosophy, I try to show how her work played a role (...) in the development of pragmatic linguistics, whose development overlapped with some aspects of analytic philosophy. I situate it in the context of an emerging ‘pragmatic Weltanschauung’ that was embraced by many working in linguistics, philology, philosophy, psychology, anthropology and what would later be called linguistic pragmatics. (shrink)

In this article I will discuss some systematic issues of Arthur Danto's philosophy of art and art history from a Hegelian perspective. Belonging to "Absolute Spirit," art can be called a "spiritual kind." Since spiritual kinds are reflective and self-determining, they are not susceptible to philosophical definition. Nevertheless, elements of essentialism can be maintained when describing art's historicity and conceptual structure. To this end, "art" can be interpreted as a two-tier concept: in inherently reflecting its concept, it projects its own (...) conditions into the past, co-opting "prehistorical" artworks as predecessors and classical examples. Hegel's view of art as conceptually structured in itself can have disenfranchising or reenfranchising consequences: either reducing art to minor philosophy, or acknowledging its privileged access to its own essence. After Danto's detachment of the philosophy of art from aesthetics, Hegel would himself be deprived of the possibility to "define" art by intuition . Even if the spirit consists of essential kinds, philosophy is not in a privileged position to establish the essence of art and thus the difference between art and philosophy. Rather, philosophy must acknowledge art as a neighbor and as partner in a dialogue. (shrink)

For language to function we clearly need two formal ordering principles: lexical entries and rules. Clahsen's target article provides multiple empirical evidence for this distinction, but this may be simply to overconfirm the undeniable and to overlook the hidden motor of language use and language development, namely, function. Since at least 1859, linguists have argued for the primacy of function, and these arguments are worth rediscovering today.

Depending on different positions in the debate on scientific realism, there are various accounts of the phenomena of physics. For scientific realists like Bogen and Woodward, phenomena are matters of fact in nature, i.e., the effects explained and predicted by physical theories. For empiricists like van Fraassen, the phenomena of physics are the appearances observed or perceived by sensory experience. Constructivists, however, regard the phenomena of physics as artificial structures generated by experimental and mathematical methods. My paper investigates the historical (...) background of these different meanings of phenomenon in the traditions of physics and philosophy. In particular, I discuss Newton’s account of the phenomena and Bohr’s view of quantum phenomena, their relation to the philosophical discussion, and to data and evidence in current particle physics and quantum optics. (shrink)

The philosophy of science community mourns the loss of Margaret Catherine Morrison, who passed away on January 9, 2021, after a long battle with cancer. Margie, as she was known to all who knew her, was highly regarded for her influential contributions to the philosophy of science, particularly her studies of the role of models and simulations in the natural and social sciences. These contributions made her a world-leading philosopher of science, instrumental in shifting philosophers' attention from the structure of (...) scientific theories to the practice of science. Her sophisticated studies of the function of models in scientific practice drew on detailed knowledge of the theories and experiments of physics as well as the history of physics. In emphasizing the autonomy of scientific models and their interventional character, her insights had some affinity with Cartwright's and Hacking’s views on phenomenological laws, entity realism, the instrumentalist interpretation of scientific theories, and the disunity of science. But Morrison’s approach was distinguished by the conviction that the existence of unobservable entities cannot be defended independently of the theories that support their evidence, and that scientific practice cannot be adequately understood without examining the reasons for theory unification. (shrink)

This book, first published in 2000, offers translations of the initial critical reactions to Kant's philosophy. Also included is a selection of writings by Kant's contemporaries who took on the task of defending the critical philosophy against early attacks. The first aim of this collection is to show in detail how Kant was understood and misunderstood by his contemporaries. The second aim is to reveal the sorts of arguments that Kant and his first disciples mounted in their defense of the (...) theoretical philosophy. The third aim of the book is to contribute to an understanding of the development of Kant's critical philosophy after its initial formulation in the Critique of Pure Reason, and in particular why Kant made the changes he did in the second edition of the work in 1787. This collection, which includes a glossary of key terms and biographical sketches of the critics on both sides of the debate, is a major addition to Kant scholarship and should be seen as a companion volume to the Cambridge Edition of the Works of Immanuel Kant. (shrink)

La Renaissance commence vraiment avec Pléthon, contemporain de Nicolas de Cues et qui se voulait comme lui romain, mais du point de vue de Constantinople. Pléthon a conçu le modèle d'une constitution qui permettrait à tous les peuples de coexister en paix. Au temps où l'Occident latin est largement aristotélicien, il plaide pour le retour à Platon, l'idéalisme, la théologie affirmative.

Astroparticle physics is a recent sub-discipline of physics that emerged from early cosmic ray studies, astrophysics, and particle physics. Its theoretical foundations range from quantum field theory to general relativity, but the underlying “standard models” of cosmology and particle physics are far from being unified. The paper explores the pragmatic strategies employed in astroparticle physics in order to unify a disunified research field, the concept of observation involved in these strategies, and their relations to scientific realism.

An important function of emoji as communicative symbols is to convey emotional content from sender to receiver in computer-mediated communication, e. g., WhatsApp. However, compared with real faces, pictures or words, many emoji are ambiguous because they do not symbolize a discrete emotion or feeling state. Thus, their meaning relies on the context of the message in which they are embedded. Previous studies investigated affective judgments of pictures, faces, and words suggesting that these stimuli show a typical distribution along the (...) big two emotion dimensions of valence and arousal. Also, emoji and emoticons have been investigated recently for their affective significance. The present study extends previous research by investigating affective ratings of emoji, emoticons and human faces and by direct comparison between them. In total, 60 stimuli have been rated by 83 participants, using the non-verbal Self-Assessment Manikin Scales for valence and arousal. The emotionality of the stimuli was measured on a 9-point Likert scale. The results show significant main effects of the factors “stimulus category” and “discrete emotion” including emotionality, valence and arousal. Also, the interaction between these two main factors was significant. Emoji elicited highest arousal, whereas stimuli related to happiness were rated highest in valence across stimulus categories. Angry emoji were rated highest in emotionality. Also, the discrete emotion was best recognized in emoji, followed by human face stimuli and lastly emoticons. (shrink)

This book provides a comprehensive account of Kant’s development from the 1755/56 metaphysics to the cosmological antinomy of 1781. With the Theory of the Heavens (1755) and the Physical Monadology (1756), the young Kant had presented an ambitious approach to physical cosmology based on an atomistic theory of matter, which contributed to the foundations of an all-encompassing system of metaphysics. Why did he abandon this system in favor of his critical view that cosmology runs into an antinomy, according to the (...) Critique of Pure Reason (CPR)? This book answers this question by focusing on Kant’s methodology and the internal problems of his 1755/56 theory of nature. A decisive role for Kant’s critical turn plays the argument from incongruent counterparts (1768), which drew much attention among philosophers of science, though not sufficiently in Kant research. Furthermore, the book analyses the genesis of the cosmological antinomy in the 1770s, the logical structure of the antinomy in the CPR, its relation to transcendental idealism, as explained in the “experiment of pure reason” (1787), and its role for the teleology of human reason. The book is addressed to Kant scholars, philosophers of science, and students of Kant’s philosophy. (shrink)

After the UN Guiding Principles on Business and Human Rights were adopted in 2011, an international treaty has been being negotiated since 2014. The two instruments reveal similarities and also conflicts regarding the adequate organization of the global economy based on human rights. The focus in this article will be on the processes leading to these instruments, because they themselves mirror different understandings of governance in the field of business and human rights as well as the struggle over the power (...) of definition and legitimacy. The UNGPs were developed on the basis of global multi-stakeholder consultations, underlining legitimacy through broad inclusion. There are varying judgements as to the success of this approach. The process towards the treaty follows the traditional path of negotiations at UN level. These negotiations reveal a struggle for recognition of the legitimacy of the process itself. Both procedures have shortcomings with regard to legitimacy and show the need for a revision concerning the inclusion of stakeholders. The complementarity of a soft and hard law instrument may enhance the creation of a level playing field in the global economy, thereby strengthening human rights. (shrink)

This is the first day of our confinement here in Paris, which soon will feel a bit like house arrest. So, to help cheer you up, in these times of doom and gloom, I have decided to bring the museum to you in the form of a virtual exhibition thrice weekly. I have picked 25 photos from a work in progress I started years ago. The photos are portraits of visitors or guards in museums. It's candid photography, capturing life on (...) the run, a moment in time. I hope you will find many other ways to - Résidence numérique - Brigitte Cavanagh. (shrink)

Selbstgerechtes Wohlwollen in der Psychoanalyse - J. Körner: Mitleid. Das Ende der Empathie - II. Moral und das Böse - P. Stoellger: Lesarten des Bösen - R. Bittner: Verwüstung durch Moral? - III. Moral als Gewalt?

Im Dezember 2014 fand das erste zweitatige Symposium von der SWIP (Society of Women In Philosophy) Austria statt, unter dem Titel: Neuere Aspekte in der Philosophie - aktuelle Projekte von Philosophinnen am Forschungsstandort Osterreich." Als Resultat dieser Tagung soll der vorliegende Band die Breite und Pluralitat der Themen und die Themenoffenheit widerspiegeln. Er enthalt 22 Beitrage aus den verschiedensten Teildisziplinen der Philosophie, wie feministische Sprachphilosophie, Performance/Philosophie, Erkenntnis- und Wissenschaftstheorie, Wissenschaftsgeschichte, philosophische Bezugnahme auf Literatur, feministisch-philosophische Literaturbetrachtung, praktische Philosophie, Religion und Ethik, (...) interkulturelle Philosophie, feministisch-politische Theorie, feministische Sozialphilosophie und queere Perspektiven.". (shrink)

Adam Smith's metaphor of the "invisible hand" and its analogue in classical physics are investigated in detail. Smith's analogue was the mechanics of the solar system. What makes the analogy fail are not the idealisations in the caricature-like model of the rational economic man . The main problem rather is that the metaphor does not employ the correct analogue, which belongs to thermodynamics and statistics. In the simplest macro-economic model, the business cycle has the same formal structure as the heat (...) flow between two heat reservoirs and a business cycle of growing efficiency works like a refrigerator: it pumps money from the poor to the rich. More complicated models do not give a friendlier image. Due to technological push, an economic system behaves like a thermodynamic system far from the equilibrium, showing chaotic behaviour and developing into unpredictable states. (shrink)

A major purpose of this essay is to show that our assumptions regarding human development in general, and in particular, the mother and child have their roots in a Christian-humanistic tradition. I also wish to locate the origins of the discourse on the mother and child within a critical historical review of notions of a changing anthropology of the human subject. The working hypothesis is as follows: A changing view of the human being is associated with a changing approach to (...) child care and child development. This changing approach to child is accompanied by a ‘new woman’. Women are newly constructed when children, and thus a future person and a future society is defined. (shrink)

Lucid dreaming refers to a dream state characterized by the dreamers awareness of being in a dream and being able to volitionally control its content. The aim of this study was to find neurophysiological evidence for the 7 criteria of lucid dreaming proposed by Paul Tholey. Each of the criteria was analyzed separately with regard to its underlying neurocircuits. We hypothesized that not one, but many regions are involved in the state of lucid dreaming. Our results have shown a satisfactory (...) overlap of the theoretical components and the brain regions activated during a lucid dream. During lucid dreaming, a brain network seems to emerge, that is more than the sum of its parts. Further research is needed to understand the psychoneurological underpinnings of lucid dreams. (shrink)

Entrepreneurs who start a business to serve both self-interests and collective interests by addressing unmet social and environmental needs are usually referred to as sustainable entrepreneurs. Compared with regular entrepreneurs, we argue that sustainable entrepreneurs face specific challenges when establishing their businesses owing to the discrepancy between the creation and appropriation of private value and social value. We hypothesize that when starting a business, sustainable entrepreneurs feel more hampered by perceived barriers, such as the institutional environment and have a different (...) risk attitude and perception than regular entrepreneurs. We use two waves of the Flash Eurobarometer survey on entrepreneurship, which contains information on start-up motivations, start-up barriers, and risk perceptions of approximately 3000 business owners across 33 countries. We find that sustainable entrepreneurs indeed perceive more institutional barriers in terms of a lack of financial, administrative, and informational support at business start-up than regular entrepreneurs. Further, no significant differences between sustainable and regular entrepreneurs are found in terms of their risk attitudes or perceived financial risks. However, sustainable entrepreneurs are more likely to fear personal failure than regular entrepreneurs, which is explained by their varied and complex stakeholder relations. These insights may serve as an important signal for both governments and private capital providers in enhancing the institutional climate. (shrink)

The roots of pragmatics reach back to Antiquity, especially to rhetoric as one of the three liberal arts. However, until the end of the 18th century proto-pragmatic insights tended to be consigned to the pragmatic, that is rhetoric, wastepaper basket and thus excluded from serious philosophical consideration. It can be said that pragmatics was conceived between 1780 and 1830 in Britain, but also in Germany and in France in post-Lockian and post-Kantian philosophies of language. These early ‘conceptions’ of pragmatics are (...) described in the first part of the book. The second part of the book looks at pragmatic insights made between 1830 and 1880, when they were once more relegated to the philosophical and linguistic underground. The main stage was then occupied by a fact-hunting historical comparative linguistics on the one hand and a newly spiritualised philosophy on the other. In the last part the period between 1880 and 1930 is presented, when pragmatic insights flourished and were sought after systematically. This was due in part to a new upsurge in empiricism, positivism and later behaviourism in philosophy, linguistics and psychology. Between 1780 and 1930 philosophers, psychologists, sociologists and linguists came to see that language could only be studied in the context of dialogue, in the context of human life and finally as being a kind of human action itself. (shrink)

On 14 July 2021, the western states of Germany, Rheinland Palatinate and North-Rhein-Westphalia experienced major flash floods and about two hundred people died. This article explores how those affected and journalists they spoke to created meaning from the mayhem of an unprecedented disaster and how social representations of flooding emerged in which language, politics and values were intimately intertwined. Combining thematic analysis with elements of social representations theory, and analysing a sample of articles from a national news magazine, we show (...) how social representations of the floods were shaped by the objectification of the floods through metonymy (mud and debris) and the anchoring of the floods through personification and metaphors (natural and mechanical forces), thus adding a new dimension to the existing body of work on flood and metaphors. We claim that the immediate focus on the extreme force of the 2021 floods, on the one hand, and the weakness of political response, on the other, may entrench feelings of helplessness and divert attention away from more systematic and long-term engagement with flood dangers in the context of climate change, including extreme weather events. (shrink)

Communicating Biological Sciences discusses the 'ethics' of science communication in light of recent developments in biotechnology and biomedicine. It focuses on the role of metaphors in the creation of visions and the framing of scientific advances, as well as their impact on patterns of public acceptance and rejection, trust and scepticism. Its rigorous investigation will appeal not only to science writers and scientists, but also to scholars of sociology, science and technology studies, media and journalism.