We consider how an epistemic network might self-assemble from the ritualization of the individual decisions of simple heterogeneous agents. In such evolved social networks, inquirers may be significantly more successful than they could be investigating nature on their own. The evolved network may also dramatically lower the epistemic risk faced by even the most talented inquirers. We consider networks that self-assemble in the context of both perfect and imperfect communication and compare the behaviour of inquirers in each. This provides a (...) step in bringing together two new and developing research programs, the theory of self-assembling games and the theory of network epistemology. (shrink)

The assembly of the major small nuclear ribonucleoprotein (snRNP)d̊ particles begins in the cytoplasm where large pools of common core proteins are preassembled in several RNA‐free intermediate particles. Newly synthesized snRNAs transiently enter the cytoplasm and complex with core particles to form pre‐snRNP particles. Subsequently, the cap structure at the 5/end of the snRNA is hypermethylated. The Resulting trimethylguanosine (TMG) cap is an integral part of the nuclear localization signal for snRNP particles and the pre‐snRNP particles are rapidly transported (...) into the nucleus. SnRNP particles mature when snRNA‐specific proteins complex with the particles, in some cases, just before or during nuclear transport, but in most instances after the particles are in the nucleus. In addition, U6 snRNA hybridizes with U4 snRNA to form a U4/U6 snRNP in the nucleus. The transport signals are retained on the snRNP particles and proteins since existing particles and proteins enter the reformed nucleus after mitosis. (shrink)

This chapter contains sections titled: Introduction Clearing Some Definitional Ground: Standards as Epistemic Objects What Counts as a Standard?: Orthodoxies and other Stories Travelling with Actor‐Network Theory: ‘It's Practice All theWay Down’6 The Project in Question: Data and Method Assemblage7 Teaching and Standards of Teaching: Performative Tales from the Field Assembling the Accomplished Teacher: Whose Assemblage Counts? The Critical Contribution of Actor‐Network Theory: Performative Politics Notes References.

Although Hurricane Katrina precipitated considerable reflection across various media, a practice crucial to our capacities to apprehend and interpret the disaster has not yet been analyzed as such. I call this practice generative assembly. I don’t mean the events of emergency and political gathering that took place in response to the massive storm and fatal, preventable levee failures—although I will propose connections between different forms of assembly. Instead I mean a kind of documentary practice. That practice, which can (...) be undertaken individually or in collaboration, and sometimes at anonymous remove, involves the work of assembling records and signifiers related to the disaster into particular kinds of media artifacts. Those artifacts— which take shape in formats as varied as comics, photobooks, paintings, films, exhibitions, and multithousand-item online archives—characteristically maintain the active appearance and interactive potential of selection and arrangement. In exhibiting such qualities, or so I will argue, these assembly-based artifacts support various articulable and often highly effective kinds of generativity. And thus, I will further suggest, these artifacts can constitute especially powerful means of intervening in prevailing conditions of representation and remembrance around events of environmental and social violence. Crucially, those material legacies of generative assembly can also fall short, fail, and deceive, and this is especially true of those assemblies that take digital forms. It is my contention, however, that we would be misguided if we thus entirely dismissed such assemblies or if we refused their potential for dissident reuse or generative reassembly. (shrink)

In this paper, I focus on a recent debate in extended cognition known as “cognitive assembly” and how cognitive assembly shares a certain kinship with the special composition question advanced in analytical metaphysics. Both the debate about cognitive assembly and the special composition question ask about the circumstances under which entities (broadly construed) compose or assemble another entity. The paper argues for two points. The first point is that insofar as the metaphysics of composition presupposes that composition (...) is a synchronic relation of dependence, then that presupposition is inconsistent with the temporal dynamics inherent in the process of cognitive assembly. The second point is that by developing a diachronic or temporally dynamic ontology for understanding the phenomenon of cognitive assembly, this lends support for a third wave of extended cognition. (shrink)

The developing vertebrate oocyte autonomously makes most of the components of the machinery for DNA and protein synthesis, as well as ‘maternal’ mRNAs, needed immediately after fertilization. However, specialized egg constituents such as yolk proteins, egg white, cholesterol, lipoproteins and egg coat substances, are formed in the liver, oviduct and perhaps in follicle cells. The assembly of the developing egg is therefore a fascinating example of division of labor among oocytes and extra‐oocyte tissues, the coordination of activities of the (...) latter being achieved by hormones. (shrink)

The Bell-Wigner locality argument is shown to be a special case of the nonexistence of certain state assembles with preassigned densities when there are restrictions on the allowable states.

The Tshwane Conference on African Information Ethics of 5-7 February 2007 forces the question, What is an African information ethics? This question is addressed with reference to the complexities of a distinctly African information ethics, taking into account the distinction between ethics and morality, and the assumptions of the language of the Tshwane Declaration on Information Ethics in Africa. Gilles Deleuze‘s concept of assem-blage, analyzed from the perspectives of Bruno Latour‘s concept of ―reassembling the social‖ and recent anthropological approaches to (...) global assemblages are put to work to investigate possibilities of an African information ethics, with special attention to the concepts of universality and African identity. The task of assembling an African information ethics is then analyzed in terms of Latour‘s call for building "livable collectives". (shrink)

Pulvermüller's work in extending Hebb's theory into the realm of language is exciting. However, we feel that what he characterizes as a single cell assembly is actually a set of cooperating cell assemblies that form parts of larger cognitive structures. These larger structures account more easily for a variety of phenomena, including the psycholinguistic.

Despite its biological importance, the mechanism of formation of cutin, the polymeric matrix of plant cuticles, has not yet been fully clarified. Here, for the first time, we show the participation in the process of lipid vesicles formed by the self‐assembly of endogenous polyhydroxy fatty acids. The accumulation and fusion of these vesicles (cutinsomes) at the outer part of epidermal cell wall is proposed as the mechanism for early cuticle formation. BioEssays 30:273–277, 2008. © 2008 Wiley Periodicals, Inc.

ABSTRACTThe aim of this paper is to draw attention to an issue which has been largely overlooked in contemporary just war theory – namely the impact that the conditions under which an army is assembled are liable to have on the judgments that are made with respect to traditional principles of jus ad bellum and jus in bello. I argue that the way in which an army is assembled can significantly alter judgments regarding the justice of a war. In doing (...) so, I present and defend a principle of ‘just assembly’ and argue that satisfying this principle is an essential part of any deliberation regarding the justice of a particular conflict. (shrink)

This article considers how a generalized signalling game may self-assemble as the saliences of the agents evolve by reinforcement on those sources of information that in fact lead to successful action. On the present account, generalized signalling games self-assemble even as the agents co-evolve meaningful representations and successful dispositions for using those representations. We will see how reinforcement on successful information sources also provides a mechanism whereby simpler games might compose to form more complex games. Along the way, I consider (...) how an old game might be appropriated to a new context by reinforcement on successful associations between old and new saliences. (shrink)

This chapter begins with a narration of a slave ship's arrival from the Dutch Gold Coast, today's Ghana, to a South American seaport, Suriname, with about 40 blacks. The uprooted Africans used what was at hand, both culturally and materially, to cobble together the beginnings of an African American culture. It appears that these cultures are not so much born as assembled. This introductory chapter attempts to answer four preliminary questions: to paraphrase cultural theorist and sociologist Stuart Hall: what is (...) the black in black aesthetics; in the same spirit: what is the aesthetic in black aesthetics; what good is a philosophy of black aesthetics; and why discuss any of this in terms of assembly. The idea of assembling black aesthetics presupposes that there is a responsible way of appealing to racial blackness. The chapter also indicates the content available in other chapters of the book. (shrink)

The endoplasmic reticulum (ER) uses various mechanisms to ensure that only properly folded proteins enter the secretory pathway. For proteins that oligomerize in the ER, the proper tertiary and quaternary structures must be achieved before their release. Although some proteins fold before oligomerization, others initiate oligomerization cotranslationally. Here, we discuss these different strategies and some of the unique problems they present for the ER quality control system. One mechanism used by the ER is thiol retention. Thiol retention operates by monitoring (...) the redox state of specific cysteine residue(s) and was discovered in studies on the assembly of IgM, a complex oligomeric glycoprotein. This system is also involved in retaining other unassembled proteins in the ER. Mutations that result in uneven numbers of cysteine residues can subject yet other proteins to thiol retention, altering their oligomerization status and function. The implications of these results on the effects of thiol retention on protein function and cell fate are discussed. BioEssays 20:546–554, 1998. © 1998 John Wiley & Sons Inc. (shrink)

[1] Diaspora, imagined in terms of a people that belong both to a place of departure and to a place of arrival, is implicitly transitive. Narrated in these terms, a diasporic people is defined by being in-between two places, by a transitive zone of indeterminacy. It is marked, at its arrival-place, by its belonging to another place, and thus as not fully belonging to the place; it is marked, at its departure-place, by its belonging to another place, and thus as (...) not fully belonging to the place.1 To be in-between departure and arrival is to be in-between places of belonging. This in-between is simultaneously articulated as a belonging-too-much (belonging to more... (shrink)

On November 7, 1594, an Assembly was held in the Monastery of St. Mary in Mat, and was attended by “Governors and General Guardians of the Macedonian and Albanian Kingdoms”. The Assembly was attended by leaders representing the Albanian provinces, such as: Gjergj Skura from Rodoni, Gjek Lalësi from Dukagjini, Vlash Koreshi from Kruja, Domenik Jonima from Mati, Jeronim Mamëli from Elbasan, and bishops of Stefaniakë and Sapas etc. A detailed project was drafted for the liberation of the (...) country from the Ottoman invaders, addressed to the Western nations, to the Pope, the Kingdom of Naples etc. in order to seek material and military support. The action plan and the demands examined during the assembly meeting were entrusted to Tomë Plezha as the almighty delegate of the Pope to the king of Spain and other European princes. It was thought that he had authority over the peoples of these parts. (shrink)

Chromosomes are not only carriers of the genetic material, but also actively regulate the assembly of complex intracellular architectures. During mitosis, chromosome‐induced microtubule polymerisation ensures spindle assembly in cells without centrosomes and plays a supportive role in centrosome‐containing cells. Chromosomal signals also mediate post‐mitotic nuclear envelope (NE) re‐formation. Recent studies using novel approaches to manipulate histones in oocytes, where functions can be analysed in the absence of transcription, have established that nucleosomes, but not DNA alone, mediate the chromosomal (...) regulation of spindle assembly and NE formation. Both processes require the generation of RanGTP by RCC1 recruited to nucleosomes but nucleosomes also acquire cell cycle stage specific regulators, Aurora B in mitosis and ELYS, the initiator of nuclear pore complex assembly, at mitotic exit. Here, we review the mechanisms by which nucleosomes control assembly and functions of the spindle and the NE, and discuss their implications for genome maintenance. (shrink)

Nurses working in outreach capacities frequently encounter disaffiliated or ‘hard to reach’ populations, such as those experiencing homelessness, those who use substances, and those with mental health concerns. Despite best efforts, nurses regularly fail to find meaningful engagement with these populations. Mobilizing the work of Deleuze and Guattari, this paper will critically examine conventional outreach nursing practices as rooted in the royal science of psychiatry, which many ‘survivors’ of psychiatric interventions reject. The field of Mad Studies offers an understanding of (...) patient resistance to outreach nursing interventions. Delueze and Guattari's concepts of packs and sorcerers provide a framework to envision alternative nursing practices as a form of resistance and creativity, where new alliances may be formed outside the coercive confines of traditional practices. In response to patient resistance, outreach nurses themselves must assemble packs and engage in acts of sorcery. (shrink)

The assembly of Cullin3‐based RING E3 ubiquitin ligase (CRL3) complexes is orchestrated in two consecutive steps: the formation of the dimeric BTB domain core and the recruitment of CUL3‐RBX1 subunits. Each step is tightly regulated to ensure the formation of complete and functional dimeric CRL3s. The first assembly step is regulated by two mechanisms: “co‐co assembly” and proteasome‐dependent degradation of aberrant heterodimers. The second step is facilitated by a conserved CUL3 N‐terminal assembly (NA) motif. The CUL3 (...) NA motif contributes to the assembly of CRL3s in two aspects: interacting with both BTB domain‐containing protein protomers to facilitate complete dimeric assembly, and enhancing the stability of CRL3s by overcoming the tensions generated by conformational entropy during ubiquitin transfer. Given that all Cullin proteins contain N‐terminal extensions, we postulate that these extensions, similar to the CUL3 NA motif‐contributed assembly, play an important role in the functional regulation of CRLs and thus warrant further investigation. (shrink)

One purpose of cognitive diagnostic model is designed to make inferences about unobserved latent classes based on observed item responses. A heuristic for test construction based on the CDM information index proposed by Henson and Douglas has a far-reaching impact, but there are still many shortcomings. He and other researchers had also proposed new methods to improve or overcome the inherent shortcomings of the CDI test assembly method. In this study, one test assembly method of maximizing the minimum (...) inter-class distance is proposed by using mixed-integer linear programming, which aims to overcome the shortcomings that the CDI method is limited to summarize the discriminating power of each item into a single CDI index while neglecting the discriminating power for each pair of latent classes. The simulation results show that compared with the CDI test assembly and random test assembly, the new test assembly method performs well and has the highest accuracy rate in terms of pattern and attributes correct classification rates. Although the accuracy rate of the new method is not very high under item constraints, it is still higher than the CDI test assembly with the same constraints. (shrink)

Each Olympic Games will provide new material for research in the field of sports philosophy and social philosophy. This article raises the problem of understanding sports as a participant in social development on the example of the 2022 Winter Olympics in Beijing. The author analyzes the phenomenon of combining the philosophy of social sports, represented by the modern Olympic movement, and traditional Chinese philosophy. The main conclusion is that sport, as a social force, is reborn in the modern era due (...) to the combination of Eastern and Western cultures and civilizations. This gives rise to new social cognition. The leadership of the countries hosting the Olympic Games gain experience and the opportunity to demonstrate their own political and economic strength and deep mental foundations. The Beijing 2022 Winter Olympics, taking place in a completely new societal environment (COVID-19 pandemic, world power realignment) is used as a case study for analysis. Using this example, the article shows the social significance of the Olympic Games and emphasizes that the social value of sports and the Olympic movement is reflected in the "spirit of fair competition" and the "spirit of peace", "human intelligence". This is a relatively new direction in the development of research in the field of physical education and social philosophy, and the special contribution of this study is to study one of the promising trends in the development of sports, that is, the modern Olympic movement, integrated with the national culture of different countries. (shrink)

This article analyses implementation of freedom of assembly within Lithuania and in some other States of the European Union. Attention is paid to the differences in the implementation practices for this freedom while analysing probability of restriction of freedom of assembly in the light of legal, political and social factors. The article aims to substantiate that the quality of decision while adopting spreading ideas and expressed views during peaceful meetings, or adopting them later, or dismissing in general, is (...) determined by the democratic society being formed in the state during a particular period. On the other hand, although physical restriction of diffusion of ideas while implementing freedom of assembly is legitimate, it should not become the main control tool, since the development of the state in this direction is absolutely opposite to the expansion of democratic ideas in the society. Legal education should become the priority area of the policy conducted by the state. Particularly since this priority provides the security for the spread of best practices in democratic states, thus laying the grounds for effective prevention of expression of illegal behaviour. Such illegal behaviour may occur in the form of incitement of hatred and aggression in respect of persons who have different faith, race, nation or sexual orientation. The article substantiates that the real challenge faced by the modern democracy is security for practical implementation rather than the formal recognition and regulation of rights and freedoms. It has been found in practice that the implementation of freedom of assembly can be faulty restricted by the procedural justice. After evaluating experience of the States of the European Union and the way in which their national legal system is structured, the recommendations are made enabling a timely dispute settlement concerning the right of assembly, i.e., in order to prevent decision making process from becoming an obstacle for the implementation of freedom of assembly. It is pointed out that settlement of the dispute concerning the permission to hold a peaceful assembly after the date of the assembly is pointless and denies social importance of right of the assembly. (shrink)

Citizen assemblies hold out the promise of reviving democracy. However, the ways that they are currently conceptualised and organised limits their egalitarian appeal.

The assembly of intermediate filaments is a fundamental property of the central rod domain of the individual subunit proteins. This rod domain, with its high propensity for α‐helix formation, is the common and identifying feature of this family of proteins. Assembly occurs in vitro in the absence of other proteins or exogenous sources of energy; in vivo, it appears as if other factors, as yet poorly understood, modulate the assembly of intermediate filaments. Parallel, in‐register dimers form via (...) coiled‐coil interactions of the rod domain. Tetramers may form from staggered arrays of parallel or antiparallel arrangements of dimers. Higher‐order polymerization, which occurs spontaneously if the ionic strength of a mixture of dimers and tetramers is raised, proceeds rapidly through poorly described intermediates to the final 10 nm filament. This process is dependent on and modulated by the non‐α‐helical end domains, as well as those amino acids present at the very beginning and end of the rod domain. The interactions governing tetramer formation are most probably the same ones that are responsible for the lateral and longitudinal associations within intermediate filaments. (shrink)

The assembly of nucleosomes and higher‐order chromatin structures has been extensively studied in vitro. Provided that non‐specific charge interactions are controlled, all the information for correct assembly is found to be inherent in the macromolecular components. Cellular extracts which can assemble chromatin in vitro with nucleosomes correctly spaced on the DNA have been studied in detail and also used to investigate the role of chromatin structure in transcription. However, the mechanisms of chromatin assembly in vivo are still (...) controversial. (shrink)

Rosario, Argentina, a city of more than one million people strategically located on the Paraná River in the heart of a fertile agricultural region, is home to a significant industrial corridor where ongoing urbanization for industry, including that associated with the port complex and agroexport industries, vies for real estate space with peri-urban and urban farming production. The city is also the site of thriving municipal programs seeking to change food production and consumption outcomes through urban and peri-urban agriculture projects (...) rooted in agroecology. This paper identifies the socio-natures critical for the formation and endurance of these agroecology assemblages. Based on interviews with 30 stakeholders in government, civil society, and agricultural production, we describe the integrated approach to environmental, social, and economic sustainability embedded in Rosario’s institutional agroecology programs. In particular, we discuss the actors and strategies, discursive renderings of socio-natures, and the marketing of agroecological materialities that form and are formed by these assemblages. We also discuss the power dynamics embedded in sustaining urban and peri-urban agroecological projects through institutional means. This research contributes to literature on agroecology, urban agriculture, and the urban metabolism through providing empirical examples of socio-natural entanglements in urban agroecological assemblages. (shrink)

The universal attempt to link computers by means of business process reengineering, enterprise integration, and the management of technology is creating large systems that structure and control the flows of information within institutions. Human work associated with these systems must be reorganized in the image of these technologies. The transformation of office work now parallels that of factory work as a result of the intellectual assembly line: Each so-called knowledge worker adds and transforms information in a manner almost entirely (...) prescribed by the system, which, in turn, takes this information to the next work station and so on. The result is a loss of control coupled with growing demands and a new kind of organizational structure. It would appear that the implications for human health are possibly even greater than those associated with traditional assembly-line work. (shrink)

Holistically ignited Hebbian models are fundamentally different from the serially organized connectionist implementations of language. This may be important for the recovery of language after injury, because connectionist models have provided useful insights into recovery of some cognitive functions. I ask whether cell assembly modelling can make an important contribution and whether the apparent incompatibility with successful connectionist modelling is a problem.

Endogenous depression is highly correlated with low levels of serotonin in the central nervous system. Does this imply or suggest that this sort of depression just is this neurochemical deficit? Scorning such an inference, Antonio Damasio writes:If feeling happy or sad … corresponds in part to the cognitive modes under which your thoughts are operating, then the explanation also requires that the chemical acts on the circuits which generate and manipulate [such thoughts]. Which means that reducing depression to a statement (...) about the availability of serotonin or norepinephrine in general- a popular statement in the days and age of Prozac- is unacceptably rude.Damasio's thought is that depression is essentially a modification of how we perceive the world, reason about it, and make decisions about how to act in it - in other words, that it is essentially cognitive. A reduced level of serotonin might cause the said modification, but no adequate account of depression would identify the malady with its cause. A proper account would minimally need to say how cognitive processing is affected by a reduced level of serotonin. (shrink)

The term ‘food security’ has been used in multiple ways and addresses not only issues around availability and accessibility of foods, but also, among others, the sustainability of livelihoods at the local community level—an issue often seen as a basis for the proliferation of local and alternative food networks. Accordingly, in this paper we attempt to develop a theoretical re-framing that is able to link food security with AFNs in arguing that the understanding of the two notions is dynamics and (...) contingent upon the elements that construct them. We use an assemblage approach to analyze a case of Dunedin, a small-size city in New Zealand, in which the community aims to achieve food security through a local food strategy. Through a series of interviews with a group of food activists and academics, public discussions, and two local food forums, we found that food security was understood and performed in its local context through assembling diverse actors and objectives within the AFN. In conclusion, we offer assemblage thinking as an analytical tool to understand how seemingly precarious local food relations are stabilized and assembled so as to open possibilities of achieving food security. (shrink)

What makes any investigative field a scientific discipline? This article argues that disciplines are ever-changing frameworks within which scientific activity is organised. Moreover, disciplinarity is not a yes or no proposition: scientific activities may achieve degrees of identity development. Degree of consensus is the key, and consensus on many questions (conceptual, methodological, institutional, and social) varies among sciences. Lastly, disciplinary development is non-teleological. Disciplines pass through no regular stages on their way from immature to mature status, designations articulated within the (...) rhetoric of discipline formation. Scientists assemble disciplines using many elements: phenomena, methods, instruments, theories, analytical techniques, and institutional tools such as journals, government bureaus, and university positions. Scientists created geophysics during the nineteenth and twentieth centuries through such a combination. Whether geophysics became a discipline depends on how discipline is defined. (shrink)

Hebbian cell-assembly theory and attractor networks are good starting points for modeling cortical processing. Detailed cell models can be useful in understanding the dynamics of attractor networks. Cell assemblies are likely to be distributed, with the cortical column as the local processing unit. Synaptic memory may be dominant in all but the first couple of seconds.

This contribution to the Common Knowledge symposium “Fuzzy Studies” reports on the rise of the “popular assemblies” movement that swept the streets of Madrid in the wake of the May 15, 2011, occupation of Puerta del Sol. Assemblies have since taken installation in public spaces as infrastructural with significant methodological implications. Their incorporation into the cityscape has demanded of participants an inventive deployment of techniques and tactics drawn from archival practices and practices of hospitality, as well as the development of (...) varieties of urban hardware. The “fuzz” or mess of the assembly — the difficulties that participants have at putting together, let alone understanding, the assembly as an urban form — offers a valuable perspective on present-day discussions concerning the city as an object of political claims and rights. (shrink)

Newton Garver - Assembling Reminders: Studies in the Genesis of Wittgenstein's Concept of Philosophy - Journal of the History of Philosophy 45:4 Journal of the History of Philosophy 45.4 671-672 Muse Search Journals This Journal Contents Reviewed by Newton Garver University at Buffalo Alan Janik. Assembling Reminders: Studies in the Genesis of Wittgenstein's Concept of Philosophy. Stockholm: Santérus Academic Press, 2006. Pp. 246. Paper, $40.00. Janik's book is a wonderful achievement, filling an obvious and long-neglected gap in Wittgenstein scholarship. The (...) plan of the book is simple and straightforward. Citing the well-known passage in Culture and Value where Wittgenstein identifies ten persons from whom he has taken seminal ideas for his work of clarification, Janik clarifies how each contributed to the development of.. (shrink)

Myosin self‐assembly is generally considered to be the major process in thick filament formation within striated muscles. The biological assembly of myosin into thick filaments is being analysed by genetic dissection as well as biochemical and morphological experiments in the nematode Caenorhabditis elegans. This work shows that the assembly of myosin is modulated by its biosynthesis and interaction with non‐myosin proteins. Assemblages which generate multiple nascent thick filaments may play a central role in a catalytic cycle of (...) myosin assembly. (shrink)

In this paper we make the case for the emergence of novel kind of bias with the use of algorithmic decision-making systems. We argue that the distinctive generative process of feature creation, characteristic of machine learning (ML), contorts feature parameters in ways that can lead to emerging feature spaces that encode novel algorithmic bias involving already marginalized groups. We term this bias _assembled bias._ Moreover, assembled biases are distinct from the much-discussed algorithmic bias, both in source (training data versus feature (...) creation) and in content (mimics of extant societal bias versus reconfigured categories). As such, this problem is distinct from issues arising from bias-encoding training feature sets or proxy features. Assembled bias is not epistemically transparent in source or content. Hence, when these ML models are used as a basis for decision-making in social contexts, algorithmic fairness concerns are compounded. (shrink)

Basement membranes are thin sheets of extracellular proteins situated in close contact with cells at various locations in the body. They have a great influence on tissue compartmentalization and cellular phenotypes from early embryonic development onwards. The major constituents of all basement membranes are collagen IV and laminin, which both exist as multiple isoforms and each form a huge irregular network by self assembly. These networks are connected by nidogen, which also binds to several other components (proteoglycans, fibulins). Basement (...) membranes are connected to cells by several receptors of the integrin family, which bind preferentially to laminins and collagen IV, and via some lectin‐type interactions. The formation of basement membranes requires cooperation between different cell types since nidogen, for example, is usually synthesized by cells other than those exposed to the basement membranes. Thus many molecular interactions, of variable affinities, determine the final shape of basement membranes and their preferred subanatomical localization. (shrink)

Cell proliferation in response to growth factors is mediated by specific high affinity receptors. Ligand‐binding by receptors of the protein tyrosine kinase family results in the stimulation of several intracellular signal transduction pathways. Key signalling enzymes are recruited to the plasma membrane through the formation of stable complexes with activated receptors. These interactions are mediated by the conserved, non‐catalytic SH2 domains present in the signalling molecules, which bind with high affinity and specificity to tyrosine‐phosphorylated sequences on the receptors. The (...) class='Hi'>assembly of enzyme complexes is emerging as a major mechanism of signal transduction and may regulate the pleiotropic effects of growth factors. (shrink)

Assemblies of God church in Nigeria, which has for over 40 years now, experienced various crises that have led to sucession and factionalism in that church. The once giant of spirituality and the mother of Pentecostalism has grappled with the problem of administration, leadership tussle and bigotry. This study is a review of previous and current crises that AG Nigeria has gone through at the General Council level in a bid to mend what seems to have torn asunder the seamless (...) coat of Christ in line with the prayer of Jesus, ‘that they may be one’. The study uses historical-critical method and phenomenological design to analyse the depth of the crack in the church in order to predict the future of Pentecostalism in Nigeria. Contribution: To chronicle the crises in Assemblies of God Nigeria through a study of current and past patterns of events with a view to recommending possible solutions. (shrink)